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Pharmacologic approaches to treatment resistant depression:Evidences and personal experience

World Journal of Psychiatry 2015年第3期5卷 330-341页

作者： Antonio Tundo Rocco de filippis Luca Proietti Istituto di Psicopatologia Private Outpatients Clinic

AIM: To review evidence supporting pharmacological treatments for treatment-resistant depression(TRD) and to discuss them according to personal clinical ***: Original studies, clinical trials, systematic reviews, and meta-analyses addressing pharmacological treatment for TRD in adult patients published from 1990 to 2013 were identified by data base queries(Pub Med, Google Scholar e Quertle Searches) using terms: "treatment resistant depression", "treatment refractory depression", "partial response depression", "non responder depression", "optimization strategy", "switching strategy", "combination strategy", "augmentation strategy", selective serotonin reuptake inhibitors antidepressants(SSRI), tricyclic antidepressants(TCA), serotonin norepinephrine reuptake inhibitors antidepressants, mirtazapine, mianserine, bupropione, monoamine oxidase inhibitor antidepressant(MAOI), lithium, thyroid hormones, second generation antipsychotics(SGA), dopamine agonists, lamotrigine, psychostimulants, dextromethorphan, dextrorphan, ketamine, omega-3 fatty acids, S-adenosil-L-metionine, methylfolat, pindolol, sex steroids, glucocorticoid agents. Other citations of interest were further identified from references reported in the accessed articles. Selected publications were grouped by treatment strategy:(1) switching from an ineffective antidepressant(AD) to a new AD from a similar or different class;(2) combining the current AD regimen with a second AD from a different class; and(3) augmenting the current AD regimen with a second agent not thought to be an antidepressant ***: Switching from a TCA to another TCA provides only a modest advantage(response rate 9%-27%), while switching from a SSRI to another SSRI is more advantageous(response rate up to 75%). Evidence supports the usefulness of switching from SSRI to venlafaxine(5 positive trials out 6), TCA(2 positive trials out 3), and MAOI(2 positive trials out 2) but not from SSRI to bupropione, duloxetine a

关键词： Treatment resistant depression Combination Augmentation Switching Non responder depression Partial response depression Major depressive disorder Antidepressants Second generation antipsychotics Dopamine-agonists

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Effect of Nitrogen and Phosphorus Starvations on <i>Chlorella vulgaris</i>Lipids Productivity and Quality under Different Trophic Regimens for Biodiesel Production

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American Journal of Plant Sciences 2013年第12期4卷 44-51页

作者： Gianluca Belotti Marco Bravi Benedetta de Caprariis Paolo de filippis Marco Scarsella department of Chemical Engineering Sapienza University of Rome Via Eudossiana Rome Italy

In this work the effects of nutrients starvations on Chlorella vulgaris were investigated in different trophic regimens. For all the tested conditions, the cellular response to nutrient starvation and trophic regimen was evaluated on specific growth rate, biomass and lipids productivity, lipids content and quality. These parameters are all crucial for microalgae biodiesel production, but in literature the lipids quality, in terms of polar and nonpolar lipids, is often neglected. Thus the typical high content of polar lipids, a class of molecules that negatively affects the biodiesel production process, of microalgae crude oil is generally not analyzed. In the tested conditions the triggering effect of nitrogen starvation on total lipids productivity is confirmed only in autotrophic regimen, while in mixotrophic and heterotrophic conditions the total lipids productivity is reduced, as a consequence of the lowered biomass productivity, but with an evident compositional shift towards nonpolar lipids production (from 0.5 mg/Ld to 41.6 mg/Ld in mixotrophic regimen). Nitrogen and phosphorus co-starvation induced the highest nonpolar lipids productivity in all trophic regimens. Maximum nonpolar lipids productivity was obtained in nitrogen limited and phosphorus deprived condition during mixotrophic growth, equal to 118.2 mg/Ld, representing the 80% of produced lipids. On the basis of the obtained results, the possibility of a short pre-harvesting cultural step to maximize the nonpolar lipids yield of the crop could be envisaged.

关键词： Biodiesel Chlorella Vulgaris Trophic Regimens Nutrients Starvation Nonpolar Lipids Productivity

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揭秘青藏高原上的万能妙药

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疯狂英语（新悦读） 2015年第9期 21-24页

作者： Jeanne Mascolo de filippis 丁一

提起西藏,你会想到蓝天、歌声、布达拉宫、藏羚羊、酥油茶……其实,西藏还有无数我们不知晓的宝藏。这次,我们去看一种埋在地下的宝贝——虫草。在过去几年里,有一门生意开始风生水起。冬虫夏草被称为喜马拉雅山的男性补药,它的受欢迎... 详细信息

提起西藏,你会想到蓝天、歌声、布达拉宫、藏羚羊、酥油茶……其实,西藏还有无数我们不知晓的宝藏。这次,我们去看一种埋在地下的宝贝——虫草。在过去几年里,有一门生意开始风生水起。冬虫夏草被称为喜马拉雅山的男性补药,它的受欢迎程度超过了人参,甚至比黄金更值钱,并时常作结婚贺礼之用。传说西藏高原的牦牛吃了虫草后,体力会增加十倍。由于其不可思议的功效,一些研究实验室毫不犹豫地称它为未来的万能特效药。可虫草究竟是什么东西呢?是催情的菌类?还是强劲的补药?虫草功效范围之广令人不禁怀疑:这其实只是一个神话抑或真有其事?

关键词：研究实验室 Cordyceps 藏羚受欢迎程度令人 Himalayan dealing fungi starts 蝙蝠蛾科

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前瞻性比较US、CT及MRI对肝硬化病人肝细胞肝癌的诊断能力

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国际医学放射学杂志 2013年第3期 294-295页

作者： M.Di Martino G.de filippis A.de Santis D.Geiger M.del Monte C.V.Lombardo 陈超 department of Radiological Sciences Oncology and Anatomical PathologyUniversity of Rome "Sapienza"

目的前瞻性比较超声(US)、多层螺旋CT(MDCT)和对比增强MRI在肝硬化肝移植病人中诊断肝细胞肝癌的能力。方法共对140例病人的163个肝细胞肝癌结节进行了US、MRI和MDCT检查。通过病理或者随访12个月病灶明显增大来确诊肝癌的诊断。研究对U... 详细信息

目的前瞻性比较超声(US)、多层螺旋CT(MDCT)和对比增强MRI在肝硬化肝移植病人中诊断肝细胞肝癌的能力。方法共对140例病人的163个肝细胞肝癌结节进行了US、MRI和MDCT检查。通过病理或者随访12个月病灶明显增大来确诊肝癌的诊断。研究对US、MDCT、MRI平扫加动态扫描、MRI平扫、动态扫描加肝胆相扫描等4种不同的成像技术数据进行分析。确定诊断准确性、敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)及相应的95%置信区间。统计分析针对所有病灶及3个不同的亚组(2cm)进行。结果平扫、动态扫描加肝胆相MRI扫描的准确度、敏感度及NPV显著高于US、MDCT和单独动态增强MRI。US的特异度及PPV显著低于MDCT、动态增强MRI和动态增强加肝胆相扫描MRI。所有的亚组分析所得到的结果相似,其中对1～2cm之间的小病灶具有特别的诊断价值。结论动态增强加肝胆相扫描MRI检查对于肝硬化病人肝癌具有更高的检出力和定性诊断价值。其最有利于诊断大小在1～2cm之间的病灶。要点①US、CT和MRI都能够识别肝硬化病人的肝细胞肝癌。②US具有良好的敏感度,但存在假阳性结果。③在肝细胞肝癌的诊断上,动态CT及MRI具有相似的诊断性能。④动态增强加肝胆相扫描MRI检查能显著提高肝癌的检出及定性诊断。⑤最有利于诊断大小在1～2cm之间的病灶。

关键词：肝癌超声多层螺旋CT MRI 肝脏特异性对比剂

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肝硬化病人中的肝细胞癌:MR钆贝酸二葡甲胺增强成像和64层CT多时相影像的定性比较

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国际医学放射学杂志 2009年第3期 287-288页

作者： D.Marin M.D.Martino A.Guerrisi G.de filippis M.Rossi C.Catalano 宋建军 department of Radiological Sciences University of Rome La SapienzaViale Regina Elena 324Rome 00161Italy

目的前瞻性研究联合MRI钆贝酸二葡甲胺动态增强和肝胆相磁共振成像是否要比单独动态磁共振成像或多层CT多时相影像能提高肝细胞癌检测的准确性。方法机构审查委员会批准,并获得病人的知情同意。52例(男39例,女13例,平均年龄68岁,范围38... 详细信息

目的前瞻性研究联合MRI钆贝酸二葡甲胺动态增强和肝胆相磁共振成像是否要比单独动态磁共振成像或多层CT多时相影像能提高肝细胞癌检测的准确性。方法机构审查委员会批准,并获得病人的知情同意。52例(男39例,女13例,平均年龄68岁,范围38～81岁)疑有肝细胞癌的病人接受钆贝酸二葡甲胺增强磁共振成像和64层CT多时相扫描检查。影像的定性由3位观察者在3个不同的期间独立读片分析。用AFROC方法来分析结果。

关键词：葡甲胺动态增强多时相影像动态磁共振成像 MR 病人 CT 肝细胞癌

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地狱里的工作:记忆术与萨里的查尔顿的壁画《末日审判》对行业的描绘

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中世纪与文艺复兴研究 2022年第1期 39-78页

作者：劳拉·伊赛比·德·菲立比斯西安外国语大学欧洲学院

收藏于萨里的查尔顿的壁画《末日审判》是12世纪的作品,其特别之处在于描绘了制造商和商人在地狱的情景。通过分析涂鸦、罗马墓碑、后期的意大利壁画等其他艺术样本,本文认为,查尔顿的末日描绘可以被当作旨在激发回忆和创造力的记忆术... 详细信息

收藏于萨里的查尔顿的壁画《末日审判》是12世纪的作品,其特别之处在于描绘了制造商和商人在地狱的情景。通过分析涂鸦、罗马墓碑、后期的意大利壁画等其他艺术样本,本文认为,查尔顿的末日描绘可以被当作旨在激发回忆和创造力的记忆术工具。

关键词：查尔顿末日审判中世纪壁画修辞记忆术罗马墓碑对行业的描绘

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Research and development of the back-end electronics for the two-dimensional improved resistive plate chambers in CMS upgrade

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Radiation detection Technology and Methods 2021年第2期5卷 181-191页

作者： P.Cao Z-A.Liu J.Zhao H.Kou J.Tao J.Song W.Gong N.Wang A.Samalan M.Tytgat N.Zaganidis G.A.Alves F.Marujo F.Torres.Da.S.ilva.de.Araujo E.M.Da Costa D.de Jesus Damiao H.Nogima A.Santoro S.Fonseca de Souza A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov M.Bonchev A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov S.J.Qian C.Bernal A.Cabrera J.Fraga A.Sarkar S.Elsayed Y.Assran M.El Sawy M.A.Mahmoud Y.Mohammed X.Chen C.Combaret M.Gouzevitch G.Grenier I.Laktineh L.Mirabito K.Shchablo I.Bagaturia D.Lomidze I.Lomidze V.Bhatnagar R.Gupta P.Kumari J.Singh V.Amoozegar B.Boghrati M.Ebraimi R.Ghasemi M.Mohammadi Najafabadi E.Zareian M.Abbrescia R.Aly W.Elmetenawee N.de filippis A.Gelmi G.Iaselli S.Leszki F.Loddo I.Margjeka G.Pugliese D.Ramos L.Benussi S.Bianco D.Piccolo S.Buontempo A.Di Crescenzo F.Fienga G.de Lellis L.Lista S.Meola P.Paolucci A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo B.Francois T.J.Kim J.Park S.Y.Choi B.Hong K.S.Lee J.Goh H.Lee J.Eysermans C.Uribe Estrada I.Pedraza H.Castilla-Valdez A.Sanchez-Hernandez C.A.Mondragon Herrera D.A.Perez Navarro G.A.Ayala Sanchez S.Carrillo E.Vazquez A.Radi A.Ahmad I.Asghar H.Hoorani S.Muhammad M.A.Shah I.Crotty department of Physics and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium Centro Brasileiro Pesquisas Fisicas R.Dr.Xavier Sigaud150-UrcaRio de JaneiroRJ 22290-180Brazil dep.de Fisica Nuclear e Altas Energias Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524BR-Rio de Janeiro 20559-900RJBrazil Bulgarian Academy of Sciences Inst.for Nucl.Res.and Nucl.EnergyTzarigradsko shaussee Boulevard 721784 SofiaBulgaria Faculty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China Institute of High Energy Physics UCAS/CAS19(B)Yuquan RoadShijingshan DistrictBeijing 100049China Universidad de Los Andes Apartado Aereo 4976Carrera 1Eno.18A 10BogotaCOColombia Egyptian Network for High Energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt The British University in Egypt(BUE) P.O.Box 43Elsherouk CitySuez Desert RoadCairo 11837Egypt Suez University Elsalam CitySuez-Cairo RoadSuez 43522Egypt department of Physics Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Center for High Energy Physics Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgian Technical University 77 Kostava Str.Tbilisi 0175Georgia department of Physics Panjab UniversityChandigarh 160014India School of Particles and Accelerators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531TehranIran School of Engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso Univ.Monte S.AngeloVia Cintia80126 NaplesItaly INFN Sezione di PaviaVia Bassi 6PaviaItaly INFN Sezione di Pavia and University of PaviaVia Bassi 6PaviaItaly Hanyang University 222 Wangsimni-roSageun-dongSeongdong

Purpose To complement and ensure redundancy in the endcap muon system of the Compact Muon Solenoid(CMS)detector and to extend the Resistive Plate Chamber(RPC)system coverage,improved RPCs(iRPCs)with either orthogonal layer strips with one-end electronics or single layer strips with two-end electronics providing more precise time measurement will be installed in the very forward pseudorapidity region of|η|detector data with Timing,Trigger and fast Control(TTC)and Slow Control(SC)into one data stream over a bi-directional optical link with a line rate of 4.8 Gb/s between the Front-End Electronics(FEE)and the Back-End Electronics(BEE).To fulfill these requirements,a prototype BEE for the iRPC 2D chamber has been researched and *** A Micro-Telecommunication and Computing Architecture(μTCA)-based processing card was designed in this study to establish a prototype system together with aμTCA *** Giga-Bit Transceiver(GBT)protocol is integrated to provide bi-directional communication between the FEE and BEE.A server is connected with the BEE by a Gigabit Ethernet(GbE)link for SC and a 10-GbE link for Data AcQuisition(DAQ).Results The Bit Error Rate(BER)test of the back-end board and a joint test with the iRPC 2D prototype chamber were *** less than 1.331×10−16 was *** timemeasurement with a resolution of 3.05 nswas successfully realized,and detector efficiencies of 97.7%for longitudinal strips and 96.0%for orthogonal strips were *** results demonstrate the correctness and reliability of the prototype *** The BEE prototype satisfies the requirements for the iRPC 2D chamber,and it worked stably and reliably during a long-term joint test run.

关键词： CMS iRPC TTC SC BEE μTCA GBT DAQ

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R&D of back-end electronics for improved resistive plate chambers for the phase 2 upgrade of the CMS end-capmuon system

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Radiation detection Technology and Methods 2022年第3期6卷 306-316页

作者： H.Kou Z.-A.Liu J.Zhao J.Song Q.Hou W.Diao P.Cao W.Gong N.Wang A.Samalan M.Tytgat M.El Sawy G.A.Alves F.Marujo E.A.Coelho F.Torres Da Silva de Araujo E.M.Da Costa H.Nogima A.Santoro S.Fonseca de Souza D.de Jesus Damiao M.Thiel M.Barroso Ferreira Filho K.Mota Amarilo A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov E.Shumka S.J.Qian C.Avila D.Barbosa A.Cabrera A.Florez J.Fraga J.Reyes Y.Assran M.A.Mahmoud Y.Mohammed I.Laktineh G.Grenier M.Gouzevitch L.Mirabito K.Shchablo C.Combaret W.Tromeur G.Galbit A.Luciol X.Chen I.Bagaturia I.Lomidze Z.Tsamalaidze V.Amoozegar B.Boghrati M.Ebraimi E.Zareian M.Mohammadi Najafabadi M.Abbrescia G.Iaselli G.Pugliese F.Loddo N.de filippis R.Aly D.Ramos W.Elmetenawee S.Leszki I.Margjeka D.Paesani L.Benussi S.Bianco D.Piccolo S.Meola S.Buontempo F.Carnevali L.Lista P.Paolucci F.Fienga A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo E.Asilar J.Choi T.J.Kim S.Y.Choi B.Hong K.S.Lee H.Y.Oh J.Goh I.Yu C.Uribe Estrada I.Pedraza H.Castilla-Valdez R.L.Fernandez A.Sanchez-Hernandez E.Vazquez M.Ramirez-Garcia N.Zaganidis A.Radi H.Hoorani S.Muhammad A.Ahmad I.Asghar M.A.Shah W.A.Khan J.Eysermans I.Crotty on behalf of the CMS Muon Group department of Physics and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium UniversitéLibre de Bruxelles Avenue Franklin Roosevelt50-1050 BruxellesBelgium Centro Brasileiro Pesquisas Fisicas R.Dr.Xavier Sigaud150UrcaRio de JaneiroRio de Janeiro 22290-180Brazil department de Fisica Nuclear e Altas Energias Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524Rio de JaneiroRio de Janeiro 20559-900Brazil Bulgarian Academy of Sciences Institute for Nuclear Researches and Nuclear EnergyTzarigradsko Shaussee Boulevard 721784 SofiaBulgaria Faculty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China State Key Laboratory of Particle detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences B325Main BuildingNo.19(A)Yuquan RoadShijingshan DistrictBeijing 100049China Universidad de Los Andes Carrera 1No.18A-12BogotáColombia Egyptian Network for High Energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt Suez University SuezCairo RoadElsalam CitySuez 43522Egypt Center for High Energy Physics(CHEP-FU) Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgian Technical University 77 Kostava Str.0175 TbilisiGeorgia School of Particles and Accelerators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531 TehranIran School of Engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso University Monte S.AngeloVia Cintia80126 NapoliItaly Dipartimento di Ingegneria Elettrica e delle Tecnologie dell’Informazione UniversitàDegli Studi di Napoli Federico II80126 NapoliI

Purpose The Large Hadron Collider(LHC)at European Organization for Nuclear Research is planned to be upgraded to the high luminosity *** the luminosity makes muon triggering reliable and ofﬂine reconstruction very *** enhance the redundancy of the Compact Muon Solenoid(CMS)Muon system and resolve the ambiguity of track reconstruction in the forward region,an improved Resistive Plate Chamber(iRPC)with excellent time resolution will be installed in the Phase-2 CMS *** iRPC will be equipped with Front-End Electronics(FEE),which can perform high-precision time measurements of signals from both ends of the *** Back-End Electronics(BEE)need to be researched and developed to provide sophisticated functionalities such as interacting with FEE with shared links for fast,slow control(SC)and data,in addition to trigger primitives(TPs)generation and data acquisition(DAQ).Method The BEE prototype uses a homemade hardware board compatible with the MTCA standard,the back-end board(BEB).BEE interacts with FEE via a bidirectional 4.8 Gbps optical paired-link that integrates clock,data,and control *** clock and fast/slow control commands are distributed from BEB to the FEE via the *** uplink is used for BEB to receive the time information of the iRPC’sﬁred strips and the responses to the fast/slow control *** have a pipelined detector data for clusterﬁnding operation,recover(deMux)the time relationship of which is changed due to the transmission protocol for the continuous incoming MUXed data from *** at each bunch crossing(BX),clusteringﬁred strips that satisfy time and spatial constraints to generate *** incoming raw MUXed detector data and TPs in a time window and latency based on the trigger signal are read out to the DAQ *** Ethernet(GbE)of SiTCP and commercial 10-GbE are used as link standards for SC and DAQ,respectively,for the BEB to interact with the *** The joint test results of

关键词： CMS iRPC BEE TP DAQ SC

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CEPC Technical design Report

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Radiation detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili deng Binglin denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio de Maria Nicola de filippis Christophe de La Taille Francesca de Mori Chiara de Sio Elisa del Core Shuangxue deng Wei-Tian deng Zhi deng Ziyan deng Bhupal dev Tang dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian deutsches Elektronen-Synchrotron deSY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical design Report(TDR)follows the Preliminary Conceptual design Report(Pre-CDR,2015)and the Conceptual design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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