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D-Aspartate, a Key Element for the Improvement of Sperm Quality

Advances in Sexual Medicine 2012年第4期2卷 45-53页

作者： Gemma D’Aniello Salvatore Ronsini Tiziana Notari Natascia Grieco vincenzo infante Nicola D’Angel Fara Mascia Maria Maddalena Di Fiore George Fisher Antimo D’Aniello Department of Clinical Chemistry Diagnostic Center “Fleming Laboratory” Brescia Italy Department of Human Clinical Chemistry of Poly-Diagnostic Center “Igea Sant’Antimo” Via degli Oleandri Sant’Antimo (NA) Italy Department of Life Science University of Naples Federico II Naples Italy Department of Obstetrics Gynaecology and Physiology of Human Reproductive (IVF Unit) Hospital “<i.S. Luca” Vallo della Lucania (SA) Italy Department of Physical Sciences Barry University Miami Schores USA

Introduction: D-Aspartate is an endogenous amino acid involved in LH and testosterone release in humans. In this study we investigate the impact of nutritional supplementation of sodium D-aspartate on the improvement of sperm quality in sub-fertile patients and the rate of pregnancies that occurred with their partners. Materials and Methods: A group of 30 patients affected by oligo-asthenozoospermia and a group of 30 patients affected by asthenozoospermia were treated with a daily dose of sodium D-aspartate for 90 days. After which, the change in spermatozoa concentration and their motility and the pregnancies that occurred with their partners were recorded. Results: We found that the supplementation of D-aspartate significantly increased the concentration and the motility of spermatozoa. In oligo- asthenozoospermic patients the increase of sperm concentration was found to be 2.0-fold, P Conclusions:Treatment of sub-fertile patients with sodium D-aspartate improved the number and the motility of the spermatozoa and consequently improved the rate of pregnancies of their partners.

关键词： D-Aspartate Oligo-Asthenozoospermia Asthenozoospermia Pregnancies

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Novel epigenetic-based therapies useful in cardiovascular medicine

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World Journal of Cardiology 2016年第2期8卷 211-219页

作者： Claudio Napoli vincenzo Grimaldi Maria Rosaria De Pascale Linda Sommese Teresa infante Andrea Soricelli Division of Immunohematology Transfusion Medicine and Transplant ImmunologyDepartment of Internal Medicine and Specialistic UnitAzienda Ospedaliera Universitaria (AOU)Second University of Naples Institute of Diagnostic and Nuclear Development(SDN) IRCCS

Epigenetic modifications include DNA methylation, his-tone modifications, and micro RNA. Gene alterations have been found to be associated with cardiovascular diseases, and epigenetic mechanisms are continuously being studied to find new useful strategies for the clinical management of afflicted patients. Numerous cardiovascular disorders are characterized by the abnormal methylation of Cp G islands and so specific drugs that could inhibit DNA methyltransferase directly or by reducing its gene expression(e.g., hydralazine and procainamide) are currently under investigation. The anti-proliferative and anti-inflammatory properties of histone deacetylase inhibitors and their cardio-protective effects have been confirmed in preclinical studies. Furthermore, the regulation of the expression of micro RNA targets through pharmacological tools is still under development. Indeed, large controlled trials are required to establish whether current possible candidate antisense micro RNAs could offer better therapeutic benefits in clinical practice. Here, we updated therapeutic properties, side effects, and feasibility of eme-rging epigenetic-based strategies in cardiovascular diseases by highlighting specific problematic issues that still affect the development of large scale novel therapeutic protocols.

关键词： Epigenetics Cardiovascular diseases Heart failure Inhibitors of histone deacetylases Antisense microRNAs

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