检索结果-南通市图书馆

Characterization of functional biliary pain and dyspeptic symptoms in patients with sphincter of Oddi dysfunction:Effect of papillotomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第42期12卷 6850-6856页

作者： l.szl. Madácsy Roland Fejes Gábor Kurucsai Ildikó Joó András Székely viktória Bertalan Attila Szepes János lonovics Department of Operative Gastroenterology and Endoscopy Fejér Megyei Szent-Gyrgy Hospital Székesfehérvár Hungary First Department of Internal Medicine University of Szeged Hungary

AIM： To characterize functional biliary pain and other gastrointestinal （GI） symptoms in postcholecystectomy syndrome （PCS） patients with and without sphincter of Oddi dysfunction （SOD） proved by endoscopic sphincter of Oddi manometry （ESOM）, and to assess the postendoscopic sphincterotomy （EST） outcome. METHODS： We prospectively investigated 85 cholecystectomized patients referred for ERCP because of PCS and suspected SOD. On admission, all patients completed our questionnaire. Physical examination, laboratory tests, abdominal ultrasound, quantitative hepatobiliary scintigraphy （QHBS）, and ERCP were performed in all patients. Based on clinical and ERCP findings 15 patients had unexpected bile duct stone disease and 15 patients had SOD biliary type Ⅰ. ESOM demonstrated an elevated basal pressure in 25 patients with SOD biliary-type Ⅲ. In the remaining 30 cholecystectomized patients without SOD, the liver function tests, ERCP, QHBS and ESOM were all normal. As a control group, 30 ‘asymptomatic＇ cholecystectomized volunteers （attended to our hospital for general cardiovascular screening） completed our questionnaire, which is consisted of 50 separate questions on GI symptoms and abdominal pain characteristics. Severity of the abdominal pain （frequency and intensity） was assessed with a visual analogue scale （VAS）. In 40 of 80 patients having definite SOD （i.e. patients with SOD biliary type Ⅰ and those with elevated SO basal pressure on ESOM）, an EST was performed just afl：er ERCP. In these patients repeated questionnaires were filled at each follow-up visit （at 3 and 6 too） and a second look QHBS was performed 3 mo after the EST to assess the functional response to EST. RESUlTS： The analysis of characteristics of the abdominal pain demonstrated that patients with common bile duct stone and definite SOD had a significantly higher score of symptomatic agreement with previously determined biliary-like pain features than patient groups of PCS without SOD and controls. In

关键词： Postcholecystectomy pain Sphincter of Oddi dysfunction Functional biliary-pain Dyspeptic symptoms Endoscopic sphincterotomy Follow-up

Role of (myo)fibroblasts in the development of vascular and connective tissue structure of the C38 colorectal cancer in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2018年第1期38卷 488-498页

作者： Edina Bugyik Vanessza Szabó Katalin Dezső András Rókusz Armanda Szücs Péter Nagy József Tóvári viktória l.szl. Balázs Döme Sándor Paku First Department of Pathology and Experimental Cancer Research Sem-melweis UniversityBudapestÜllőiút 261085Hungary Department of Experimental Pharmacology National Institute of OncologyBudapest 1122Hungary Department of Thoracic Surgery Semmelweis University-National Institute of OncologyBudapest 1122Hungary. Department of Thoracic Surgery Medical University of ViennaWaehringer Guertel 18-201090 ViennaAustria Department of Biomedical Imaging and Image-guided Therapy Medical University of Vienna1090 ViennaAustria National Koranyi Institute of Pulmonology Budapest 1122Hungary. Tumor Progression Research Group Hungarian Academy of Sciences-Semmelweis UniversityBudapest 1085Hungary

Background:It remains unclear if the vascular and connective tissue structures of primary and metastatic tumors are intrinsically determined or whether these characteristics are defined by the host *** we examined the microanatomical steps of vasculature and connective tissue development of C38 colon carcinoma in different ***:Tumors produced in mice at five different locations(the cecal wall,skin,liver,lung,and brain)were ana-lyzed using fluorescent immunohistochemistry,electron microscopy and quantitative real-time polymerase chain ***:We found that in the cecal wall,skin,liver,and lung,resident fibroblasts differentiate into collagenous matrix-producing myofibroblasts at the tumor *** activated fibroblasts together with the produced matrix were incorporated by the *** connective tissue development culminated in the appearance of intratumoral tissue columns(centrally located single microvessels embedded in connective tissue and smooth muscle actin-expressing myofibroblasts surrounded by basement membrane).Conversely,in the brain(which lacks fibroblasts),C38 metasta-ses only induced the development of vascularized desmoplastic tissue columns when the growing tumor reached the fibroblast-containing ***:Our data suggest that the desmoplastic host tissue response is induced by tumor-derived fibrogenic molecules acting on host tissue *** concluded that not only the host tissue characteristics but also the tumor-derived fibrogenic signals determine the vascular and connective tissue structure of tumors.

关键词： Metastasis Vasculature Myofibroblasts Incorporation

Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第1期12卷 110-113页

作者： Judit Bene Katalin Komlósi viktória Havasi Gábor Talián Beáta Gasztonyi Krisztina Horváth Gyula Mózsik Béla Hunyady Béla Melegh Mária Figler MTA PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs PécsHungary Department of Medical Genetics and Child DevelopmentUniversity of PécsPécsHungary Department of Medical Genetics and Child Development University of PécsPécsHungary Department of Medicine School of MedicineUniversity of PécsPécsHungary

AIM： To determine the plasma carnitine ester profile in adult patients with ulcerative culitis （UC） and compared with healthy control subjects. METHOD： Using ESI triple quadrupole tandem mass spectrometry, the carnitine ester profile was measured in 44 patients with UC and 44 age- and sex-matched healthy controls. RESUlTS： There was no significant difference in the fasting free carnitine level between the patients with UC and the healthy controls. The fasting propionyl- （0.331 ± 0.019 vs 0.392 ± 0.017 μmol/l）, butyryl- （0.219 ± 0.014 vs 0.265 ± 0.012）, and isovalerylcarniUne （0.111 ± 0.008 vs 0.134 ± 0.008） levels were decreased in the UC patients. By contrast, the level of octanoyl- （0.147 ± 0.009 vs 0.114 ± 0.008）, decanoyl- （0.180 ± 0.012 vs 0.137 ± 0.008）, myristoyl- （0.048 ± 0.003 vs 0.039 ± 0.003）, palmitoyl- （0.128 ± 0.006 vs 0.109 ± 0.004）, palmitoleyl- （0.042±0.003 vs 0.031 ± 0.002） and oleylcarnitine （0.183 ± 0.007 vs 0.163 ± 0.007; P 〈 0.05 in all comparisons） were increased in the patients with UC. CONClUSION： Our data suggest selective involvement of the carnitine esters in UC patients, probably due to their altered metabolism.

关键词： Carnitine Carnitine ester profile Ulcerativecolitis

Bone disorders in experimentally induced liver disease in growing rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第45期11卷 7169-7173页

作者： viktória Ferencz Csaba Horváth Béla Kári János Gaál Szilvia Mészáros Zsuzsanna Wolf Dalma Heged(?)s Andrea Horváth Anikó Folhoffer Ferenc Szalay 1st Department of Internal Medicine Department of Diagnostic Radiology and Oncotherapy Department of Polymer Engineering and Textile Technology

AIM： To investigate the change of bone parameters in a new model of experimentally induced liver cirrhosis and hepatocellular carcinoma （HCC） in growing rats. METHODS： Fischer-344 rats （n = 55） were used. Carbon tetrachloride （CCh）, phenobarbital （PB）, and a single diethylnitrosamine （DEN） injection were used. Animals were killed at wk 8 and 16. Bone mineral content, femoral length, cortical index （quotient of cortical thickness and whole diameter） and ultimate bending load （Fmax） of the femora were determined. The results in animals treated with DEN＋PB＋CCh （DPC, n = 21） were com- pared to those in untreated animals （UNT, n = 14） and in control group treated only with DEN＋PB （DP, n = 20）. RESUlTS： Fatty liver and cirrhosis developed in each DPC-treated rat at wk 8 and HCC was presented at wk 16. No skeletal changes were found in this group at wk 8, but each parameter was lower （P〈0.05 for each） at wk 16 in comparison to the control group. Neither fatty liver nor cirrhosis was observed in DP-treated animals at any time point. Femoral length and Fmax values were higher （P〈0.05 for both） in DP-treated animals at wk 8 compared to the UNT controls. However, no difference was found at wk 16. CONClUSION： Experimental liver cirrhosis and HCC are accompanied with inhibited skeletal growth, reduced bone mass, and decreased mechanical resistance in growing rats. Our results are in concordance withthe data of other studies using different animal models. A novel finding is the transiently accelerated skeletal growth and bone strength after a 8-wk long phenobarbital treatment following diethylnitrosamine injection.

关键词： Bone disorder Bone mineral content Mechanical resistance Experimental liver cirrhosis Growingrat

Antioxidant potential,tannin and polyphenol contents of seed and pericarp of three Coffea species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 356-362页

作者： va Brigitta Patay Nikolett Sali Tams Kszegi Rita Csepregi viktória lilla Blaz Tibor Sebastian Németh Tibor Németh Nóra Papp Institute of Pharmacognosy Medical SchoolUniversity of PcsRókus 2.PcsHungary7624 Department of laboratory Medicine Medical SchoolUniversity of PcsIfjúsg 13 PcsHungary76243 Jnos Szentgothai Research Center Ifjúsg 20 PcsHungary.76244 Department of Pharmacognosy Faculty of Medicine and PharmacyUniversity of Oradea

Objective:To investigate the antioxidant activity,total phenolic and total tannin content of the pericarp and the seed of Coffea benghalensis(***) and Coffea liberica compared to Coffea arabica(***).Methods:The antioxidant potential,total tannin and polyphenol contents of the immature and mature seed and pericarp of *** and Coffea liberica were quantified and compared to *** chemiluminescence(ECl).2,2-diphenyl-1-picrylhydruzyl(DPPH).oxygen radical absorbance capacity,Folin-Ciocaltcau method and total tannin content assays were ***:Trolox equivalent(TE/g plant material) values obtained by ECl and DPPH methods showed loose correlation(r^2=0.587)while those measured by oxygen radical absorbance capacity assay were higher without correlation in each plant.A closer correlation was detected between the ECl method and the percentage antioxidant activity of the DPPH technique(r^2=0.610 7) in each species,however the immature pericarp of *** showed much higher DPPH scavenging potential than was seen in the ECl *** immature pericarp of *** expressed the highest tannin and polyphenol content,and a high polyphenol level was also detected in the immature seed of *** immature pericarp of Bengal and liberian coffees showed the largest amount of phenolic ***:The obtained data highlight the potential role of *** as a new source of natural antioxidants and polyphenols compared to ***.

关键词： Coffee 2,2-diphcnyl-1-picrylhydrazyl Enhanced chemiluminescence Folin-Ciocalteau Oxygen radical absorbance capacity Total tannin method

(肌)成纤维细胞在C38结直肠癌小鼠模型血管和结缔组织结构发展中的作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

癌症 2019年第3期38卷 91-102页

作者： Edina Bugyik Vanessza Szabó Katalin Dezso András Rókusz Armanda Szücs Péter Nagy József Tóvári viktória l.szl. Balázs Dome Sándor Paku First Department of Pathology and Experimental Cancer Research Semmelweis UniversityBudapestüll?iút 261085Hungary Department of Experimental Pharmacology National Institute of OncologyBudapest 1122Hungary Department of Thoracic Surgery Semmelweis University-National Institute of OncologyBudapest 1122Hungary Department of Thoracic Surgery Medical University of ViennaWaehringer Guertel 18?201090 ViennaAustria Department of Biomedical Imaging and Image?guided Therapy Medical University of Vienna1090 ViennaAustria National Koranyi Institute of Pulmonology Budapest 1122Hungary Tumor Progression Research Group Hungarian Academy of Sciences-Semmelweis UniversityBudapest 1085Hungary.

背景与目的关于原发和转移性肿瘤的血管和结缔组织结构是由本身决定还是由宿主组织决定,目前尚不清楚。因此,我们研究了不同组织中C38结直肠癌血管和结缔组织发展的显微解剖过程。方法采用免疫荧光染色、电镜和实时定量聚合酶链反应等... 详细信息

背景与目的关于原发和转移性肿瘤的血管和结缔组织结构是由本身决定还是由宿主组织决定,目前尚不清楚。因此,我们研究了不同组织中C38结直肠癌血管和结缔组织发展的显微解剖过程。方法采用免疫荧光染色、电镜和实时定量聚合酶链反应等方法对小鼠盲肠壁、皮肤、肝脏、肺和大脑5个不同部位生成的肿瘤进行分析。结果我们发现在盲肠壁、皮肤、肝脏和肺的成纤维细胞分化成胶原蛋白基质,在肿瘤周围产生肌成纤维细胞。这些活化的成纤维细胞和生成的基质被肿瘤吸收利用。结缔组织的发展最终引起瘤内组织柱的出现(位于中心位置的单个微血管包埋在结缔组织和表达平滑肌肌动蛋白的肌成纤维细胞中,最外围由基底膜包围)。相反,在缺乏成纤维细胞的大脑中,仅当增生的肿瘤接触到含有成纤维细胞的脑膜时,C38转移才能诱导血管生成的促结缔组织增生性纤维柱的形成。结论我们的数据表明,作用于宿主组织成纤维细胞的肿瘤源性纤维生成分子诱导了促结缔组织增生的宿主组织反应。我们认为宿主组织特征和肿瘤来源的纤维生成信号共同决定了肿瘤的血管和结缔组织的结构。

关键词：转移血管肌成纤维细胞合并