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Molecular diagnostic approaches in detecting rearranged during transfection oncogene mutations in multiple endocrine neoplasia type 2

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World Journal of Clinical Cases 2024年第31期12卷 6436-6440页

作者： Sambasivam gopinath Velmurugan Ramaiyan Department of Pharmacy Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India

Different types of neuroendocrine cancer,including medullary thyroid cancer(MTC)and thyroid C-cell hyperplasia,are part of multiple endocrine neoplasia type 2(MEN2).A proto-oncogene mutation of the rearranged during transfection(RET)gene changes the way that receptor tyrosine kinases *** endocrine neoplasia,a pathological condition,involves these *** the RET protooncogene changes,it can cause endocrine adenomas and hyperplasia to happen at the same time or one after the ***,medullary thyroid carcinoma,and hyperparathyroidism,alone or in combination,are present in MEN2A *** patients may also have skin lichen amyloidosis or Hirschsprung's *** with MEN2A often present with *** is aggressive and has the worst prognosis,as most patients exhibit lymph node *** is one of the important causes of death in patients with *** mutation analysis aids in identifying MEN2A symptoms and monitoring levels of calcium,thyroid hormones,calcitonin,normetanephrine,fractionated metanephrines,and parathyroid *** earlier diagnosis of MTC significantly improves survival and prompts better management of *** this editorial,we will discuss the significance of molecular diagnostic approaches in detecting RET oncogene mutations in MEN2A.

关键词： Multiple endocrine neoplasia type 2 Medullary thyroid cancer Pheochromocytoma Thyroidectomy Rearranged during transfection

A Review on the Advancement of Renewable Natural Fiber Hybrid Composites: Prospects, Challenges, and Industrial Applications

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Journal of Renewable Materials 2024年第7期12卷 1237-1290页

作者： Mohammed Mohammed Jawad K.Oleiwi Aeshah M.Mohammed Anwar Ja’afar Mohamad Jawad Azlin F.Osman Tijjani Adam Bashir O.Betar Subash C.B.gopinath Center of Excellence Geopolymer&Green Technology(CEGeoGTech) Universiti Malaysia PerlisArau02600Malaysia Faculty of Chemical Engineering Technology Universiti Malaysia Perlis(UniMAP)Arau02600Malaysia Department of Materials Engineering University of TechnologyBaghdad10070Iraq Department of Chemical Materials University of Bagdad College of Education for Pure Science Ibn-AlhaithamBaghdad10001Iraq Department of Computer Techniques Engineering Al-Rafidain University CollegeBaghdad10001Iraq Faculty of Electronics Engineering Technology Universiti Malaysia PerlisKampus Uniciti Alam Sg.ChuchuhPerlis02100Malaysia Research Center(NANOCAT) University of MalayaKuala Lumpur50603Malaysia Institute of Nano Electronic Engineering Universiti Malaysia PerlisPerlis01000Malaysia Center for Global Health Research Saveetha Medical College&HospitalSaveetha Institute of Medical and Technical Sciences(SIMATS)Tamil Nadu602105India

Naturalﬁbre(NFR)reinforced functional polymer composites are quickly becoming an indispensable sustainable material in the transportation industry because of their lightweight,lower cost in manufacture,and adaptability to a wide variety of ***,the major difﬁculties of using theseﬁbres are their existing poor dimensional stability and the extreme *** assessing the mechanical properties(MP)of composites,the interfacial bonding(IB)happening between the NFR and the polymer matrix(PM)plays an incredibly signiﬁcant *** compared to NFR/syntheticﬁbre hybrid composites,hybrid composites(HC)made up of two separate NFR are less prevalent;yet,these hybrid composites also have the potential to be valuable materials in terms of environmental issues.A new dimension to theﬂexibility of composites reinforced with NFR is added by the cost-effective manufacture of hybrid composites utilising *** purpose of this study is to offer an over-view of the keyﬁndings that were presented on hybrid *** emphasis was focused on the factors that inﬂuence the performance of the naturalﬁber composites,diverse approaches to enhancing MP,physical,electri-cal,and thermal characteristics of the *** study in polymer science gains interest for applications in con-struction and automotive industries.

关键词： Renewable naturalﬁber hybrid composites sustainability nanomaterial greener material

Incidence of exclusive extrapelvic skeletal metastasis in prostate carcinoma on bone scintigraphy

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World Journal of Radiology 2024年第7期16卷 265-273页

作者： Parneet Singh Kanhaiyalal Agrawal Ashique Rahman Tejasvini Singhal Girish Kumar Parida gopinath Gnanasegaran Department of Nuclear Medicine All India Institute of Medical SciencesBhubaneshwar 751019OdishaIndia Department of Nuclear Medicine Royal Free HospitalLondon NW32QGUnited Kingdom

BACKGROUND Bone is one of the common sites of metastasis from prostate *** scintigraphy(BS)is one of the most sensitive imaging modalities currently used for bone metastatic *** metastasis in prostate carcinoma commonly involves pelvic bones but rarely involves extrapelvic-extraspinal *** To retrospectively analyze the BS data to determine the pattern of skeletal metastases in the prostate *** This retrospective observational study involves patients with biopsy-proven prostate carcinoma referred for BS for staging *** with abnormal BS were evaluated for the pattern of skeletal involvement and data were pre-sented in descriptive format in the form of *** A total of 150 patients with biopsy-proven prostate cancer who were referred for staging were included in the *** of 150 patients(8.67%)had no abnormal uptake on planar images,ruling out metastatic ***-four patients(16%)had heterogeneous uptake in the spine with distribution charac-teristic of degenerative disease and no scan pattern of metastatic *** patients(20%)had multifocal uptake involving both pelvic and extra pelvic bones on planar images typical for skeletal metastasis and were considered ***-three out of 150 patients(55.3%)had increased tracer uptake,which was indeterminate,thus,single photon emission computed tomography-computed tomography(SPECT-CT)was acquired,which showed 51 with metastatic disease,31 benign lesions,and one indeterminate *** of 150 patients had exclusive pelvic bone uptake,which was found to be metastatic in 4/7 patients in *** six out of 150 patients showed exclusive extrapelvic tracer uptake,of which only 3 had vertebral metastatic *** of the patients with increased uptake exclusively in the extrapelvic-extraspinal location was *** The incidence of exclusive extrapelvic skeletal metastatic disease in prostate carcinom

关键词： Pelvic Prostate cancer Bone scan Single photon emission computed tomography-computed tomography Skeletal metastasis

Stress enhances expression of calcium-binding proteins and NMDAR subunit genes in the rat hippocampus

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Neuroprotection 2024年第2期2卷 167-178页

作者： Aravind Parthasarathy Ramesha Hanumanthappa Sarojini R.Bulbule Kiran P.C. Hemalatha Nanjaiah gopinath G. Siddaiah B.M. David Muniswamy Devaraju Kuramkote Shivanna Neurochemistry Lab Department of BiochemistryKarnatak UniversityDharwadIndia Department of Microbiology and Immunology University of Maryland School of MedicineBaltimoreMarylandUSA Department of Zoology Karnatak UniversityDharwadIndia

Backgrounds:Oxidative stress impairs the function of calcium-binding proteins and deregulates calcium signaling in living *** have previously explored the overexpression of calcium-binding protein genes in a reactive oxygen and nitrogen species-induced in vitro cell model of stress that leads to ***,in in vivo models,low levels of stress leads to depressive-like ***,we aimed to analyze gene expression of major calcium-binding proteins(calcineurin,calmodulin,calsyntenin,synaptotagmin,and calreticulin)and N-methyl-D-aspartic acid(NMDA)receptor subunits(glutamate receptor ionotropic[GluN]GluN1,GluN2A,and GluN2B)in the hippocampus of stress-induced ***:Six-week-old male Wistar rats were assigned to two stress induction groups and a control group without stress(n=6).Stress was induced by using H_(2)O_(2)(3%in water)or by immobilization(using a sticky mat)over a period of 30 *** of calcium-binding protein genes in the hippocampus,antioxidant assays,structural alterations in hippocampal neurons,and depressive-like behavior were ***:Expression of genes encoding calcium-binding proteins calcineurin,calsyntenin,synaptotagmin and NMDA receptor subunit GluN1 was enhanced in both chemical and physical stress-induced rats compared with control rats(4.25±0.05 vs.1.03±0.02,p<0.05,2.05±0.08vs.1.03±0.02,p<0.005;2.2±0.4 vs.1.02±0.03,p<0.05,1.98±0.07 vs.1.02±0.03,p<0.005;1.4±0.6 vs.1.15±0.09,p<0.05,1.39±0.05 vs.1.15±0.09,p<0.005),*** stress-induced rats,neurons in the CA2 region of the hippocampus were fewer and appeared disorganized compared with control ***,stressinduced rats showed decreased mobility and lower sucrose preference in behavioral studies compared with control ***:Lower levels of reactive oxygen and nitrogen species(RONS)can also lead to stress in rats by affecting their calcium signaling,buffering capacity in the neurons leading to depressive symptoms.

关键词： calcineurin H_(2)O_(2) hippocampus immobilization NMDA receptors

Experimental investigation on concrete overlaid with textile reinforced mortar:Influences of mix,temperature,and chemical exposure

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 271-283页

作者： Smitha gopinath Ramesh GOPAL Hemalatha THIYAGARAJAN CSIR-Structural Engineering Research Centre Chennai 600113India

Textile reinforced mortar is widely used as an overlay for the repair,rehabilitation,and retrofitting of concrete ***,textile reinforced concrete has been identified as a suitable lining material for improving the durability of existing concrete *** this study,we developed a textile-reinforced mortar mix using river sand and evaluated the different characteristics of the textile-reinforced mortar under various exposure *** were carried out in two *** the first phase,the pullout strength,temperature resistance,water absorption,and compressive and bending strength values of three different textile-reinforced mortar mixes with a single type of textile reinforcement were *** the second phase,the chemical resistance of the mix that showed the best performance in the abovementioned tests was examined for use as an overlay for a concrete *** were performed on three different thicknesses of the textile reinforced mortar overlaid on concrete specimens that were subjected to acidic and alkaline *** flexural responses and degradations of the textile reinforced mortar overlaid specimens were examined by performing bending *** experimental findings indicated the feasibility of using textile reinforced mortar as an overlay for durable concrete construction practices.

关键词： textile reinforced mortar bending tests acid and alkaline environment concrete overlay

Stationary Analysis and Optimal Control Under Multiple Working Vacation Policy in a GI/Ma,b/1 Queue

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Journal of Systems Science & Complexity 2018年第4期31卷 1003-1023页

作者： PANDA gopinath BANIK Abhijit Datta GUHA Dibyajyoti School of Mathematical Sciences National Institute of Science Education and Research Bhubaneswar-752050 India School of Basic Sciences Indian Institute of Technology Bhubaneswar-752050 India International Management Institute Kolkata-700027 India

This paper considers an infinite buffer renewal input queue with multiple working vacation policy wherein customers are served by a single server according to general bulk service （a,b）-rule （1 ≤ a ≤ b）. If the number of waiting customers in the system at a service completion epoch （during a normal busy period） is lower than ＇a＇, then the server starts a vacation. During a vacation if the number of waiting customers reaches the minimum threshold size ＇a＇, then the server starts serving this batch with a lower rate than that of the normal busy period. After completion of a batch service during working vacation, if the server finds less than takes another vacation, otherwise the server rate. The maximum allowed size of a batch a＇ customers accumulated in the system, then the server continues to serve the available batch with that lower in service is ＇b＇. The authors derive both queue-length and system-length distributions at pre-arrival epoch using both embedded Markov chain approach and the roots method. The arbitrary epoch probabilities are obtained using the classical argument based on renewal theory. Several performance measures like average queue and system-length, mean waiting-time, cost and profit optimization are studied and numerically computed.

关键词： Bulk service cost optimization mean idle period multiple working vacations roots method system-length

Magnetohydrodynamic stagnation-point flow of Sisko nanofluid over a stretching sheet with suction

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Propulsion and Power Research 2020年第4期9卷 408-422页

作者： Dulal Pal gopinath Mandal Department of Mathematics Institute of ScienceVbva-Bharati UniversitySantiniketanWest Bengal731235India Siksha Satra Visva-BharatiSriniketanWest Bengal731236India

A numerical investigation is presented to show the effects of thermo-diffusion on the hydromagnetic stagnation-point flow of Sisko nanofluid over a linearly stretching sheet by considering viscous dissipation and Joule heating with suction/injection.A suitable set of similarity transformations is considered in order to convert the basic partial differential equations into a set of coupled nonlinear ordinary differential *** efficient numerical method along with shooting technique is involved in older to solve the reduced governing basic *** influences of several emerging physical parameters of Sisko nanofluid on the profiles of velocity,temperature,solutal concentration,nanoparticle volume fraction,skin-friction coefficient,Nusselt number,and Sherwood number have been studied and analyzed in detail through graphs and *** is found that the skin friction coefficient decays more rapidly against the material parameter of Sisko ***,it is noticed that the Brownian motion and thermophoresis parameter have the reverse effects on Sisko nanofluid Sherwood num*** is analyzed that the Nusselt number decreases with an increase in the values of thermophoresis *** motion parameter,and Eckert number,while its value increases with material parameter and Dufour solutal Lewis *** is observed that the Sherwood number has ascending behavior for thermophoresis *** motion parameters,whereas nanofluid Sherwood number gets amplified with a hike in the nano Lewis number parameter for all the values of Brownian motion parameter.

关键词： Magnetohydrodynamics Stagnation-point Siskona nofluid Suction Joule heating

A Pathway to Explore the Hidden Specialty in the Design of Fifteen Level Inverter in Grid Connected PV System

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Computer Modeling in Engineering & Sciences 2018年第6期115卷 359-386页

作者： C.gopinath M.Rajvikram Department of Electrical and Electronics Engineering Sri Venkateswara College of Engineering(Autonomous)SriperumbudurTamilnaduIndia

This research paper proposes a single phase fifteen level inverter for a grid connected PV *** proposed inverter is also called cascaded asymmetric multilevel *** adopting appropriate hybrid modulation technique improved output voltage is obtained with minimum number of power electronic *** reducing the number of gate triggering circuits of the switches,the size and power consumption of the driving circuits can be *** total harmonic distortion of the output of the inverter is improved by this *** proposed inverter developed by cascading a full bridge inverter with modified H bridge multilevel *** validity of the proposed system is verified through MATLAB simulations.

关键词： Hybrid modulation multilevel inverter photo voltaic system grid connected inverter

A new design of 3D-printed orthopedic bone plates with auxeticstructures to mitigate stress shielding and improve intra-operative bending

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Bio-Design and Manufacturing 2020年第2期3卷 98-108页

作者： Sanjairaj Vijayavenkataraman Akhil gopinath Wen F.Lu Division of Engineering New York University Abu DhabiAbu DhabiUAE Department of Mechanical and Aerospace Engineering Tandon School of EngineeringNew York UniversityBrooklynNYUSA Department of Mechanical Engineering National University of Singapore(NUS)SingaporeSingapore

Orthopedic bone plates are most commonly used for bone fracture fixation for more than 100 *** bone plate design had evolved over time overcoming many challenges such as insufficient strength and excessive plate–bone contact affecting the blood ***,it is only made of two materials,either stainless steel(AISI 316L)or titanium(Ti–6Al–4V).There are two main limitations of metallic bone implants,namely stress shielding and the problem of malocclusion caused by the displacement of the fracture site during *** overcome the two problems,a new bone plate design with the incorporation of auxetic structures is proposed in this *** study aims to use auxetic structure section in the bone plate that would decrease the stiffness of the region,thereby mitigating the stress-shielding effect and at the same time act as a deformable section to enable intra-operative bending for effective alignment while having enough bending strength and *** different auxetic structures namely re-entrant honeycomb and missing rib structures were *** auxetic structure incorporated bone plates were designed,finite element analysis was done,fabricated using direct metal laser sintering technique,and *** results indicate that the re-entrant honeycomb structure incorporated bone plates serve as an effective bone design compared to the conventional bone plate design,in terms of stress shielding and intra-operative bending while offering similar mechanical and bending strength.

关键词： Bone plates Negative Poisson's ratio structures 3D printing Additive manufacturing Stress shielding