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Belatacept in renal transplantation in comparison to tacrolimus and molecular understanding of resistance pattern:Meta-analysis and systematic review

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World Journal of Transplantation 2021年第3期11卷 70-86页

作者： Jayant Kumar Isabella Reccia Francesco virdis Mauro Podda Ajay Kumar Sharma Ahmed Halawa Department of Cancer and Surgery Imperial CollegeLondon W120HSUnited Kingdom Department of Emergency General Surgery Royal Free HospitalLondon NW32QGUnited Kingdom Department of Surgery GeneralEmergency and Robotic Surgical UnitSan Francesco HospitalNuoro 08100Italy Department of Transplantation Royal Liverpool University HospitalLiverpool L78XPUnited Kingdom Department of Surgery Sheffield Teaching HospitalsSheffield S102JFUnited Kingdom

BACKGROUND The T-cell costimulation blocking agent belatacept has been identified as a possible substitute for calcineurin inhibitors,however,no consensus has been established against its use over the standard care agent *** To evaluate the effectiveness of belatacept based maintenance immunosuppressive regimens in comparison to tacrolimus in renal *** We did extensive search of all the available literature comparing the role of belatacept to tacrolimus in renal transplant recipients by searching the PubMed,Embase,Cochrane,Crossref,Scopus,clinical trials registry on October 5,*** The literature search identified four randomized controlled trials(n=173 participants)comparing belatacept with *** was no significant difference in estimated renal function at 12 mo[mean difference 4.12 mL/min/1.73 m^(2),confidence interval(CI):-2.18 to 10.42,P=0.20].Further,belatacept group was associated with significant increase in biopsy proven acute rejection[relative risk(RR)=3.27,CI:0.88 to 12.11,P=0.08]and worse 12 mo allograft survival(RR=4.51,CI:1.23 to 16.58,P=0.02).However,incidence of new onset diabetes mellitus was lower with belatacept at 12 mo(RR=0.26,CI:0.07 to 0.99,P=0.05).CONCLUSION The evidence reviewed in this meta-analysis suggested that belatacept-based maintenance immunosuppression regimens were associated with an increased risk allograft loss in renal transplant recipients with equivalent renal functioning against standard tacrolimus;however,observed significantly reduced new onset diabetes mellitus after transplantation incidence and lower serum low density lipid profile levels in belatacept *** addition,the adaptation of belatacept in renal transplantation has been forestalled by increased rates of rejection and resistance owing to development of various effector memory T cells through,parallel differentiation and immunological plasticity.

关键词： Adverse events Calcineurin inhibitors Belatacept Tacrolimus Graft failure Kidney transplantation

Hemophagocytic lymphohistiocytosis caused by primary Epstein-Barr virus in patient with Crohn's disease

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World Journal of Gastrointestinal Surgery 2013年第11期5卷 306-308页

作者： Francesco virdis Sara Tacci Federico Messina Massimo Varcada Department of Emergency General Surgery Royal Free HospitalLondonGreater London NW3 2QGUnited Kingdom

We present a case of a 19-year-old man with a 6-year history of Crohn's disease(CD), previously treated with 6-mercaptopurine, who was admitted to our department for Epstein-Barr virus(EBV) infection and subsequently developed a hemophagocytic lymphohistiocytosis(HLH). HLH is a rare disease which causes phagocytosis of all bone marrow derived cells. It can be a primary form as a autosomic recessive disease, or a secondary form associated with a variety of infections; EBV is the most common, the one with poorer prognosis. The incidence of lymphoproliferative disorders was increased in patients with inflammatory bowel disease(IBD) treated with thiopurines. Specific EBV-related clinical and virological management should be considered when treating a patient with IBD with immunosuppressive therapy. Moreover EBV infection in immunosuppressed patient can occur with more aggressive forms such as encephalitis and diffuse large B cell lymphoma. Our case confirms what is described in the literature; patients with IBD, particularly patients with CD receiving thiopurine therapy, who present 5 d of fever and cervical lymphadenopathy or previous evidence of lymphopenia should be screened for HLH.

关键词： Crohn’s disease Hemophagocytic lymphohistiocytosis Epstein-Barr virus infection Immunosupressive therapy Thiopurines

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迈米西62 新工作室

建筑技术及设计 2007年第10期 18-23页

作者： Davide virdis

新的MIMESI62建筑设计工作室是由一个废弃的木料加工厂改建而成，这座建筑有着20世纪初木料加工厂的一些典型特点，比如隆起的屋顶，下嵌的拱形窗，所有建筑元素都是对称的。

关键词：设计工作室建筑元素加工厂木料改建屋顶

Clinical outcomes of non-operative management and clinical observation in non-angioembolised hepatic trauma: A systematic review of the literature

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Chinese Journal of Traumatology 2022年第5期25卷 257-263页

作者： Francesco virdis Mauro Podda Salomone Di Saverio Jayant Kumar Roberto Bini Carlos Pilasi Isabella Reccia Trauma and Acute Care Surgery Unit Ospedale NiguardaMilano20162Italy General and Emergency Surgery Policlinico Universitario di MonserratoCagliari0910 Italy General and Endocrine Surgery Ospedaledi CircoloFondazione MacchiVarese21100 Italy Abdominal Transplantation Surgery University of ChicagoChicago5801USA General and Trauma Surgery San Juan de Dios HospitalSantiago8350488Chile Haepato-Biliary-Pancreatic Uni Hammersmith Hospital Imperial CllegeLondonW120TSUK

Purpose: Liver is the most frequently injured organ in abdominal trauma. Today non-operative management (NOM) is considered as the standard of care in hemodynamically stable patients, with or without the adjunct of angioembolisation (AE). This systematic review assesses the incidence of complications in patients who sustained liver injuries and were treated with simple clinical observation. Given the differences in indications of treatment and severity of liver trauma and acknowledging the limitations of this study, an analysis of the results has been done in reference to the complications in patients who were treated with AE. Methods: A systematic literature review searched "liver trauma" , "hepatic trauma" , "conservative management" , "non operative management" on MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials databases, EMBASE, and Google Scholar, to identify studies published on the conservative management of traumatic liver injuries between January 1990 and June 2020. Patients with traumatic liver injuries (blunt and penetrating) treated by NOM, described at least one outcome of interests and provided morbidity outcomes from NOM were included in this study. Studies reported the outcome of NOM without separating liver from other solid organs;studies reported NOM complications together with those post-intervention;case reports;studies including less than 5 cases;studies not written in English;and studies including patients who had NOM with AE as primary management were excluded. Efficacy of NOM and overall morbidity and mortality were assessed, the specific causes of morbidity were investigated, and the American Association for the Surgery of Trauma classification was used in all the studies analysed. Statistical significance has been calculated using the Chi-square test. Results: A total of 19 studies qualified for inclusion criteria were in this review. The NOM success rate ranged from 85% to 99%. The most commonly reported complications

关键词： Liver Trauma Non-operative management Angioembolization

性别对健康青少年由隐蔽性高血压发展为高血压的影响

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中华高血压杂志 2013年第7期21卷 699-699页

作者： virdis a Bacca A Colucci R Duranti E Fornai M Materaz-zi G Ippolito C Bernardini N Blandizzi C Bernini G Taddei S 刘莉叶鹏

健康青少年由隐蔽性高血压（动态血压升高但常规测量血压正常）发展成高血压相关的危险因素尚未确定。该研究为一项长期随访研究，旨在评估伴有隐蔽性高血压的健康青少年随时间变化高血压的发生发展情况，分析性别对高血压发病率和发病... 详细信息

健康青少年由隐蔽性高血压（动态血压升高但常规测量血压正常）发展成高血压相关的危险因素尚未确定。该研究为一项长期随访研究，旨在评估伴有隐蔽性高血压的健康青少年随时间变化高血压的发生发展情况，分析性别对高血压发病率和发病时间的影响。方法：随访时间中位数为36月，总共纳人常规测量血压正常的健康青少年272名（6～18岁，55．8％为女性），其中39名在基线时伴有隐蔽性高血压。

关键词：健康青少年高血压隐蔽性性别血压正常危险因素血压升高随访研究

预测20年总死亡与心血管病死亡风险增加的尿酸阈值

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中华高血压杂志 2020年第1期28卷 99-99页

作者： virdis a Masi S Casiglia E Tikhonoff V Cicero AFG Ungar A Rivasi G Salvetti M Barbagallo CM Bombelli M Dell'Oro R Bruno B Lippa L D'Elia L Verdecchia P MallamaciF Cirillo M Rattazzi M Cirillo P Gesualdo L Mazza A Giannattasio C Maloberti A Volpe M Tocci G GeorgiopoulosG Iaccarino G Nazzaro P Parati G Palatini P Galletti F Ferri C Desideri G Viazzi F Pontremoli R Muiesan ML Grassi G Borghi C 赵狄(摘译) 刘莉(审校) 不详

目前识别心血管病风险不同分层的血清尿酸水平仍未确定。采用基于人群的大数据,研究人员评估了总死亡和与心血管病死亡(cardiovascular mortality,CVM)风险增加的血清尿酸水平。尿酸与心脏健康(uric acid right for heart health,URRAH... 详细信息

目前识别心血管病风险不同分层的血清尿酸水平仍未确定。采用基于人群的大数据,研究人员评估了总死亡和与心血管病死亡(cardiovascular mortality,CVM)风险增加的血清尿酸水平。尿酸与心脏健康(uric acid right for heart health,URRAH)研究是一项收集意大利几个基于大型人群纵向研究大数据的多中心回顾性观察性研究(随访20年),患者均在意大利高血压协会的高血压诊所就诊。

关键词：心血管病尿酸水平死亡风险