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Modif.ing action of.heavy metal salts on an-ti-inf.ammatory aspirin action

Health 2010年第6期2卷 630-633页

作者： Denis R. Husainov viktoriya V. Shylina lvan l Korenyuk viktor f. shulgin 不详

Nowadays pollution of.the environment is one of.the major problems of.mankind. Moreover, studying of.the ef.ect of.dif.erent kinds of.med- icine on selected, specially bred, non-exposed to external pollutants animals is becoming distant f.om reality. Thus in this work we have investigated the modif.ing action of.heavy metals on anti-inf.ammatory ef.ect of.aspirin. The investigation were carried out on rats which were injected during 7 days intraperitoneally by PbCl3, HgCl2, CdCl2 in concentration of.100, 20, 1 mg/kg accordingly, modulating accumulation of.the metals in the organism tissues. On the 8 days inf.ammation was invoked by f.rmalin. As anti-inf.ammatory medicine was use aspirin. Judging by obtained results the conclusion can be drawn that cadmium in concentration 1 mg/kg signif.cantly increases anti-inf.ammatory aspirin activity. The observed outcome can be explained in the f.llowing way. It is generally known that zinc in a certain concentration demonstrates anti-inf.ammatory properties. Be- ing an element of.the same group cadmium has similar properties and also can have anti-inf.ammatory action. Lead and mercury suppre- ssed anti-inf.ammatory aspirin activity. Obvious inhibitory action of.mercury and lead salts on aspirin action related to the f.ct that these elements by themselves were inf.ammation f.ctors. f.om the obtained results the f.llowing conclusion can be drawn: a def.nite dose of.anti-inf.ammatory medicine (aspirin) which is suf.icient in normal conditions became less ef.ective against the background of.accumulation of.ions of.some heavy metals in an organism.

关键词： Heavy Metals Lead Mercury Cadmium Acetylsalicylic Acid Prostaglandin Inf.ammation Anti-Inf.ammatory Activity

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Modif.ing action of.heavy metal salts on anti-inf.ammatory aspirin action

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Health（健康） 2010年第6期

作者： Denis R. Husainov viktoriya V. Shylina lvan l Korenyuk viktor f. shulgin

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