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Neuroplasticity in Spinal Trauma: A Current Narrative Review of Treatments

World Journal of Neuroscience 2021年第2期11卷 91-107页

作者： vinicius benatti freire Lucas Cressoni de Souza Mario Henrique de Lima Martinelli Leonardo Moysés Sacchi Thales Andolfo de Souza Antonio Eduardo Damin Medical Students of the Nove de Julho University (Campus Vergueiro) S&#227o Paulo Brazil Department of Neurology of the Nove de Julho University Medical School Neurologist and Professor of Neurology at Nove de Julho University Medical School S&#227o Paulo Brazil

Neuroplasticity is a condition that is present from birth, being found in the central and peripheral nervous system, in both physiological and pathological terms. Based on the findings, therapeutic and non-therapeutic attempts were tested on spinal cord trauma to recover locomotor function below the level of the injury. The work defined and showed other forms of the term neuroplasticity, talk about some pathological and non-pathological conditions, and, finally, show neuroplasticity and some of its treatments in the spinal cord injury process. A narrative literature review from 2000 to 2020 of the PubMed platform was conducted and analysis of two books for the elaboration of this work. Animal/human studies were included that addressed pathologies, forms of treatment for spinal trauma, and qualis from B1 to A1. Pre-2000 articles, which addressed neuroplasticity only to understand the molecular mechanisms and articles that were not in English, were excluded. As a result, the main molecules and structures that inhibit neuroplasticity were found, and, based on their knowledge, forms of treatments were developed to inhibit these molecules and structures to assist in neuroplasticity and assist in possible functional recovery. It can be concluded that the physiological barriers are already being overcome by the most recent forms of treatment and that soon new studies may propose a form of treatment that is protocoled for all patients.

关键词： Neuroplasticity Spinal Cord Injury Regeneration Nanomaterials Stem Cell Pharmacology

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Effects of Light Emitting Diode in Erythrocytes

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Modern Research in Inflammation 2014年第3期3卷 122-127页

作者： Hennes Gentil de Araújo Patricia Froes Meyer Mario Bernardo Filho Eric Heleno freire Frederico Sebastiao David dos Santos Filho Marcus vinicius de Mello Pinto Universidade Federal do Rio Grande do Norte(UFRN) NatalBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Universidade Estadual do Rio de Janeiro(UERJ) Rio de JaneiroBrazil Instituto Celulare Centro de Tratamento a Laser e Terapia CelularRio de JaneiroBrazil

The Light Emitting Diode (LED) is a phototherapy equipment, poorly studied, which is able of acting on blood level and it has frequently appeared in clinical practice of physiotherapy to aid on skin rejuvenation, control inflammation and wound healing. The aim of the study was to evaluate the effects of LED on red blood cells through the spectrophotometer. This is an experimental study with a sample of 5 male Wistar rats weighting between 200 g and 350 g, randomly selected, anesthetized and 4 ml of blood was collected by cardiac puncture. The blood collected was divided into four groups, one control and three treated, these individually irradiated by blue LED (420 - 490 nm), green LED (515 - 570 nm) and red LED (620 - 680 nm) at an output of 3 watts, for 10 minutes and 5 cm apart from the surface of the blood, then it was analyzed by a spectrophotometer at 540 nm. The results were submitted to Anova and Post-roch Turkey (p < 0.05). All wavelengths tested produced hemolysis greater than the control in hypotonic solutions of NaCl (range 0.02 to 0.06 M) (p < 0.01). Only the band between 515 - 570 nm provides a higher hemolysis (range 0.06 to 0.1) when compared to the control group (p < 0.05). The irradiation of blood through the LED therapy was able to weaken the cell membrane of the red blood cells. It is likely that hemolysis does not bring harm the body, because as it is a local therapy, the amount of hemolysis that can be caused is small and it will induce the reproduction of new red blood cells, thus improving their physiological functions.

关键词： LED Blood Spectrophotometer

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Oncolytic virus therapy in cancer: A current review

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World Journal of Virology 2021年第5期10卷 229-255页

作者： Jonathan Santos Apolonio vinicius Lima de Souza Goncalves Maria Luisa Cordeiro Santos Marcel Silva Luz Joao Victor Silva Souza Samuel Luca Rocha Pinheiro Wedja Rafaela de Souza Matheus Sande Loureiro Fabricio freire de Melo Universidade Federal da Bahia Instituto Multidisciplinar em SaudeVitoria da Conquista 45029-094BahiaBrazil Universidade Estadual do Sudoeste da Bahia Campus Vitoria da ConquistaVitoria da Conquista 45083-900BahiaBrazil

In view of the advancement in the understanding about the most diverse types of cancer and consequently a relentless search for a cure and increased survival rates of cancer patients,finding a therapy that is able to combat the mechanism of aggression of this disease is extremely ***,oncolytic viruses(OVs)have demonstrated great benefits in the treatment of cancer because it mediates antitumor effects in several *** can be used to infect cancer cells,especially over normal cells,to present tumor-associated antigens,to activate“danger signals”that generate a less immune-tolerant tumor microenvironment,and to serve transduction vehicles for expression of inflammatory and immunomodulatory *** success of therapies using OVs was initially demonstrated by the use of the genetically modified herpes virus,talimogene laherparepvec,for the treatment of *** this time,several OVs are being studied as a potential treatment for cancer in clinical ***,it is necessary to be aware of the safety and possible adverse effects of this therapy;after all,an effective treatment for cancer should promote regression,attack the tumor,and in the meantime induce minimal systemic *** this manuscript,we will present a current review of the mechanism of action of OVs,main clinical uses,updates,and future perspectives on this treatment.

关键词： Oncolytic viruses Antitumor response Tumor lysis Tumor cells Mechanism Therapy

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