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Ginkgo biloba supplement modulates mTOR/ERK1/2 activities to mediate cardio-protection in cyclosporin-A-induced cardiotoxicity in Wistar rats

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Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 32-42页

作者： Jerome Ndudi Asiwe Benneth Ben-Azu Godwin D.Yovwin vincent-Junior Onoriode Igben Benjamin Oritsemuelebi Israel Ofejiro Efejene Olusegun Gafar Adebayo Nicholas Asiwe Anthony Emeka Ojieh Department of Physiology Faculty of Basic Medical SciencesDelta State UniversityAbraka 330105Delta StateNigeria Department of Physiology Faculty of Basic Medical SciencesUniversity of IbadanIbadan 200223Oyo StateNigeria Department of Pharmacology Faculty of Basic Medical SciencesDelta State UniversityAbraka 330105Delta StateNigeria Department of Family Medicine Faculty of Clinical MedicineDelta State University330105Delta StateNigeria Department of Physiology Faculty of Basic Medical SciencesNovena UniversityOgume 322103Delta StateNigeria Department of Physiology PAMO University of Medical SciencesPort-HarcourtPort-Harcourt 500262Rivers StateNigeria Department of Anatomy University of Port-HarcourtPort-Harcourt 500262Rivers StateNigeria

Background:Cyclosporine-A(Cs-A),an immunosuppressant drug indicated for organ transplant patients has been associated with toxicities arising from activation of pathological *** Ginkgo biloba supplement(GBS)is an antioxidant-enhancing herbal product widely used for treating neurological and vascular ***:This study investigated the ameliorative effect of GBS on cyclosporine-A induced cardiotoxicity in Wistar ***:The study included 20 Wistar rats(n=5)and they were treated as follows:group 1 received distilled water(10 mL/kg),group 2 received Cs-A(25 mg/kg),group 3 received GBS(50 mg/kg)and group 4 received Cs-A(25 mg/kg)and GBS(50 mg/kg).All treatment were done intraperitoneal for 14 days and thereafter,animals were euthanised and heart tissues were harvested for biochemical assays as well as immunohistochemical *** was also collected for serum biochemical ***:Our results revealed that GBS reduces Cs-A induced increase of AST,ALT,ALP,LDH,and GGT levels in serum relative to Cs-A ***,increased oxido-nitrergic markers like MDA,NO,together with elevated concentrations of cholesterol,triglycerides,LDL,creatine kinase-MB,troponin-I,as well as pro-inflammatory cytokines(IL-6,and TNF-α)and heart weight index were reduced by *** Cs-A induced suppression of low-density lipoprotein,antioxidant(GSH,SOD,CAT),Na-K ATPase activities and antiapoptotic element,Bcl-2 were increased by ***,signalling pathways including ERK1/2,and mTOR as well as ventricular thickness were significantly alleviated by GBS ***:The findings suggest that GBS ameliorated Cs-A-induced cardiotoxicity by activating mTOR/ERK1/2 signalling pathways.

关键词： Apoptosis Antioxidant Cyclosporine-A Ginkgo biloba supplement Inflammation

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Psychological Experience of Mothers of Children with Sickle Cell Disease Followed at the Pediatric Department of Bouaké University Teaching Hospital

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Open Journal of Pediatrics 2024年第1期14卷 149-163页

作者： Akanji Iburaima Alamun Aka-Tanoh Koko Aude Hélène Yao Kouassi Christian Adou Leioh Romeo Sahi Gnantin Josette Landryse Amani Ehi Alexise Eleonore Boune Aboulaye Asse Kouadio vincent Paediatrics Department Bouaké University Teaching Hospital Bouaké C&#244te d’Ivoire

Introduction: Sickle cell disease has physical and emotional repercussions on the child and his family. The aim of this study was to describe the psychosocial experiences of mothers of children with sickle cell disease in order to improve the overall care of the child. Methods: This was a descriptive cross-sectional study carried out in the pediatrics department of Bouaké University Teaching Hospital from June to September 2023. It focused on mothers of major sickle-cell-affected children followed up in the pediatrics department of the Bouaké University Teaching Hospital. The variables studied were sociodemographic, psychological, social and economic. Results: Of the 40 mothers surveyed, 15% were not in school and 32.5% were unemployed. For them, sickle cell disease was of natural (genetic) origin in 90% and supernatural in 10%. They stated that the child had an average age of 36 months (extremes 7 and 108 months) when the disease was discovered. And 52% of them were satisfied with the way the disease was clearly and completely announced. Following the announcement, the questioned mothers said they had felt shock (35%), sadness (31.7%), guilt (23.3%) and discouragement (10%). Anxiety and depression were experienced by 77.5% and 22.5% respectively. In 60% of cases, they stated that the disease was incurable, and the outcome was fatal in 2.5% of cases. The child’s illness was a source of problems in the home in 25% of cases, represented by arguments in 92% and divorce in 8%. In 97.5% of cases, the mother told her family and friends about the child’s illness. In 90% of cases, the mother and child benefited from psychological support from family and friends. Conclusion: Sickle cell disease is a serious illness with a psychological and social impact on mothers. We recommend psychological support for mothers from the moment of diagnosis and throughout follow-up.

关键词： Psychosocial Experience Sickle Cell Disease Côte d’Ivoire

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Effectiveness of post-COVID-19 primary care attendance in improving survival in very old patients with multimorbidity:a territory-wide target trial emulation

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Family Medicine and Community Health 2024年第3期12卷 25-35页

作者： Cuiling Wei vincent Ka Chun Yan Camille Maringe Wenxin Tian Rachel Yui Ki Chu Wenlong Liu Boyan Liu Yuqi Hu Lingyue Zhou Celine Sze Ling Chui Xue Li Eric Yuk Fai Wan Ching Lung Cheung Esther Wai Yin Chan William Chi Wai Wong Ian Chi Kei Wong Francisco Tsz Tsun Lai Centre for Safe Medication Practice and Research Department of Pharmacology and PharmacyLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Health Services Research and Policy Faculty of Public Health and PolicyLondon School of Hygiene and Tropical MedicineLondonUK School of Nursing Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong School of Public Health Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Laboratory of Data Discovery for Health(D24H) Hong KongHong Kong Advanced Data Analytics for Medical Science(ADAMS)Limited Hong KongHong Kong Department of Medicine School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Family Medicine and Primary Care School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Pharmacy The University of Hong Kong-Shenzhen HospitalShenzhenPeople's Republic of China Aston Pharmacy School Aston UniversityBirminghamUK School of Pharmacy Macao University of Science and TechnologyTaipaMacao

Objectives Older individuals with multimorbidity are at an elevated risk of infection and complications from *** of post-COVID-19 interventions or care models in reducing subsequent adverse outcomes in these individuals have rarely been *** study aims to examine the effectiveness of attending general outpatient within 30 days after discharge from COVID-19 on 1-year survival among older adults aged 85 years or above with *** Retrospective cohort study emulating a randomised target trial using electronic health *** We used data from the Hospital Authority and the Department of Health in Hong Kong,which provided comprehensive electronic health records,COVID-19 confirmed case data,population-based vaccination records and other individual characteristics for the *** Adults aged 85 years or above with multimorbidity who were discharged after hospitalisation for COVID-19 between January 2020 and August *** Attending a general outpatient within 30 days of last COVID-19 discharge defined the exposure,compared to no outpatient *** outcome measures Primary outcome was all-cause mortality within one *** outcomes included mortality from respiratory,cardiovascular and cancer *** A total of 6183 eligible COVID-19 survivors were included in the *** all-cause mortality rate following COVID-19 hospitalisation was lower in the general outpatient visit group(17.1 deaths per 100 person-year)compared with non-visit group(42.8 deaths per 100 person-year).After adjustment,primary care consultations within 30 days after discharge were associated with a significantly greater 1-year survival(difference in 1-year survival:11.2%,95%CI 8.1%to 14.4%).We also observed significantly better survival from respiratory diseases in the general outpatient visit group(difference in 1-year survival:6.3%,95%CI 3.5%to 8.9%).In a sensitivity analysis for different grace period lengths

关键词： morbidity visit records

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LBD12转录因子调控毛果杨木材形成研究

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南京林业大学学报（自然科学版） 2024年第1期48卷 29-38页

作者：高源孙佳彤周晨光姜立泉李伟李爽林木遗传育种全国重点实验室(东北林业大学) 黑龙江哈尔滨150040 辽宁省森林经营研究所辽宁丹东118000

【目的】创制毛果杨(Populus trichocarpa)LBD12(lateral organ boundaries domain 12)转录因子的过量表达植株,分析表型特征,初步探究PtrLBD12转录因子在毛果杨木材形成中的生物功能。【方法】基于前期的研究,筛选出了木材形成关键调... 详细信息

【目的】创制毛果杨(Populus trichocarpa)LBD12(lateral organ boundaries domain 12)转录因子的过量表达植株,分析表型特征,初步探究PtrLBD12转录因子在毛果杨木材形成中的生物功能。【方法】基于前期的研究,筛选出了木材形成关键调控因子PtrbHLH186调控的下游转录因子PtrLBD12,通过基因克隆获得PtrLBD12基因;创制PtrLBD12过量表达毛果杨植株,测定并统计生长30、60、90 d毛果杨野生型和过表达植株的生长指标;对生长120 d的转基因及野生型植株各茎节进行石蜡切片、化学染色观察及不同细胞类型的统计分析;通过定量PCR测定过表达PtrLBD12基因对22个木质素单体合成酶基因表达水平的影响。【结果】获得毛果杨PtrLBD12过表达植株;与野生型相比,转基因植株的株高、地径等生长指标水平明显降低;纤维和导管细胞的数量显著增多,导管细胞的孔径减小,形成层细胞的形态结构无明显变化;木质素沉积水平增加,木质化程度增强;PtrLBD12的过量表达促进了木质素合成酶基因的表达。【结论】LBD12转录因子在毛果杨木材形成过程中发挥重要的调控作用,可调节木质素单体合成酶基因的表达,改变木质素沉积方式。此外,该基因也可以改变木质部细胞形态结构,影响植株生长发育。

关键词：毛果杨木材形成遗传转化转录因子 PtrLBD12

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Multicomponent flow modeling

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Science China Mathematics 2012年第1期55卷 285-308页

作者： GIOVANGIGLI vincent CMAP-CNRS Ecole

We present multicomponent flow models derived from the kinetic theory of gases and investigate the symmetric hyperbolic-parabolic structure of the resulting system of partial differential *** address the Cauchy problem for smooth solutions as well as the existence of deflagration waves,also termed anchored *** further discuss related models which have a similar hyperbolic-parabolic structure,notably the SaintVenant system with a temperature equation as well as the equations governing chemical equilibrium *** next investigate multicomponent ionized and magnetized flow models with anisotropic transport fluxes which have a different mathematical *** finally discuss numerical algorithms specifically devoted to complex chemistry flows,in particular the evaluation of multicomponent transport properties,as well as the impact of multicomponent transport.

关键词： multicomponent reactive flow Cauchy problem deflagration wave multicomponent transport

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Isolation and Characterization of SARS-CoV-2 in Kenya

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American Journal of Molecular Biology 2024年第2期14卷 66-83页

作者： Albina Makio Robinson Mugasiali Irekwa Matthew Mutinda Munyao Caroline Wangui Njoroge Peter Kipkemboi Rotich Tonny Teya Nyandwaro Joanne Jepkemei Yego Anne Wanjiru Mwangi James Hungo Kimotho Ronald Tanui vincent Rutto Samson Muuo Nzou Center for Traditional Medicine and Drug Research Kenya Medical Research Institute Nairobi Kenya Center for Microbiology Research Kenya Medical Research Institute Nairobi Kenya Production Department Kenya Medical Research Institute Nairobi Kenya Department of Biochemistry and Microbiology Rhodes University Grahamstown South Africa Center for Virus Research Kenya Medical Research Institute Nairobi Kenya

The discovery of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) in Wuhan, Hubei province, China, in December 2019 raised global health warnings. Quickly, in 2020, the virus crossed borders and infected individuals across the world, evolving into the COVID-19 pandemic. Notably, early signs of the virus’s existence were observed in various countries before the initial outbreak in Wuhan. As of 12th of April, the respiratory disease had infected over 762 million people worldwide, with over 6.8 million deaths recorded. This has led scientists to focus their efforts on understanding the virus to develop effective means to diagnose, treat, prevent, and control this pandemic. One of the areas of focus is the isolation of this virus, which plays a crucial role in understanding the viral dynamics in the laboratory. In this study, we report the isolation and detection of locally circulating SARS-CoV-2 in Kenya. The isolates were cultured on Vero Cercopithecus cell line (CCL-81) cells, RNA extraction was conducted from the supernatants, and reverse transcriptase-polymerase chain reaction (RT-PCR). Genome sequencing was done to profile the strains phylogenetically and identify novel and previously reported mutations. Vero CCL-81 cells were able to support the growth of SARS-CoV-2 in vitro, and mutations were detected from the two isolates sequenced (001 and 002). Genome sequencing revealed the circulation of two isolates that share a close relationship with the Benin isolate with the D614G common mutation identified along the S protein. These virus isolates will be expanded and made available to the Kenya Ministry of Health and other research institutions to advance SARS-CoV-2 research in Kenya and the region.

关键词： SARS-CoV-2 COVID-19 Whole Genome Sequencing Phylogenetic Analysis Nucleotide Substitutions Amino Acid Changes

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Experimental study of path planning problem using EMCOA for a holonomic mobile robot

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Journal of Systems Engineering and Electronics 2021年第6期32卷 1450-1462页

作者： MOHSENI Alireza DUCHAINE vincent WONG Tony Department of System Engineering École de Technologie SupérieureMontreal QC H3C 1K3Canada

In this paper,a comparative study of the path planning problem using evolutionary algorithms,in comparison with classical methods such as the A*algorithm,is presented for a holonomic mobile *** configured navigation system,which consists of the integration of sensors sources,map formatting,global and local path planners,and the base controller,aims to enable the robot to follow the shortest smooth path ***-based mapping is used for scoring paths efficiently,allowing the determination of collision-free trajectories from the initial to the target *** work considers the evolutionary algorithms,the mutated cuckoo optimization algorithm(MCOA)and the genetic algorithm(GA),as a global planner to find the shortest safe path among others.A non-uniform motion coefficient is introduced for MCOA in order to increase the performance of this algorithm.A series of experiments are accomplished and analyzed to confirm the performance of the global planner implemented on a holonomic mobile *** results of the experiments show the capacity of the planner framework with respect to the path planning problem under various obstacle layouts.

关键词： holonomic robot path planning evolutionary algorithm(EA)

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Scattering and diffraction of plane P-waves in a 2-D elastic half-space Ⅱ：shallow arbitrary shaped canyon

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Earthquake Engineering and Engineering Vibration 2017年第3期16卷 459-485页

作者： Heather P.Brandow vincent Lee Civil and Environmental Engineering University of Southern California Los Angeles 90089 United States

Scattering and Diffraction of elastic in-plane P-and SV-waves by a surface topography such as an elastic canyon at the surface of a half-space is a classical problem which has been studied by earthquake engineers and strong-motion seismologists for over forty years. The case of out-of-plane SH waves on the same elastic canyon that is semi-circular in shape on the half-space surface is the first such problem that was solved by analytic closed form solutions over forty years ago by Trifunac. The corresponding case of in-plane P-and SV-waves on the same circular canyon is a much more complicated problem because, the in-plane P-and SV-scattered waves have different wave speeds and together they must have zero normal and shear stresses at the half-space surface. It is not until recently in 2014 that analytic solution for such problem is found by the author in the work of Lee and Liu. This paper uses the technique of Lee and Liu of defining these stress-free scattered waves to solve the problem of the scattered and diffraction of these in-plane waves on an almost-circular surface canyon that is arbitrary in shape.

关键词： diffraction elastic P-waves SV-waves weighted-residual method arbitrary-shaped canyon

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General compliance transformation relations for all seven crystal systems

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Science China(Physics,Mechanics & Astronomy) 2013年第4期56卷 694-700页

作者： ZHANG Yan JI vincent ICMMO/LEMHE UMR CNRS 8182 Université Paris-Sud 11Orsay Cedex 91405 France

For crystals, the compliance (sij) and the stiffness (cij) matrices are specified in the orthogonal coordinate systems (Yi), which do not coincide with the crystal axes (Xi) commonly used except for cubic and orthorhombic crystal systems. Transformations have been done in this paper and the general compliance transformation relations from the orthogonal coordinate systems (Yi) to the measurement systems (Mi) are given for all seven crystal systems. Accordingly, useful expressions for Young's modulus E and Poisson's ratio are also derived.

关键词： elasticity theory compliance Young’s modulus Poisson’s ratio

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Cropping leads to loss of soil organic matter: How can we prevent it?

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Pedosphere 2023年第1期33卷 8-10页

作者： vincent CHAPLOT Pete SMITH Institut de Recherche pour le Développement(IRD) Laboratoire d’Océanographie et du ClimatExpérimentations et Approches NumériquesUMR 7159IRD-CNRS-UPMC-MNHNCedex 05Paris 75252France Institute of Biological and Environmental Sciences School of Biological SciencesUniversity of AberdeenAberdeen AB243UUUK

Soil organic matter(SOM),which associates carbon(C)to key plant nutrients,has been stored in soil for thousands of *** have long recognised its positive impact on key environmental functions such as food production and climate *** soon as a virgin land(forest or grassland)is cultivated,there is a tendency for the soil to lose its SOM,and we still largely misunderstand the underlying mechanisms,leading to inappropriate decisions being taken to fight soil,climate,and overall ecosystem degradation.

关键词： soil grassland forest

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