检索结果-南通市图书馆

Differences in phenotype,homing properties and suppressive activities of regulatory T cells induced by epicutaneous,oral or sublingual immunotherapy in mice sensitized to peanut

引用

Cellular & Molecular Immunology 2017年第9期14卷 770-782页

作者： vincent dioszeghy Lucie Mondoulet Emilie Puteaux Véronique Dhelft Mélanie Ligouis Camille Plaquet Christophe Dupont Pierre-Henri Benhamou Research Department DBV TechnologiesParis92220France Pédiatrie-Gastroentérologie Université Paris Descartes&APHP-Hôpital NeckerParis75743France

Allergen-specific immunotherapy has been proposed as an attractive strategy to actively treat food allergy using the following three different immunotherapy routes:oral(OIT),sublingual(SLIT)and epicutaneous(EPIT)immunotherapy.Regulatory T cells(Tregs)have been shown to have a pivotal role in the mechanisms of immunotherapy.The aim of this study was to compare the phenotype and function of Tregs induced in peanut-sensitized BALB/c mice using these three routes of treatment.We show that although EPIT,OIT and SLIT were all able to effectively desensitize peanut-sensitized mice,they induced different subsets of Tregs.Foxp3+Tregs were induced by the three treatment routes but with greater numbers induced by EPIT.EPIT and OIT also increased the level of LAP+Tregs,whereas SLIT induced IL-10+cells.The suppressive activity of EPIT-induced Tregs did not depend on IL-10 but required CTLA-4,whereas OIT acted through both mechanisms and SLIT was strictly dependent on IL-10.Moreover,the three routes influenced the homing properties of induced Tregs differently,with a larger repertoire of chemokine receptors expressed by EPIT-induced Tregs compared with OIT-and SLIT-induced cells,resulting in different protective consequences against allergen exposure.Furthermore,whereas OIT-or SLIT-induced Tregs lost their suppressive activities after treatment was discontinued,the suppressive activities of EPIT-induced Tregs were still effective 8 weeks after the end of treatment,suggesting the induction of a more long-lasting tolerance.In summary,EPIT,OIT and SLIT mediated desensitization through the induction of different subsets of Tregs,leading to important differences in the subsequent protection against allergen exposure and the possible induction of tolerance.

关键词： allergy immunotherapy mechanisms regulatory T cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：