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Quality of life and symptom distress after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

World Journal of Clinical Cases 2022年第32期10卷 11775-11788页

作者： Ya-Fen Wang Ting-Yao Wang Tzu-Ting Liao Meng-hung Lin Tzu-Hao Huang Meng-Chiao Hsieh vincent chin-hung chen Li-Wen Lee Wen-Shih Huang Chao-Yu chen Cancer Center Chang Gung Memorial HospitalChiayiTaiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayiTaiwan Division of Case Management Cancer CenterChang Gung Memorial HospitalChiayiTaiwan Health Information and Epidemiology Laboratory Chang Gung Memorial HospitalChiayiTaiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayiTaiwan Division of Colorectal Surgery Department of SurgeryChang Gung Memorial HospitalChiayiTaiwan Department of Psychiatry Chang Gung Memorial HospitalChiayi and Chang Gung UniversityTaoyuanTaiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayiTaiwanCollege of MedicineChang Gung UniversityTaoyuanTaiwan Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayiTaiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiungTaiwanDepartment of Early Childhood Care and EducationShu-Zen Junior College of Medicine and ManagementKaohsiungTaiwan

BACKGROUND Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy(CRS/HIPEC)for peritoneal surface malignancy can effectively control the disease,however it is also associated with adverse effects which may affect quality of life(QoL).AIM To investigate early perioperative QoL after CRS/HIPEC,which has not been discussed in *** This single institution,observational cohort study enrolled patients who received CRS/*** assessed QoL using the Taiwan residents version of the MD Anderson Symptom Inventory(MDASI-T)and European Organization Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ-C30).Participants completed the questionnaires before CRS/HIPEC(S1),at the first outpatient follow-up(S2),and 3 mo after CRS/HIPEC(S3).RESULTS Fifty-eight patients were *** was no significant perioperative difference in global health *** changes in physical and role functioning scores decreased at S2,and fatigue and pain scores increased at S2 but returned to baseline at *** regression analysis showed that age and performance status were significantly correlated with *** the MDASI-T questionnaire,distress/feeling upset and lack of appetite had the highest scores at S1,compared to fatigue and distress/feeling upset at S2,and fatigue and lack of appetite at *** leading interference items were working at S1 and S2 and activity at ***-T scores were significantly negatively correlated with the EORTC QLQ-C30 *** QoL and symptom severity improved or returned to baseline in most categories within 3 mo after CRS/*** findings can help with preoperative consultation and perioperative care.

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal carcinomatosis Quality of life Symptom distress Perioperative care

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Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1, MAPK, NF-κB signaling

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chinese Journal of Natural Medicines 2025年第1期23卷 90-101页

作者： Yongxian Li Jinbo Yuan Wei Deng Haishan Li Yuewei Lin Jiamin Yang Kai chen Heng Qiu Ziyi Wang vincent Kuek Dongping Wang Zhen Zhang Bin Mai Yang Shao Pan Kang Qiuli Qin Jinglan Li Huizhi Guo Yanhuai Ma Danqing Guo Guoye Mo Yijing Fang Renxiang Tan chenguang Zhan Teng Liu Guoning Gu Kai Yuan Yongchao Tang De Liang Liangliang Xu Jiake Xu Shuncong Zhang The First Clinical Academy Guangzhou University of Chinese Medicine The First Affiliated Hospital of Guangzhou University of chinese Medicine Lingnan Medical Research Center of Guangzhou University of chinese Medicine School of Biomedical Sciences University of Western Australia Curtin Medical School Curtin University Foshan Hospital of Traditional chinese Medicine School of Public Health and Management Guangzhou University of Chinese Medicine The State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional Biomolecules Nanjing University

Osteoporosis is a prevalent skeletal condition characterized by reduced bone mass and strength, leading to increased fragility. Buqi-Tongluo(BQTL) decoction, a traditional chinese medicine(TCM) prescription, has yet to be fully evaluated for its potential in treating bone diseases such as osteoporosis. To investigate the mechanism by which BQTL decoction inhibits osteoclast differentiation in vitro and validate these findings through in vivo *** employed MTS assays to assess the potential proliferative or toxic effects of BQTL on bone marrow macrophages(BMMs) at various concentrations. TRAc P experiments were conducted to examine BQTL's impact on osteoclast differentiation. RT-PCR and Western blot analyses were utilized to evaluate the relative expression levels of osteoclast-specific genes and proteins under BQTL stimulation. Finally, in vivo experiments were performed using an osteoporosis model to further validate the in vitro findings. This study revealed that BQTL suppressed receptor activator of NF-κB ligand(RANKL)-induced osteoclastogenesis and osteoclast resorption activity in vitro in a dose-dependent manner without observable *** inhibitory effects of BQTL on osteoclast formation and function were attributed to the downregulation of NFATc1 and c-fos activity, primarily through attenuation of the MAPK, NF-κB, and Calcineurin signaling pathways. BQTL's inhibitory capacity was further examined in vivo using an ovariectomized(OVX) rat model, demonstrating a strong protective effect against bone loss. BQTL may serve as an effective therapeutic TCM for the treatment of postmenopausal osteoporosis and the alleviation of bone loss induced by estrogen deficiency and related conditions.

关键词： Buqi-Tongluo Estrogen deficiency MAPK NF-κB NFATc1 Osteoclast Osteoporosis

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Adam revisited:a weighted past gradients perspective

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Frontiers of Computer Science 2020年第5期14卷 61-76页

作者： Hui Zhong Zaiyi chen Chuan Qin Zai Huang vincent W.Zheng Tong Xu Enhong chen Anhui Province Key Laboratory of Big Data Analysis and Application University of Science and Technology of ChinaHefei230027China Zhejiang Cainiao Supply Chain Management Co.Ltd Hangzhou311122China Advanced Digital Sciences Center Singapore138602Singapore

Adaptive learning rate methods have been successfully applied in many fields,especially in training deep neural *** results have shown that adaptive methods with exponential increasing weights on squared past gradients(i.e.,ADAM,RMSPROP)may fail to converge to the optimal *** many algorithms,such as AMSGRAD and ADAMNC,have been proposed to fix the non-convergence issues,achieving a data-dependent regret bound similar to or better than ADAGRAD is still a challenge to these *** this paper,we propose a novel adaptive method weighted adaptive algorithm(WADA)to tackle the non-convergence *** AMSGRAD and ADAMNC,we consider using a milder growing weighting strategy on squared past gradient,in which weights grow *** on this idea,we propose weighted adaptive gradient method framework(WAGMF)and implement WADA algorithm on this ***,we prove that WADA can achieve a weighted data-dependent regret bound,which could be better than the original regret bound of ADAGRAD when the gradients decrease *** bound may partially explain the good performance of ADAM in ***,extensive experiments demonstrate the effectiveness of WADA and its variants in comparison with several variants of ADAM on training convex problems and deep neural networks.

关键词： adaptive learning rate methods stochastic gradient descent online learning

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Electronic structure of aqueous two-dimensional photocatalyst

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npj Computational Materials 2021年第1期7卷 431-439页

作者： Dawei Kang Xianghua Kong vincent Michaud-Rioux Ying-Chih chen Zetian Mi Hong Guo School of Physics and Engineering Henan University of Science and TechnologyLuoyangChina College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenChina Department of Physics McGill UniversityMontrealQCCanada Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMIUSA

The electronic structure,in particular the band edge position,of photocatalyst in presence of water is critical for photocatalytic water *** propose a direct and systematic density functional theory(DFT)scheme to quantitatively predict band edge shifts and their microscopic origins for aqueous 2D photocatalyst,where thousands of atoms or more are able to be *** scheme is indispensable to correctly calculate the electronic structure of 2D photocatalyst in the presence of water,which is demonstrated in aqueous MoS_(2),GaS,InSe,GaSe and *** is found that the band edge of 2D photocatalysts are not rigidly shifted due to water as reported in previous studies of aqueous ***,the CBM shift is quantitatively explained by geometric deformation,water dipole and charge redistribution effect while the fourth effect,i.e.,interfacial chemical contact,is revealed in the VBM ***,the revealed upshift of CBM in aqueous MoS2 should thermodynamically help carriers to participate in hydrogen evolution reaction(HER),which underpin the reported experimental findings that MoS2 is an efficient HER *** work paves the way to design 2D materials in general as low-cost and high-efficiency photocatalysts.

关键词： catalyst structure quantitatively

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Federated Learning for 6G:Applications,Challenges,and Opportunities

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Engineering 2022年第1期8卷 33-41页

作者： Zhaohui Yang Mingzhe chen Kai-Kit Wong H.vincent Poor Shuguang Cui Department of Electronic and Electrical Engineering University College LondonLondon WC1E 6BTUK Department of Electrical and Computer Engineering Princeton UniversityPrincetonNJ 08544USA Shenzhen Research Institute of Big Data The Chinese University of Hong KongShenzhen 518172China School of Science and Engineering and Future Network of Intelligence Institute The Chinese University of Hong KongShenzhen 518172China

Standard machine-learning approaches involve the centralization of training data in a data center,where centralized machine-learning algorithms can be applied for data analysis and ***,due to privacy restrictions and limited communication resources in wireless networks,it is often undesirable or impractical for the devices to transmit data to parameter *** approach to mitigate these problems is federated learning(FL),which enables the devices to train a common machine learning model without data sharing and *** paper provides a comprehensive overview of FL applications for envisioned sixth generation(6G)wireless *** particular,the essential requirements for applying FL to wireless communications are first *** potential FL applications in wireless communications are *** main problems and challenges associated with such applications are ***,a comprehensive FL implementation for wireless communications is described.

关键词： Federated learning 6G Reconfigurable intelligent surface Semantic communication Sensing Communication and computing

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Selective thermal emission and infrared camouflage based on layered media

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chinese Journal of Aeronautics 2023年第3期36卷 212-219页

作者： Qingxiang JI Xueyan chen vincent LAUDE Jun LIANG Guodong FANG Changguo WANG Rasoul ALAEE Muamer KADIC National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150001China Institute FEMTO-ST CNRSUniversity Bourgogne Franche-Comte´Besanc¸on 25000France Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China Department of Physics University of OttawaOttawaK1N 6N5Canada Institute of Theoretical Solid State Physics Karlsruhe Institute of TechnologyKarlsruhe D-76131Germany

Infrared camouflage based on artificial thermal metasurfaces has recently attracted significant *** eliminating thermal radiation differences between the object and the background,it is possible to hide a given object from infrared *** camouflage is an important element that increases the survivability of aircraft and missiles,by reducing target susceptibility to infrared guided ***,a simple and practicable design is theoretically presented based on a multilayer film for infrared stealth,with distinctive advantages of scalability,flexible fabrication,and structural *** multilayer medium consists of silicon substrate,carbon layer and zinc sulfide film,the optical properties of which are determined by transfer matrix *** locally changing the thickness of the coating film,the spatial tunability and continuity in thermal emission are demonstrated.A continuous change of emissive power is further obtained and consequently implemented to achieve thermal camouflage *** addition,other functionalities,like thermal illusion and thermal coding,are demonstrated by thickness-engineered multilayer films.

关键词： Heat transfer manipulation Infrared camouflage Multilayer media Selective thermal emission Thermal illusion Transfer matrix method

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Impossible meet-in-the-middle fault analysis on the LED lightweight cipher in VANETs

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Science china(Information Sciences) 2018年第3期61卷 118-130页

作者： Wei LI vincent RIJMEN Zhi TAO Qingju WANG Hua chen Yunwen LIU Chaoyun LI Ya LIU School of Computer Science and Technology Donghua University imec-COSIC KU Leuven Shanghai Key Laboratory of Integrate Administration Technologies for Information Security Department of Computer Science and Engineering Shanghai Jiao Tong University Department of Applied Mathematics and Computer Science Technical University of Denmark Trusted Computing and Information Assurance Laboratory Institute of SoftwareChinese Academy of Sciences College of Science National University of Defense Technology Department of Computer Science and Engineering University of Shanghai for Science and Technology

With the expansion of wireless technology, vehicular ad-hoc networks(VANETs) are emerging as a promising approach for realizing smart cities and addressing many serious traffic problems, such as road safety, convenience, and efficiency. To avoid any possible rancorous attacks, employing lightweight ciphers is most effective for implementing encryption/decryption, message authentication, and digital signatures for the security of the VANETs. Light encryption device(LED) is a lightweight block cipher with two basic keysize variants: LED-64 and LED-128. Since its inception, many fault analysis techniques have focused on provoking faults in the last four rounds to derive the 64-bit and 128-bit secret keys. It is vital to investigate whether injecting faults into a prior round enables breakage of the LED. This study presents a novel impossible meet-in-the-middle fault analysis on a prior round. A detailed analysis of the expected number of faults is used to uniquely determine the secret key. It is based on the propagation of truncated differentials and is surprisingly reminiscent of the computation of the complexity of a rectangle attack. It shows that the impossible meet-in-the-middle fault analysis could successfully break the LED by fault injections.

关键词： VANETs LED lightweight cipher impossible meet-in-the-middle fault analysis

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science china(Life Sciences) 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Innovation Research Institute of Traditional chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Experiment Center for Science and Technology Shanghai University of Traditional Chinese MedicineShanghai 201203China

Dear Editor,Phenotypic drug discovery,which observes compound effects on physiology,has given way to targeting specific molecules,but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(vincent et al.,2022).Osteoarthritis(OA)is a prevalent chronic joint disorder,primarily affecting knee joints,with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).This imbalance and the discharge of inflammatory mediators perpetuate the cycle of inflammation and tissue ***,controlling inflammation and modulating osteoclastogenesis are critical therapeutic targets for managing OA.

关键词： inflammation drugs

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Accelerating peripheral nerve regeneration using electrical stimulation of selected power spectral densities

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Neural Regeneration Research 2022年第4期17卷 781-782页

作者： Wei-Ming Yu Madelyn A.McCullen vincent C.-F.chen Department of Biology Loyola University of ChicagoChicagoILUSA Engineering Program Loyola University of ChicagoChicagoILUSA

Peripheral nerve injuries are common consequences of extremity trauma or chronic compression with a prevalence of 43.8 per1 million people(on average)reported in the U nited States annually,accompanied by a yearly inc... 详细信息

关键词： stimulation injuries annually

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Electromagnetic shielding effectiveness of amorphous metallic spheroidal-and flake-based magnetodielectric composites

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Journal of Materials Science & Technology 2021年第24期83卷 256-263页

作者： Kun Qian Qifan Li Alexander Sokolov chengju Yu Piotr Kulik Ogheneyunume Fitchorova Yajie chen chins chinnasamy vincent G.Harris Center for Microwave Magnetic Materials and Integrated Circuits Department of Electrical and Computer EngineeringNortheastern UniversityBostonMA02115USA KRI at Northeastern University LLC141 South Bedford StreetBurlingtonMA01803USA Rogers Innovation Center Rogers Corporation141 South Bedford StreetBurlingtonMA01803USA Carpenter Technology Corporation ReadingPA19601USA

Flexible,lightweight,conductive materials,having both high rf losses and high permeability,are extremely desirable for applications as electromagnetic(EM)*** atomized spherical FeSi-based ferromagnetic metallic particles,having a mean diameter of 14.6μm with a standard deviation of 7.3μm,were measured to have a room temperature saturation magnetic flux density of 1.49 T with a coercivity of 160 A/*** milling of the amorphous particles led to aspect ratios from 1:1(spherical)to>100:1(flake-like).Flake-like particles,suspended in paraffin,were found to not only increase the surface area of fillers enhancing the polarization mechanism but also increase the complex permeability and complex permittivity,and thus provide broadband shielding effectiveness.A loading factor of 40 vol.%of the∼15μm diameter powders provided the largestΔW_(RL=-20 dB)of 9.49 GHz(i.e.,6.55

关键词： Amorphous particle Magnetic alloy powders Microwave absorption Electromagnetic interference shielding

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