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A measure of ionospheric irregularities:zonal velocity and its implications for L-band scintillation at low-latitudes

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Earth and Planetary Physics 2021年第5期5卷 450-461页

作者： Claudio Cesaroni Luca Spogli Giorgiana De Franceschi Juliana Garrido Damaceno Marcin Grzesiak Bruno Vani Joao Francisco Galera Monico vincenzo romano Lucilla Alfonsi Massimo Cafaro Istituto Nazionale di Geofisica e Vulcanologia Italy SpacEarth Technology Italy Space Research Centre of the Polish Academy of Sciences Poland Instituto Federal de Educação Ciência e Tecnologia de São PauloBrazil Universidade Estadual Paulista“Júlio de Mesquita Filho” Brazil University of Salento Italy

We estimate the zonal drift velocity of small-scale ionospheric irregularities at low latitude by leveraging the spaced-receivers technique applied to two GNSS receivers for scintillation monitoring installed along the magnetic parallel passing in Presidente Prudente(Brazil,magnetic latitude 12.8°S).The investigated ionospheric sector is ideal to study small-scale irregularities,being located close to the expected position of the southern crest of the equatorial ionospheric anomaly.The measurement campaign took place between September 2013 and February 2014,i.***.equinox and summer solstice seasons under solar maximum,during which the probability of formation of small-scale irregularities is expected to maximize.We found that the hourly average of the velocity increases up to 135 m/s right after the local sunset at ionospheric altitudes and then smoothly decreases in the next hours.Such measurements are in agreement with independent estimations of the velocity made by the Incoherent Scatter Radar located at the Jicamarca Radio Observatory(magnetic latitude 0.1°N),by the Boa Vista Ionosonde(magnetic latitude 12.0°N),and by applying a recently-developed empirical regional short-term forecasting model.Additionally,we investigated the relationship with the percentage occurrence of amplitude scintillation;we report that it is exponentially dependent on the zonal velocity of the irregularities that cause it.

关键词： ionospheric irregularities GNSS scintillation plasma drift velocity low-latitude ionosphere spaced receivers Equatorial Plasma Bubbles

The Istituto Nazionale di Geofisica e Vulcanologia Data Management System for the Arctic Sciences

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环境科学与工程：B 2016年第11期5卷 549-556页

作者： Umberto Apponi vincenzo romano Giorgiana De Franceschi Paola Del Carlo Ilaria Isola Patrizia Macri Giovanni Muscari Leonardo Sagnotti Luca Spogli Stefano Urbini Spacearth Technology S.r.l. Via di Vigna Murata 605 00143 Rome Italy lstituto Nazionale di Geofisica e Vulcanologia Environment Department Via di Vigna Murata 605 00148-Rome Italy Istituto Nazionale di Geofisica e Vulcanologia Volcanoes Department Via della Faggiola 32-56126 Pisa Italy

Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease

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Journal of Geriatric Cardiology 2016年第8期13卷 701-711页

作者： Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi vincenzo Flati Deodato Assanelli Francesco S Dioguardi Department of Clinical & Experimental Sciences Division of Human Anatomy & Physiopathology University of Brescia Brescia Italy 'S.Maugeri Foundation ' IRCCS Cardiology Division Medical Centre of Lumezzane Brescia Italy Zena and Michael A Wiener Cardiovascular Institute Mount Sinai Medical Center New York USA Center for Heart and Vessel Preclinical Studies St. John Hospital & Medical Center Wayne State University School of Medicine Detroit USA VA Ann Arbor Health Care System University of Michigan Ann Arbor USA Department of Cardiovascular Surgery 'San Rocco' Hospital Ome Brescia Italy Department of Biotechnological and Applied Clinical Sciences University of L 'Aquila L 'Aquila Italy Division of Sport-Internal Medicine Department of Clinical & Experimental Sciences University of Brescia Brescia Italy Department of Clinical Sciences and Community Health University of Milan Milan Italy

BackgroundKlotho 蛋白质(α； - 并且 β；) 是基于膜的传播调整细胞新陈代谢的蛋白质，以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险，建议 ... 详细信息

BackgroundKlotho 蛋白质(α； - 并且 β；) 是基于膜的传播调整细胞新陈代谢的蛋白质，以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险，建议 Klotho 有在心血管的疾病的一个保护的角色。然而，尽管到目前为止它在各种各样的机关被识别了，它是未知的是否，并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF ， FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到，估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视，我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示，并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示，氧化应力，发炎并且 fibrosis.ResultsOnly ，有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示，但是 FGF 的更高的表情。而且，更高心血管的风险与增加的表示被联系氧化并且网状的应力，发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示， Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的，当压力相关的分子的表示显著地被增加时。

关键词：动脉粥样硬化患者疾病 Cardiomyocytes 心血管的风险人的心 Klotho

Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第28期14卷 4454-4461页

作者： Luciana Rigoli Claudio romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries Dipartimento di Scienze Pediatriche Mediche e Chirurgiche Università di MessinaMessina 98125Italy Dipartimento di Patologia Umana Università di MessinaMessina 98125Italy Dipartimento di Medicina Interna e Terapia Medica Università di MessinaMessina 98125Italy

AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD.

关键词：结肠疾病肠溃疡核苷酸治疗方法

Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience

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World Journal of Hepatology 2016年第22期8卷 949-956页

作者： Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna Francesco Cesario vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De Marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni vincenzo Messina Roberto Monarca vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone Depart-ment of Medicine Center for Liver Diseases "Buon Consiglio" -Fatebenefratelli Hospital Internal Medicine Unit Second University of Naples VI Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Gastro- enterology Casa Sollievo Sofferenza Hospital IRCCS Division of Infectious Diseases Belcolle Hospital IX Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Clinical of Infectious Disease University of Sassari Infectious Disease IRCCS San Matteo Division of Infectious Diseases and Liver Unit "G. Iazzolino" Hospital Division of Infectious Diseases "Annunziata" Hospital Depart-ment of Internal Medicine Umberto I Hospital Internal Medicine Ospedale Evangelico Villa Betania Division of Gastroenterology IRCCS "S.de Bellis" Hospital Internal Medicine Unit Pescara-Penne Hospital Gastroenterology Unit Marcianise Hospital Liver Unit AORN Cardarelli Liver Unit Policlinico "Mater Domini" Service of Medical Day Hospital "Rummo" Hospital Internal Medicine Regina Margherita Hospital Division of Gastroenterology "Annunziata" Hospital Infectious Disease Matera Hospital First Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Infectious Diseases AO Melacrino- Bianchi-Morelli Infectious and Tropical Disease Policlinico Umberto I Division of Infectious Disease Maria SS Addolorata Hospital Division of Infectious Diseases S. Anna and S. Sebastiano Hospital Outpatients Service for Liver Diseases "Loreto Crispi" Hospital V Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Department of Medical Surgical Neurological Geriatric and Metabolic Sciences Second Univer-sity of Naples Liver Unit Policlinico Casilino Medicine and Health Unit for Prisoners Belcolle Hospital Internal Medicine Unit "Ascalesi" Hospital Gastrointestinal and Liver Department National Institute for Health Migration and Poverty Liver Unit Azienda Ospedaliera San Camillo Forlanini VII Division of Infectious Diseases

AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin.

关键词： Boceprevir Telaprevir Chronic hepatitis Antiviral therapy Peg-interferon Ribavirin