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The association of layperson characteristics with the quality of simulated cardiopulmonary resuscitation performance

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World Journal of Emergency medicine 2017年第1期8卷 12-18页

作者： marion Leary David G.Bucmer Daniel J.Ikeda Daiane A.Saraiva Robert A.Berg vinay m.nadkarni Audrey L.Blewer Benjamin S.Abella Center for Resuscitation Science and Department of Emergency medicine Department of Emergency MedicinePerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA School of Nursing University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Children's Hospital of Philadelphia PhiladelphiaPennsylvaniaUSA

BACKGROUND: Few studies have examined the association of layperson characteristics with cardiopulmonary resuscitation(CPR) provision. Previous studies suggested provider characteristics, including age and gender, were associated with CPR quality, particularly chest compression(CC) depth. We sought to determine the association of subject characteristics, including age and gender with layperson CPR quality during an unannounced simulated CPR event. We hypothesized shallower CC depth in females, and older-aged ***: As part of a larger multicenter randomized controlled trial of CPR training for cardiac patients' caregivers, CPR skills were assessed 6 months after training. We analyzed associations between subject characteristics and CC rate, CC depth and no-? ow time. Each variable was analyzed independently; signi? cant predictors determined via univariate analysis were assessed in a multivariate regression ***: A total of 521 laypersons completed a 6-month CPR skills assessment and were included in the analysis. mean age was 51.8±13.7 years, 75% were female, 57% were Caucasian. Overall, mean CC rate was 88.5±25.0 per minute, CC depth was 50.9±2.0 mm, and mean no-flow time was 15.9±2.7 sec/min. CC depth decreased signi? cantly in subjects >62 years(Pmale subjects performed deeper CCs than female subjects(47.5±1.7 vs. 41.9±0.6, P62 years and female gender are associated with shallower CC depth.

关键词： Cardiac arrest Cardiopulmonary resuscitation Bystander CPR quality Layperson Demographics

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Elements of disturbance that affect epiphyte vitality in a temperate rainforest:an experimental approach

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Journal of Plant Ecology 2019年第2期12卷 306-313页

作者： Nalini m.nadkarni Kevin D.Kohl Department of Biology University of Utah257 South 1400 EastSalt Lake CityUT 84112USA Department of Biological Sciences University of Pittsburgh403B Clapp Hall4249 Fifth AvenuePittsburghPA 115260USA

Aims Epiphytes are an abundant and diverse component of many wet temperate forests and have significant roles in ecosystem *** is known about the processes and rates of their death and decomposition when they fall from the canopy,which limits our understanding of their role in forest carbon sequestration and nutri-ent *** the temperate rainforest of the Quinault River Valley,Washington State,our aim was to test hypotheses regarding four elements of disturbance that might contribute to their *** We established set of experiments in which we placed samples of canopy epiphytes and their branch segments:(i)in the canopy versus forest floor microenvironment(stratum);(ii)attached to live versus dead branch substrates;(iii)subjected to physical disruption and‘jarring’;and(iv)in direct versus indirect con-tact with the forest *** the 2-year study,we assigned a non-destructive‘vitality index’(based on color and appar-ent mortality and dryness)to each sample every 2-3 months to compare effects of the experimental treatments and analyzed with a statistical model and post hoc pairwise comparisons of *** Findings The canopy versus ground stratum and live/dead branch status sig-nificantly affected epiphyte *** of physical disruption and ground contact were not *** were seasonal effects(low vitality during the sampling times in the summer,revitalization upon sampling times in the winter)for all treatments except samples in contact with the *** implication of these results relates to effects of climate change,which is predicted to shift to hotter,drier summers and wetter *** change may affect forest dynamics and nutrient cycling in unpredictable *** also point to future experiments to understand biotic and abiotic effects on epiphyte disturbance and dynamics.

关键词： disturbance epiphytes forest canopy forest dynamics moss Olympic rainforest

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Advancements in Liver Tumor Detection:A Comprehensive Review of Various Deep Learning models

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Computer modeling in Engineering & Sciences 2025年第1期142卷 91-122页

作者： Shanmugasundaram Hariharan D.Anandan murugaperumal Krishnamoorthy vinay Kukreja Nitin Goyal Shih-Yu Chen Deptartment of Artificial Intelligence and Data Science Vardhaman College of EngineeringHyderabad501218India Deptartment of CSE V.S.B College of EngineeringKarur639111India Deptartment of Electrical and Electronics Engineering Vardhaman College of EngineeringHyderabad501218India Centre for Research Impact&Outcome Chitkara UniversityRajpura140401PunjabIndia Department of Computer Science and Engineering School of Engineering and TechnologyCentral University of HaryanaMahendergarh123031HaryanaIndia Department of Computer Science and Information Engineering National Yunlin University of Science and TechnologyYunlin64002Taiwan Intelligence Recognition Industry Service Research Center National Yunlin University of Science and TechnologyYunlin64002Taiwan

Liver cancer remains a leading cause of mortality worldwide,and precise diagnostic tools are essential for effective treatment *** Tumors(LTs)vary significantly in size,shape,and location,and can present with tissues of similar intensities,making automatically segmenting and classifying LTs from abdominal tomography images crucial and *** review examines recent advancements in Liver Segmentation(LS)and Tumor Segmentation(TS)algorithms,highlighting their strengths and limitations regarding precision,automation,and *** metrics are utilized to assess key detection algorithms and analytical methods,emphasizing their effectiveness and relevance in clinical *** review also addresses ongoing challenges in liver tumor segmentation and identification,such as managing high variability in patient data and ensuring robustness across different imaging *** suggests directions for future research,with insights into technological advancements that can enhance surgical planning and diagnostic accuracy by comparing popular *** paper contributes to a comprehensive understanding of current liver tumor detection techniques,provides a roadmap for future innovations,and improves diagnostic and therapeutic outcomes for liver cancer by integrating recent progress with remaining challenges.

关键词： Liver tumor detection liver tumor segmentation image processing liver tumor diagnosis feature extraction tumor classification deep learning machine learning

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Scaling of residual displacements in terms of elastic and inelastic spectral displacements for existing SDOF systems

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Earthquake Engineering and Engineering Vibration 2020年第1期19卷 71-85页

作者： m.G.Harikrishnan vinay K.Gupta Department of Civil Engineering Indian Institute of Technology Kanpur

Structures undergoing inelastic displacements during earthquake ground motions are known to sustain some amount of residual displacements, which may make them unusable or unsafe. In this study an attempt is made to estimate residual displacements for elastic-perfectly-plastic single-degree-of-freedom oscillators with a given lateral strength ratio. It is observed in the case of a class of ground motions that there are no trends in the dependence of residual displacement on the temporal features of the ground motion, and thus any estimation of residual displacements should be carried out only in the statistical sense. Statistical estimation of residual displacement spectrum via normalization with respect to inelastic or elastic spectral displacements is considered, and it is found that normalization with respect to inelastic spectral displacements is preferable. Expressions for residual displacement spectra are proposed for both types of normalizations and for the givenlateral-strength-ratio type oscillators.

关键词： residual displacement spectrum lateral strength ratio elastic-perfectly-plastic oscillator inelastic displacement spectrum elastic displacement spectrum horizontal ground motions

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

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Direct scaling of residual displacements for bilinear and pinching oscillators

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 129-149页

作者： mohammad Saifullah vinay K.Gupta Department of Civil Engineering Indian Institute of Technology KanpurKanpur 208016India

The estimation of residual displacements in a structure due to an anticipated earthquake event has increasingly become an important component of performance-based earthquake engineering because controlling these displacements plays an important role in ensuring cost-feasible or cost-effective repairs in a damaged structure after the *** attempt is made in this study to obtain statistical estimates of constant-ductility residual displacement spectra for bilinear and pinching oscillators with 5%initial damping,directly in terms of easily available seismological,site,and model *** of the available models for the bilinear and pinching oscillators are useful when design spectra for a seismic hazard at a site are not *** statistical estimates of a residual displacement spectrum are proposed in terms of earthquake magnitude,epicentral distance,site geology parameter,and three model parameters for a given set of ductility demand and a hysteretic energy capacity coefficient in the case of bilinear and pinching models,as well as for a given set of pinching parameters for displacement and strength at the breakpoint in the case of pinching model *** proposed scaling model is applicable to horizontal ground motions in the western *** earthquake magnitudes less than 7 or epicentral distances greater than 20 km.

关键词： residual displacement spectrum bilinear hysteresis model pinching hysteresis model nonlinear analysis scaling model

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