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The Artificial Disc Nucleus and Other Strategies for Replacement of the Nucleus Pulposus:Past,Present and Future Designs for an Emerging Surgical Solution

Engineered Regeneration

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Engineered Regeneration 2024年第2期5卷 269-281页

作者： Greg Sacks vincent destefano Claire Parker Ryan Lebens Harry Mushlin Renaissance School of Medicine at Stony Brook University Stony BrookNYUSA

Nucleus Pulposus(NP)Replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs(IVDs).This article provides necessary context regarding the patholo-gies treated with this technology,the biomechanical structure and function of the IVD,and the procedures this technology aims to ***,it provides an overview and discussion of commercial and experimental preformed and in situ curing prosthesis designs reported in the scientific literature and summarizes the results of biomechanical and clinical studies evaluating their *** and updated information on the most recent research into NP replacement with novel hydrogel and tissue engineering(TE)strategies is *** of the NP allows for potential improvement in the treatment of degenerative spinal pathologies through minimally invasive surgical techniques.

关键词： Nucleus Pulposus Intradiscal Prosthesis Hydrogel Artificial Disc Implant Spine Surgery

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PETG:Applications in Modern Medicine

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Engineered Regeneration 2024年第1期5卷 45-55页

作者： Catherine Yan Corinne Kleiner Aaron Tabigue Veer Shah Gregory Sacks Darshi Shah vincent destefano Renaissance School of Medicine at Stony Brook University Stony BrookNYUSA Department of Biology Niagara UniversityLewistonNYUSA Stony Brook University Stony BrookNYUSA Department of Mechanical and Industrial Engineering Northeastern UniversityBostonMAUSA

Polyethylene terephthalate glycol,PETG,is a miscible,transparent thermoplastic known to have strong tensile properties,high ductility,as well as resistance to heat and chemical *** may be manufactured in several ways,most notably 3D printing *** such,PETG has emerged as a viable biomaterial for a variety of medical applications such as tissue engineering,dentistry,optometry,vascular health,cardiology,orthopedics,neurology,gynecology,and *** also serves a valuable role in biomedical research and engineering by offering improvements in cell studies,drug carriers,and anti-bacterial *** medical research and innovation utilizing PETG will better characterize its value as an inexpensive and versatile biomaterial.

关键词： Polyethylene terephthalate glycol Tissue Engineering 3D Printing Clinical Applications Biomedical Research

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Applications of PLA in modern medicine

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再生工程(英文) 2020年第1期1卷 76-87页

作者： vincent destefano Salaar Khan Alonzo Tabada Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA

Polylactic acid(PLA)is a versatile *** is synthesized with ease from abundant renewable resources and is *** has shown promise as a biomaterial in a plethora of healthcare applications such as tissue engineering or regenerative medicine,cardiovascular implants,dental niches,drug carriers,orthopedic in-terventions,cancer therapy,skin and tendon healing,and lastly medical tools/*** has demonstrated instrumental importance as a three-dimensionally(3D)printable biopolymer,which has further been bolstered by its role during the Coronavirus Disease of 2019(Covid-19)global *** an abundant filament,PLA has created desperately needed personal protective equipment(PPE)and ventilator *** polymer chemistry continues to advance,so too will the applications and continued efficacy of PLA-based modalities.

关键词： Polylactic acid Polymers Tissue engineering Cardiovascular Drug carriers Dental Orthopedics Cancer therapy skin/tendon healing surgical tools

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