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The genetic framework for development of nephrolithiasis

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Asian Journal of Urology 2017年第1期4卷 18-26页

作者： vinaya vasudevan Patrick Samson Arthur D.Smith Zeph Okeke Smith Institute for Urology Hofstra Northwell School of MedicineLake SuccessNYUSA

Over 1%-15% of the population worldwide is affected by nephrolithiasis,which remains the most common and costly disease that urologists manage *** of atrisk individuals remains a theoretical and technological *** search for monogenic causes of stone disease has been largely unfruitful and a technological challenge;however,several candidate genes have been implicated in the development of *** this review,we will review current data on the genetic inheritance of stone disease,as well as investigate the evolving role of genetic analysis and counseling in the management of nephrolithiasis.

关键词： Genetics Hypercalciuria Nephrolithiasis Urolithiasis Calcium sensing receptor Cystinuria Medullary sponge kidney Autosomal dominant polcystic kidney disease Uric acid nephrolithiasis Hypercalciuria

FPGA Accelerators for Computing Interatomic Potential-Based Molecular Dynamics Simulation for Gold Nanoparticles:Exploring Different Communication Protocols

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Computers, Materials & Continua 2024年第9期80卷 3803-3818页

作者： Ankitkumar Patel Srivathsan vasudevan Satya Bulusu Department of Electrical Engineering Indian Institute of Technology IndoreIndore453552India Department of Chemistry Indian Institute of Technology IndoreIndore453552India

Molecular Dynamics(MD)simulation for computing Interatomic Potential(IAP)is a very important High-Performance Computing(HPC)*** simulation on particles of experimental relevance takes huge computation time,despite using an expensive high-end *** computing,a combination of the Field Programmable Gate Array(FPGA)and a computer,is proposed as a solution to compute MD simulation *** such heterogeneous computation,communication between FPGA and Computer is *** such MD simulation,explained in the paper,is the(Artificial Neural Network)ANN-based IAP computation of gold(Au_(147)&Au_(309))*** simulation calculates the forces between atoms and the total energy of the chemical *** work proposes the novel design and implementation of an ANN IAP-based MD simulation for Au_(147)&Au_(309) using communication protocols,such as Universal Asynchronous Receiver-Transmitter(UART)and Ethernet,for communication between the FPGA and the host *** improve the latency of MD simulation through heterogeneous computing,Universal Asynchronous Receiver-Transmitter(UART)and Ethernet communication protocols were explored to conduct MD simulation of 50,000 *** this study,computation times of 17.54 and 18.70 h were achieved with UART and Ethernet,respectively,compared to the conventional server time of 29 h for Au_(147) *** results pave the way for the development of a Lab-on-a-chip application.

关键词： Ethernet hardware accelerator heterogeneous computing interatomic potential(IAP) MDsimulation peripheral component interconnect express(PCIe) UART

Approach to loss of response to advanced therapies in inflammatory bowel disease

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World Journal of Gastroenterology 2024年第22期30卷 2902-2919页

作者： Nikil Vootukuru Abhinav vasudevan Department of Gastroenterology and Hepatology Eastern HealthVictoriaBox Hill 3128Australia Eastern Health Clinical School Monash UniversityVictoriaBox Hill 3128Australia

BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel *** now have the unique opportunity to provide individualized treatment that can achieve and sustain remission in many ***,issues of primary non-response(PNR)and secondary loss of response(SLOR)to non-tumour necrosis factor inhibitor(TNFi)therapies remains a common *** issues include the choice of optimization of therapy,identifying when dose optimization will recapture response,establishing optimal dose for escalation and when to switch *** To explores the issues of PNR and SLOR to non-TNFi *** This review explores the current evidence and literature to elucidate management options in cases of PNR/*** will also explore potential predictors for response following SLOR/PNR to therapies including the role of therapeutic drug monitoring(TDM).RESULTS In the setting of PNR and loss of response to alpha-beta7-integrin inhibitors and interleukin(IL)-12 and IL-23 inhibitors dose optimization is a reasonable option to capture *** Janus kinase inhibitors dose optimization can be utilized to recapture response with loss of *** The role of TDM in the setting of advanced non-TNFi therapies to identify patients who require dose optimization and as a predictor for clinical remission is not yet established and this remains an area that should be addressed in the future.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn Biologics Interleukin-12 and interleukin-23 inhibitors Alpha-beta7-integrin inhibitors Janus kinase inhibitors Sphingosine-1-phosphate receptor modulators

Examining dietary interventions in Crohn’s disease

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World Journal of Gastroenterology 2024年第34期30卷 3868-3874页

作者： Lynna Chen Ashish Srinivasan Abhinav vasudevan Department of Gastroenterology and Hepatology Eastern HealthBox Hill 3128Australia Eastern Clinical School Monash UniversityBox Hill 3128Australia

This editorial builds on the article by Shakhshir et *** conducted an overview of evidence-based dietary interventions in adults with inflammatory bowel disease(IBD).In the IBD population,there may be a role for the Mediterranean diet due to its anti-inflammatory effects,long-term sustainability,and role in improving cardiovascular *** active Crohn’s disease,the use of exclusive enteral nutrition,the Crohn’s disease exclusion diet,or the specific carbohydrate diet may be used as a short-term adjunct to medical therapy and may improve mucosal *** low-FODMAP diet can assist in reducing symptoms for patients without evidence of active bowel *** interest in nutritional therapy increases amongst clinicians and patients alike,it is integral that dietary therapies are understood and discussed in routine management of patients with IBD as part of holistic care,ideally through a multidisciplinary setting with involvement of experienced *** serves to improve clinician-patient engagement and reduce complications of IBD including micro and micronutrient deficiencies.

关键词： Inflammatory bowel disease Nutrition Dietary therapies Inflammation Malnutrition

Efficacy of a Diabetes Specific Nutrition Supplement on Glycemic, Anthropometric, Dietary and Gut Health Markers in Adults with Type 2 Diabetes: An RCT

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Food and Nutrition Sciences 2024年第8期15卷 846-867页

作者： Deepti Khanna Hema S. Gopalan Kuzhandaivelu Abirami vasudevan Sudha Rajagopal Gayatri Kejal Joshi-Reddy Jaladhi Bhatt Raman Ganesh Jeevan Karthikeyan Parkavi Vadivel Deepika Manoj Pareek Ranjit Mohan Anjana Viswanathan Mohan R&D Department Hindustan Unilever Limited Gurugram India Department of Foods Nutrition & Dietetics Research Madras Diabetes Research Foundation Chennai India Department of Diabetology Dr. Mohans Diabetes Specialities Centre Chennai India

With increasing incidence of diabetes, use of diabetes specific nutrition supplements (DSNS) is common for better management of the disease. To study effect of 12-week DSNS supplementation on glycemic markers, anthropometry, lipid profile, SCFAs, and gut microbiome in individuals with diabetes. Markers studied were glycemic [Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG), HbA1c, Incremental Area under curve (iAUC), Mean Amplitude of Glycemic Excursions (MAGE), Time in/above Range (TIR/TAR)], anthropometry [weight, Body Mass Index (BMI), waist circumference (WC)], lipid profile, diet and gut health [plasma short chain fatty acids (SCFAs)]. N = 210 adults were randomized to receive either DSNS with standard care (DSNS + SC;n = 105) or standard care alone (SC alone;n = 105). After 12 weeks, significant differences between DSNS + SC versus SC alone was observed in FBG [−3 ± 6 vs 14 ± 6 mg/dl;p = 0.03], PPG [−35 ± 9 vs −3 ± 9 mg/dl;p = 0.01], weight [−0.6 ± 0.1 vs 0.2 ± 0.1 kg;p = 0.0001], BMI [−0.3 ± 0.1 vs 0.1 ± 0.1 kg/m2;p = 0.0001] and WC [−0.3 ± 0.2 vs 0.2 ± 0.2 cm;p = 0.01]. HbA1C and low-density lipoprotein (LDL) were significantly reduced in DSNS + SC [−0.2 ± 0.9;p = 0.04 and −5 mg/dl;p = 0.03] respectively with no change in control. Continuous Glucose Monitoring (CGM) reported significant differences between DSNS + SC versus SC alone for mean glucose [−12 ± 65 vs 28 ± 93 mg/dl;p < 0.01], TAR 180 [−9 ± 42 vs 7 ± 45 mg/dl;p = 0.04], TAR 250 [−3 ± 27 vs 9 ± 38 mg/dl;p = 0.05], iAUC [−192 (1.1) vs −48 (1.1) mg/dl;p = 0.03]. MAGE was significantly reduced for both DSNS + SC (−19 ± 67;p < 0.001) and SC alone (−8 ± 70;p = 0.04), with reduction being more pronounced for DSNS + SC. DSNS + SC reported a decrease in carbohydrate energy % [−9.4 (−11.3, −7.6) %;p < 0.0001] and amount [−47.4 (−67.1, −27.7) g;p < 0.0001], increased dietary fiber [9.5 (7.2, 11.8) g;p < 0.0001] and protein energy % [0.9 (0.5, 1.3) %;p < 0.0001] versus SC alone. DSNS + SC reported signi

关键词： Diabetes Specific Nutrition Supplement Standard of Care Diabetes Glycemic Markers HbA1C

Role of nutrients in the utilization of polycyclic aromatic hydrocarbons by halotolerant bacterial strain

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Journal of Environmental Sciences 2011年第2期23卷 282-287页

作者： Pugazhendi Arulazhagan Namsivayam vasudevan Department of Civil and Environmental Engineering Sung Kyun Kwan University300 CheonCheon-DongJangan-GuSuwon Gyeonggi-Do 440-746Republic of Korea Centre for Environmental Studies Anna UniversityChennai-600 025India

A halotolerant bacterial strain VA1 isolated from marine environment was studied for its ability to utilize polycylic aromatic hydrocarbons （PAHs） under saline condition. Anthracene and pyrene were used as representatives for the utilization of PAH by the bacterial strain. Glucose and sodium citrate were used as additional carbon sources to enhance the PAH utilization. The strain VA1 was able to utilize anthracene （73%） and pyrene （66%） without any additional substrate. In the presence of additional carbon sources （glucose]sodium citrate） the utilization of PAH was faster. PAH was utilized faster by VA 1 in the presence of glucose than sodium citrate. The stain utilized 87% and 83% of anthracene and pyrene with glucose as carbon source and with sodium citrate the strain utilized 81% and 76% respectively in 4 days. Urea as an alternative source of nitrogen also enhanced the utilization of PAHs （anthracene and pyrene） by the bacterial strain up to 88% and 84% in 4 days. Sodium nitrate as nitrogen source was not able to enhance the PAH utilization rate. Phenotypic and phlyogenetic analysis proved that the PAHs utilizing halotolerant strain VA1 belongs to Ochrobactrum sp.

关键词： biodegradation polycyclic aromatic hydrocarbons hatotolerant, Ochrobactrum sp

Local outlier factor and stronger one class classifier based hierarchical model for detection of attacks in network intrusion detection dataset

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Frontiers of Computer Science 2016年第4期10卷 755-766页

作者： Alampallam Ramaswamy vasudevan Subramanian SELVAKUMAR CDBR-SSE Lab Department of Computer Science and Engineering National Institute of Technology Tiruchirappalli (NITT) Tiruchirappalli 620015 India

Identification of attacks by a network intrusion detection system （NIDS） is an important task. In signature or rule based detection, the previously encountered attacks are modded, and signatures/rules are extracted. These rules are used to detect such attacks in future, but in anomaly or outlier detection system, the normal network traffic is modeled. Any deviation from the normal model is deemed to be an outlier/attack. Data mining and machine learning techniques are widely used in offline NIDS. Unsupervised and supervised learning techniques differ the way NIDS dataset is treated. The characteristic features of unsupervised and supervised learning are finding patterns in data, detecting outliers, and determining a learned function for input features, generalizing the data instances respectively. The intuition is that if these two techniques are combined, better performance may be obtained. Hence, in this paper the advantages of unsupervised and supervised techniques are inherited in the proposed hierarchical model and devised into three stages to detect attacks in NIDS dataset. NIDS dataset is clustered using Dirichiet process （DP） clustering based on the underlying data distribution. Iteratively on each cluster, local denser areas are identified using local outlier factor （LOF） which in turn is discretized into four bins of separation based on LOF score. Further, in each bin the normal data instances are modeled using one class classifier （OCC）. A combination of Density Estimation method, Reconstruction method, and Boundary methods are used for OCC model. A product rule combination of the three methods takes into consideration the strengths of each method in building a stronger OCC model. Any deviation from this model is considered as an attack. Experiments are conducted on KDD CUP＇99 and SSENet-2011 datasets. The results show that the proposed model is able to identify attacks with higher detection rate and low false alarms.

关键词： hierarchical model DP clustering LOF Dis-cretizer one class classifier NIDS

Effect of process parameters on springback behaviour during air bending of electrogalvanised steel sheet

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第3期12卷 183-189页

作者： Durairaj vasudevan Rajumani SRINIVASAN Palani PADMANABHAN Department of Mechanical Engineering PSNA College of Engineering and Technology Department of Mechanical Engineering RVS College of Engineering and Technology Bharath Niketan Engineering College

This work aims to study the springback behaviour of electrogalvanised (EG) steel sheets during the air bending *** have been conducted to analyse the influence of various parameters such as coating thickness,orientation of the sheet,punch radius,die radius,die opening,punch velocity,and punch travel on springback *** is established that the springback increases with increasing coating thickness,punch radius,punch travel,die radius,die opening,and punch *** 90° orientation exhibits higher springback than 0° orientation.

关键词： Springback Electrogalvanised (EG) steel Air bending

Tailoring electrical conductivity of two dimensional nanomaterials using plasma for edge electronics: A mini review

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Frontiers of Chemical Science and Engineering 2019年第3期13卷 427-443页

作者： Aswathy vasudevan Vasyl Shvalya Aleksander Zidansek Uros Cvelbar Jozef Stefan Institute 1000 LjubljanaSlovenia Jozef Stefan International Postgraduate School 1000 LjubljanaSlovenia Faculty of Natural Sciences and Mathematics University of Maribor2000 MariborSlovenia

Since graphene has been discovered, twodimensional nanomaterials have attracted attention due to their promising tunable electronic properties. The possibility of tailoring electrical conductivity at the atomic level allows creating new prospective 2D structures for energy harvesting and sensing-related applications. In this respect, one of the most successful way to manipulate the physical properties of the aforementioned materials is related to the surface modification techniques employing plasma. Moreover, plasma-gaseous chemical treatment can provide a controlled change in the bandgap, increase sensitivity and significantly improve the structural stability of material to the environment as well. This review deals with recent advances in the modification of 2D carbon nanostructures for novel ‘edge’ electronics using plasma technology and processes.

关键词： graphene edge electronics 2D nanomaterials plasma electrical conductivity