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FOXO3a as a sensor of unilateral nerve injury in sensory neurons ipsilateral, contralateral and remote to injury

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Neural Regeneration Research 2020年第12期15卷 2353-2361页

作者： Jovan CDHasmatali Jolly De Guzman Jayne MJohnston Hossein Noyan Bernhard HJuurlink vikram Misra Valerie MKVerge Department of Anatomy Physiologyand PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada Department of Veterinary Microbiology University of SaskatchewanSaskatoonSKCanada

Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron,with alterations in associated transcription factors detected both locally and remote to the ***-induced nuclear translocation of the transcription factor forkhead class box O3a(FOXO3a)was initially linked to activation of apoptotic genes in many neuronal ***,a more complex role of FOXO3a has been suggested in the injury response of sensory neurons,with the injured neuron expressing less *** elucidate this response and test whether non-injured sensory neurons also alter FOXO3a expression,the temporal impact of chronic unilateral L4–6 spinal nerve transection on FOXO3a expression and nuclear localization in adult rat dorsal root ganglion neurons ipsilateral,contralateral or remote to injury relative to na?ve controls was *** na?ve neurons,high cytoplasmic and nuclear levels of FOXO3a colocalized with calcitonin gene related peptide,a marker of the nociceptive *** hour post-injury,an acute increase in nuclear FOXO3a in small size injured neurons occurred followed by a significant decrease after 1,2 and 4 days,with levels increasing toward pre-injury levels by 1 week post-injury.A more robust biphasic response to the injury was observed in uninjured neurons contralateral to and those remote to *** levels of FOXO3a peaked at 1 day,decreased by 4 days,then increased by 1 week post-injury,a response mirrored in C4 dorsal root ganglion neurons remote to *** altered expression contralateral and remote to injury supports that spinal nerve damage has broader systemic impacts,a response we recently reported for another stress transcription factor,Luman/*** early decreased expression and nuclear localization of FOXO3a in the injured neuron implicate these changes in the cell body response to injury that may be ***,the broader systemic changes support the existence of stress/inj

关键词： cell body response contralateral response dorsal root ganglion peripheral nerve injury plasticity sciatic nerve sensory neuron stress systemic transcription factor unilateral peripheral nerve injury

The Potential Contribution of Wildlife Sanctuary to Forest Conservation: A Case Study from Binsar Wildlife Sanctuary

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Journal of Mountain Science 2013年第5期10卷 854-865页

作者： Balwant RAWAT vikram S.NEGI Janhvi MISHRA RAWAT Lalit M.TEWARI Laxmi RAWAT G.B. Pant Institute of Himalayan Environment and Development Kosi-Katarmal Forest Research Institute DehradunMolecular TaxonomyBotany Division Department of Botany D.S.B. CampusKumaun University Forest Research Institute DehradunForest Ecology and Environment Division

Forest vegetation of a protected area （Binsar Wildlife Sanctuary） in Kumaun region （west Himalaya） was analysed for structure, composition and representativeness across three different altitudinal belts, lower （1,6oo-1,8oo m a.s.1.）, middle （1,900-2,100 m a.s.1.） and upper （2,200-2,400 m a.s.1.） during 2oo9-2011 using standard phytosociological methods. Four aspects （east, west, north and south） in each altitudinal belt were chosen for sampling to depict maximum representation of vegetation in the sanctuary. Population structure and regeneration behaviour was analysed seasonally for two years to show the establishment and growth of tree species. A total of 147 plant species were recorded from the entire region of which 27 tree species were selected for detailed study. Highest number was recorded at upper （18 species）, and lowest at lower altitudinal belt （15 species）. The relative proportion of species richness showed higher contribution of tree layer at each altitudinal belt. The population structure, based on the number of individuals, revealed a greater proportion of seedling layer at each altitudinal belt. The relative proportion of seedlings increases significantly along altitudinal belts （p〈0.05） while opposite trends were observed in sapling and tree layers. The density of sapling and seedling species varied non-significantly across seasons （p〉0.05）. The density values decreased in summer and increased during rainy season. As far as the regeneration status is concerned, middle and upper altitudinal belts showed maximum number of species with fair regeneration as compared to lower altitudinal belt. Overall density diameter distribution of tree species showed highest species density and richness in the smallest girth class and decreased in the succeeding girth classes. This study suggests that patterns of regeneration behaviour would determine future structural and compositional changes in the forest communities. It is suggested that the compositional changes v

关键词： Altitudinal gradient Populationstructure Regeneration status West Himalaya Wildlife Sanctuary.

Bietti’s crystalline dystrophy in an African American patient: an unusual racial demographic for a condition more common in individuals of East Asian descent

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1291-1292页

作者： Virang Kumar vikram Brar Jordyn Prell Ann Jewell Natario Couser Virginia Commonwealth University School of Medicine RichmondVA 23298USA Department of Ophthalmology Virginia Commonwealth University School of MedicineRichmondVA 23298USA Department of Human and Molecular Genetics Virginia Commonwealth University School of MedicineRichmondVA 23298USA Department of Pediatrics Virginia Commonwealth University School of MedicineRichmondVA 23298USA

Dear Editor,The study outlining the manifestations of Bietti’s crystalline dystrophy(BCD)in five Chinese patients offered insights into common disease-causing variants associated with Chinese patients as well as a novel mutation[1].This genetic condition is commonly reported among East Asian populations and to some extent Mediterranean populations[2].

关键词： dystrophy crystalline condition

Risk factors of thrombosis in abdominal veins

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World Journal of Gastroenterology 2008年第28期14卷 4518-4522页

作者： Amit Kumar Dutta Ashok Chacko Biju George Joseph Anjilivelil Joseph Sukesh Chandran Nair vikram Mathews Department of Gastrointestinal Sciences Christian Medical College & HospitalVellore 632 004India Department of Clinical Pathology Christian Medical College & HospitalVellore 632 004India Department of Hematology Christian Medical College & HospitalVellore 632 004India

AIM: To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes (BCS) and splanchnic vein thrombosis (SVT). METHODS: In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group (hepatic vein, IVC thrombosis) and splanchnic venous thrombosis group (portal, splenic, superior mesenteric veins) based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients. RESULTS: Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients (28%) had hereditary and 10 patients (28%) acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group (SVT vs BCS: 45% vs 7%, χ2 = 5.7, P = 0.02) while hereditary risk factors did not show significant differences between the two groups (SVT vs BCS: 25% vs 36%, χ2 = 0.46, P = 0.7). Multiple risk factors were present in one (7%) patient with BCS and in 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT. CONCLUSION: Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factorsare significantly more common in SVT patients while hereditary factors are similar in both groups.

关键词： Budd Chiari syndrome Splanchnic vein thrombosis Risk factors Hereditary Risk comparison

RSS-Based Selective Clustering Technique Using Master Node for WSN

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Computers, Materials & Continua 2021年第12期69卷 3917-3930页

作者： vikram Rajpoot Vivek Tiwari Akash Saxena Prashant Chaturvedi Dharmendra Singh Rajput Mohammed Alkahtani Mustufa Haider Abidi GLA University MathuraIndia DPSM IIIT Naya RaipurIndia Compucom Institute of Technology&Management JaipurIndia Lakshmi Narain College of Technology BhopalIndia Vellore Institute of Technology Vellore632014India Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia Raytheon Chair for Systems Engineering Advanced Manufacturing InstituteKing Saud UniversityRiyadh11421Saudi Arabia

Wireless sensor networks(WSN)are designed to monitor the physical properties of the target *** received signal strength(RSS)plays a significant role in reducing sensor node power consumption during data *** utilization of RSS values with clustering is required to harvest the energy of each network node to prolong the network life *** paper introduces the RSS-based energy-efficient selective clustering technique using a master node(RESCM)to improve energy utilization using a master *** master node positioned at the center of the network area and base station(BS)is placed outside the network *** cluster head(CH)selection,the node with a high RSS value is more likely to become *** network is divided into segments according to the distance from the master *** nodes near BS or master node transmit their data using direct transmission without the clustering *** simulation results showed that the RESCM method improves the total network lifespan effectively.

关键词： Wireless sensor network received signal strength clustering base station master node

Climate change impact in the Western Himalaya:people's perception and adaptive strategies

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Journal of Mountain Science 2017年第2期14卷 403-416页

作者： vikram S.Negi Rakesh K.Maikhuri Dalbeer Pharswan Shinny Thakur Pitamber P.Dhyani G.B.Pant National Institute of Himalayan Environment and Sustainable Development Kosi-KatarmalAlmoraUttarakhandIndia G.B.Pant National Institute of Himalayan Environment and Sustainable Development Garhwal UnitSrinagar(Garhwal)UttarakhandIndia

The Himalaya represents a vast mountain system and globally valued for its significant role in regulation of global as well as regional climate that has direct impact on biodiversity and ecosystem services crucial for sustenance of millions of people in Himalaya and adjoining areas. However, mountain regions worldwide are impacted by climate change and at the same time represent distinctive area for the assessment of climate related impacts. Climate change impacts in Himalayan region have its implications on food production, natural ecosystems,retreat of glacier, water supply, human and animal health and overall human well being. The livelihood and food security of the people inhabited in region largely depend on climate sensitive sectors ***, livestock, forestry and their interlinkages with each other, and has the potential to break down food and nutritional security as well as livelihood support systems. People's perception and understanding of climate can be an important asset when it comes to adaptation to climate change impact;however it is not taken into consideration for the development of policy design and implementation of modern mitigation and adaptation strategies by governments and other civil society *** knowledge of local people and farming communities for rural landscape management and sustainable use of bioresources is gaining credence as a key strategy to cope up with the climate ***, the present study analyzes the indigenous knowledge of local people and their perceptions on climate change, and also documented adaptation approaches at local level in mountain ecosystem of western Himalaya. The study could be useful to policy makers to design appropriate adaptation strategies to cope up with the impacts of climate change.

关键词： Western Himalaya Climate change People's perception Traditional knowledge Adaptation

Comprehensive application of modern technologies in precise liver resection

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Hepatobiliary & Pancreatic Diseases International 2013年第3期12卷 244-250页

作者： Nian-Song Qian Yong-Hui Liao Shou-Wang Cai vikram Raut Jia-Hong Dong Department of Hepatobiliary Surgery PLA General Hospital Department of Hepatobiliary Surgery Hainan Branch of PLA General Hospital Department of Anatomy Fourth Military Medical University Department of Hepatobiliary Surgery Graduate School of Medicine Kyoto University

BACKGROUND: Liver surgery has gone through the phases of wedge liver resection, regular resection of hepatic lobes, irregular and local resection, extracorporeal hepatectomy, hemi-extracorporeal hepatectomy and Da Vinci surgical system-assisted hepatectomy. Taking advantage of modern technologies, liver surgery is stepping into an age of precise liver resection. This review aimed to analyze the comprehensive application of modern technologies in precise liver resection. DATA SOURCE: PubMed search was carried out for English-language articles relevant to precise liver resection, liver anatomy, hepatic blood inflow blockage, parenchyma transection, and down-staging treatment. RESULTS: The 3D image system can imitate the liver operation procedures, conduct risk assessment, help to identify the operation feasibility and confirm the operation scheme. In addition, some techniques including puncture and injection of methylene blue into the target Glisson sheath help to precisely determine the resection. Alternative methods such as Pringle maneuver are helpful for hepatic blood inflow blockage in precise liver resection. Moreover, the use of exquisite equipment for liver parenchyma transection, such as cavitron ultrasonic surgical aspirator, ultrasonic scalpel, Ligasure and Tissue Link is also helpful to reduce hemorrhage in liver resection, or even operate exsanguinous liver resection without blocking hepatic blood flow. Furthermore, various down-staging therapies including transcatheter arterial chemoembolization and radio-frequency ablation were appropriate for unresectable cancer, which reverse the advanced tumor back to early phase by local or systemic treatment so that hepatectomy or liver transplantation is ***: Modern technologies mentioned in this paper are the key tool for achieving precise liver resection and can effectively lead to maximum preservation of anatomical structural integrity and functions of the remnant liver. In addition, large rand

关键词： precise liver resection anatomy parenchyma transection down-staging treatment

Recent Advances in Nano‑Enabled Seed Treatment Strategies for Sustainable Agriculture:Challenges,Risk Assessment,and Future Perspectives

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Nano-Micro Letters 2023年第4期15卷 153-189页

作者： Amruta Shelar Shivraj Hariram Nile Ajay vikram Singh Dirk Rothenstein Joachim Bill Jianbo Xiao Manohar Chaskar Guoyin Kai Rajendra Patil Department of Technology Savitribai Phule Pune UniversityPuneMaharashtra 411007India Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health School of Pharmaceutical ScienceJinhua AcademyZhejiang Chinese Medical UniversityHangzhou 310053ZhejiangPeople’s Republic of China Department of Chemical and Product Safety German Federal Institute for Risk Assessment(BfR)Max‑Dohrn‑Strasse10589 BerlinGermany Institute for Materials Science University of Stuttgart70569 StuttgartGermany International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013People’s Republic of China Faculty of Science and Technology Savitribai Phule Pune UniversityPuneMaharashtra 411007India Department of Biotechnology Savitribai Phule Pune UniversityPuneMaharashtra 411007India

Agro seeds are vulnerable to environmental stressors,adversely affecting seed vigor,crop growth,and crop *** agrochemical-based seed treatments enhance seed germination,but they can also cause damage to the environment;therefore,sustainable technologies such as nano-based agrochemicals are urgently *** can reduce the dose-dependent toxicity of seed treatment,thereby improving seed viability and ensuring the controlled release of nanoagrochemical active ingredients However,the applications of nanoagrochemicals to plants in the field raise concerns about nanomaterial safety,exposure levels,and toxicological implications to the environment and human *** the present comprehensive review,the development,scope,challenges,and risk assessments of nanoagrochemicals on seed treatment are ***,the implementation obstacles for nanoagrochemicals use in seed treatments,their commercialization potential,and the need for policy regulations to assess possible risks are also *** on our knowledge,this is the first time that we have presented legendary literature to readers in order to help them gain a deeper understanding of upcoming nanotechnologies that may enable the development of future generation seed treatment agrochemical formulations,their scope,and potential risks associated with seed treatment.

关键词： Agro seeds Environmental seed stressors Nanoagrochemicals Toxicological implications Risk regulations

Development and validation of analytical method for the estimation of lamivudine in rabbit plasma

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Journal of Pharmaceutical Analysis 2011年第4期1卷 251-257页

作者： Akhilesh vikram Singh Lila K.Nath Nihar R.Pani Department of Pharmaceutical Sciences Dibrugarh UniversityDibrugarhAssamIndia Gayatri College of Pharmacy SambalpurOrissaIndia

Lamivudine has been widely used in the treatment of HIV disease. A reliable, sensitive reversed phase high performance liquid chromatography （RP-HPLC） method was developed and validated for lamivudine in rabbit plasma. The method was developed on Hypersil BDS C-18 column （250 mm ＊ 4.6 mm, 5 μm） using a mobile phase of 0.25% Triethylamine buffer （pH 3.0）： acetonitrile （70：30, v/v）. The efficient was monitored by UV detector at 256 nm. The total run time was 15 min with a flow rate of 1.0 mL/min. Calibration curve was linear over the concentration range of 25-2000 ng/mL. The retention times of lamivudine and internal standard （Nelfinavir） were 8.78 min and 10.86 min, respectively. The developed RP-HPLC method can be successfully applied for the quantitative pharmacokinetic parameters determination of lamivudine in rabbit model.

关键词： Lamivudine Rabbit plasma Pharmacoldnetics RP.HPLC