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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana Rafael Soares Nunes Pinheiro Daniel Reis Waisberg Liliana Ducatti Lopes Rubens Macedo Arantes vinicius rocha santos Rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

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Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 194-200页

作者： vinicius rocha-santos Estela RR Figueira Joel A rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado Luiz AC D'Albuquerque Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestinal Transplantation Hospital das Clinicas University of Sao Paulo School of Medicine Discipline of Anesthesiology Hospital das Clinicas University of Sao Paulo School of Medicine Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestina Hospital das Clinicas University of Sao Paulo School of Medicinel Transplantation

BACKGROUND：Liver ischemia reperfusion（IR）injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver ***（PTX）and hypertonic saline solution（HTS）have been identified to have beneficial effects against IR *** study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR ***： Male Wistar rats were allocated into three groups. Control rats underwent 60 minutes of partial liver ischemia, HTS rats were treated with 0.4 mL/kg of intravenous 7.5% NaCl 15 minutes before reperfusion, and HPTX group were treated with 7.5% NaC1 plus 25 mg/kg of PTX 15 minutes before reperfusion. Samples were collected after reperfusion for determination of ALT, AST, TNF-α, IL-6, IL-10, mitochondrial respiration, lipid peroxidation, pulmonary permeability and myeloperoxidase. RESULTS： HPTX significantly decreased TNF-α 30 minutes after reperfusion. HPTX and HTS significantly decreased ALT,AST, IL-6, mitochondrial dysfunction and pulmonary myelo- peroxidase 4 hours after reperfusion. Compared with HTS only, HPTX significantly decreased hepatic oxidative stress 4 hours after reperfusion and pulmonary permeability 4 and 12 hours after reperfusion. CONCLUSION： This study showed that PTX added the beneficial effects of HTS on liver IR injury through decreases of hepatic oxidative stress and pulmonary permeability.

关键词： pentoxifylline hypertonic saline solution hepatic oxidative stress ischemia reperfusion injury pulmonary permeability

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Determinant variables on the isotopic values of particulate organic matter in a neotropical floodplain

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JOURNAL OF OCEANOLOGY AND LIMNOLOGY 2024年第4期42卷 1-13页

作者： Urbano, vinicius de Andrade Scoarize, Matheus Maximilian Ratz Alves, Gustavo Henrique Zaia Delanira-santos, Driele Caetano, Marcela da Silva Benedito, Evanilde Univ Estadual Maringa UEM Dept Biol DBI Lab Ecol Energet BR-87020900 Maringa Brazil Univ Estadual Maringa UEM Programa Posgrad Ecol Ambientes Aquat Continentais BR-87020900 Maringa Brazil Griffith Univ Australian Rivers Inst ARI Kessels Rd Nathan Qld 4111 Australia Univ Estadual Ponta Grossa UEPG Dept Biol Geral Campus Uvaranas BR-84030900 Ponta Grossa Brazil

Particulate organic matter (POM) is an important energy source for aquatic consumers, understanding its origin and composition is essential for understanding the energetic dynamics of aquatic environments. The aim of this study was to analyze the relationship between POM and phytoplankton (isotopic values and chlorophyll concentration) and abiotic variables during dry and rainy seasons. Sampling was conducted in rivers and lagoons in the floodplain of the Upper Paran & aacute; River. We found a greater difference in delta 13C values of POM between sampling points than between seasons, indicating that the composition of regional sources influences the composition of POM more than dry and rainy seasons. In addition, the concentration of chlorophyll during the dry season was positively correlated with delta 13C values during that rainy period. Additionally, we found a relationship between factors limiting the growth of phytoplankton and delta 13C values of POM, such as phosphate ions, indicating that variables that regulate phytoplankton growth tend to influence the composition of POM in river floodplains. Therefore, maintaining the variables that regulate the phytoplankton community is of fundamental importance for the composition of POM, an important energy source in aquatic environments.

关键词： freshwater wetland stable isotopes food web subtropical environment PARANA RIVER FLOODPLAIN BOTTOM-FEEDING FISH STABLE-ISOTOPES TROPHIC POSITION CARBON PHYTOPLANKTON VARIABILITY ENRICHMENT DIVERSITY POC

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Living-donor liver transplantation in Budd-Chiari syndrome with inferior vena cava complete thrombosis:A case report and review of the literature

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World Journal of Hepatology 2021年第1期13卷 151-161页

作者： vinicius rocha-santos Daniel Reis Waisberg Rafael Soares Pinheiro Lucas Souto Nacif Rubens Macedo Arantes Liliana Ducatti Rodrigo Bronze Martino Luciana Bertocco Haddad Flavio Henrique Galvao Wellington Andraus Luiz Augusto Carneiro-D'Alburquerque Department of Gastroenterology Abdominal Organs Transplantation DivisionHospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo(HC-FMUSP)Sao Paulo 05403900SPBrazil Department of Gastroenterology Laboratory of Medical Investigation 37(LIM-37)Faculdade de Medicina da Universidade de Sao Paulo(FMUSP)Sao Paulo 01246903Brazil

BACKGROUND Budd-Chiari syndrome(BCS)is a challenging indication for liver transplantation(LT)due to a combination of massive liver,increased bleeding,retroperitoneal fibrosis and frequently presents with stenosis of the inferior vena cava(IVC).Occasionally,it may be totally thrombosed,increasing the complexity of the procedure,as it should also be *** challenge is even greater when performing living-donor LT as the graft does not contain the retrohepatic IVC;thus,it may be necessary to reconstruct *** SUMMARY A 35-year-old male patient with liver cirrhosis due to BCS and hepatocellular carcinoma beyond the Milan criteria underwent living-donor LT with IVC *** was necessary to remove the IVC as its retrohepatic portion was completely thrombosed,up to almost the right atrium.A right-lobe graft was retrieved from his sister,with outflow reconstruction including the right hepatic vein and the branches of segment V and VIII to the middle hepatic *** to massive subcutaneous collaterals in the abdominal wall,venovenous bypass was implemented before incising the *** right atrium was reached via a transdiaphragramatic *** was performed en bloc with the retrohepatic vena *** was reconstructed with an infra-hepatic vena cava graft obtained from a deceased *** patient remains well on outpatient clinic follow-up 25 mo after the procedure,under an anticoagulation protocol with *** Living-donor LT in BCS with IVC thrombosis is feasible using a meticulous surgical technique and tailored strategies.

关键词： Liver transplantation Living donors Budd-Chiari syndrome Hepatic venoocclusive disease Inferior vena cava Case report

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Role of the portal system in liver regeneration:From molecular mechanisms to clinical management

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Liver Research 2024年第1期8卷 1-10页

作者： Hanzhi Xu Xun Qiu Zhoucheng Wang Kai Wang Yawen Tan Fengqiang Gao Marcos vinicius Perini Xiao Xu Zhejiang University School of Medicine HangzhouZhejiangChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province HangzhouZhejiangChina Department of Surgery University of MelbourneAustin HealthHeidelbergVictoriaAustralia

The liver has a strong regenerative capacity that ensures patient recovery after hepatectomy and liver *** portal system plays a crucial role in the dual blood supply to the liver,making it a significant factor in hepatic *** surgical strategies,such as portal vein ligation,associating liver partition and portal vein ligation for staged hepatectomy,and dual vein embolization,have high-lighted the portal system's importance in liver *** hepatectomy or liver trans-plantation,the hemodynamic properties of the portal system change dramatically,triggering regeneration via shear stress and the induction of ***,excessive portal hyperperfusion can harm the liver and negatively affect patient ***,as the importance of the gut-liver axis has gradually been revealed,the effect of metabolites and cytokines from gut microbes carried by portal blood on liver regeneration has been *** these perspectives,this review outlines the molecular mechanisms of the portal system's role in liver regeneration and summarizes therapeutic strategies based on the portal system intervention to promote liver regeneration.

关键词： Portal system Liver regeneration Hemodynamic properties Gut microbiota Therapeutic strategies

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A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)

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Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah J.Hardcastle Chloe Maxwell-Smith vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale Jacob McCormick Craig Lynch Paul A.Cohen Max Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.John of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hospital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received PA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary ***:Eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change Exercise Health disparities Oncology Wearable technology

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Treatment of Vulvovaginal Candidiasis with A Strategy Based on Phototherapy (M.A.C.^® Scar Acceleration Method)

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Modern Research in Inflammation 2024年第1期13卷 1-7页

作者： Marcus vinicius de Mello Pinto Karin Yuri Fernández Iturra Aline Ronis Sampaio María Elena Silva Álvarez Esteban Fortuny Celulare Institute Petrópolis Brazil Bienus Clinic Santiago Chile Fisiocare Curicó Chile Universidad Finis Terrae Santiago Chile

Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAC® Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAC®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

关键词： Treatment of vulvovaginal Candidiasis Candidiasis Candida M.A.C. MAC®

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Bioremediation Potential of the Macroalga Ulva lactuca (Chlorophyta) for Ammonium Removal in Elastomer Industry Wastewater

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Advances in Bioscience and Biotechnology 2024年第6期15卷 325-343页

作者： Diego Lelis Alex Enrich-Prast Camille R. Chaves Thuane Mendes Anacleto Roberta R. C. Pereira vinicius P. de Oliveira Programa de Ps-Graduao em Biotecnologia Vegetal e Bioprocessos Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Unidade Multiusurio de Anlises Ambientais Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Institute of Marine Science Federal University of So Paulo (IMar/UNIFESP) Santos Brazil Department of Thematic StudiesEnvironmental Change and Biogas Solutions Research Center (BSRC) Linkping University Linkping Sweden Department of Marine Biology Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil

During the production of nitrile rubber, significant amounts of nitrogen in the form of ammonium are generated in the wastewater. The discharge of this high-nitrogen wastewater can lead to serious environmental issues, including eutrophication, disruption of aquatic ecosystems, and groundwater contamination. To mitigate these impacts, this research explored the bioremediation capabilities of the macroalgae Ulva lactuca (Chlorophyta) for removing nitrogen from nitrile rubber production wastewater. The study employed single-phase and Michaelis-Menten decay models based on ammonium consumption, using various dilutions of wastewater to identify the optimal concentration for treatment. The physiological state of the macroalgae was monitored by measuring the photosynthetic capacity and specific growth rate during the experiments. In the presence of U. lactuca, ammonium concentrations decreased in all treatment groups, confirming that the ammonium kinetics conformed to both applied models. Our results show that U. lactuca effectively reduces ammonium concentrations, with an approximate removal rate of 0.020 µM·g−1·min−1 across different wastewater concentrations (70%, 80%, 90%, and 100%). Notably, the treatments with 70%, 80%, and 90% wastewater strength achieved about 67% reduction in ammonium, demonstrating the alga’s capacity to treat high-nitrogen wastewater. The photosynthetic performance of U. lactuca initially declined in control conditions but stabilized across all treatments, highlighting its adaptability. The kinetic analysis using the Michaelis-Menten model indicated a Vmax of 1342 μM·g−1·DMh−1, suggesting a robust capacity for ammonium uptake when fully saturated. Our study underscores the potential of Ulva lactuca as a cost-effective and efficient agent for wastewater bioremediation, particularly in settings with high nitrogen loads.

关键词： Photosynthetic Quantum Yield One-Phase Decay Model Michaelis-Menten Model Nitrogen Physiological Parameters Elastomers

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A mathematical model for shortening waiting time in pancreas-kidney transplantation

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World Journal of Gastrointestinal Surgery 2011年第8期3卷 119-122页

作者： Eleazar Chaib Marcelo Augusto F Ribeiro Jr vinicius rocha santos Roberto Ferreira Meirelles Jr Luiz Augusto Carneiro D'Albuquerque Eduardo Massad Liver and Pancreas Transplantation Surgery Unit LIM 37 and LIM 01 Department of Gastroenterology University of Sao Paulo School of Medicine

AIM: To simulate a hypothetical increase of 50% in the number of pancreas-kidney (PK) transplantations using less-than-ideal donors by a mathematical model. METHODS: We projected the size of the waiting list by taking into account the incidence of new patients per year, the number of PK transplantations carried out in the year and the number of patients who died on the waiting list or were removed from the list for other reasons. These variables were treated using a model developed elsewhere. RESULTS: We found that the waiting list demand will meet the number of PK transplantation by the year 2022. CONCLUSION: In future years, it is perfectly possible to minimize the waiting list time for pancreas transplantation through expansion of the donor pool using less-than-ideal donors.

关键词： Pancreas-Kidney transplantation Waiting list Mathematical model

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狂人米莱的另一面

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商业周刊（中文版） 2024年第1期 24-25页

作者： Manuela Tobias Ignacio Olivera Doll vinicius Andrade 晴川(译) 不详

2023年11月19日晚上,在华尔街做交易员的德米安·瑞德尔(Demian Reidel)开心得上下跳,挥舞着拳头,指向哈维尔·米莱(Javier Milei)设在布宜诺斯艾利斯市中心酒店的竞选总部。“我们赢啦!”他喊着,“我的总统!”但不到一周后,瑞德尔就拒... 详细信息

2023年11月19日晚上,在华尔街做交易员的德米安·瑞德尔(Demian Reidel)开心得上下跳,挥舞着拳头,指向哈维尔·米莱(Javier Milei)设在布宜诺斯艾利斯市中心酒店的竞选总部。“我们赢啦!”他喊着,“我的总统!”但不到一周后,瑞德尔就拒绝了米莱让他执掌央行的邀请,选择飞回他在迈阿密的家,眼见着这位当选总统抛弃了其激进经济纲领的关键支柱,瑞德尔倍感丧。

关键词：米莱另一面交易员迈阿密华尔街央行

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