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Contamination of Camel Milk (Heavy Metals, Organic Pollutants and Radionuclides) in Kazakhstan

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Journal of Environmental Protection 2011年第1期2卷 90-96页

作者： Gaukhar Konuspayeva Stefan Jurjanz gerard Loiseau vincent Barci Shynar Akhmetsadykova Aliya A. Meldebekova Bernard Faye 不详

In Kazakhstan, camel breeding mainly occupies areas sometimes close to polluting industries or other sources of pollu- tion as industrial agriculture, mainly cotton. Products issued from camel farms close to these sources as camel raw milk and fermented milk (shubat), wool and meat, traditionally used by humans could be contaminated. We investigated camel raw milk and fermented milk for the content of heavy metals (lead, cadmium, zinc and copper), radionuclide and some organic pollutants (PAHs, pesticides and indicator PCBs) in samples from different regions with a priori high risk of pollution (Atyrau, Kyzylorda, South-Kazakhstan and Almaty region). In the present paper, only some milk samples presented high lead concentration (> 500 ppb). After analysis for organic pollutants, it was observed some traces of hexachlorocyclohexane, lindane, hexanchlorothalonil in milk samples from different regions. One sample was also slightly contaminated with radionuclide. These preliminary results allow establishing a first map of risk for camel farming. As the whole, South-Kazakhstan appeared the most exposed region.

关键词： Camel Milk Pollutant Heavy Metal Pesticides Radionuclides

Retrospective evaluation of FOLFIRI3 alone or in combination with bevacizumab or aflibercept in metastatic colorectal cancer

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World Journal of Clinical Oncology 2019年第2期10卷 75-85页

作者： Madeline Devaux Laura gerard Corentin Richard Leila Bengrine-Lefevre Julie vincent Antonin Schmitt Fran?ois Ghiringhelli Department of Medical Oncology Centre George Fran?ois Leclerc Platform of Transfer in Biological Oncology Centre George Fran?ois Leclerc

BACKGROUND The treatment of metastatic colorectal cancer(mCRC) relies of chemotherapy. The efficacy of the standard FOLFIRI-therapy could be improved by a modification of the regimen by splitting the dose of irinotecan on day 1 and day 3 in the FOLFIRI3 *** To determine safety and efficacy of FOLFIRI3 *** This is a monocentric retrospective study evaluating the efficacy and safety of the FOLFIRI3 regimen given alone or in combination with bevacizumab or aflibercept in patients with previously treated *** One hundred and fifty-three consecutive patients were included(18 treated with FOLFIRI3, 99 with FOLFIRI3 plus bevacizumab and 36 with FOLFIRI3 plus aflibercept). The overall response rate(ORR) and disease control rate were 51%and 62%, respectively. Similar ORRs were observed in all 3 cohorts. Median progression-free survival(PFS) and overall survival(OS) were 3.9 mo(95%CI:3.2-4.9) and 9.4 mo(95%CI: 6.6-12), respectively. Median PFS and OS values were improved in the FOLFIRI3 plus aflibercept group. The most common grade 3-4 adverse events were diarrhoea(21.6%) and neutropenia(11.8%), and these toxicities were more frequent in the FOLFIRI3 plus aflibercept group. According to the multivariate Cox proportional model, previous surgery of metastasis andaflibercept were associated with *** The modification of the FOLFIRI regimen impacted treatment response of mCRC patients. The addition of an antiangiogenic agent, in particular aflibercept,enhanced the clinical benefit and improved survival.

关键词： Colorectal cancer Chemotherapy Irinotecan Second-line Aflibercept

Primary Abscess of the Psoas of the Child: About a Case Observed at the University Hospital Center of Bouake

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Open Journal of Pediatrics 2018年第2期8卷 154-157页

作者： Benie Adoubs Celestin Asse Kouadio vincent Irie Bi Gohi Serge Kakou Aka gerard Lohourou Grah Franck Traore Ibrahim Kouassi Aya Adelaide Natacha Kpangni AhuaJean Bertrand Department of Pediatric Surgery University Hospital Center of BouakeBouakeIvory Coast Pediatric Department University Hospital Center of BouakeBouakeIvory Coast Anesthesia-Resuscitation Department University Hospital Center of BouakeBouakeIvory Coast Department of General and Digestive Surgery University Hospital Center of BouakeBouakeIvory Coast Department of Traumatology-Orthopedics University Hospital Center of BouakeBouakeIvory Coast

The primary abscess of the psoas of the child is a rare affection, the pathogenesis of which is still unexplained. The positive diagnosis of this condition is difficult and relies mainly on medical imaging. We report a case of primary psoas abscess in an immunocompetent child, whose diagnosis was facilitated by the provision of abdominal radiography without preparation and abdominal ultrasound. The evolution was favorable thanks to the combination of antibiotic therapy and surgery.

关键词： Primary Abscess of the Psoas Child Ultrasound Surgery

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舒曼集团总部

城市环境设计 2010年第1期 114-119页

作者： Juliette Bekkering Monica Adams Frank Venhorst Paul Michielsen vincent Hector Albert-Jan Vermeulen Sander van Schaik Michel Leunis Manuel Aust gerard Heerink Bekkering Adams建筑事务所

舒曼集团的新址选置优越,位于能俯瞰荷兰北部的A9高速公路边上,并与一个自然保护区相邻。作为一个独立建筑,它的每个侧面都有独特的特征和外观。建筑四角作了升高处理,为项目特殊的功能需要提供空间。

关键词：集团总部舒曼天井矿井