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Neuroplasticity in Spinal Trauma: A Current Narrative Review of Treatments

World Journal of Neuroscience 2021年第2期11卷 91-107页

作者： vinicius benatti freire Lucas Cressoni de Souza Mario Henrique de Lima Martinelli Leonardo Moysés Sacchi Thales Andolfo de Souza Antonio Eduardo Damin Medical Students of the Nove de Julho University (Campus Vergueiro) S&#227o Paulo Brazil Department of Neurology of the Nove de Julho University Medical School Neurologist and Professor of Neurology at Nove de Julho University Medical School S&#227o Paulo Brazil

Neuroplasticity is a condition that is present from birth, being found in the central and peripheral nervous system, in both physiological and pathological terms. Based on the findings, therapeutic and non-therapeutic attempts were tested on spinal cord trauma to recover locomotor function below the level of the injury. The work defined and showed other forms of the term neuroplasticity, talk about some pathological and non-pathological conditions, and, finally, show neuroplasticity and some of its treatments in the spinal cord injury process. A narrative literature review from 2000 to 2020 of the PubMed platform was conducted and analysis of two books for the elaboration of this work. Animal/human studies were included that addressed pathologies, forms of treatment for spinal trauma, and qualis from B1 to A1. Pre-2000 articles, which addressed neuroplasticity only to understand the molecular mechanisms and articles that were not in English, were excluded. As a result, the main molecules and structures that inhibit neuroplasticity were found, and, based on their knowledge, forms of treatments were developed to inhibit these molecules and structures to assist in neuroplasticity and assist in possible functional recovery. It can be concluded that the physiological barriers are already being overcome by the most recent forms of treatment and that soon new studies may propose a form of treatment that is protocoled for all patients.

关键词： Neuroplasticity Spinal Cord Injury Regeneration Nanomaterials Stem Cell Pharmacology

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