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Gestational diabetes mellitus: Challenges for different ethnic groups

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World Journal of Diabetes 2015年第8期6卷 1024-1032页

作者： Lili Yuen vincent W wong Diabetes and Endocrine Service Liverpool Hospital Liverpool Diabetes Collaborative Research Unit Ingham Institute of Applied Science South Western Sydney Clinical School University of New South Wales

Ethnicity is defined as"belonging to a social groupthat has a common national or cultural tradition".Membership of certain ethnic groups has long been associated with increased risk of gestational diabetes mellitus(GDM).Studies that examined ethnic differences amongst women with GDM were often conducted in western countries where women from various ethnic backgrounds were *** prevalence of GDM appears to be particularly high among women from South Asia and South East Asia,compared to Caucasian,African-American and Hispanic *** some,but not all ethnic groups,the body mass index is a risk factor for the development of *** within a particular ethnic group,those who were born in their native countries have a different risk profile for GDM compared to those born in western *** terms of treatment,medical nutrition therapy(MNT)plays a key role in the management of GDM and the prescription of MNT should be culturally *** studies have shown that women who live in an English-speaking country but predominantly speak a language other than English,have lower rates of dietary understanding compared with their English speaking counterparts,and this may affect compliance to *** therapy also plays an important role and there appears to be variation as to the progression of women who progress to requiring insulin among different *** for peri-natal outcomes,women from Pacific Islander countries have higher rates of macrosomia,while women from Chinese backgrounds had lower adverse pregnancy *** a maternal outcome point of view,pregnant women from Asia with GDM have a higher incidence of abnormal glucose tolerance test results post-partum and hence a higher risk of future development of type2 diabetes *** the other hand,women from Hispanic or African-American backgrounds with GDM are more likely to develop hypertension *** review highlights the fact that management needs to be indiv

关键词： Gestational diabetes mellitus Ethnicity Perinataloutcomes Medical nutrition therapy Prevalence

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基于应激颗粒的中药神经保护研究设想

中草药 2022年第16期53卷 5185-5192页

作者：陈畅罗婉君段飞鹏王寓平胥雄飞杨萌楚姜金铸谢永艳黄锦伟黄丽萍江西中医药大学药学院江西南昌330004 澳门科技大学中药质量研究国家重点实验室中国澳门999078 中国中医科学院中药研究所北京100700

应激颗粒是存在于胞质的一种无膜致密颗粒,通过包裹mRNA、转录起始因子、RNA结合蛋白等翻译起始阶段的重要元件,使细胞在遭受不利刺激时出现短暂的蛋白翻译阻滞,从而起到细胞保护作用。研究发现,应激颗粒广泛分布于海马和皮层的神经元... 详细信息

应激颗粒是存在于胞质的一种无膜致密颗粒,通过包裹mRNA、转录起始因子、RNA结合蛋白等翻译起始阶段的重要元件,使细胞在遭受不利刺激时出现短暂的蛋白翻译阻滞,从而起到细胞保护作用。研究发现,应激颗粒广泛分布于海马和皮层的神经元细胞、星形胶质细胞、小胶质细胞和浦肯野细胞等神经细胞中,生物过程涉及蛋白异常聚集、突触的成熟和可塑性、免疫调节、抗氧化应激反应、抑制细胞凋亡等,在急性缺血性脑卒中和神经退行性疾病的发生发展中发挥着重要作用。尤其是其多样化的物质组成和广泛参与的生物过程,为中医证候生物学及“同病异治”“整体调节”等中医药传统理论和治法的研究提供了崭新的思路和视野。对应激颗粒的基本特征、神经保护及研究方法等进行系统的梳理,同时以急性缺血性脑卒中为范例,尝试将应激颗粒这一现代生物学现象纳入到中医药现代研究中,提出研究设想和思路,以期用科学的语言阐释传统中医药相关理论与治法,也为行业同仁的相关研究提供参考。

关键词：应激颗粒脑缺血 RNA结合蛋白 Ras-GTPase活化蛋白SH3结构域结合蛋白1 神经保护

Validation of NINDS-CSN neuropsychological battery for vascular cognitive impairment in Chinese stroke patients

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Validation of NINDS-CSN neuropsychological battery for vascu...

第四届全国痴呆与认知障碍学术研讨会及高级讲授班

作者： Xiangliang Chen Adrian wong Ruidong Ye Lulu Xiao Zhaojun wa.g Ying Lin Fang Yang Hua Li Ting Feng Lihui Duan Yunfei Han Qiliang Dai Juan Du Gelin Xu vincent Mok Yunyun Xiong Xinfeng Liu Department of Neurology Jinling Hospital Medical School of Nanjing University Department of Medicine and Therapeutics The Chinese University of Hong Kong

Background The NINDS-Canadian Stroke Network(NINDS-CSN)recommended a neuropsychological battery of three protocols to diagnose vascular cognitive impairment(VCI),however,due to culture and language differences,the battery cannot be directly used in *** of the battery in mandarin Chinese is *** study investigated the reliability and validity of the adapted

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血管性认知障碍的神经心理学评估

血管性认知障碍的神经心理学评估

中华医学会第十八次全国神经病学学术会议

作者：陈响亮 Adrian wong 叶瑞东肖露露王昭君林颖杨昉李华冯婷段立晖韩云飞代齐良杜鹃徐格林 vincent Mok 熊云云刘新峰南京军区南京总医院神经内科香港中文大学内科与药物治疗系

目的在2006年,美国国立神经病学与卒中研究院、加拿大卒中网络(NINDS-CSN)推荐了评估血管性认知障碍(Vascular Cognitive Impairment,VCI)的神经心理学量表,包括60分钟,30分钟和5分钟的三套方案,而由于文化、语言的差异,该方案无法在中...

目的在2006年,美国国立神经病学与卒中研究院、加拿大卒中网络(NINDS-CSN)推荐了评估血管性认知障碍(Vascular Cognitive Impairment,VCI)的神经心理学量表,包括60分钟,30分钟和5分钟的三套方案,而由于文化、语言的差异,该方案无法在中国人群直接使用。因此,本研究旨在对以上方案的普通话版进行人群验证,探讨其在中国脑卒中人群的信效度。方法研究纳入50例轻度脑卒中患者(NIHSS评分中位

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帕金森病患者跌倒的危险因素分析

广东医学 2011年第9期32卷 1117-1119页

作者：陈仰昆邓伟光肖卫民黄家星莫仲棠广东省东莞市人民医院神经内科 523000 香港中文大学精神科学系香港中文大学内科及药物治疗学系

目的回顾性研究帕金森病(PD)患者跌倒的危险因素。方法选择香港3所医院133例的神经科专科门诊PD患者纳入研究。收集患者的人口学及临床资料,并进行躯体功能、精神、智能及跌倒方面的评估。应用logistic多元回归分析研究PD患者跌倒的危... 详细信息

目的回顾性研究帕金森病(PD)患者跌倒的危险因素。方法选择香港3所医院133例的神经科专科门诊PD患者纳入研究。收集患者的人口学及临床资料,并进行躯体功能、精神、智能及跌倒方面的评估。应用logistic多元回归分析研究PD患者跌倒的危险因素。结果 44例(33.1%)患者在最近1年内有1次以上的跌倒,平均跌倒的次数为(1.9±0.7)次。logistic多元回归显示,婚姻状况(丧偶、离异或未婚)(OR=1.965,95%CI1.203～3.208,P=0.007)、Schwa.和England日常生活能力评分低(OR=0.973,95%CI 0.955～0.991,P=0.003)及服用3种以上抗PD药物(OR=0.973,95%CI 0.955～0.991,P=0.026)是跌倒的独立危险因素。结论跌倒是PD患者一个很常见的问题。服用多种抗PD药物、日常生活能力及婚姻状况对跌倒均有明显的影响,提示在跌倒的预防与评估中,疾患内在因素和社会因素均需考虑。

关键词：帕金森病跌倒危险因素

CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis

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CXCL10 plays a key role as an inflammatory mediator and a no...

第九届全国免疫学学术大会

作者： Xiang Zhang Jiayun Shen Kwa. Man Eagle S.H.Chu Tung On Yau Joanne C.Y.sung Minnie Y.Y.Go Jun Deng Liwei Lu vincent W.S.wong Joseph J.Y.sung Geoffrey Farrell Jun Yu Institute of Digestive Disease and The Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseThe Chinese University of Hong Kong

Perpetuate liver inflammation is crucial in the pathogenesis of non-alcoholic steatohepatitis(NASH).Expression of CXCL10,a pro-inflammatory cytokine that can recruit inflammatory cells to site of tissue damage,correlates positively with obesity and type 2 *** CXCL10 plays a role in NASH wa. *** we investigated the functional

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Using proteomic approach to discover the treatment mechanism of（Z）3,4,5,4’-trans-tetramethoxystilbene for inhibition of gefitinib-resistant non-small cell lung cancer

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Using proteomic approach to discover the treatment mechanism...

第21届全国色谱学术报告会及仪器展览会

作者： Xing-Xing Fan Xiao-Jun Yao So Wei Xu vincent Kam-wa. wong Jian-Xing He Jian Ding Min Huang Jun Huang Da-Kai Xiao Ze-Bo Jiang Yan-Ling Zhou Richard Kin-Ting Kam Liang Liu Elaine Lai-Han Leung State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health Macau University of Science and Technology Guangzhou Institute of Respiratory Disease State Key Laboratory of Respiratory DiseaseThe 1st Affiliated Hospital of Guangzhou Medical College State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academic of Sciences Department Chemical Pathology Faculty of Medicinethe Chinese University of Hong Kong

Calcium is a second messenger which is required for regulation of many cellular processes. However,excessive elevation or prolonged activation of calcium signaling would lead to cell death. As such,selectively regulating calcium signaling could be an alternative approach for anti-cancer therapy. Recently,we have identified an effective analogue of resveratrol,（Z）3,4,5,4’-trans-tetramethoxystilbene（TMS） which selectively elevated the intracellular calcium level in gefitinib-resistant（G-R） non-small-cell lung cancer（NSCLC） cells. TMS exhibited significantly inhibitory effect on G-R NSCLC cells, but not other NSCLC cells and normal lung epithelial cells. The phosphorylation and activation of EGFR wa. inhibited by TMS in G-R cells. TMS induced caspase-independent apoptosis and autophagy by directly binding to SERCA and causing endoplasmic reticulum（ER） stress and AMPK activation. Using i TRAQ proteomics analysis,we have further confirmed that mTOR pathwa., which is the downstream of AMPK, wa. significantly suppressed by TMS. JNK, the cross-linker of ER stress and mTOR pathwa. wa. significantly activated by TMS. In addition, the inhibition of JNK activation can partially block the effect of TMS. Taken together,TMS showed promising anti-cancer activity by mediating calcium signaling pathwa. and inducing apoptosis as well as autophagy in G-R NSCLC cells, providing strategy in designing multi-targeting drug for treating G-R patients.

关键词： (Z)3,4,5,4’-trans-tetramethoxystilbene(TMS) non-small-cell lung cancer gefitinib resistance mTOR and autophagy

Search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHCb

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中国物理C:英文版 2023年第9期47卷 14-26页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi P.Adlarson H.Afsharnia C.Agapopoulou C.A.Aidala Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle R.Amalric S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Benane G.Bencivenni E.Ben-Haim A.Berezhnoy *** *** Andres D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc J.E.Blank S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev C.S.Bolognani R.Bolzonella N.Bondar F.Borgato S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo J.Brown D.Brundu A.Buonaura L.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse M.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cognera Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−*** significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization *** upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,*** is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction

Search for the doubly heavy baryon Ξ_(bc)^(+)→ decaying to J/ψΞ_(c)^(+)

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中国物理C:英文版 2023年第9期47卷 1-13页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.Agapopoulou C.A.Aidala S.Aiola Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev N.Bondar S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura L.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse M.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard deviations at masses of 6571 and 6694 MeV/c2, respectively. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relative to that of the B+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 TeV, in the Ξ+bc and in the B+c rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV/c, respectively. Upper limits are presented as a function of the Ξ+bc mass and lifetime.

关键词： QCD B physics charm physics spectroscopy