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Gastrointestinal mucosal immunity and COVID-19

World Journal of Gastroenterology 2021年第30期27卷 5047-5059页

作者： Tsvetelina Velikova violeta snegarova Alexander Kukov Hristiana Batselova Antoaneta Mihova Radislav Nakov Department of Clinical Immunology University Hospital LozenetzMedical FacultySofia UniversitySt.Kliment OhridskiSofia 1407Bulgaria Clinic of Internal Diseases Naval Hospital-VarnaMilitary Medical AcademyMedical FacultyMedical UniversityVarna 9000Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital"St George"Plovdiv 6000Bulgaria Clinic of Gastroenterology Tsaritsa Joanna University HospitalMedical University of SofiaSofia 1527Bulgaria

As the gastrointestinal tract may also be a crucial entry or interaction site of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the role of the gut mucosal immune system as a first-line physical and immunological defense is ***,gastrointestinal involvement and symptoms in coronavirus disease 2019(COVID-19)patients have been linked to worse clinical *** review discusses recent data on the interactions between the virus and the immune cells and molecules in the mucosa during the *** carrying out appropriate investigations,the mucosal immune system role in SARS-CoV-2 infection in therapy and prevention can be *** line with this,COVID-19 vaccines that stimulate mucosal immunity against the virus may have more advantages than the others.

关键词： Mucosa Gut mucosa Mucosa-associated lymphoid tissue SARS-CoV-2 COVID-19 Secretory immunoglobulin A Gut microbiota

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Mucosal COVID-19 vaccines:Risks,benefits and control of the pandemic

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World Journal of Virology 2022年第5期11卷 221-236页

作者： Dimitrina Miteva Monika Peshevska-Sekulovska violeta snegarova Hristiana Batselova Radostina Alexandrova Tsvetelina Velikova Department of Genetics Sofia University“St.Kliment Ohridski”Faculty of BiologySofia 1164Bulgaria Department of Gastroenterology University Hospital LozenetzSofia 1407Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Clinic of Internal Diseases Naval Hospital-VarnaMilitary Medical AcademyMedical FacultyMedical UniversityVarna 9000Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital“St George”Plovdiv 6000Bulgaria Department of Pathology Institute of Experimental MorphologyPathology and Anthropology with MuseumBulgarian Academy of SciencesSofia 1000Bulgaria Department of Clinical Immunology University Hospital LozenetzSofia 1407Bulgaria

Based on mucosal immunization to promote both mucosal and systemic immune responses,next-generation coronavirus disease 2019(COVID-19)vaccines would be administered intranasally or *** goal of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines is to provide adequate immune protection and avoid severe disease and *** vaccine candidates for COVID-19 including vector vaccines,recombinant subunit vaccines and live attenuated vaccines are under ***,subunit protein vaccines and virus-vectored vaccines have made substantial progress in preclinical and clinical settings,resulting in SARS-CoV-2 intranasal vaccines based on the previously successfully used nasal *** to their ability to trigger stable,protective immune responses at the sites of pathogenic infection,the development of‘specific’mucosal vaccines targeting coronavirus antigens could be an excellent option for preventing future ***,their efficacy and safety should be confirmed.

关键词： SARS-CoV-2 COVID-19 vaccine Mucosal immunity Intranasal vaccination Oral vaccines Resident memory T cells Vaccine safety Vaxart OraPro-COVID-19 vaccine RPS-vector system platform

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COVID-19 in patients with gastrointestinal stromal tumors: Recommendations for management and vaccination

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World Journal of Gastrointestinal Pathophysiology 2022年第5期13卷 170-177页

作者： violeta snegarova Dimitrina Miteva Milena Gulinac Monika Peshevska-Sekulovska Hristiana Batselova Tsvetelina Velikova Clinic of Internal Diseases Naval Hospital–VarnaMilitary Medical AcademyMedical FacultyMedical UniversityVarna 9000Bulgaria Faculty of Biology Department of GeneticsSofia University"St.Kliment Ohridski"Sofia 1164Bulgaria Department of General and Clinical Pathology Medical FacultyMedical University of PlovdivPlovdiv 4000Bulgaria Department of Gastroenterology University Hospital LozenetzSofia 1407Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407OthersBulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital"St George"Plovdiv 6000Bulgaria Department of Clinical Immunology University Hospital LozenetzSofia 1407Bulgaria

The coronavirus disease 2019(COVID-19)pandemic profoundly affected the management and treatment of patients with *** on the progress reported in the literature,we reviewed the recommendations for treatment and vaccination in patients with gastrointestinal stromal tumor(GIST)during *** focus on whether there is a risk and what could be the possible effects of vaccinating patients with GIST/*** the situation is quickly changing,and the health services have been severely disrupted,the diagnosis,treatment and recommendations for vaccination of these patients against COVID-19 are still not *** approval of vaccines in the pandemic gave hope that we would soon be able to return to a more normal ***,the oncology community needs to adapt and provide the most effective treatment and care models for patients with rare cancer,such as *** data on the impact of vaccination in patients with GIST/cancer also will be beneficial in expanding knowledge about the future planning of treatment strategies and optimizing care in the event of a subsequent pandemic.

关键词： Gastrointestinal stromal tumor GIST Cancer COVID-19 vaccination efficacy Treatment strategy Side effects

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Long-term effectiveness,outcomes and complications of bariatric surgery

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World Journal of Clinical Cases 2023年第19期11卷 4504-4512页

作者： Milena Gulinac Dimitrina Georgieva Miteva Monika Peshevska-Sekulovska Ivan P Novakov Svetozar Antovic Milena Peruhova violeta snegarova Plamena Kabakchieva Yavor Assyov Georgi Vasilev Metodija Sekulovski Snezhina Lazova Latchezar Tomov Tsvetelina Velikova Department of General and Clinical Pathology Medical University of PlovdivPlovdiv 4000Bulgaria Department of Genetics Sofia University"St.Kliment Ohridski"Faculty of BiologySofia 1164Bulgaria Department of Gastroenterology University Hospital LozenetzSofia 1407Bulgaria Department of Thoraco-abdominal Surgery Medical University PlovdivPlovdiv 6000Bulgaria University Clinic for Digestive Surgery Medical FacultySkopjeSkopje 1000North Macedonia Department of Gastroenterology Heart and Brain HospitalBurgasBurgas 1000Bulgaria Clinic of Internal Diseases Naval Hospital-VarnaMilitary Medical AcademyMedical FacultyMedical UniversityVarna 9000Bulgaria Clinic of Internal Diseases Naval Hospital-VarnaMilitary Medical AcademyVarna 9010Bulgaria Clinic of Endocrinology University Hospital AlexandrovskaSofia 1431Bulgaria Department of Internal Diseases Medical University–SofiaSofia 1431Bulgaria Clinic of Endocrinology and Metabolic Disorders UMHAT"Sv.Georgi"Plovdiv 4000Bulgaria Department of Anesthesiology and Intensive Care University Hospital LozenetzSofia 1407Bulgaria Medical Faculty Sofia UniversitySt.Kliment OhridskiSofia 1407Bulgaria Department of Pediatric University Hospital"N.I.Pirogov"Sofia 1606Bulgaria Department of Healthcare Faculty of Public Health"Prof.Tsekomir VodenicharovMDDSc"Sofia 1527Bulgaria Department of Informatics New Bulgarian UniversitySofia 1618Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria

Dietary imbalance and overeating can lead to an increasingly widespread *** considerations aside,obesity is defined as an excess of adipose tissue that can lead to serious health problems and can predispose to a number of pathological changes and clinical diseases,including diabetes;hypertension;atherosclerosis;coronary artery disease and stroke;obstructive sleep apnea;depression;weight-related arthropathies and endometrial and breast cancer.A body weight 20%above ideal for age,gender and height is a severe health *** surgery is a set of surgical methods to treat morbid obesity when other treatments such as diet,increased physical activity,behavioral changes and drugs have *** two most common procedures currently used are sleeve gastrectomy and gastric *** procedure has gained popularity recently and is generally considered safe and *** current data show that perioperative mortality is low and better control of comorbidities and short-term complications is achieved,more randomized trials are needed to evaluate the long-term outcomes of bariatric *** review aims to synthesize and summarize the growing evidence on the long-term effectiveness,outcomes and complications of bariatric surgery.

关键词： Bariatric surgery Long-term outcomes Obesity Roux-en-Y gastric bypass sleeve gastrectomy Effectiveness Safety Quality of life

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