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Transactions of Nonferrous metals Society of China 2014年第3期24卷 884-892页

作者： Neboja D.NIKOLI Djendji Dj.VATAG Vesna m.mAKSImOVI Goran BRANKOVI ICTm- Institute of Electrochemistry University of Belgrade Faculty of Sciences University of Novi Sad Trg D. Obradovia 3 Novi Sad Serbia Department of material science INN Vina University of Belgrade Institute for multidisciplinary Research University of Belgrade Kneza Vieslava 1a Belgrade Serbia

Lead powder obtained by potentiostatic electrodeposition from alkaline electrolyte, based on hydroxide ions, was investigated. The shape of lead crystals strongly depends on overpotentials of electrodeposition. The regular crystals are formed in the ohmic control. The shape of dendrites formed in the control of diffusion has a function of overpotentials of the electrodeposition. Increasing overpotential leads to branching of dendrites from primary type to those with developed tertiary branches. Formation of the very branchy dendrites of the strong （111） preferred orientation is explained on the basis of the affiliation of this electrolyte to the group of the complex Pb electrolytes.

关键词： lead powder electrodeposition crystal dendrite

Histone Acetylation, VERNALIZATION INSENSITIVE 3, FLOWERING LOCUS C, and the Vernalization Response

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molecular Plant 2009年第4期2卷 724-737页

作者： Donna m. Bond Elizabeth S. Dennis Barry J. Pogson E. Jean Finnegan CSIRO Plant Industry Canberra Australia ARC Centre of Excellence in Plant Energy Biology School of Biochemistry and Molecular Biology Australian National University Canberra Australia

The quantitative induction of vin3 by low temperatures is required for PRC2 repression of FLC and promotion of flowering （vernalization） in Arabidopsis. Histone acetylation, a chromatin modification commonly associated with gene transcription, increased on vin3 chromatin in two spatially and temporally distinct phases in response to low temperatures. During short-term cold exposure, histone H3 acetylation at the transcription start site rapidly increased, implying that it is required for VlN3 induction. Subsequent changes in histone H3 and H4 acetylation occurred following continued vin3 transcription during prolonged cold exposure. members of the SAGA-like transcriptional adaptor complex, including the histone acetyltransferase GCNS, which induces expression of the cold acclimation pathway genes, do not regulate VlN3 induction during cold exposure, indicating that the cold acclimation pathway and the cold-induction of VlN3 are regulated by different transcriptional mechanisms. mutations in the other 11 histone acetyltransferase genes did not affect VlN3 induction. However, nicotinamide, a histone deacetyiase inhibitor, induced vin3 and altered histone acetylation at the vin3 locus. vin3 induction was proportional to the length of nicotinamide treatment, which was associated with an early-flowering phenotype and repression of FLC. However, unlike vernalization, the repression of FLC was independent of vin3 activity. Nicotinamide treatment did not cause a change in the expression of any genes in the autonomous pathway or members of the PRC2 complex, the well characterized repressors of FLC. Our data suggest that FLC is repressed via a novel pathway involving the SIR2 class of histone deacetylases.

关键词： Cold acclimation histone acetyltransferase histone deacetylase SIR2 nicotinamide.

Effects of Sodium Citrate plus Sodium Diacetate and Buffered vinegar on Quality Attributes of Enhanced Beef Top Rounds

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Food and Nutrition Sciences 2012年第3期3卷 354-362页

作者： Amudhan Ponrajan mark A. Harrison Timothy D. Pringle Jacob R. Segers Bradley K. Lowe Russell O. mcKeith Alexander m. Stelzleni 1Department of Animal and Dairy Sciences Meat Science Technology Center University of Georgia Athens USA 2Department of Food Science and Technology University of Georgia Athens USA. Department of Animal and Dairy Sciences Meat Science Technology Center University of Georgia Athens USA Department of Food Science and Technology University of Georgia Athens USA.

The effect of two antimicrobials in the enhancement solution was investigated in this study. Sensory and shelf-life characteristics were measured for beef top rounds enhanced to 110% with 0.5% sodium chloride and 0.4% sodium tripolyphosphate (CNT);CNT with a 1% solution of 80% sodium citrate plus 20% sodium diacetate (SC + D);or CNT with 2% buffered vinegar (vin) in the final product. SC + D and vin had less (P 0.05). However, SC + D had lower (P 0.05) for all enhancement solutions within each day. After 7 days of retail display, SC + D retarded (P vin or CNT samples. Sodium citrate plus sodium diacetate or buffered vinegar may be included in enhancement solutions without having a large influence on subjective color, and may aid in improving sensory tenderness.

关键词： Beef Enhancement Quality Sensory Shelf-Life

维生素B_2/长波紫外线(UVA)光交联:治疗LASIK术后角膜膨出的一种新法

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 59-59页

作者： Kohlhaas m. Spoerl E. Speck A. 陈立军 Universitts-Augenklinik Carl Gustav Carus Dresden Fetscherstraβe 74 01307 Dresden GermanyDr.

Background: Keratectasia is one of the most severe complications after refract ive laser surgery. Usually penetrating keratoplasty is the treatment of choice t o achieve an optical rehabilitation in such cases. Patients and methods: We repo rt on a female patient who developed keratectasia in both eyes 4 weeks after LAS IK. Due to a severe keratectasia 10 months after LASIK, a treatment with ribofla vin/UVA cross-linking was performed. Results: Due to the induced collagen cross linking the biomechanical status of the cornea was stabilized and a progression of the keratectasia was prevented. The postoperative refraction and corneal topo graphy have been stable for 18 months. Conclusion: Collagen cross-linking leads to a stiffening of the anterior parts of the corneal stroma. The increase of bi omechanical stability can stop the progression of a keratectasia after LASIK by means of a simple procedure.

关键词：角膜膨出 LASIK术 UVA 长波紫外线光交联角膜地形图屈光性激光手术全层角膜移植术力学稳定性

用间-四羟苯基-氯(Foscan~)对女阴表皮内肿瘤进行光动力治疗

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 13-13页

作者： Campbell S.m. Gould D.J. Salter L. 冯义国 Cornwall Dermatol. Research Project Royal Cornwall Hospital Truro Cornwall TR1 3LJUnitedKingdom

Background: Photodynamic therapy (PDT) has unique properties which make it suitable for the local treatment of superficial epithelial disorders; it has been suggested as a useful treatment for carcinoma in situ of the vulva. Objectives: To evaluate the effect of the systemic photosensitizing agent metatetrahydroxyphenyl-chlorin(mTHPC or temoporfin; Foscan., Biolitec, Edinburgh, U.K.) in vulval intraepithelial neoplasia type III (vin III). methods: PDT using mTHPC was performed in six patients with vin III. A dose of 0.1 mg kg-1 body weight mTHPC was injected intravenously and the area of vin irradiated 96 h later with 652-nm light from a diode laser. Patients were reviewed 1 week, 6 months and 2 years following treatment. Results: Patients experienced only minimal pain from the initial treatment but two patients subsequently developed severe pain at the treated site for up to 2 weeks following PDT. All patients developed oedema and slough formation at the treated site and one patient developed cellulitis. At 6 months two patients had developed small recurrences of vin at the original site and one patient had an area of vin at a new site. These were treated either with further PDT or with a small excision. At 2 years there was no recurrence of vin at the original site in all patients reviewed. Conclusions: This small case series demonstrates that mTHPC-PDT is a useful initial treatment for vin III. It is relatively selective, shows good cosmesis and conserves form and function. This is a major advantage over surgery. Repeat treatments are also possible, which is important in a condition such as vin, which tends to be multifocal. Systemic mTHPC-PDT appears to have an advantage over topical 5-aminolaevulinic acid-PDT as the photosensitizer is distributedwidely in areas of disease and consequently identifies foci which may not be apparent clinically but become evident when illuminated.

关键词：光动力治疗 Foscan 羟苯基女阴光敏剂用间小样本研究氨基乙酰丙酸蜂窝织炎二极管激光器

5%米喹莫特霜剂治疗12例未分化外阴上皮内肿瘤的前瞻性研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 9-9页

作者： Wendling J. Saiag P. Berville-Levy S. m.moyal-Barracco 罗素菊冯义国 Serv. Dermatol. Gen. et Oncologique H.opital Ambroise-Par'e 9 Avenue Charles-de-Gaulle 92104 Boulogne Cedex France Dr.

Objective: To assess the efficacy of 5%imiquimod cream on undifferentiated vulvar intraepithelial neoplasia (vin), a disease caused by high-risk human papillomavirus. Design: Prospective, uncontrolled study. Setting: University hospital vulvar clinic. Patients: Twelve consecutive patients treated with 5%imiquimod cream for undifferentiated vin between march 1, 1999, and may 31, 2001. Intervention: Self-application of 5%imiquimod cream, initially 3 times a week, then adjusted according to tolerance, for up to 7 months according to clinical response. main Outcome measures: Therapeutic response, clinically assessed by successive photographs and histologically confirmed for complete responders, was scored as complete, partial (≥50%decrease in lesion size), or failure. Tolerance was evaluated at each visit. Results: A total of 3, 4, and 5 patients achieved complete response, partial response (≥75%reduction in lesion size for all such cases), and failure, respectively. mean duration of treatment was 3.6 months (37.3 applications), 5.0 months (50.7 applications), and 3.4 months (25.2 applications) for complete responders, partial responders, and failures, respectively. Follow-up after treatment was 5 to 18, 14 to 32, and 2 to 28 months, respectively, with 1 partial responder lost to long-term follow-up. No patient developed invasive carcinoma. All but 2 patients experienced vulvar discomfort, resulting in treatment withdrawal for 3. Two patients had flulike symptoms. Conclusions: Imiquimod cream could be a therapeutic option for undifferentiated vin. Although poorly tolerated, this self-applied treatment could spare patients, either totally or partially, the classic painful and sometimesmutilating treatments of vin. Controlled, randomized studies are needed to evaluate its efficacy and tolerance.

关键词：外阴上皮内肿瘤莫特霜剂人类乳头瘤病毒组织学检查临床反应用药次数侵袭性癌流感样症状大学医院

小鼠肝脏肿瘤模型中经皮射频消融术后联合热敏脂质体长春瑞滨能否提高终点生存率?

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国际医学放射学杂志 2016年第4期 438-438页

作者： S.Wang X.G.mei S.N.Goldberg m.Ahmed J.C.Lee W.Gong 李畅 Key Laboratory of Carcinogenesis and Translational Research (ministry of Education) Department of Ultrasound Peking University Cancer Hospital and Institute

摘要目的研究热敏脂质体包裹的长春瑞滨（Thermovin）联合射频（RF）消融对肝脏肿瘤的疗效。材料与方法所有动物实验均通过动物管理委员会的批准。首先,在体外(H22细胞)37℃或42℃下评估Thermo-vin的72 h内抗癌效果。接下来,将203个H22... 详细信息

摘要目的研究热敏脂质体包裹的长春瑞滨（Thermovin）联合射频（RF）消融对肝脏肿瘤的疗效。材料与方法所有动物实验均通过动物管理委员会的批准。首先,在体外(H22细胞)37℃或42℃下评估Thermo-vin的72 h内抗癌效果。接下来,将203个H22肝细胞癌种植到191只小鼠体内研究。

关键词：长春瑞滨生存率热敏脂质体小鼠小家鼠