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Role of the portal system in liver regeneration:From molecular mechanisms to clinical management

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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

肝脏研究（英文） 2024年第1期8卷 1-10页

作者： Hanzhi Xu Xun Qiu Zhoucheng Wang Kai Wang Yawen Tan Fengqiang Gao Marcos vinicius Perini Xiao Xu Zhejiang University School of Medicine HangzhouZhejiangChina Zhejiang University School of Medicine HangzhouZhejiangChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province HangzhouZhejiangChina Department of Surgery University of MelbourneAustin HealthHeidelbergVictoriaAustralia

The liver has a strong regenerative capacity that ensures patient recovery after hepatectomy and liver *** portal system plays a crucial role in the dual blood supply to the liver,making it a significant factor in hepatic *** surgical strategies,such as portal vein ligation,associating liver partition and portal vein ligation for staged hepatectomy,and dual vein embolization,have high-lighted the portal system's importance in liver *** hepatectomy or liver trans-plantation,the hemodynamic properties of the portal system change dramatically,triggering regeneration via shear stress and the induction of ***,excessive portal hyperperfusion can harm the liver and negatively affect patient ***,as the importance of the gut-liver axis has gradually been revealed,the effect of metabolites and cytokines from gut microbes carried by portal blood on liver regeneration has been *** these perspectives,this review outlines the molecular mechanisms of the portal system's role in liver regeneration and summarizes therapeutic strategies based on the portal system intervention to promote liver regeneration.

关键词： Portal system Liver regeneration Hemodynamic properties Gut microbiota Therapeutic strategies

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana Rafael Soares Nunes Pinheiro Daniel Reis Waisberg Liliana Ducatti Lopes Rubens Macedo Arantes vinicius Rocha Santos Rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)

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Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah J.Hardcastle Chloe Maxwell-Smith vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale Jacob McCormick Craig Lynch Paul A.Cohen Max Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.John of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hospital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received PA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary ***:Eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change Exercise Health disparities Oncology Wearable technology

Treatment of Vulvovaginal Candidiasis with A Strategy Based on Phototherapy (M.A.C.^® Scar Acceleration Method)

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Modern Research in Inflammation 2024年第1期13卷 1-7页

作者： Marcus vinicius de Mello Pinto Karin Yuri Fernández Iturra Aline Ronis Sampaio María Elena Silva Álvarez Esteban Fortuny Celulare Institute Petrópolis Brazil Bienus Clinic Santiago Chile Fisiocare Curicó Chile Universidad Finis Terrae Santiago Chile

Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAC® Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAC®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

关键词： Treatment of vulvovaginal Candidiasis Candidiasis Candida M.A.C. MAC®

Bioremediation Potential of the Macroalga Ulva lactuca (Chlorophyta) for Ammonium Removal in Elastomer Industry Wastewater

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Advances in Bioscience and Biotechnology 2024年第6期15卷 325-343页

作者： Diego Lelis Alex Enrich-Prast Camille R. Chaves Thuane Mendes Anacleto Roberta R. C. Pereira vinicius P. de Oliveira Programa de Ps-Graduao em Biotecnologia Vegetal e Bioprocessos Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Unidade Multiusurio de Anlises Ambientais Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Institute of Marine Science Federal University of So Paulo (IMar/UNIFESP) Santos Brazil Department of Thematic StudiesEnvironmental Change and Biogas Solutions Research Center (BSRC) Linkping University Linkping Sweden Department of Marine Biology Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil

During the production of nitrile rubber, significant amounts of nitrogen in the form of ammonium are generated in the wastewater. The discharge of this high-nitrogen wastewater can lead to serious environmental issues, including eutrophication, disruption of aquatic ecosystems, and groundwater contamination. To mitigate these impacts, this research explored the bioremediation capabilities of the macroalgae Ulva lactuca (Chlorophyta) for removing nitrogen from nitrile rubber production wastewater. The study employed single-phase and Michaelis-Menten decay models based on ammonium consumption, using various dilutions of wastewater to identify the optimal concentration for treatment. The physiological state of the macroalgae was monitored by measuring the photosynthetic capacity and specific growth rate during the experiments. In the presence of U. lactuca, ammonium concentrations decreased in all treatment groups, confirming that the ammonium kinetics conformed to both applied models. Our results show that U. lactuca effectively reduces ammonium concentrations, with an approximate removal rate of 0.020 µM·g−1·min−1 across different wastewater concentrations (70%, 80%, 90%, and 100%). Notably, the treatments with 70%, 80%, and 90% wastewater strength achieved about 67% reduction in ammonium, demonstrating the alga’s capacity to treat high-nitrogen wastewater. The photosynthetic performance of U. lactuca initially declined in control conditions but stabilized across all treatments, highlighting its adaptability. The kinetic analysis using the Michaelis-Menten model indicated a Vmax of 1342 μM·g−1·DMh−1, suggesting a robust capacity for ammonium uptake when fully saturated. Our study underscores the potential of Ulva lactuca as a cost-effective and efficient agent for wastewater bioremediation, particularly in settings with high nitrogen loads.

关键词： Photosynthetic Quantum Yield One-Phase Decay Model Michaelis-Menten Model Nitrogen Physiological Parameters Elastomers

Feasibility of performing the 3-minute step test with remote supervision in children and adolescents with cystic fibrosis: A comparative study

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Pediatric Investigation 2024年第2期8卷 83-90页

作者： Fernanda Maria Vendrusculo Gisele Apolinario da Costa Maria Amelia Bagatini Brenda Maria Henrique Maia Lemes Carolina Aguiar Faria Larissa Carvalhaes de Oliveira Evanirso da Silva Aquino Marcio vinicius Fagundes Donadio Laboratory of Pediatric Physical Activity Infant CenterPontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto AlegreBrazil Hospital Infantil Joao Paulo II-Fundacao Hospitalar do Estado de Minas Gerais(FHEMIG) Belo HorizonteBrazil Departament of Physiotherapy Pontificia Universidade Catolica de Minas Gerais(PUCMG)-Campus BetimBetimBrazil Department of Physiotherapy Faculty of Medicine and Health SciencesUniversitat Internacional de Catalunya(UIC)BarcelonaSpain

Importance:The 3-min step test is a simple option to monitor submaximal exercise capacity,although its use via remote video monitoring has not been investigated in children with cystic fibrosis(CF).Objective:This study aimed to assess the feasibility and reproducibility of performing the 3-min step test with remote ***:A cross-sectional study including CF patients(6-18 years)from two CF services were ***,anthropometric,clinical,and lung function data were collected and two 3-min step tests were performed:(i)in-person supervision,and(ii)remotely supervised by video *** and after the tests,heart rate(HR),oxygen saturation(SpO2),and the Borg score for dyspnea and lower limb fatigue were ***:Twenty-three patients(10.7±3.7 years)with a mean FEV1 of 89.5%±23.2%were *** were no significant differences between tests,with mean differences(95%confidence intervals)in final HR of-3.3(-8.9,2.4),change in HR of-1.9(-6.1,2.1),final SpO2 of 0.3(-0.4,1.0),and final dyspnea of 0.1(-0.8,0.9).The intraclass correlation coefficient was 0.852(final HR),0.762(final SpO2),and 0.775(final lower limb fatigue).Significant and moderate correlations were found between tests for final HR(r=0.75),change in HR(r=0.61),and final SpO2(r=0.61).The Bland-Altman analysis showed a mean difference in final SpO2 between tests of 0.3%(limit of agreement-3.0%,3.5%).Interpretation:Physiological responses between tests were similar,indicating it was feasible to perform the 3-min step test with remote supervision in CF children.

关键词： Children Cystic fibrosis Exercise test Telehealth

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狂人米莱的另一面

商业周刊（中文版） 2024年第1期 24-25页

作者： Manuela Tobias Ignacio Olivera Doll vinicius Andrade 晴川(译) 不详

2023年11月19日晚上,在华尔街做交易员的德米安·瑞德尔(Demian Reidel)开心得上下跳,挥舞着拳头,指向哈维尔·米莱(Javier Milei)设在布宜诺斯艾利斯市中心酒店的竞选总部。“我们赢啦!”他喊着,“我的总统!”但不到一周后,瑞德尔就拒... 详细信息

2023年11月19日晚上,在华尔街做交易员的德米安·瑞德尔(Demian Reidel)开心得上下跳,挥舞着拳头,指向哈维尔·米莱(Javier Milei)设在布宜诺斯艾利斯市中心酒店的竞选总部。“我们赢啦!”他喊着,“我的总统!”但不到一周后,瑞德尔就拒绝了米莱让他执掌央行的邀请,选择飞回他在迈阿密的家,眼见着这位当选总统抛弃了其激进经济纲领的关键支柱,瑞德尔倍感丧。

关键词：米莱另一面交易员迈阿密华尔街央行

Free Cyclic Actions on Surfaces and the Borsuk-Ulam Theorem

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Acta Mathematica Sinica,English Series 2022年第10期38卷 1803-1822页

作者： Daciberg Lima GONCALVES John GUASCHI vinicius Casteluber LAASS Departamento de Matematica IMEUniversidade de Sao PauloRua do Matao 1010 CEP:05508-090Sao Paulo-SPBrazil Normandie Univ. UNICAENCNRSLMNO14000 CaenFrance Universidade Federal da Bahia IMEDepartamento de MatematicaAv.Milton SantosS/N Ondina CEP:40170-110Salvador-BABrazil

Let M and N be topological spaces,let G be a group,and letτ:G×M→M be a proper free action of *** this paper,we define a Borsuk-Ulam-type property for homotopy classes of maps from M to N with respect to the pair(G,τ)that generalises the classical antipodal Borsuk-Ulam theorem of maps from the n-sphere S^(n) to R^(n).In the cases where M is a finite pathwise-connected CWcomplex,G is a finite,non-trivial Abelian group,τis a proper free cellular action,and N is either R^(2) or a compact surface without boundary different from S^(2) and RP^(2),we give an algebraic criterion involving braid groups to decide whether a free homotopy class β∈[M,N]has the Borsuk-Ulam *** an application of this criterion,we consider the case where M is a compact surface without boundary equipped with a free actionτof the finite cyclic group *** terms of the orient ability of the orbit space Mof M by the actionτ,the value of n modulo 4 and a certain algebraic condition involving the first homology group of M,we are able to determine if the single homotopy class of maps from M to R^(2) possesses the Borsuk-Ulam property with respect to(Z_(n),τ).Finally,we give some examples of surfaces on which the symmetric group acts,and for these cases,we obtain some partial results regarding the Borsuk-Ulam property for maps whose target is R^(2).

关键词： Borsuk-Ulam theorem cyclic groups braid groups surfaces

Machine learning inspired workflow to revise field development plan under uncertainty

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Petroleum Exploration and Development 2023年第6期50卷 1455-1465页

作者： LOOMBA Ashish Kumar BOTECHIA vinicius Eduardo SCHIOZER Denis José Universidade Estadual de Campinas SP 13084-778Brazil

We present an efficient and risk-informed closed-loop field development (CLFD) workflow for recurrently revising the field development plan (FDP) using the accrued information. To make the process practical, we integrated multiple concepts of machine learning, an intelligent selection process to discard the worst FDP options and a growing set of representative reservoir models. These concepts were combined and used with a cluster-based learning and evolution optimizer to efficiently explore the search space of decision variables. Unlike previous studies, we also added the execution time of the CLFD workflow and worked with more realistic timelines to confirm the utility of a CLFD workflow. To appreciate the importance of data assimilation and new well-logs in a CLFD workflow, we carried out researches at rigorous conditions without a reduction in uncertainty attributes. The proposed CLFD workflow was implemented on a benchmark analogous to a giant field with extensively time-consuming simulation models. The results underscore that an ensemble with as few as 100 scenarios was sufficient to gauge the geological uncertainty, despite working with a giant field with highly heterogeneous characteristics. It is demonstrated that the CLFD workflow can improve the efficiency by over 85% compared to the previously validated workflow. Finally, we present some acute insights and problems related to data assimilation for the practical application of a CLFD workflow.

关键词： field development plan closed-loop field development reservoir model machine learning reservoir uncertainty optimization reservoir simulation efficiency