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Tribological characteristics of friction stir processed graphite and tin/LM24 surface composites

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Friction 2021年第3期9卷 569-582页

作者： vipin SHARMA Ujjwal PRAKASH B.Venkata MANOJ kuma. Department of Metallurgical and Materials Engineering Indian Institute of Technology RoorkeeRoorkee 247667India

Friction stir processing(FSP)is an emerging solid-state technique for preparing surface composites using various reinforcements.Ceramics and metallic particles are easily reinforced in a matrix by this technique.Surface composites made from an LM24 alloy reinforced with graphite and tin,with good wettability and material flow owing to the low melting point of tin,were fabricated by FSP at two rotational speeds of 1,400 and 1,000 rpm.Despite its low hardness,the graphite/LM24 surface composite fabricated at a higher rotational speed of 1,400 rpm exhibited better wear resistance.However,its frictional behavior was not significantly affected by the reinforcement.The fabricated surface composites with graphite and tin reinforcement as well as graphite-only reinforcement exhibited contradicting behaviors under sliding wear conditions.The post wear analysis indicated that abrasion,adhesion,layer formation,and delamination occurred on the composite surfaces.

关键词： composites friction stir processing graphite tin Al-Si alloy wear

在一些新供体中水稻白叶枯病抗性基因的等位关系和遗传

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国外作物育种 1998年第4期17卷 22-24页

作者： kuma.,AR 向平

Perceived effectiveness of infection control practices in Laundry of a tertiary healthcare centre

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World Journal of Emergency Medicine 2019年第2期10卷 114-115页

作者： Raman Sharma Ashok kuma. vipin Koushal Department of Hospital Administration PGIMER

Hospital management in modern milieu has become patient oriented and good patient outcome is a result of effective and effi cient medical care along with provisions of hygienic food,clean linen,safe environment,congenial atmosphere and good interpersonal relationship.^[1]Laundry is one such important support service which ensures prevention as well as containment of hospital infections and is also a determining factor for maintenance of good image of a hospital[2].

关键词： Hospital management modern milieu oriented

为满足“空气洁净法”要求而改变燃用煤种对电厂的影响

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热力发电译丛 1992年第4期 28-35,59页

作者： kuma.,KS 李小江

Prevention of macrovascular complications in patients with type 2 diabetes mellitus: Review of cardiovascular safety and efficacy of newer diabetes medications

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World Journal of Diabetes 2019年第6期10卷 324-332页

作者： Ravi Kant Kashif M Munir Arshpreet Kaur vipin Verma Division of Endocrinology Diabetes and Nutrition Medical University of South Carolina/Anmed Campus Anderson SC 29621 United States Division of Endocrinology Diabetes and Nutrition University of Maryland School of Medicine Baltimore MD 21201 United States Division of Endocrinology Diabetes and Nutrition Sinai Hospital Baltimore MD 21215 United States Department of Medicine Medical University of South Carolina/Anmed Campus Anderson SC 29621 United States

Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized controversy surrounding cardiovascular (CV) safety of rosiglitazone resulted in major changes in United States Food and Drug Administration policy in 2008 regarding approval process of new antidiabetic medications, which has resulted in revolutionary data from several large CV outcome trials over the last few years. All drugs in glucagon-like peptide-1 receptor agonist (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitor classes have shown to be CV safe with heterogeneous results on CV efficacy. Given twofold higher CV disease mortality in patients with DM than without DM, GLP-1 RAs and SGLT-2-inhibitors are important additions to clinician’s armamentarium and should be second line-therapy particularly in patients with T2DM and established atherosclerotic CV disease or high risks for CV disease. Abundance of data and heterogeneity in CV outcome trials results can make it difficult for clinicians, particularly primary care physicians, to stay updated with all the recent evidence. The scope of this comprehensive review will focus on all major CV outcome studies evaluating CV safety and efficacy of GLP-1 RAs and SGLT-2 inhibitors.

关键词： Newer antidiabetic medications Glucagon-like peptide-1 receptor agonist Sodium-glucose cotransporter-2 inhibitors Type 2 diabetes mellitus Macrovascular complications Cardiovascular outcome trials Major cardiovascular events Heart failure Prevention of heart disease

Double-face urethroplasty in patients with obliterative bulbar strictures post-transurethral resection of the prostate mid-term outcomes in high-volume referral center

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Asian Journal of Urology 2023年第4期10卷 512-517页

作者： Pankaj M.Joshi Manuel Hevia Yatam Lakshmi Sreeranga Marco Bandini Amey Patil Shreyas Bhadranavar vipin Sharma Sandeep Bafna Sanjay B.Kulkarni Kulkarni Reconstructive Urology Center 3Rajpath SocietyPaud RoadPune 411038India Urology Department Ramón y Cajal University HospitalIRYCISUniversity of AlcaláMadridSpain Urological Research Institute(URI) Unit of UrologyIRCCS Ospedale San RaffaeleVita SaluteSan Raffaele UniversityMilanMIItaly

Objective Incidences of post-transurethral resection of the prostate(post-TURP)strictures are between 2.2%and 9.8%.Stricture commonly occurs within the first 6 months.Our objective was to assess the outcomes of patients with obliterative strictures post-TURP that underwent a double-face urethroplasty.Methods This is a single-center prospective study of 17 patients with obliterative proximal bulbar stricture post-TURP who underwent double-face graft urethroplasty by two surgeons between January 2014 and January 2020.We defined post-TURP obliterative strictures as those patients who presented with complete or almost complete obstruction of the urethral lumen and who have had a history of acute urine retention.We have excluded patients with bladder neck contracture.Primary outcome was treatment success,defined as the no need for further treatments.Secondary outcome was post-urethroplasty continent rate.Results Seventeen patients were included in the study with median age of 66(interquartile range 40-77)years;median time of follow-up was 24(interquartile range 12-84)months;median stricture length was 4(interquartile range 2-6)cm.Of the 17 patients,15(88.2%)were successful.All patients were continent after urethroplasty.Conclusion With mid-term follow-up,treatment of obliterative proximal bulbar strictures with double-face buccal mucosa graft is a safe and effective procedure.Obliterative proximal bulbar strictures merit double-face urethroplasty with high-rate success and functional outcomes.

关键词： Double-face urethroplasty Obliterative urethral stricture Post-transurethral resection of prostate Urethral stricture Spongiofibrosis Iatrogenic stricture

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草甘膦对甘蔗的促熟试验

国外农学（甘蔗） 1990年第1期 18-21页

作者： kuma.,A. 邹宗兰

Genetic differentiation between three ecological variants （‘type’, ＇mysorensis＇ and ‘intermediate’） of malaria vector Anopheles stephensi （Diptera： Culicidae）

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Insect Science 2010年第4期17卷 335-343页

作者： vipin Madhulika Dube S. K. Gakhar Advanced Centre for Biotechnology Department of Statistics Maharshi Dayanand University Rohtak India

Anopheles stephensi is the main vector of urban malaria in South Asia. Three ecological variants （‘type’, ‘mysorensis’ and ‘intermediate’） of An. stephensi have been reported on the basis of ecology and egg morphology. However, it is unclear if there is any genetic isolation between the three variants. We analyzed the three variants of An. stephensi using eight microsatellite loci and found that large and significant genetic differentiation exists between them （mean FST = 0.393 and mean RST = 0.422）. Pairwise estimates of genetic differentiation between the variants were ‘type’ versus ‘mysorensis’ （mean FsT = 0.411 and mean RST = 0.308）, ‘type’ versus‘intermediate’ （mean FsT = 0.388 and mean RST = 0.518） and ‘intermediate’versus ＇mysorensis＇（mean FST = 0.387 and mean RST = 0.398） and all were statistically significant （P 〈 0.05）. The greater sensitivity of RST in differentiation indicated that mutations and not genetic drift had generated the differences between three variants of An. stephensi. The present study indicated large genetic differentiation and presence of non-significant low level ofgene flow between the three variants （‘type’,‘ mysorensis’ and ‘intermediate’） of An. stephensi.

关键词： Anopheles stephensi ecological variants gene flow intermediate mysorensis type

Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration

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Cellular & Molecular Immunology 2016年第2期13卷 206-216页

作者： Stephanie Mathews Dechun Feng Igor Maricic Cynthia Ju vipin kuma. Bin Gao Laboratory of Liver Diseases National institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD USA Laboratory of Autoimmunity Torrey Pines Institute for Molecular Studies San Diego CA USA Skaggs School of Pharmacy and Pharmaceutical Sciences and Integrated Immunology University of Colorado Anschutz Medical Campus Aurora CO USA

Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol feeding synergistically induces hepatic recruitment of neutrophils, which contributes to liver injury. In this paper, we investigated the roles of invariant natural killer T （iNKT） cells in chronic-plus-binge ethanol feeding-induced hepatic neutrophil infiltration and liver injury. Wild-type and two strains of iNKT cell-deficient mice （CDld- and Ja18-deficient mice） were subjected to chronic-plus-binge ethanol feeding. Liver injury and inflammation were examined. Chronic-plus-binge ethanol feeding synergistically increased the number of hepatic iNKT cells and induced their activation, compared with chronic feeding or binge alone, iNKT cell-deficient mice were protected from chronic-plus-binge ethanol-induced hepatic neutrophil infiltration and liver injury. Moreover, chronic-plus-binge ethanol feeding markedly upregulated the hepatic expression of several genes associated with inflammation and neutrophil recruitment in wild-type mice, but induction of these genes was abrogated in iNKT cell-deficient mice. Importantly, several cytokines and chemokines （e.g., MIP-2, MIP-1, IL-4, IL-6 and osteopontin） involved in neutrophil infiltration were upregulated in hepatic NKT cells isolated from chronic-plus-binge ethanol-fed mice compared to pair-fed mice. Finally, treatment with CDld blocking antibody, which blocks iNKT cell activation, partially prevented chronic-plus-binge ethanol-induced liver injury and inflammation. Chronic-plus-binge ethanol feeding activates hepatic iNKT cells, which play a critical role in the development of early alcoholic liver injury, in part by releasing mediators that recruit neutrophils to the liver, and thus, iNKT cells represent a potential therapeutic target for the treatment of alcoholic liver disease.

关键词： alcoholic hepatitis CDld inflammation liver