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Improved diagnostic yield of endoscopic ultrasound-fine needle biopsy with histology specimen processing

World Journal of Gastrointestinal Endoscopy 2020年第8期12卷 212-219页

作者： Lawrence ku Mohammad A Shahshahan Linda A Hou viktor E Eysselein Sofiya Reicher Department of Medicine Division of Gastroenterology and HepatologyHarbor-UCLA Medical CenterTorranceCA 90509United States

BACkGROUND Endoscopic ultrasound-guided fine needle biopsy(EUS-FNB)has emerged as a safe,efficacious alternative to fine needle aspiration(FNA)for tissue ***-FNB is reported to have higher diagnostic yield while preserving specimen tissue ***,data on the optimal method of EUS-FNB specimen processing is *** To evaluate EUS-FNB with specimen processing as histology vs EUS-FNA cytology with regards to diagnostic yield and specimen *** All EUS-FNA and EUS-FNB performed at our institution from July 1,2016,to January 31,2018,were retrospectively *** collected data on demographics,EUS findings,pathology,clinical outcomes,and procedural complications in two periods,July 2016 through March 2017,and April 2017 through January 2018,with predominant use of FNB in the second data collection time *** specimens were processed as cytology with cell block technique and reviewed by a cytopathologist;FNB specimens were fixed in formalin,processed for histopathologic analysis and immunohistochemical staining,and reviewed by an anatomic *** diagnosis was based on surgical pathology when available,repeat biopsy or imaging,and length of clinical follow *** One hundred six EUS-FNA and EUS-FNB procedures were *** alone was performed in 17 patients;in 56 patients,FNB alone was done;and in 33 patients,both FNA and FNB were *** all indications,diagnostic yield was 47.1%(8/17)in FNA alone cases,85.7%(48/56)in FNB alone cases,and 84.8%(28/33)in cases where both FNA and FNB were performed(P=0.0039).Specimens were adequate for pathologic evaluation in 52.9%(9/17)of FNA alone cases,in 89.3%(50/56)of FNB alone cases,and 84.8%(28/33)in cases where FNA with FNB were performed(P=0.0049).Tissue could not be aspirated for cytology in 10.0%(5/50)of cases where FNA was done,while in 3.4%(3/89)of FNB cases,tissue could not be obtained for *** patients who underwent FNA with FNB,there was a stat

关键词： Fine needle biopsy Endoscopic ultrasound Fine needle aspiration Pancreatic cancer Histology Cytopathology

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Cadmium Stannates Synthesis via Thermal Treatment of Coprecipitated Salts

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Materials Sciences and Applications 2011年第9期2卷 1219-1224页

作者： Andrey V. Sidorak viktor V. Ivanov Alexander A. Shubin 不详

Cadmium meta- and orthostannate were synthesized by thermal treatment using the coprecipitation method. Tin (IV) chloride, cadmium acetate were used as the initial components, the ammonium carbonate was a precipitant. The coprecipitated compounds and the thermolysis products were analyzed by TGA/DSC methods, the thermal treatment samples were studied by XRD and SEM. The formation of proper products in soft thermal treatment conditions was confirmed. The stannates formation in terms of submicron sized particles was observed by microscopial investigation.

关键词： Cadmium Metastannate Cadmium Orthostannate Chemical Precipitation Powders Thermolysis Synthesis

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Quantitative Changes in Microtubule Distribution Correlate with Guard Cell Function in Arabidopsis

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Molecular Plant 2012年第3期5卷 716-725页

作者： William R. Eisinger viktor kirik Charlotte Lewis David W. Ehrhardt Winslow R. Briggs Department of Biology Santa Clara University Santa Clara CA 95053 USA Department of Plant Biology Carnegie Institution for Science Stanford CA 94305 USA School of Biological Sciences Illinois State University Normal IL 61790 USA

Radially arranged cortical microtubules are a prominent feature of guard cells. We observed guard cells expressing GFP-tubulin （GFP-TUA6） with confocal microscopy and found recognizable changes in the appearance of micro- tubules when stomata open or close （Eisinger et al., 2012）. In the present study, analysis of fluorescence distribution showed a dramatic increase in peak intensities of microtubule bundles within guard cells as stomata open. This increase was correlated with an increase in the total fluorescence that could be attributed to polymerized tubulin, Adjacent pave- ment cells did not show similar changes in peak intensities or integrated fluorescence when stomatal apertures changed. Imaging of RFP-tagged end binding protein 1 （EB1） and YFP-tagged ^-tubulin expressed in the same cell revealed that the number of microtubules with growing ends remained constant, although the total amount of polymerized tubulin was higher in open than in closed guard cells. Taken together, these results indicate that the changes in microtubule array organization that are correlated with and required for normal guard cell function are characterized by changes in micro- tubule clustering or bundling.

关键词： cell differentiation/specialization cytoskeleton fluorescence imaging organelle biogenesis/function Ara- bidopsis

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The Automated System of Unified Templates as an Element of Trainability of Microprocessor Relay Protection Devices

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Journal of Applied Mathematics and Physics 2021年第12期9卷 3045-3057页

作者： viktor Nikolaevich Sizykh Aleksey Vasilyevich Daneev Maksim viktorovich Vostrikov konstantin Vladimirovich Menaker Irkutsk State Transport University Irkutsk Russia The Transbaikal Institute of Railway Transport Chita Russia

The article discusses the possibility of further modernization of the standard microprocessor relay protection of AC overhead system feeders DPA-27.5-TNF, which is operated on the Trans-Baikal Railway by creating an additional automated system of unified templates necessary for the occurrence of “trainability” elements. The templates will be formed via a separate dedicated channel for transmission, processing and storage of the necessary information, not related to the operation of the terminal, with its subsequent visualization at the workplace of the duty personnel of traction substations, together with information from the “GID” software received via another dedicated wired channel. With the help of such a base of unified preset templates, in the future, it will be possible not only to identify the specific causes of each emergency shutdown but also to reduce their number by dynamically adjusting the existing presets of the standard operation algorithm.

关键词： Automated System Microprocessor Relay Protection Devices Feeder Traction Substation

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Giant Cell Tumor： Role of Conservative Treatment

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Journal of Health Science 2014年第8期2卷 389-392页

作者： Anatolii Diedkov Pavlo kovalchuk Marija kukushkina Sergey Bojchuk viktor kostyuk Department of Orthopaedic Oncology National Cancer Institute Kiev 03022 Ukraine Department of Skin and Soft Tissue Tumors National Cancer Institute Kiev 03022 Ukraine

Giant cell tumor is aggressive bone tumor. Surgical treatment is considered to be the only effective method of treatment ofthese tumors. The problem of inoperable patients with giant cell tumors is a challenge. A total of 8 patients had giant cell bone tumorsof pelvis and sacrum. 3 patients were treated by bisphosphonates, radiation therapy and embolization of tumor-nutrient arteries. 5patients received denosumab. The efficiency was assessed according to clinical data and CT scan control. Median follow up is 28months. All 8 patients had reduction of pain intensity. Treatment with denosumab demonstrated more than 30% tumor regression. Allof the patients are in remission.

关键词： Giant cell tumors, conservative treatment, denosumab.

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Comprehensive Automation of Microprocessor Protection Relay Terminals Operated on AC Railways

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Journal of Applied Mathematics and Physics 2022年第2期10卷 491-503页

作者： Vostrikov Maksim viktorovich Daneev Aleksey Vasilyevich Menaker konstantin Vladimirovich Sizykh viktor Nikolaevich Zabaikalsk Rail Transport Institute A Branch of Irkutsk State Transport University Chita Russia Irkutsk State Transport University Irkutsk Russia

The article discusses the possibility of a potential reduction in the number of operations of microprocessor relay protection of feeders of the contact network of AC railways TsZA-27.5-FkS (FTS) for unknown reasons. Real statistics on the number of microprocessor relay protection operations at the Buryatskaya traction substation are presented, simulation of the real train situation (in accordance with the regime maps of the throughput capacity of the sections of the Trans-Baikal railway) was carried out in the specialized software complex “kORTES”. Based on the results of the analysis of simulation modeling, the process of forming a unified template of settings using neural network technologies is considered, which characterizes only this specific regular train situation. To protect objects in the event of pre-emergency and emergency modes of operation of the traction power supply system, a variant of changing the standard operation algorithm of the TsZA-27.5-FkS (FTS) terminal by introducing additional blocks for calculating the predictive functions of current and voltage has been proposed.

关键词： Automated System Microprocessor Relay Protection Devices Feeder Traction Substation

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Nonlinear wave mechanisms of very fast chemical and phase transformations in solids. applications to cosmic chemistry processes near to 0 k, to explosive-like decays of metastable solid phases and to catastrophic geotectonic phenomena

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Natural Science 2010年第12期2卷 1356-1359页

作者： viktor Barelko Dmitryi kiryukhin Igor Barkalov Galina kichigina Alain Pumir 不详

In the Universe, chemical reactions occur at very low temperature, very close to 0k. According to the standard Arrhenius mechanism, these reactions should occur with vanishingly small efficiency. However, cold planets of the solar system, such as Pluto, are covered by a crust composed of ammonia and methane, produced on earth only at very high temperature and pressure, in the presence of catalysts. This observation is incompatible with the predictions of Arrhenius kinetics. Here, we propose a general mechanism to explain the abundance of chemical reactions at very low temperature in the Universe. We postulate that the feedback between mechanical stress and chemical reaction provides, through fracture propagation, the energy necessary to overcome the activation barrier in the absence of thermal fluctuations. The notion described in this work can also be applied to other fields such as explosive-like solid phase transformations and catastrophical geotectonics phenomena (earthquakes).

关键词： Nonlinear Waves Coupling between Chemistry and Mechanics Combustion at Very Low Temperature Geochemistry Cosmochemistry Geotectonics

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《多语言语篇产出：历时和共时视角》述评

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现代外语 2016年第6期39卷 867-871页

作者：庞双子 Svenja kranich viktor Becher Steffen H?der Juliane House 天津外国语大学北京外国语大学

1.引言翻译与目标语语言发展研究是当前语料库翻译研究的新话题。语言通过翻译进行接触是语言接触中亟待研究的领域。过去几十年间,关于两种语言通过翻译方式相互接触的研究寥寥,未引起足够关注。随着语料库语言学与描写翻译研究的有效... 详细信息

1.引言翻译与目标语语言发展研究是当前语料库翻译研究的新话题。语言通过翻译进行接触是语言接触中亟待研究的领域。过去几十年间,关于两种语言通过翻译方式相互接触的研究寥寥,未引起足够关注。随着语料库语言学与描写翻译研究的有效结合,翻译文本与原创文本比较的语料库实证研究正在兴起,使书面语言接触的考察成为了可能。

关键词：共时多语翻译文本翻译方式文本类型历史语言学翻译领域语义韵实证性研究心理语言学

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Multipotent stromal cells stimulate liver regeneration by influencing the macrophage polarization in rat

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World Journal of Hepatology 2018年第2期10卷 287-296页

作者： Andrey Elchaninov Timur Fatkhudinov Natalia Usman Irina Arutyunyan Andrey Makarov Anastasia Lokhonina Irina Eremina viktor Surovtsev Dmitry Goldshtein Galina Bolshakova Valeria Glinkina Gennady Sukhikh National Medical Research Center for Obstetrics Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian FederationMoscow 117997Russia Peoples Friendship University of Russia(RUDN University) Moscow 117198Russia Scientific Research Institute of Human Morphology Moscow 117418Russia Pirogov Russian National Research Medical University Ministry of Healthcare of the Russian FederationMoscow 117997Russia Research Center of Medical Genetics Moscow 115478Russia

AIM To investigate the influence of the umbilical cordderived multipotent stromal cells(MSCs) on recovery of the liver after the subtotal resection, that is, removal of 80% of the organ mass, a renowned model of the small-for-size liver remnant syndrome. METHODS The MSCs were obtained from the intervascular tissue of umbilical cords, dissected from rat fetuses, by the explant culture technique. The vital labeling of MSCs with РКН26 was carried out on the 3 rd passage. The subtotal resection was performed on male Sprague-Dawley rats. The experimental group animals received a transplant 106 MSCs infused into the spleen. Hepatocyte proliferation was assessed by counting of either mitotic figures or ki67-positive cells in microscopic images. MSC differentiation was assessed with antibodies to hepatocyte-specific marker cytokeratin 18(Ck18), cholangiocyte-specific protein Ck19, smooth muscle cell-specific protein α-SMA, the endothelial cell marker CD31, or the active fibroblast marker FAPα. Total macrophages of the liver were selectively stained in cryosections incubated with antiCD68 antibodies(1:100, Abcam), while the M2 a and M2 c macrophage populations were selectively stained with anti-CD206 antibodies. Expression of interleukin and growth factor genes was evaluated with *** Intrasplenic allogeneic transplantation of the umbilical cord-derived multipotent stromal cells stimulates reparative processes within the residual liver tissue after subtotal resection(removal of 80% of the organ mass), as indicated by increased rates of hepatocyte proliferation and accelerated organ mass recovery. These effects may result from paracrine influence of the transplanted cells on the resident macrophage population of the liver. The transplantation favors polarization of macrophages to M2 phenotype(the M2-polarized macrophages specifically express CD206; they are known to suppress inflammation and support tissue repair). No differentiation of the transplanted cells into a

关键词： Liver Regeneration Multipotent stromal cells Macrophages

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俄罗斯-蒙古地学断面地壳模型的地质-地球物理资料综合研究

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地学前缘 2021年第5期28卷 260-282页

作者： Evgeny kh.TURUTANOV Evgeny V.SkLYAROV Valentina V.MORDVINOVA Anatoly M.MAZUkABZOV viktor S.kANAYkIN Institute of the Earth's Crust Siberian Branch of the Russian Academy of Science Lermontov ave.128Irkutsk 664033Russia Irkutsk National Research Technical University Lermontov ave.83Irkutsk 664074Russia

地学断面是指地壳的垂直剖面,主要通过对地质和地球物理资料的综合分析来揭示构造带的性质及其空间关系。横断面的研究所采用的数据基本包括100 km宽区域地质图、上地壳的地质剖面图、重磁图(沿横断面的重磁剖面图)以及地壳的地震波速... 详细信息

地学断面是指地壳的垂直剖面,主要通过对地质和地球物理资料的综合分析来揭示构造带的性质及其空间关系。横断面的研究所采用的数据基本包括100 km宽区域地质图、上地壳的地质剖面图、重磁图(沿横断面的重磁剖面图)以及地壳的地震波速度、密度和其他地球物理属性的剖面图。这些数据被用于构建综合的数据剖面图(结果图),以展示各种地球动力学条件下(裂谷、海洋、碰撞带、造山盆地、大陆地台和岩浆弧,包括安第斯岛弧、活动大陆边缘、海沟、弧前和弧后盆地)的特定的岩石组构。本项目的研究目标是根据研究区现存的地质和地球物理数据的综合解释,统一图例,建立研究区深部剖面,以确定地体的空间关系及其在板块构造方面的地球动力学性质。前人已分别对东西伯利亚南部和蒙古境内的多个地体进行了构造划分,并对它们的地球动力学性质和时空关系进行了分析。研究结果显示该系列地体为早古生代、中晚古生代和晚古生代—早中生代的岛弧和微大陆。此外,研究还识别出了中-晚古生代和晚古生代-早中生代安第斯型活动大陆边缘、晚古生代-早中生代被动大陆边缘和早白垩世裂谷。与岛弧和安第斯型活动大陆边缘相关的岩体被推覆至相邻大陆和微陆块上,部分推覆宽度可达150 km。目前已开展泥盆纪到晚侏罗世时期蒙古鄂霍次克海地区的古地球动力学重建。“非地槽”型花岗岩类岩浆作用在板块构造方面找到了直接且合理的解释,其中泥盆纪-石炭纪和二叠纪-三叠纪岩浆作用区域对应于安第斯型活动大陆边缘,中—晚侏罗世岩浆作用则与西伯利亚/蒙古中国大陆板块碰撞有关。碰撞岩浆作用中亚碱性(地幔)元素的存在及其所在的构造区域在很大程度可以说明蒙古鄂霍次克海闭合后,巨厚大陆岩石圈下曾经发生过持续的大洋裂谷活动(地幔热点)。在早白垩世时期,大陆裂谷活动影响到了同一时期正在发生的大陆汇聚作用。西伯利亚南部边界大部分具有安第斯型活动大陆边缘性质,这也是蒙古—鄂霍次克缝合线沿线蛇绿岩数量较少的原因。因为当汇聚大陆一个具有安第斯类型的活动边缘,而另一个具有被动边缘时,前者的大陆地壳会最终逆冲到后者之上,并因此破坏掉先前出露的蛇绿杂岩体。部分被破坏的蛇绿岩块是俯冲带保留下来的海山残余,其可能成为增生俯冲楔体的混沌复合体的一部分。然而,由于快速俯冲作用,这种楔形体在晚二叠世—早侏罗世的积累并不是西伯利亚活动边缘的典型特征。沿地学断面综合的地质和地球物理资料分析表明,亚洲大陆是在显生宙时期由部分前寒武纪微陆块构造拼贴而成的。前寒武纪地块间存在不同宽度的已变形且剥蚀强烈的显生宙火山弧,它们也被归类为特定地体。

关键词：地质地球物理地壳横断面

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