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GOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer

World Journal of Clinical Oncology 2022年第4期13卷 237-266页

作者： Nuria Rodriguez De Dios Arturo Navarro-Martin Cristina Cigarral Rodolfo Chicas-Sett Rafael garcia virginia garcia Jose Antonio Gonzalez Susana Gonzalo Mauricio Murcia-Mejia Rogelio Robaina Amalia Sotoca Carmen Vallejo German Valtuena Felipe Counago Department of Radiation Oncology Hospital del MarBarcelona 08003Spain Radiation Oncology Research Group Hospital Del Mar Medical Research InstitutionBarcelona 08003Spain Department of Experimental and Health Sciences Pompeu Fabra UniversityBarcelona 08003Spain Department of Radiation Oncology Thoracic Malignancies UnitHospital Duran i Reynals.ICOL´Hospitalet de LLobregat 08908Spain Department of Radiation Oncology Hospital Clinico de SalamancaSalamanca 37007Spain Department of Radiation Oncology ASCIRES Grupo BiomedicoValencia 46004Spain Department of Radiation Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario Arnau de VilanovaLleida 25198Spain Department of Radiation Oncology Genesis Care-SpainSevilla 41092Spain Department of Radiation Oncology Hospital Universitario La PrincesaMadrid 28006Spain Department of Radiation Oncology Hospital Universitario Sant Joan de ReusReus 43204TarragonaSpain Department of Radiation Oncology Hospital Universitario Ramon y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Clinico Universitario Lozano BlesaZaragoza 50009Spain Department of Radiation Oncology Hospital Universitario QuirónsaludMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Department of Clinical Universidad EuropeaMadrid 28670Spain

Non-small cell lung cancer(NSCLC) is a heterogeneous disease accounting for approximately 85% of all lung cancers. Only 17% of patients are diagnosed at an early stage. Treatment is multidisciplinary and radiotherapy plays a key role in all stages of the disease. More than 50% of patients with NSCLC are treated with radiotherapy(curative-intent or palliative). Technological advancesincluding highly conformal radiotherapy techniques, new immobilization and respiratory control systems, and precision image verification systems-allow clinicians to individualize treatment to maximize tumor control while minimizing treatment-related toxicity. Novel therapeutic regimens such as moderate hypofractionation and advanced techniques such as stereotactic body radiotherapy(SBRT) have reduced the number of radiotherapy sessions. The integration of SBRT into routine clinical practice has radically altered treatment of early-stage disease. SBRT also plays an increasingly important role in oligometastatic disease. The aim of the present guidelines is to review the role of radiotherapy in the treatment of localized, locally-advanced, and metastatic NSCLC. We review the main radiotherapy techniques and clarify the role of radiotherapy in routine clinical practice. These guidelines are based on the best available evidence. The level and grade of evidence supporting each recommendation is provided.

关键词： Radiotherapy Non-small cell lung cancer Guidelines Stereotactic radiation therapy Hypofractionated radiation Oligometastasis

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Determination of Perillic Acid in Bioconversion Supernatants by Gas Chromatography

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American Journal of Analytical Chemistry 2017年第10期8卷 636-644页

作者： Eliane G. Carvalho Antonio C. Siani Igor C. Cardoso virginia garcia Correia Maria A. Ferrara Elba P. S. Bon Marcelo R. Romero Tappin Medicine and Drug Technology Institute Oswaldo Cruz Foundation Rio de Janeiro Brazil Chemistry Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil

Perillic acid can be obtained from microbial oxidation of the exocyclic methyl group of limonene. Due to the pharmacological potential of such a metabolite, the biotransformation processes leading to its synthesis have been approached in recent studies. A robust analytical method is needed to assess the performance of such studies. An analytical method was developed and validated to determine perillic acid in the supernatants of a yeast-induced bioconversion of limonene, involving gas chromatography (GC) and an acid-induced precipitation during the sample preparation. GC analysis was performed using a column with polyethylene glycol as stationary phase (HP-Innowax) which resulted in higher loads and better peak shape. The sample preparation involved the supernatant initial filtration and precipitation with 0.6 M HCl followed by centrifugation and dissolution in ethyl acetate. GC analysis conditions were oven from 50°C to 250°C at 20°C·min-1, and then held 5 min (total runtime 15 min). Injector was set at 280°C, and detector at 300°C. Helium was the carrier gas at 1 ml·min-1. Injections of 1.0 μl were at the split ratio 25:1. The method was validated: Linearity with R2 of 0.9992, Accuracy of 98.3% in the range 190 - 950 μg·ml-1;Limit of detection of 10.4 μg·ml-1;Repeatability of 2.1% RSD. Thus, a complete methodology to determine perillic acid in a bioconversion supernatant was developed and validated. This overall approach may be useful for bioconversions of monoterpenes by other microorganisms that metabolize limonene.

关键词： Limonene Perillic Acid Sample Preparation Gas Chromatography

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HYPHENATED LIQUID PHASE-MASS SPECTROMETRIC TECHNIQUES FOR METABOLOMIC STUDIES OF ANTICANCER ACTIVITY OF DIETARY POLYPHENOLS. THE LONG WAY TO A GLOBAL FOODOMICS APPROACH

HYPHENATED LIQUID PHASE-MASS SPECTROMETRIC TECHNIQUES FOR ME...

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第十四届北京分析测试学术报告会暨展览会(BCEIA 2011)

作者： Carolina SIMO Clara IBA?EZ virginia garcia-CA?AS Alberto VALDES Miguel HERRERO Lourdes ROCAMORA-REVERTE Elena IBA?EZ Jose A.FERRAGUT Alejandro CIFUENTES Laboratory of Foodomics CIAL (CSIC) Institute of Molecular and Cellular Biology Miguel Hernandez University

Currently,advanced"omics"tools and bioinformatics are being applied in food science and nutrition together with in-vitro,in-vivo and/or clinical assays to investigate topics unapproachable few years *** this context,o...

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Eosinophilic esophagitis in patients with esophageal atresia and chronic dysphagia

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World Journal of Gastroenterology 2014年第47期20卷 18038-18043页

作者： Sirvart Kassabian virginia Baez-Socorro Thomas Sferra Reinaldo garcia Department of Pediatric Gastroenterology Nutrition and HepatologyAkron Children’s HospitalAkronOH 44308United States Division of Pediatric Gastroenterology Nutrition and HepatologyRainbow Babies and Children’s HospitalClevelandOH 44106United States

Esophageal atresia(EA)is defined as a discontinuity of the lumen of the esophagus repaired soon after *** is a common symptom in these patients,usually related to stricture,dysmotility or peptic *** present 4 cases of patients with EA who complained of dysphagia and the diagnosis of Eosinophilic esophagitis(Eo E)was made,ages ranging from9 to 16 *** our patients were on acid suppression years after their EA repair,they presented with acute worsening of *** and/or barium swallow did not show stricture and biopsies revealed elevated eosinophil counts consistent with Eo *** of 4 patients improved symptomatically with the topical *** is important to note that all our patients have asthma and 3 out of 4 have tested positive for food *** of our patients developed recurrent anastomotic strictures that improved with the treatment of the Eo E.A previous case report linked the recurrence of esophageal strictures in patients with EA repair with Eo *** the Eo E was treated the strictures *** the other hand,based on our observation,Eo E could be present in patients without recurrent anastomotic *** appears to be a spectrum in the disease *** are suggesting that Eo E is a frequent concomitant problem in patients with history of congenital esophageal deformities,and for this reason any of these patients with refractory reflux symptoms or dysphagia(with or without anastomotic stricture)may benefit from an endoscopic evaluation with biopsies to rule out Eo E.

关键词： Eosinophilic esophagitis Esophageal atresia Tracheoesophageal fistula Dysphagia

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Barriers and facilitators to mexican-american participation in clinical trials: physician and patient focus group perspectives

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Health 2010年第7期2卷 742-752页

作者： Jesse Nodora Tomas Nuno Ken O’Day virginia Yrun Francisco garcia National Center of Excellence in Women’s Health and the Arizona Cancer Center University of ArizonaTucsonUSA National Center of Excellence in Women’s Health and the Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Xcenda Palm HarborUSA

Racial/ethnic minority populations are under- represented in clinical trials and Hispanic participation rates are particularly low. This study assessed barriers and facilitators to clinical trials participation by Medicaid eligible Mexican- Americans and their serving physicians. Qualitative data from two focus groups conducted among Mexican-American Medicaid eligible patients and four physician focus groups were analyzed. Mexican-American patients have a basic understanding of clinical trials. While most are open to participating in clinical research, not speaking English, time, and transportation were identified as barriers. Physicians believe that desperation and financial need are the primary patient motivators for participation. Barriers to physician recruitment and referral include: lack of information about clinical trials, concern that study participation may not be in the patient’s best interest, and lack of staffing and time to conduct trials. Ample opportunities exist to engage providers and patients in future efforts to increase Mexican-American patient recruitment into clinical trials.

关键词： Clinical Trials Participation Mexican-American Hispanic Medicaid Patients Medicaid Physicians Focus Groups Qualitative Methods

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Grasshoppers Sphenarium Purpurascens Ch Source of Proteins and Essential Amino Acids

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Journal of Chemistry and Chemical Engineering 2015年第7期9卷 472-476页

作者： Melo-Ruiz virginia Quirino-Barreda Tomas garcia-Nunez Maritza Diaz-garcia Rafael Sanchez-Herrera Karina Schettino-Bermudez Beatriz Departament of Biological Systems Universidad Autonoma Metropolitana-Xochimilco Mexico D. F. 04960 Mexico

Protein malnutrition is quite common worldwide; its deficiency has adverse effects in all organs. Edible insect＇s traditional cultural food, commonly consumed in rural communities, now intake is also being incorporated in some countries. Grasshoppers comprise proteins, the building blocks of AA （amino acids）, that are one of the five classes of complex biomolecules found in cells and tissues that play an important role in human metabolism and nutrition. This research was conducted to determine proximal composition of Sphenarium purpurascens Ch, grasshoppers, focused on proteins and AA. Sampling was performed during autumn, 2013, in Oaxaca State. Dry raw adult insects were ground and proceeded to macro molecules proximal analysis, protein by Kjeldahl AOAC （Association of Official Analytical Chemists） method and essential AA in a Beckman 6300 equipment. Obtained data were： total proteins 71.56%; lipids 8.14%; minerals 3.52%; fiber 7.48%; soluble carbohydrates 9.30%. Essential AA （mg/16 g-N）： isoleucine 4.5; leucine 8.1; lysine 5.4; methionine ＋ cysteine 5.1; phenylalanine ＋ tyrosine 8.5; threonine 3.5; tryptophan 0.6; valine 5.5. Sphenarium purpurascens Ch, Grasshoppers represent a good source of proteins and essential AA that can grow almost everywhere, available mostly all year round and affordable to all social groups, thus being a good option to improve human health.

关键词： Proteins essential AA nutrition grasshoppers Sphenarium purpurascen.

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Macronutrient Composition of Giant Water Bug （Lethocerus sp.） Edible Insect in Mexico and Thailand

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Journal of Agricultural Science and Technology(A) 2016年第5期6卷 349-354页

作者： virginia Melo-Ruiz Consuelo Moreno-Bonett Karina Sanchez-Herrera Rafael Diaz-garcia Cesar Gazga-Urioste Department of Biologic Systems Metropolitan Autonomous University Mexico City 04960 Mexico Department of Health Care Metropolitan Autonomous University Mexico City 04960 exico

The health benefits of nutrients provided by edible insects are not properly studied, even though insect intake in LatinAmerican and Asia is a cultural tradition since ancient times. Insects from the giant water bug （Belostomidae family） are consumedboth in Mexico and Thailand, and are known as ＂Cucarachon de agua＂（Lethocerus americanus） and ＂Mangda＂（Lethocerus indicus）,respectively. Raw samples of these insects were collected on 2014 at Xochimilco channels from Mexico and from Warorot nightmarket in Chiang Mai, Thailand to further analyze nutrient composition of samples according to official methods of analysis （AOAC）techniques. The nutrient compositions were as following： proteins 60.12% and 53.11%; lipids 5.72% and 8.15%; minerals 5.46% and6.75%; fiber 10.95 % and 12.23%; soluble carbohydrates 17.75% and 19.74%, for insects obtained from Mexico and Thailand,respectively. Giant water bug shows differences in nutrient composition. It may be the consequence of differences in the environmentwhere they acquire the nutrients necessary for growth and reproduction. However, giant water bugs are available all year around andare a good source of proteins that could help people to obtain a cheaper source of this important macronutrient.

关键词： Giant water bug, edible insect, nutrition, health, nutraceutical.

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Iron Profile of Octopus Hubbsorum （Cephalopoda： Octopodidae） for Enrichment of the Mexican Diet

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Journal of Chemistry and Chemical Engineering 2016年第5期10卷 241-244页

作者： Palacios-Abrantes Juliano Melo-Ruiz virginia Diaz-garcia Rafael Gazga-Urioste Cesar Urbano Brian Departamento de Sistemas Biologicos Universidad Autonoma Metropolitana Unidad Xoehimilco. Calzada del hueso 1100 Col. Villa Quietud Delegacion Coyoacan C.P. 04960 D.F. MExico Laboratorio de Malacologia Instituto de Ciencias del mary Limnologia Universidad Nacional Aut6noma de Mdxico. Exterior s/nCiudad Universitaria Coyoacan 04510 Ciudad de D.F. Mexico

FAO （Food and Agriculture Organization of the United Nations） declared that 12% of the world＇s population is undernourished while in Mexico the number is around 5%. Minerals are essential for the daily diet; iron （Fe） is an important mineral on human welfare because it has a main role on the function of the immune and central nervous systems, among others. Most Mexicans fulfill their iron requirements from vegetables, which are poorly absorbed; nevertheless, in coastal populations, where seafood-rich in ironis available, it is not consumed on a regular diet. The aim of this work was to analyze minerals, focusing on the iron content of Octopus hubbsorum B （Cephalopoda： Octopodidae）, an animal of the Mexican Pacific coast. Three specimens were analyzed, two from the north and one from central Pacific Ocean. Data obtained for the central Pacific Octopus was 0.008% and data for the North Pacific were 0.008% and 0.011%, repectively. In conclusion, the supply of iron for the Mexican diet provided by Octopus hubbsorum B is significant, therefore is recommended to consume more of this resource, to diminish iron deficiency, a world-wide problem, and to improve human health.

关键词： Iron Mexico octopus nutrition food security.

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Chia Seeds （Salvia hispanica L） Wild Plant Rich in Nutrients

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Journal of Life Sciences 2016年第5期10卷 221-227页

作者： virginia Melo-Ruiz Beatriz Schettino-Bermudez Jesris Rodriguez-Diego Rafael Diaz-garcia ConcepcionCalvo-Carrillo Cesar Gazga-Urioste Biologic Systems Department Metropolitan Autonomous University Mexico City 04960 Mexico Agricultural and Animal Production Department Metropolitan Autonomous University Mexico City 04960 Mexico Health Care Department Metropolitan Autonomous University Mexico City 04960 Mexico

Chia seeds played an important role in different ethnic group＇s diet at pre-Hispanic times. Later, it was domesticated due to high demand by the population and nowadays it＇s cultivated in several states of Mexico. However, seeds are not part of the Mexican average diet. The aim of this research was to asses Chia seed＇s macronutrients and promote consumption among population to decrease malnutrition. Chia seeds were collected at Puebla State （2015） and analyzed according to AOAC [1] methods. Data obtained （g/100 g dry basis） were： proteins 18.51%; lipids 31.33%; minerals 4.45%; fiber 24.45%; soluble carbohydrates 21.38%. Chia seeds absorb water about ten times its weight, is gluten free and contain a good amount of proteins, indispensable for human life In addition, Chia seeds have a balanced amount of polyunsaturated essential lipids, which are important for brain function, minerals, fiber and soluble carbohydrates. Chia seeds are available all year and are well accepted by all social groups, therefore it could be a good option to improve human health.

关键词： Chia seeds nutraceutic benefits nutritional plant.

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Nutraceutical Effect of Cuetlas （Arsenura armida C.） Edible Insects as Local Food at Ixcaquixtla, Mexico

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Journal of Agricultural Science and Technology(A) 2016年第6期6卷 423-428页

作者： virginia Melo-Ruiz Tomas Quirino-Barreda Susana Macin-Cabrera Karina Sanchez-Herrera Rafael Diaz-garcia Cesar Gazga-Urioste Department of Biologic Systems Metropolitan Autonomous University Mexico City PC 04960 Mexico Department of Health Care Metropolitan Autonomous University Mexico City PC 04960 Mexico

Insect＇s nutrient composition may provide a good source of macro- and micro-nutrients with nutraceutical functions that could help people from semirural areas, such as Ixcaquixtla, located southeast of the Puebla State, Mexico. The aim of this study was to assess macro- and micro-nutrients in Cuetlas （Arsenura armada C.） larvae and inform local people about the nutraceutical benefits that those insects could provide. Cuetlas larvae samples were collected from Jonote tree on August, 2014 to analyze minerals and macro-nutrient of raw larvae according to AOAC （1995） techniques. Results showed that Cuetlas larvae contained 56.93% proteins, 14.76% lipids, 2.95% minerals, 2.13% fiber and 23.23% soluble carbohydrates. Cuetlas larvae have a good amount of proteins, essential macromolecules for human life as well as essential fatty acids that are important sources of fuel for brain cells and in particular for cardiac and skeletal muscle, minerals, not determined individually, which are important for metabolism processes, fiber for digestive processes and soluble carbohydrates as energy source.

关键词： Cuetlas edible insects nutrition health nutraceutical.

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