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Machine Learning Empowered Security and Privacy Architecture for IoT Networks with the Integration of Blockchain

Intelligent Automation & Soft Computing 2024年第2期39卷 353-379页

作者： Sohaib Latif M.Saad Bin Ilyas Azhar Imran Hamad Ali Abosaq Abdulaziz Alzubaidi vincent karovic jr. Department of Computer Science The University of ChenabGujrat50700Pakistan Department of Creative Technologies Air UniversityIslamabad42000Pakistan Computer Science Department College of Computer Science and Information SystemsNajran UniversityNajran66244Saudi Arabia Department of Computer Science Umm Alqura UniversityAlQunfudah28821Saudi Arabia Department of Information Systems Faculty of ManagementComenius University in BratislavaBratislava82005Slovakia

The Internet of Things(IoT)is growing rapidly and impacting almost every aspect of our lives,fromwearables and healthcare to security,traffic management,and fleet management *** has generated massive volumes of data and security,and data privacy risks are increasing with the advancement of technology and network *** access control solutions are inadequate for establishing access control in IoT systems to provide data protection owing to their vulnerability to single-point OF ***,conventional privacy preservation methods have high latency costs and overhead for resource-constrained *** machine learning approaches were also unable to detect denial-of-service(DoS)*** study introduced a novel decentralized and secure framework for blockchain *** avoid single-point OF failure,an accredited access control scheme is incorporated,combining blockchain with local peers to record each transaction and verify the signature to ***-based attribute-based cryptography is implemented to protect data storage privacy by generating threshold parameters,managing keys,and revoking users on the *** innovative contract-based DOS attack mitigation method is also incorporated to effectively validate devices with intelligent contracts as trusted or untrusted,preventing the server from becoming *** proposed framework effectively controls access,safeguards data privacy,and reduces the risk of *** results depict that the suggested framework outperforms the results in terms of accuracy,precision,sensitivity,recall,and F-measure at 96.9%,98.43%,98.8%,98.43%,and 98.4%,respectively.

关键词： Machine learning internet of things blockchain data privacy security Industry 4.0

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Cancer: Principles And Practice Of Oncology Single Volume (Book With CD-ROM) Phila. :

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2001年

作者： vincent T. DeVita jr. MD Samuel Hellman Steven A

ISBN: (纸本)9780781722292

Acclaimed by the worldwide medical community as the standard-setting oncology reference, Cancer: Principles and Practice of Oncology is now in its Sixth Edition. This thoroughly revised and updated classic reflects the latest breakthroughs in every aspect of oncology, from molecular biology, to multimodality treatment, to new data on cancer prevention by drugs and *** edition places increased emphasis on the role of molecular biology in cancer diagnosis and treatment. In light of the growing clinical importance of biological therapy, a new section on Pharmacology of Cancer Biotherapeutics has been added. Chapters describe new radiotherapy techniques such as intensity-modulated radiation therapy and innovative surgical techniques such as radiofrequency ablation of tumors, isolation-perfusion for visceral cancers, and image-guided surgery. Rehabilitation is integrated into each of this edition's chapters on organ-specific cancers. Also included are new chapters on information systems in oncology, particularly on accessing information from the World Wide *** edition now includes a CD-ROM bound into the book. The CD-ROM has advanced search capabilities and gives you full text, high-quality video and color slides not found in the book, direct links to PubMed, and links to our new oncology portal, ***. The CD-ROM is also available separately

关键词： volume book single oncology principles practice cancerBiochemistry Biological Sciences Science & Math

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Antiviral activities of extracts from Hong Kong seaweeds

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第12期9卷 969-976页

作者： Hui WANG Engchoon vincent OOI Put O. ANG jr Medical College Jinan University Guangzhou 510632 China Department of Biology the Chinese University of Hong Kong Shatin N. T. Hong Kong China

We extracted six Hong Kong brown seaweed species with hot water for their antiviral properties. The cytotoxicity and antiviral activity of these extracts were tested by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenlytetrezolium bromide] method, cytopathic effect reduction assay, and plaque reduction assay. The antiviral effect was further determined by flow cytometric analysis. The results showed that most of these extracts inhibited the propagation of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) standard strains with very low cytotoxicity to the host cells. The extracts of Hydroclathrus clathratus and Lobophora variegata showed more potential anti-HSV activities than the extracts of the other four seaweeds. They also had moderate anti- respiratory syncytial virus (RSV) activities but could not inhibit influenza A virus. Hydroclathrus clathratus was further extracted by diluted acid and alkali and the antiviral effects of the extracts were also detected. The result showed that the hot water extract contained the main carbohydrate components that exhibited the antiviral activities against various strains of HSV, including the acyclovir-resistant strain. HI-3, a compound fractionated from this hot water extract, showed a dose-dependent anti-HSV activity in flow cytometric analysis and plaque reduction assay.

关键词：植物药医用疗效功能

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Antiviral polysaccharides isolated from Hong Kong brown seaweed Hydroclathrus clathratus

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Science China(Life Sciences) 2007年第5期50卷 611-618页

作者： OOI Engchoon vincent ANG Put O jr. Department of Biology the Chinese University of Hong Kong Shatin N.T. Hong Kong SAR China

Two relatively pure polysaccharides H3-a1 and H3-b1 had been isolated from the brown seaweed Hy-droclathrus clathratus. They were characterized by HPLC, ultraviolet scanning, gas chromatography, infrared spectroscopy and elemental analysis, and shown to be two different sulfated polysaccharides with different monosaccharide content, but both with high relative molecular mass. They contained some proteins and uronic acid respectively. The sulfate content and bioactivity of these polysaccha-rides varied during purification. The fractions derived from the hot water extract also exhibited low anticoagulant effect. This is the first time that the antiherpetic and anticoagulant activities were evaluated for the polysaccharides from the Hong Kong brown seaweed Hydroclathrus clathratus.

关键词： Hong Kong seaweed, Hydroclathrus clathratus, antiviral polysaccharide, polysaccharide characterization

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现代建筑

现代建筑

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1975年

作者： vincent XCULLY jr. 黄定国译

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The Introduction of Bedaquiline Regimen for Drug-Resistant Tuberculosis in the Philippines: An Operational Study

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Journal of Tuberculosis Research 2022年第4期10卷 205-219页

作者： vincent M. Balanag jr. Vivian S. Lofranco Mariquita J. Mantala Mary Rosary T. Santiago Patrice Jamie E. Cabasis Arnyl G. Araneta Anna Marie Celina G. Garfin Lung Center of the Philippines National Center for Pulmonary Research Quezon Philippines Department of Health National Tuberculosis Control Program Management Office Manila Philippines Philippine Business for Social Progress The Global Fund Project Manila Philippines Department of Health Disease Prevention and Control Bureau Manila Philippines

Objectives: Bedaquiline (BDQ) is the first new anti-tuberculosis (TB) drug introduced to the market after 45 years. Recent studies have shown the potential benefits of adding bedaquiline to regimens for drug-resistant TB (DR-TB). In search of more effective regimens for DR-TB, bedaquiline was introduced in the TB program in the Philippines under operational research to assess its effectiveness, safety, and tolerability when given with background regimens among patients with multi-or extensively DR-TB (MDR/XDR-TB). Design: A prospective cohort study of patients with MDR/XDR-TB was given with a bedaquiline-containing regimen from June 2016 to May 2017. Demographic data, presence of comorbidities, and microbiologic profile on entry were recorded. Bedaquiline was administered at the recommended dose of 400 mg once daily for 14 days, then 200 mg three times a week for 22 weeks together with World Health Organization (WHO)-compliant background regimen. The time to culture conversion, interim outcomes at the 6th month of treatment, end-of-treatment outcomes, and post-treatment follow-up outcomes after one year was determined. The frequency and severity of adverse events (SAE) were recorded as part of pharmacovigilance. Results: Seventy-five patients were given with bedaquiline-containing regimen during the study period. Forty-two (56.0%) had second-line injectable resistance, 23 (30.7%) had fluoroquinolone-resistance, 6 (8.0%) had MDR-TB, and 4 (5.3%) had XDR-TB. In the 6th month of post-enrolment, 79% were culture-negative. The treatment success rate was 65.3% (37 were cured and 12 completed treatment), 7 (9.3%) died, 17 (22.7%) lost to follow-up, and 2 (2.7%) were withdrawn from treatment. Adverse events included vomiting (80%), dizziness (69%), nausea (52%), cough (44%), and headache (36%). The post-treatment follow-up of 49 patients in the 12th month showed 92% were culture-negative while 8% of TBC were not done. Conclusion: Bedaquiline-containing regimens for patients

关键词： Bedaquiline Drug-Resistant TB XDR-TB

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随机扩增多态性DNA技术研究发现二氧化钛纳米颗粒对西葫芦具有基因毒性(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第8期15卷 618-623页

作者： Fabiola MORENO-OLIVAS vincent U.GANT jr. Kyle L.JOHNSON Jose R.PERALTA-VIDEA Jorge L.GARDEA-TORRESDEY Depertment of Chemistry The University of Texas at El Paso El Paso TX 79968 USA University of California Center for Environmental Implications of Nanotechnology (UC CEIN) The University of Texas at El Paso El Paso TX 79968 USA Department of Biological Sciences and Border Biomedical Research Center The University of Texas at El Paso El Paso TX 79968 USA Environmental Science and Engineering PhD Program The University of Texas at El Paso El Paso TX 79968 USA

研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具... 详细信息

研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具有毒性特别是是否会产生植物基因毒性至今尚不清楚。因此,本文使用随机扩增多态性DNA技术研究TiO2纳米颗粒是否对西葫芦具有基因毒性,为TiO2纳米颗粒排放进入环境后的潜在植物毒性风险评价提供依据。创新要点:首次发现了TiO2纳米颗粒对西葫芦具有基因毒性。重要结论:采用随机扩增多态性DNA技术,发现TiO2纳米颗粒污染处理的西葫芦样品与未处理样品的基因组DNA图谱相比,不仅在谱带强度有明显差异,而且存在谱带消失和新谱带产生现象,表明TiO2纳米颗粒对西葫芦具有基因毒性。

关键词：随机扩增多态性DNA技术 TiO2 纳米颗粒基因组DNA 西葫芦毒性

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Effect of different intensities of physical activity on cardiometabolic markers and vascular and cardiac function in adult rats fed with a high-fat high-carbohydrate diet

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Journal of Sport and Health Science 2018年第1期7卷 109-119页

作者： Romeo B.Batacan jr.Mitch J.Duncan vincent J.Dalbo Geraldine L.Buitrago Andrew S.Fenning School of Medical and Applied Sciences Central Queensland University Centre for Physical Activity Studies Central Queensland University School of Medicine & Public Health Priority Research Centre for Physical Activity and Nutrition Faculty of Health and MedicineThe University of Newcastle University Drive Clinical Biochemistry Laboratory Central Queensland University Centre for Biodiscovery and Molecular Development of Therapeutics Australian Institute of Tropical Health and MedicineJames Cook University

Background: Physical activity(PA) and diet are 2 lifestyle factors that affect cardiometabolic risk. However, data on how a high-fat highcarbohydrate(HFHC) diet influences the effect of different intensities of PA on cardiometabolic health and cardiovascular function in a controlled setting are yet to be fully established. This study investigated the effect of sedentary behavior, light-intensity training(LIT), and high-intensity interval training(HIIT) on cardiometabolic markers and vascular and cardiac function in HFHC-fed adult ***: Twelve-week-old Wistar rats were randomly allocated to 4 groups(12 rats/group): control(CTL), sedentary(SED), LIT, and *** indices, glucose and lipid control, inflammatory and oxidative stress markers, vascular reactivity, and cardiac electrophysiology of the experimental groups were examined after 12 weeks of HFHC-diet feeding and PA ***: The SED group had slower cardiac conduction(p = 0.0426) and greater thoracic aortic contractile responses(p < 0.05) compared with the CTL group. The LIT group showed improved cardiac conduction compared with the SED group(p = 0.0003), and the HIIT group showed decreased mesenteric artery contractile responses compared with all other groups and improved endothelium-dependent mesenteric artery relaxation compared with the LIT group(both p < 0.05). The LIT and HIIT groups had lower visceral(p = 0.0057 for LIT, p = 0.0120 for HIIT)and epididymal fat(p < 0.0001 for LIT, p = 0.0002 for HIIT) compared with the CTL ***: LIT induced positive adaptations on fat accumulation and cardiac conduction, and HIIT induced a positive effect on fat accumulation,mesenteric artery contraction, and endothelium-dependent relaxation. No other differences were observed between groups. These findings suggest that few positive health effects can be achieved through LIT and HIIT when consuming a chronic and sustained HFHC diet.

关键词：高脂肪心脏老鼠食谱脉管标记成年物理

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Effectiveness and Safety of 9-Month Treatment Regimen for Multidrug-Resistant Tuberculosis in the Philippines

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Journal of Tuberculosis Research 2022年第2期10卷 75-86页

作者： Vivian S. Lofranco vincent M. Balanag jr.Lawrence O. Raymond Noel G. Macalalad Alex Golubkov Mary Rosary T. Santiago Anna Marie Celina G. Garfin National Center for Pulmonary Research-Lung Center of the Philippines Quezon City Philippines National TB Reference Laboratory-Research Institute for Tropical Medicine Muntinlupa City Philippines Global Health Bureau Infectious Diseases Office TB Division U.S. Agency for International Development (USAID) Washington USA Disease Prevention and Control-Department of Health Manila Philippines

Background: The Philippines has a burden of drug-resistant tuberculosis (DR-TB). One of the key challenges in the programmatic management of DR-TB (PMDT) is the high rate of loss to follow-up (38% in the 2010 cohort). An urgent need for a shorter, more tolerable, less expensive treatment regimen exists. The aim of the operational study is to determine the efficacy and safety of the short treatment regimen among drug resistant TB. Methods: This is a prospective single-arm cohort study evaluating the effectiveness and safety of a shorter 9 - 11-month treatment regimen (9MTR) for rifampicin-resistant/multi-drug resistant TB (RR/MDR-TB) in 10 PMDT facilities. All eligible consenting adult patients with rifampicin-resistant TB were enrolled and received the standardized 9-month treatment regimen (9MTR), including injectables, with a follow-up after 12 months of treatment completion. Results: A total of 329 patients were enrolled from July 2015 to December 2016. At the 6th month post-enrollment, 256 (77.8%) of them had culture-negative test results. The end-of-treatment success rate was 74.1% (224 [68.0%] were cured and 20 [6.1%] completed the treatment). On the other hand, 10 (3.0%) died, 41 (12.5%) lost to follow-up, 33 (10.0%) withdrawn, 1 (0.3%) treatment failure. In the 12th month after 9MTR completion, among the 244 patients with successful treatment, 198 (81.1%) had culture-negative results, while there were 46 patients whose culture tests were not done. One patient developed TB relapse with fluoroquinolone resistance. The majority of the adverse events were mild that occurred mostly during the first 6 months of treatment. Conclusion: The 9-month treatment regimen had a high treatment success rate with a favorable safety profile. The loss to follow-up was reduced;however, it was still a challenge. The introduction of the 9MTR via operational research had a major impact on building national capacity and infrastructure for the programmatic adoption of a new regimen.

关键词： MDR-TB Short Treatment Regimen Treatment Outcomes Prospective Studies

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Tax distortions in cross-border flows of intangible assets

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International Journal of Innovation Studies 2018年第3期2卷 101-121页

作者： Thomas Neubig Sacha Wunsch-vincent Tax Sage Network WashingtonD.C.USA Economics and Statistics Division World Intellectual Property Organization(WIPO)CH-1211 GenevaSwitzerland

The phenomenon of global fragmented production and associated trade in intermediate products,including intangible assets,has changed how economists study globalization and how new public policies are *** cross-border flows of disembodied knowledge,often associated with intellectual property(IP),is essential for analyzing how modern economies *** data to document these international IP-related knowledge flowsdnamely cross-border payments for IPdare distorted by various *** planning by multinational enterprises has seriously distorted the measurement of cross-border IP flows,affecting national measurements of imports,exports,GDP,and *** tax-induced mismeasurement could be more than 35% of global charges for use of intellectual property,and greater for individual countries,particularly high-taxrate *** initiatives to address the effects of tax base erosion,profit shifting,and other statistical initiatives on global value chains will improve future measurements of cross-border IP flows,improving the understanding of both the creation and uses of IP.

关键词： Global value chain Intellectual property Intangible assets Tax Base erosion Profit shifting Cross-border flows Charges for the use of intellectual property

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