检索结果-南通市图书馆

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

引用

Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay vincentém.nd martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanomaterials for Fighting multidrug-Resistant Biofilm Infections

引用

Biomedical Engineering Frontiers 2023年第1期4卷 133-143页

作者： vincent m.Rotello Department of Chemistry University of Massachusetts Amherst710 North Pleasant StreetAmherstMA 01003USA

multidrug-resistant bacterial infections represent a dire threat to global *** development of antibiotic resistance in bacteria coupled with the lack of development of new antibiotics is creating infections requiring antibiotics of last resort,and even some infections for which we have no available ***-based infections present some of the most challenging targets for *** biofilm matrix provides a physical barrier that can impede access of antibiotics and antimicrobials to resident *** phenotypic diversity found in biofilms further exacerbates the difficulty of eliminating infections,with quiescent“persister”cells evading therapeutics and re-initiating infections after *** provide a tool for combatting these refractory biofilm *** distinctive size regime and physical properties of nanomaterials provide them with the capability to penetrate and disrupt *** can also access antimicrobial pathways inaccessible to conventional antimicrobials,providing a synergistic strategy for treating biofilm *** review will summarize key challenges presented by antibiotic resistance and biofilms when treating infection and provide selected examples of how nanomaterials are being used to address these challenges.

关键词： resort initiating eliminating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tourism Developments Increase Tsunami Disaster Risk in Pangandaran, West Java, Indonesia

引用

International Journal of Disaster Risk Science 2021年第5期12卷 764-769页

作者： vincent Nijman Department of Social Sciences Oxford Brookes UniversityOxford OX30BP.United Kingdom

On 17 July 2006,the tourist resort of Pangandaran on Java’s south coast was hit by a tsunami,resulting in 413 fatalities and severe damage to *** tsunami resulted in major rebuilds with a focus on mass *** of the impact of a future tsunami focussed on building development and suggest limited change since *** article presents a case study on the development of(largely domestic)tourism in Pangandaran and how this has increased the tsunami disaster *** numbers were stable at about 900,000 visitors a year prior to the tsunami,down to slightly over 250,000 visitors a year in its aftermath,and from 2007 onwards numbers are doubling every three years to about 4 million visitors in *** increase has been most pronounced during *** to 2006,Pangandaran was characterized by wooden structures and one-and two-story buildings of clay-brick masonry;by 2019,14 three to sixstory hotels have been erected along the *** many more visitors,most of whom are unfamiliar with tsunami risks,and shelter facilities for less than a quarter of visitors during peak times,future impacts and the potential cost to life are considerably higher now than in 2006,especially if a tsunami were to hit over a *** tourists upon arrival and throughout their stay should be better informed about the risks of tsunamis,and of the location of tsunami shelters and evacuation routes.

关键词： Disaster resilience Effective warning Indonesia Risk mitigation Tourism Tsunami

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strain and stress analysis on Zn multicrystal film by XRD method

引用

中国有色金属学会会刊：英文版 2006年第B02期16卷 735-738页

作者： vincent JI LIm UmR CNRS8006ENSAm 151Boulevard de I'Hopital75013 ParisFrance

A new method was denonstrated to determine stress in a single crystal for multicrystal material and this new method could be specially applied for any symmetric crystalline systems. The strain tensor e was determined by the change of the metric tensor G before the initial state and after the deformed state in the crystal reference system. Then stress tensor at grain scale was calculated by the HOOK's law. The stress evaluations were carried out in coarse grains of a thin galvanized coating on a steel substrate during tensile loading. This makes it possible to link the microstructure evolution to the elastic heterogeneity at grain scale or between the grains.

关键词：锌多晶膜单晶应力应变分析 XRD法锌镀层

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Toward a Deeper Appreciation of Inherited Conventions

引用

Language and Semiotic Studies 2021年第3期7卷 32-54页

作者： vincent m.Colapietro The Pennsylvania State University(University Park)and University of Rhode Island USA

Conventionalism makes far too much of conventions,alleging that not only matters of fact,but also the adoption of a framework,are merely matters of ***,experiential,and other forms of compulsion are,tout court,*** Buchler,however,crafts a general theory of human judgment in which both conventionality and compulsion are given their due.1 moreover,he does so in a manner attuned to the axiological dimensions of human communication(whatever its modes or media).These conventions are hardly an ultimately dispensable *** are rather intrinsically constitutive *** also are in countless instances *** nature and authority of the normative constraints inherent in many shared conventions(more often than not,enabling constraints)are,however,neither appreciated nor ***’s account facilitates us in appreciating and understanding such constraints and much else.

关键词： arbitrariness Buchler Cavell compulsion contingency judgment justification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Engineering carbon quantum dots for photomediated theranostics

引用

Nano Research 2018年第1期11卷 1-41页

作者： mahbub Hassan vincent G. Gomes Alireza Dehghani Sara m. Ardekani School of Chemical and Biomolecular Engineering The University of Sydney NSW 2006 Australia

Carbon quantum dots （CQDs） have emerged as potential alternatives to classical metal-based semiconductor quantum dots （QDs） due to the abundance of their precursors, their ease of synthesis, high biocompatibility, low cost, and particularly their strong photoresponsiveness, tunability, and stability. Light is a versatile, tunable stimulus that can provide spatiotemporal control. Its interaction with CQDs elicits interesting responses such as wavelength-dependent optical emissions, charge/electron transfer, and heat generation, processes that are suitable for a range of photomediated bioapplications. The carbogenic core and surface characteristics of CQDs can be tuned through versatile engineering strategies to endow specific optical and physicochemical properties, while conjugation with specific moieties can enable the design of targeted probes. Fundamental approaches to tune the responses of CQDs to photo-interactions and the design of bionanoprobes are presented, which enable biomedical applications involving diagnostics and therapeutics. These strategies represent comprehensive platforms for engineering multifunctional probes for nanomedicine, and the design of QD probes with a range of metal-free and emer^in~ 2D materials.

关键词： carbon quantum dots nanobiophotonics therapeutics diagnostics nanomedicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small fishes crossed a large mountain range:Quaternary stream capture events and freshwater fishes on both sides of the Taebaek mountains

引用

Integrative Zoology 2017年第4期12卷 292-302页

作者： Daemin KIm m.vincent HIRT Yong-Jin WON Andrew m.SImONS Division of EcoScience Ewha Womans UniversitySeoulKorea Department of Fisheries Wildlife and Conservation BiologySaint PaulMinnesotaUSA Bell museum of Natural History University of Minnesota100 Ecology BuildingSaint PaulMinnesotaUSA

The Taebaek mountains in Korea serve as the most apparent biogeographic barrier for Korean freshwater fishes,resulting in 2 distinct ichthyofaunal assemblages on the eastern(East/Japan Sea slope)and western(Yellow Sea and Korea Strait slopes)sides of the mountain *** nearly 100 species of native primary freshwater fishes in Korea,only 18 species occur naturally on both sides of the mountain ***,there are 5 rheophilic species(Phoxinus phoxinus,Coreoleuciscus splendidus,Ladislavia taczanowskii,Iksookimia koreensis and Koreocobitis rotundicaudata)found on both sides of the Taebaek mountains that are geographically restricted to the Osip River(and several neighboring rivers,for *** and ***)on the eastern side of the mountain *** Osip River and its neighboring rivers also shared a rheophilic freshwater fish,Liobagrus mediadiposalis,with the Nakdong River on the western side of the mountain *** assessed historical biogeographic hypotheses on the presence of these rheophilic fishes,utilizing DNA sequence data from the mitochondrial cytochrome b *** of our divergence time estimation indicate that ichthyofaunal transfers into the Osip River(and several neighboring rivers in East Sea slope)have occurred from the Han(Yellow Sea slope)and Nakdong(Korea Strait slope)Rivers since the Late *** inferred divergence times for the ichthyofaunal transfer across the Taebaek mountains were consistent with the timing of hypothesized multiple reactivations of the Osip River Fault(Late Pleistocene),suggesting that the Osip River Fault reactivations may have caused stream capture events,followed by ichthyofaunal transfer,not only between the Osip and Nakdong Rivers,but also between the Osip and Han Rivers.

关键词： biogeographic barrier comparative phylogeography divergence time Korean fishes Osipcheon fault

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

multicomponent flow modeling

引用

Science China mathematics 2012年第1期55卷 285-308页

作者： GIOVANGIGLI vincent CmAP-CNRS Ecole

We present multicomponent flow models derived from the kinetic theory of gases and investigate the symmetric hyperbolic-parabolic structure of the resulting system of partial differential *** address the Cauchy problem for smooth solutions as well as the existence of deflagration waves,also termed anchored *** further discuss related models which have a similar hyperbolic-parabolic structure,notably the SaintVenant system with a temperature equation as well as the equations governing chemical equilibrium *** next investigate multicomponent ionized and magnetized flow models with anisotropic transport fluxes which have a different mathematical *** finally discuss numerical algorithms specifically devoted to complex chemistry flows,in particular the evaluation of multicomponent transport properties,as well as the impact of multicomponent transport.

关键词： multicomponent reactive flow Cauchy problem deflagration wave multicomponent transport

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implementation of distortion symmetry for the nudged elastic band method with DiSPy

引用

npj Computational materials 2019年第1期5卷 685-693页

作者： Jason m.munro vincent S.Liu Venkatraman Gopalan Ismaila Dabo Department of materials Science and Engineering and materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Penn State Institutes of Energy and the Environment The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Physics The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Engineering Science and mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA

The nudged elastic band(NEB)method is a commonly used approach for the calculation of minimum energy pathways of kinetic ***,the final paths obtained rely heavily on the nature of the initially chosen *** often necessitates running multiple calculations with differing starting points in order to obtain accurate ***,it has been shown that the NEB algorithm can only conserve or raise the distortion symmetry exhibited by an initial *** this knowledge,symmetryadapted perturbations can be generated and used as a tool to systematically lower the initial path symmetry,enabling the exploration of other low-energy pathways that may ***,the group and representation theory details behind this process are presented and implemented in a standalone piece of software(DiSPy).The method is then demonstrated by applying it to the calculation of ferroelectric switching pathways in LiNbO_(3).Previously reported pathways are more easily obtained,with new paths also being found which involve a higher degree of atomic coordination.

关键词： symmetry distortion details

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental study of path planning problem using EmCOA for a holonomic mobile robot

引用

Journal of Systems Engineering and Electronics 2021年第6期32卷 1450-1462页

作者： mOHSENI Alireza DUCHAINE vincent WONG Tony Department of System Engineering École de Technologie SupérieureMontreal QC H3C 1K3Canada

In this paper,a comparative study of the path planning problem using evolutionary algorithms,in comparison with classical methods such as the A*algorithm,is presented for a holonomic mobile *** configured navigation system,which consists of the integration of sensors sources,map formatting,global and local path planners,and the base controller,aims to enable the robot to follow the shortest smooth path ***-based mapping is used for scoring paths efficiently,allowing the determination of collision-free trajectories from the initial to the target *** work considers the evolutionary algorithms,the mutated cuckoo optimization algorithm(mCOA)and the genetic algorithm(GA),as a global planner to find the shortest safe path among others.A non-uniform motion coefficient is introduced for mCOA in order to increase the performance of this algorithm.A series of experiments are accomplished and analyzed to confirm the performance of the global planner implemented on a holonomic mobile *** results of the experiments show the capacity of the planner framework with respect to the path planning problem under various obstacle layouts.

关键词： holonomic robot path planning evolutionary algorithm(EA)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：