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Hindi translation and validation of the English version of the gastrointestinal symptom rating scale questionnaire:An observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 33-39页

作者： Neha Jindal Anuraag Jena Krishan kumar Bijaya K Padhi Rajni sharma Vaneet Jearth Usha Dutta Vishal sharma Department of Gastroenterology Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Psychiatry Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Advanced Pediatric Centre Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India

BACKGROUND The gastrointestinal symptom rating scale(GSRS)is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome(IBS)and peptic ulcer *** validated scale has questions on around 15 items and has been validated in patients with dyspepsia and *** To translate and validate the English version of the GSRS questionnaire to the Hindi *** The purpose of the present work was to create a Hindi version of this questionnaire for use in the Indian *** process involved various steps as per the World Health Organization methodology including initial forward translation,backward translation,and assessment by an expert *** pilot testing was followed by testing in healthy and diseased *** The Hindi translation was pilot tested in 20 individuals and further validated in healthy controls(n=30,15 females)and diseased individuals(n=72,27 females).The diseased group included patients with functional dyspepsia and ***'s alpha for internal consistency on the final translated GSRS questionnaire was 0.715 which is considered *** questions significantly differentiated the diseased population from the healthy population(P value<0.05)in the translated Hindi version of the *** The translated Hindi GSRS can be used to evaluate gastrointestinal function in clinical trials and community surveys in Hindi speaking populations.

关键词： Irritable bowel syndrome Gut health Dyspepsia Symptoms Pain Constipation Diarrhoea

Echocardiographic predictors and associated outcomes of multiple vegetations in infective endocarditis:A pilot study

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World Journal of Cardiology 2024年第6期16卷 318-328页

作者： Ajay kumar Mishra Kannu Bansal Ibragim Al-Seykal Pradnya B Bhattad Anu Anna George Anil Jha Nitish sharma Jennifer Sargent Mark J Kranis Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Medicine Division of CardiologySaint Vincent HospitalWorcesterMA 01608United States Division of Cardiovascular Medicine Saint Vincent HospitalWorcesterMA 01608United States

BACKGROUND Infective endocarditis(IE)is a life-threatening infection with an annual mortality of 40%.Embolic events reported in up to 80%of *** of>10 mm size are associated with increased embolic events and poor *** is a paucity of literature on the association of multiple vegetations with *** To study the echocardiographic(ECHO)features and outcomes associated with the presence of multiple *** In this retrospective,single-center,cohort study patients diagnosed with IE were recruited from June 2017 to June 2019.A total of 84 patients were diagnosed to have IE,of whom 67 with vegetation were *** demographic,clinical,laboratory,and ECHO parameters were *** that were studied included recurrent admission,embolic phenomenon,and *** Twenty-three(34%)patients were noted to have multiple vegetations,13(56.5%)were male and 10(43.5%)were *** mean age of these patients was ***(35%)had a prior episode of *** features of moderate to severe valvular regurgitation[odds ratio(OR)=4],presence of pacemaker lead(OR=4.8),impaired left ventricle(LV)relaxation(OR=4),and elevated pulmonary artery systolic pressure(PASP)(OR=2.2)are associated with higher odds of multiple *** these moderate to severe valvular regurgitation(P=0.028),pacemaker lead(P=0.039)and impaired relaxation(P=0.028)were statistically *** patients were noted to have an increased association of recurrent admissions(OR=3.6),recurrent bacteremia(OR=2.4),embolic phenomenon(OR=2.5),intensive care unit stay(OR=2.8),hypotension(OR=2.1),surgical intervention(OR=2.8)and device removal(OR=4.8).Of this device removal(P=0.039)and recurrent admissions(P=0.017)were statistically *** This study highlights the associations of ECHO predictors and outcomes in patients with IE having multiple *** features of moderate to severe regurgitation,presence of pacemaker lead,impai

关键词： Endocarditis Echocardiography Vegetations Predictors Outcome

A randomized controlled trial on triamcinolone versus saline impregnated merocel post endoscopic sinus surgery:Our experience in a tertiary care centre

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 193-199页

作者： Ananya Sood Khushboo Goel SSanjeev Bhagat Dimple Sahni Dinesh kumar sharma Vishav Yadav Department of Otorhinolaryngology and Head&Neck Surgery Government Medical CollegePatialaPunjabIndia

Purpose:To assess the potential benefit of impregnating Merocel(a non-absorbable nasal dressing)with a topical steroid solution,for use as a direct and slow local delivery system of steroids after sinus surgery to improve postoperative wound ***:In this randomized controlled trial,40 patients with bilateral chronic rhinosinusitis with nasal polyposis were subjected to functional endoscopic sinus *** the completion of the surgery,Merocel packs were inserted in the bilateral nasal cavities and infiltrated with 4 mL triamcinolone(40 mg/mL)in one nasal cavity(treatment group)and 4 mL normal saline in the other(control group).Nasal packs were removed on the third postoperative day and postoperative healing assessment was done on postoperative Weeks 1,2,4,and *** findings were noted as per Lund Kennedy(LKES)and perioperative sinus endoscopy(POSE)scores and compared on both ***:Significant(P<0.05)improvement was noted in Lund Kennedy score for crusting and polyp at Week 12,for edema at Week 1,and nasal discharge at Weeks 1 and 12,but there was no significant improvement in scarring at any ***,the difference between the treatment and control arms was statistically significant at all postoperative visits except at Week ***,there was a significant improvement in POSE scores at Weeks 1,2,and 12 but not at Week ***:This study positively concludes that the nasal cavity packed with drug-soaked packs had less scarring and edema in the postoperative period and the overall wound healing was much better as compared to saline-soaked packs.

关键词： chronic rhinosinusitis functional endoscopic sinus surgery Lund Kennedy merocele perioperative sinus endoscopy triamcinolone

Predictors of cerebrospinal fluid GeneXpert MTB/RIF positivity in patients with tuberculous meningitis:A prospective cohort study

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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 465-472页

作者： Priyanka Gupta Neeraj kumar Ravindra kumar Garg Hardeep Singh Malhotra Imran Rizvi Rajesh Verma Praveen kumar sharma Ravi Uniyal Shweta Pandey Amita Jain Parul Jain Department of Neurology King George’s Medical UniversityLucknowIndia Department of Microbiology King George’s Medical UniversityLucknowIndia

Objective:To identify the clinical,laboratory,and radiological markers that could predict a positive GeneXpert result in patients suspected of tuberculous ***:In this prospective,observational study,patients with tuberculous meningitis were systematically *** clinical,laboratory[including cerebrospinal fluid(CSF)microscopy,culture,and GeneXpert],and neuroimaging factors were *** participants were administered anti-tuberculous treatment and corticosteroids.A six-month follow-up was done to evaluate the ***:Of the 116 patients studied,54(46.6%)tested positive for GeneXpert,while 62(53.4%)were *** cranial nerve involvement(OR 3.71,95%CI 1.052-13.09,P=0.04)and the presence of basal exudates on neuroimaging(OR 5.22,95%CI 2.03-13.42,P=0.001)emerged as independent predictive factors for a positive GeneXpert result.A positive CSF GeneXpert result(P=0.002)and drug resistance(P=0.004)were significantly linked to adverse ***,a high score on the Medical Research Council stageⅢ(OR 5.64,95%CI 1.18-26.87,P=0.03)and elevated CSF cell counts(OR 1.002,95%CI 1.00-1.001,P=0.03)were identified as independent predictors of poor ***:Third cranial nerve involvement and the presence of basal exudates were significant indicators of a positive GeneXpert *** stageⅢdisability and elevated CSF cell counts predicted poor outcomes.

关键词： Tuberculous meningitis Mycobacterium tuberculosis Cerebrospinal fluid Ziehl-Neelsen staining GeneXpert

Derated Mode of Power Generation in PV System Using Modified Perturb and Observe MPPT Algorithm

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1183-1192页

作者： vinit kumar Mukesh Singh Thapar Institute of Engineering and Technology PatialaPunjabIndia

In a grid-integrated photovoltaic system(GIPVS),there exist issues such as surplus active power and inadequate performance of maximum power point tracking(MPPT).A surplus active power causes the overvoltage problem at the point of common coupling in low-or medium-voltage grid during the peak hours of power ***,the inadequate performance of the MPPT algorithm results in power loss due to high settling time during the sudden change of ***,to solve the surplus power problem,the curtailment of active power is suggested with improved MPPT algorithm under variable irradiance *** this paper,a derated power generation mode(DPGM)control strategy is presented for the curtailment of active ***,a drift-free(named as modified)perturb and observe(P&O)technique is also proposed to improve the performance of the MPPT ***,the DPGM control scheme with the intermediate boost converter shaves the surplus active power during the peak hours of power ***,the modified MPPT algorithm deals with the fluctuation of irradiance during non-peak ***,the proposed control scheme delivers in a more efficient system during the peak hours of power *** addition,it reduces the power loss and settling time during the change of irradiance for non-peak *** on the proposed control scheme,a 30 kW system has been simulated in MATLAB/Simulink using Simpower tools under different environmental conditions.

关键词： Derated power generation mode(DPGM) gridintegrated photovoltaic system intermediate boost converter modified perturb and observe voltage source inverter

A review on current status of municipal solid waste management in India

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Journal of Environmental Sciences 2015年第11期27卷 206-217页

作者： Neha Gupta Krishna kumar Yadav vinit kumar Institute of Environment and Development Studies Bundelkhand University

Municipal solid waste management is a major environmental issue in India. Due to rapid increase in urbanization, industrialization and population, the generation rate of municipal solid waste in Indian cities and towns is also increased. Mismanagement of municipal solid waste can cause adverse environmental impacts, public health risk and other socio-economic problem. This paper presents an overview of current status of solid waste management in India which can help the competent authorities responsible for municipal solid waste management and researchers to prepare more efficient plans.

关键词： Municipal solid waste Characteristic Management India Disposal

In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity:Insights from national inpatient sample 2020

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World Journal of Hepatology 2024年第6期16卷 912-919页

作者： Sashwath Srikanth Vibhor Garg Lakshmi Subramanian Jyoti Verma Hansika sharma Harroop Singh Klair Shrenil A Kavathia Jithin Kolli Teja Nikhil Sai Vasireddy kumar Anmol Dhanush Kolli Shruti Sanjay Bodhankar Sobya Hashmi Shaylika Chauhan Rupak Desai Department of Medicine ECU Health Medical CenterGreenvilleNC 27834United States Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 10461United States Department of Medicine North Alabama Medical CentreFlorenceAL 35630United States Department of General Medicine Gandhi Medical CollegeSecunderabad 500003TelanganaIndia Department of Medicine Government Medical CollegePatiala 147001PunjabIndia Department of Medicine B.J.Medical CollegeAhmedabad 380016GujaratIndia Department of Medicine JSS Medical CollegeMysore 570015KarnatakaIndia Department of Internal Medicine Gandhi Medical CollegeSecunderabad 500003TelanganaIndia Department of Medicine Kasturba Medical CollegeManipal 575001KarnatakaIndia Clinical Extern Department of Internal MedicineBeaumont HospitalDearbornMI 48124United States Department of Internal Medicine Geisinger Health SystemWilkes-BarrePA 18702United States Independent Researcher AtlantaGA 30079United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular diseases independently of other risk ***,data on its effect on cardiovascular outcomes in coronavirus disease 2019(COVID-19)hospitalizations with varied obesity levels is *** management and patient care depend on understanding COVID-19 admission results in NAFLD patients with varying obesity *** To study the in-hospital outcomes in COVID-19 patients with NAFLD by severity of *** COVID-19 hospitalizations with NAFLD were identified using International Classification of Disease-10 CM codes in the 2020 National Inpatient Sample *** and Obesity Classes Ⅰ,Ⅱ,and Ⅲ(body mass index 30-40)were *** adverse cardiac and cerebrovascular events(MACCE)(all-cause mortality,acute myocardial infarction,cardiac arrest,and stroke)were compared between *** regression analyses adjusted for sociodemographic,hospitalization features,and *** Our analysis comprised 13260 hospitalizations,7.3% of which were overweight,24.3% Class Ⅰ,24.1% Class Ⅱ,and 44.3% Class Ⅲ.Class Ⅲ obesity includes younger patients,blacks,females,diabetics,and hypertensive *** multivariable logistic analysis,Class Ⅲ obese patients had higher risks of MACCE,inpatient mortality,and respiratory failure than Class Ⅰ obese *** Ⅱ obesity showed increased risks of MACCE,inpatient mortality,and respiratory failure than Class I,but not *** obesity classes had non-significant risks of MACCE,inpatient mortality,and respiratory failure compared to the overweight *** Class Ⅲ obese NAFLD COVID-19 patients had a greater risk of adverse outcomes than class Ⅰ.Using the overweight group as the reference,unfavorable outcomes were not significantly *** obesity had a greater risk of MACCE regardless of the referent group(overweight or Class Ⅰ obese)compared to overweight NAFLD patients admitte

关键词： Non-alcoholic fatty liver disease Obesity Obese Body mass index Major adverse cardiac and cerebrovascular events Mortality Acute myocardial infarction Cardiac arrest Stroke

Systematic review with expert consensus on use of extracorporeal hemoadsorption in septic shock:An Indian perspective

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World Journal of Critical Care Medicine 2024年第1期13卷 65-75页

作者： Yatin Mehta Abdul Samad Ansari Amit kumar Mandal Dipanjan Chatterjee Gauri Shankar sharma Prachee Sathe Purvesh V Umraniya Rajib Paul Sachin Gupta Vinod Singh Yogendra Pal Singh Institute of Critical Care and Anesthesiology Medanta The MedicityGurgaon 122001HaryanaIndia Department of Critical Care Nanavati Max Super Specialty HospitalMumbai 400065India Department of Pulmonology Sleep and Critical CareFortis HospitalMohaliPunjabMohali 160062PunjabIndia Department of Cardio-Puimonary Critical Care Medica Superspecialty HospitalKolkata 700099India Department of Critical Care Medicine Fortis HospitalNew Delhi 110070India Department of Critical Care Medicine D.Y.Patil Medical CollegeSant Tukaram NagarPimpri ColonyPimpri-ChinchwadPune 411018India Department of Critical Care Medicine Bhailal Amin General HospitalVadodara 390003GujaratIndia Department of Internal Medicine Apollo HospitalsJubilee HillsHyderabad 500033India Department of Anaesthesiology Narayana Superspeciality HospitalGurugram 122002India Department of Critical Care Medicine Institute of Critical Care MedicineHospital Name-Sir Ganga Ram HospitalNew Delhi 110001India Department of Critical Care Medicine Max Super Speciality HospitalDelhi 110092India

BACKGROUND Septic shock is a severe form of sepsis characterised by deterioration in circulatory and cellular-metabolic *** standard therapy,the outcomes are *** adjuvant therapy,such as CytoSorb®extracorporeal haemoadsorption device,has been investigated and shown promising ***,there is a lack of some guidance to make clinical decisions on the use of CytoSorb®haemoadsorption as an adjuvant therapy in septic shock in Indian ***,this expert consensus was *** To formulate/establish specific consensus statements on the use of CytoSorb®haemoadsorption treatment based on the best available evidence and contextualised to the Indian *** We performed a comprehensive literature on CytoSorb®haemoadsorption in sepsis,septic shock in PubMed selecting papers published between January 2011 and March 20232021 in English *** statements for a consensus document were developed based on the summarised literature analysis and identification of knowledge *** a modified Delphi approach combining evidence appraisal and expert opinion,the following topics related to CytoSorb®in septic shock were addressed:need for adjuvant therapy,initiation timeline,need for Interleukin-6 levels,duration of therapy,change of adsorbers,safety,prerequisite condition,efficacy endpoints and management *** expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** Eleven expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** 11 experts in the consensus group(100%)participated in the first,second and third round of *** three iterative voting rounds and adapting two statements,consensus was achieved on nine statements out of nine *** consensus expert panel also recognised the necessity to form an associatio

关键词： Consensus CytoSorb Cytokine Hemoadsorption Refractory Sepsis Septic shock

Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid power system

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Frontiers in Energy 2015年第4期9卷 472-485页

作者： Nitin kumar SAXENA Ashwani kumar sharma Deptment of Electrical Engineering NIT Kumkshetra Haryana 136119 India

It is well recognized that the voltage stability of a power system is affected by the load model and hence, to effectively analyze the reactive power compensation of an isolated hybrid wind-diesel based power system, the loads need to be considered along with the generators in a transient analysis. This paper gives a detailed mathematical modeling to compute the reactive power response with small voltage perturbation for composite load. The composite load is a combination of the static and dynamic load model. To develop this composite load model, the exponential load is used as a static load model and induction motors （IMs） are used as a dynamic load model. To analyze the dynamics of IM load, the fifth, third and first order model of IM are formulated and compared using differential equations solver in Matlab coding. Since the decentralized areas have many small consumers which may consist large numbers of IMs of small rating, it is not realistic to model either a single large rating unit or all small rating IMs together that are placed in the system. In place of using a single large rating IM, a group of motors are considered and then the aggregate model of IM is developed using the law of energy conservation. This aggregate model is used as a dynamic load model. For different simulation studies, especially in the area of voltage stability with reactive power compensation of an isolated hybrid power system, the transfer function AQ/AV of the composite load is required. The transfer function of the composite load is derived in this paper by successive derivation for the exponential model of static load and for the fifth and third order IM dynamic load model using state space model.

关键词： isolated hybrid power system (IHPS) compo- site load model static load dynamic load induction motorload model aggregate load