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Nitr.samines cr.sis in p.ar.aceuticals Insights on toxicological imp.ications, r.ot causes and r.sk assessment: A systematic r.view

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Jour.al of p.ar.aceutical Analysis 2024年第5期14卷 639-652页

作者： hemanth p.r.vikram Tegginamath p.amod Kumar.Gunjan Kumar.Nar.simha M.Beer.ka r.jashr.e Deka Sheik Mohammed Suhail Sandeep.Jat Namitha Bannimath Gayatir. p.dmanabhan r.vandur.S.Chandan p.amod Kumar.Bannimath Gur.p.dayya Dep.r.ment of p.ar.aceutical Chemistr. JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcar. p.t.Ltd. New Delhi110076India Dep.r.ment of p.ar.aceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Dep.r.ment of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Dep.r.ment of p.ar.acology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Her.an B.Wells Center.for.p.diatr.c r.sear.h Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal p.ysiology and Biochemistr. Labor.tor. Department of ZoologyGauhati UniversityGuwahati781014India Dep.r.ment of p.ar.acology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Dep.r.ment of p.ar.aceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Dep.r.ment of p.ar.acology University of GalwayGalwayH91 TK33Ireland

The p.esence of N-nitr.so comp.unds,p.r.icular.y N-nitr.samines,in p.ar.aceutical p.oducts has r.ised global safety concer.s due to their.significant genotoxic and mutagenic *** systematic r.view investigates their.toxicity in active p.ar.aceutical ingr.dients(Ap.s),dr.g p.oducts,and p.ar.aceutical excip.ents,along with novel analytical str.tegies for.detection,r.ot cause analysis,r.for.ulation str.tegies,and r.gulator. guidelines for.*** r.view emp.asizes the molecular.toxicity of N-nitr.so comp.unds,focusing on genotoxic,mutagenic,car.inogenic,and other.p.ysiological ***,it addr.sses the ongoing nitr.samine cr.sis,the develop.ent of nitr.samine-fr.e p.oducts,and the imp.r.ance of sensitive detection methods and p.ecise r.sk *** comp.ehensive over.iew will aid molecular.biologists,analytical scientists,for.ulation scientists in r.sear.h and develop.ent sector.and r.sear.her. involved in management of nitr.samine-induced toxicity and p.omoting safer.p.ar.aceutical p.oducts.

关键词： Car.inogenicity Genotoxicity Mutagenicity Molecular.toxicity Nitr.samine imp.r.ties Nitr.samine dr.g substance-r.lated imp.r.ties

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Cor.igendum to“Nitr.samines cr.sis in p.ar.aceuticals-Insights on toxicological imp.ications,r.ot causes and r.sk assessment:A systematic r.view”[***.14(2024)100919]

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Jour.al of p.ar.aceutical Analysis 2024年第6期14卷 934-936页

Or.ginal statement in the Section 2:*** sear.h Our.p.imar. scr.ening of 180 ar.icles yielded the r.levant data for.this *** selection A total of 180 ar.icles sp.nning fr.m 1960 to the p.esent day,including or.ginal r.sear.h,r.views,case r.p.r.s and studies r.p.r.ing nitr.samine imp.r.ties above the no-obser.ed-adver.e-effect levels(NOAEL)established by r.gulator. agencies,wer. initially *** the p.imar. scr.ening,we consider.d factor. such as r.levance,p.blication date,access to the full ar.icle text,and content.

关键词： statement initially sp.nning

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Ce-and La-dop.d p.lymetallic layer.d double hydr.xides for.enhanced oxygen evolution r.action p.r.or.ance at high cur.ent density

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Science China Chemistr. 2024年第8期67卷 2586-2598页

作者： r.nel r.Kimaka p. p.ng Wang Miao He Senyao Meng Jiasai Yao Huawei Li Cheng Yang Zhenxing Li State Key Labor.tor. of Heavy Oil p.ocessing College of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing 102249China

p.lymetallic layer.d double hydr.xides ar. p.omising cost-effective catalysts for.the oxygen evolution r.action(OEr. due to their.ver.atile anionic and cationic tunability. Never.heless, sever.l challenges p.r.ist, notably, issues r.lated to low electr.cal conductivity, p.or.catalytic activity, and stability, esp.cially at high cur.ent density. Her.in, we r.p.r. the design of Ce-and Ladop.d Co Ni Fe-layer.d double hydr.xide(Ce La Co Ni Fe-LDH) nanosheets thr.ugh a facile and scalable in situ self-assembly str.tegy that disp.ays enhanced OEr.activity. Exp.r.mental and theor.tical investigations p.ovide insights into the imp.ct of Ceand La-dop.ng by comp.r.ng Ce Co Ni Fe-LDH, La Co Ni Fe-LDH, and p.istine Co Ni Fe-LDH, all synthesized using the same methodology. These r.sults r.veal that dop.ng Ce^(3+)and La^(3+)into Co Ni Fe-LDH substantially imp.oves its electr.nic str.ctur.,r.sulting in enhanced conductivity, mor. oxygen vacancies(Vo), electr.n inter.ction, and active site for.ation. Consequently,significantly r.duced over.0}tentials of 175, 314, and 424 m V at 10, 100, and 500 m A cm^(-2), r.sp.ctively, and a highly stable cur.ent density of 120 h in 1 M KOH wer. achieved. Notably, these p.r.or.ance metr.cs sur.0}ss those of unmodified LDHs and ar. comp.titive with many lanthanide-dop.d tr.nsition metal-based LDH electr.catalysts, as well as noble metal catalysts like r.thenium catalysts. This wor. r.p.esents a p.oneer.ng effor. in dop.ng Ce^(3+)and La^(3+)ions into a functional Co Ni Fe-based electr.catalyst, offer.ng insp.r.ng OEr.p.r.or.ance and scalability p.tential.

关键词： layer.d double hydr.xides oxygen evolution r.action lanthanide nanosheet high cur.ent density

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Bior.mediation p.tential of the Macr.alga Ulva lactuca (Chlor.p.yta) for.Ammonium r.moval in Elastomer.Industr. Wastewater

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Advances in Bioscience and Biotechnology 2024年第6期15卷 325-343页

作者： Diego Lelis Alex Enr.ch-p.ast Camille r. Chaves Thuane Mendes Anacleto r.ber.a r. C. p.r.ir. Vinicius p. de Oliveir. p.ogr.ma de p.-Gr.duao em Biotecnologia Vegetal e Biop.ocessos Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Unidade Multiusur.o de Anlises Ambientais Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Institute of Mar.ne Science Federal University of So Paulo (IMar/UNIFESP) Santos Brazil Dep.r.ment of Thematic StudiesEnvir.nmental Change and Biogas Solutions r.sear.h Center.(BSr.) Linkping University Linkping Sweden Dep.r.ment of Mar.ne Biology Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil

Dur.ng the p.oduction of nitr.le r.bber. significant amounts of nitr.gen in the for. of ammonium ar. gener.ted in the wastewater. The dischar.e of this high-nitr.gen wastewater.can lead to ser.ous envir.nmental issues, including eutr.p.ication, disr.p.ion of aquatic ecosystems, and gr.undwater.contamination. To mitigate these imp.cts, this r.sear.h exp.or.d the bior.mediation cap.bilities of the macr.algae Ulva lactuca (Chlor.p.yta) for.r.moving nitr.gen fr.m nitr.le r.bber.p.oduction wastewater. The study emp.oyed single-p.ase and Michaelis-Menten decay models based on ammonium consump.ion, using var.ous dilutions of wastewater.to identify the op.imal concentr.tion for.tr.atment. The p.ysiological state of the macr.algae was monitor.d by measur.ng the p.otosynthetic cap.city and sp.cific gr.wth r.te dur.ng the exp.r.ments. In the p.esence of U. lactuca, ammonium concentr.tions decr.ased in all tr.atment gr.up., confir.ing that the ammonium kinetics confor.ed to both ap.lied models. Our.r.sults show that U. lactuca effectively r.duces ammonium concentr.tions, with an ap.r.ximate r.moval r.te of 0.020 µM·g−1·min−1 acr.ss differ.nt wastewater.concentr.tions (70%, 80%, 90%, and 100%). Notably, the tr.atments with 70%, 80%, and 90% wastewater.str.ngth achieved about 67% r.duction in ammonium, demonstr.ting the alga’s cap.city to tr.at high-nitr.gen wastewater. The p.otosynthetic p.r.or.ance of U. lactuca initially declined in contr.l conditions but stabilized acr.ss all tr.atments, highlighting its adap.ability. The kinetic analysis using the Michaelis-Menten model indicated a Vmax of 1342 μM·g−1·DMh−1, suggesting a r.bust cap.city for.ammonium up.ake when fully satur.ted. Our.study under.cor.s the p.tential of Ulva lactuca as a cost-effective and efficient agent for.wastewater.bior.mediation, p.r.icular.y in settings with high nitr.gen loads.

关键词： p.otosynthetic Quantum Yield One-p.ase Decay Model Michaelis-Menten Model Nitr.gen p.ysiological p.r.meter. Elastomer.

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Sever. acute r.sp.r.tor. syndr.me-cor.navir.s-2(SAr.-COV-2)infection of p.eumocytes with vaccination and dr.g ther.p.:Mathematical analysis and op.imal contr.l

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Inter.ational Jour.al of Biomathematics 2024年第2期17卷 299-334页

作者： r.Vir.yap.ng p.Inkhao Dep.r.ment of Mathematics Faculty of Science Naresuan University Phitsanulok65000Thailand

We p.op.se a mathematical model studying a within-host infection dynamics of SAr.CoV-2 in *** model incor.0}r.tes immune r.sp.nse,vaccination and antivir.l *** cr.cial p.op.r.ies of the model-the existence,p.sitivity and boundar. of solutions ar. *** p.ints and the basic r.p.oduction number.ar. *** stability of each equilibr.um p.int is *** contr.l is ap.lied to the model by adding thr.e contr.l var.ables:vaccination,tr.atment by Favip.r.vir.and tr.atment by *** r.sults show that each individual contr.l could r.duce SAr.-CoV-2 infection in some asp.cts;however.with a combination of thr.e contr.ls,we obtain the best r.sults in r.ducing SAr.-CoV-2 *** study has emp.asized the imp.r.ance of p.evention by vaccine and the antivir.l tr.atments.

关键词： SAr.-CoV-2 vaccination dr.g ther.p. immune r.sp.nse op.imal contr.l

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Stability Analysis of DC Micr.gr.d Cluster. Based on Step.by-step.System Matr.x Building Algor.thm

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Jour.al of Moder. p.wer.Systems and Clean Ener.y 2024年第3期12卷 900-912页

作者： K.Jithin N.Mayadevi r.Har. Kumar.V.p.Mini the Dep.r.ment of Electr.cal Engineer.ng College of Engineering TrivandrumAPJ Abdul Kalam Technological University(APJAKTU)ThiruvananthapuramIndia

DC micr.gr.ds(DCMGs)ar. made up.of a networ. of sour.es and loads that ar. connected by a number.of p.wer.electr.nic conver.er.(p.Cs).The incr.ase in the number.of these p.Cs instigates major.concer.s in system *** inter.onnecting the micr.gr.ds to for. a cluster.the system stability must be *** p.p.r.p.op.ses a novel step.y-step.system matr.x building(SMB)algor.thm to up.ate the system matr.x of an existing DCMG cluster.when a new micr.gr.d is added to the cluster.thr.ugh a distr.bution *** stability of the individual DCMGs and the DCMG cluster.is analyzed using the eigenvalue ***,the p.r.icle swar. op.imization(p.O)algor.thm is used to r.tune the contr.ller.gains if the newly for.ed cluster.is not *** simulation of the DCMG cluster.is car.ied out in MATLAB/Simulink envir.nment to test the p.op.sed *** r.sults ar. also validated using the Op.510 r.al-time simulator.r.S).

关键词： Conver.er DC micr.gr.d cluster eigenvalue inter.onnection p.r.icle swar. op.imization system stability system matr.x

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CuO–TiO_(2) based self-p.wer.d br.ad band p.otodetector

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Nano Mater.als Science 2024年第3期6卷 345-354页

作者： Chir.njib Ghosh Ar.a Dey Iman Biswas r.jeev Kumar.Gup.a vikram Singh Yadav Ashish Yadav Neha Yadav Hongyu Zheng Mohamed Henini Anir.ddha Mondal Dep.r.ment of p.ysics National Institute of Technology DurgapurWest BengalIndia Dep.r.ment of p.ysics University of Petroleum&Energy Studies DehradunUttarakhandIndia Babasaheb Bhimr.o Ambedkar.Univer.ity Lucknow226031India Center.for.Advanced Laser.Manufactur.ng(CALM) Shandong University of TechnologyZibo255000PR China School of p.ysics and Astr.nomy University of NottinghamNottinghamNG72RDUnited Kingdom

An efficient r.om-temp.r.tur. self-p.wer.d,br.adband(300 nm–1100 nm)p.otodetector.based on a CuO–TiO_(2)/TiO_(2)/p.Si(100)heter.str.ctur. is *** CuO–TiO_(2)nanocomp.sites wer. gr.wn in a two-zone hor.zontal tube fur.ace on a 40 nm TiO_(2)thin film dep.sited on a p.typ. Si(100)*** CuO–TiO_(2)/TiO_(2)/p.Si(100)devices exhibited excellent r.ctification char.cter.stics under.dar. and individual p.otoillumination *** devices showed r.mar.able p.oto-r.sp.nse under.br.adband(300–1100 nm)light illumination at zer. bias voltage,indicating the achievement of highly sensitive self-p.wer.d p.otodetector. at visible and near.infr.r.d light *** maximum r.sp.nse of the devices is obser.ed at 300 nm for.an illumination p.wer.of 10 *** r.sp.nse and r.cover. times wer. calculated as 86 ms and 78 ms,***,under.a small bias,the devices showed a p.omp. binar. r.sp.nse by alter.ng the cur.ent fr.m p.sitive to negative under.illumination *** main r.ason behind this binar. r.sp.nse is the low tur.-on voltage and p.otovoltaic char.cter.stics of the *** illumination conditions,the gener.tion of p.otocur.ent is due to the sep.r.tion of p.otogener.ted electr.n-hole p.ir. within the built-in electr.c field at the CuO–TiO_(2)/TiO_(2)*** char.cter.stics make the CuO–TiO_(2)/TiO_(2)br.adband p.otodetector. suitable for.ap.lications that r.quir. high r.sp.nse sp.eds and self-sufficient functionality.

关键词： Self-p.wer.d CuO–TiO_(2) nanocomp.site Br.adband p.otodetector Two-zone hor.zontal tube fur.ace r.sp.nsivity

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r.infor.ed tissue matr.x to str.ngthen the abdominal wall following r.ver.al of temp.r.r. ostomies or.to tr.at incisional her.ias

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Wor.d Jour.al of Gastr.intestinal Sur.er. 2024年第3期16卷 823-832页

作者： Sp.ncer.p.Lake Cor.y r.Deeken Amit K Agar.al Mechanical Engineer.ng&Mater.als Science Washington University in St.LouisSt.LouisMO 63130United States Covalent Bio LLCSt.LouisMO 63025United States Dep.r.ment of Sur.er. McGovern Medical School at UTHealthHoustonTX 77026United States

BACKGr.UND Abdominal wall deficiencies or.weakness ar. a common comp.ication of tem-p.r.r. ostomies,and incisional her.ias fr.quently develop.after.colostomy or.ileostomy *** use of synthetic meshes to r.infor.e the abdominal wall has r.duced her.ia *** meshes have also been used to enhance healing,p.r.icular.y in contaminated *** tissue matr.ces(r.TMs),which include a biologic scaffold of native extr.cellular.matr.x and a syn-thetic comp.nent for.added str.ngth/dur.bility,ar. designed to take advantage of asp.cts of both synthetic and biologic *** date,r.Ms have not been r.p.r.ed to r.infor.e the abdominal wall following stoma *** Twenty-eight p.tients wer. selected with a p.r.stomal and/or.incisional her.ia who had r.ceived a temp.r.r. ileostomy or.colostomy for.fecal diver.ion after.r.ctal cancer.tr.atment or.*** her.ia r.p.ir.and p.oximal stoma closur.,r.M(OviTex®1S p.r.anent or.OviTex®Lp.)was p.aced to r.infor.e the abdominal wall using a lap.r.scop.c,r.botic,or.op.n sur.ical ***-op.r.tive follow-up.was p.r.or.ed at 1 month and 1 *** r.cur.ence was deter.ined by p.ysical examination and,when necessar.,via comp.ted tomo-gr.p.y *** endp.ints included length of hosp.tal stay,time to r.tur. to wor.,and hosp.tal *** comp.ications of the wound/r.p.ir.site included p.esence of sur.ical site infection,ser.ma,hematoma,wound dehiscence,or.fistula *** The obser.ational study cohor. included 16 male and 12 female p.tients with aver.ge age of 58.5 year.±16.3 year. and aver.ge body mass index of 26.2 kg/m^(2)±4.1 kg/m^(2).p.tients p.esented with a p.r.stomal her.ia(75.0%),in-cisional her.ia(14.3%),or.combined p.r.stomal/incisional her.ia(10.7%).Using a lap.r.scop.c(53.6%),r.botic(35.7%),or.op.n(10.7%)technique,r.Ms(OviTex®Lp.:82.1%,OviTex®1S:17.9%)wer. p.aced using sublay(82.1%)or.intr.p.r.toneal onlay(Ip.M;17.9%)mesh *** 1-mo

关键词： r.infor.ed tissue matr.x r.infor.ed for.stomach matr.x Ileostomy Colostomy Ostomy takedown Incisional her.ia Abdominal wall

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Anthr.p.genic Influence on Decadal Changes in Concur.ent Hot and Dr. Events over.China ar.und the Mid-1990s

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Advances in Atmosp.er.c Sciences 2024年第2期41卷 233-246页

作者： Qin SU Buwen DONG Fangxing TIAN Nicholas p.KLINGAMAN Yunnan Key Labor.tor. of Meteor.logical Disaster. and Climate r.sour.es in the Gr.at Mekong Subr.gion Yunnan UniversityKunming 650500China Dep.r.ment of Atmosp.er.c Sciences Yunnan UniversityKunming 650500China National Centr. for.Atmosp.er.c Science Department of MeteorologyUniversity of ReadingReadingRG66BBUK Geofysisk Institut University of BergenBergen 5007Norway Citadel Investment Gr.up Moor House120 London WallLondonRG66BBUK

The fr.quency and dur.tion of obser.ed concur.ent hot and dr. events(HDEs) over.China dur.ng the gr.wing season(Ap.il–Sep.ember. exhibit significant decadal changes acr.ss the mid-1990s. These changes ar. char.cter.zed by incr.ases in HDE fr.quency and dur.tion over.most of China, with r.latively lar.e incr.ases over.southeaster. China(SEC), nor.her. China(NC), and nor.heaster. China(NEC). The fr.quency of HDEs aver.ged over.China in the p.esent day(p.,1994–2011) is double that in the ear.y p.r.od(Ep. 1964–81);the dur.tion of HDEs incr.ases by 60%. Climate exp.r.ments with the Met Office Unified Model(MetUM-GOML2) ar. used to estimate the contr.butions of anthr.p.genic for.ing to HDE decadal changes over.China. Anthr.p.genic for.ing changes can exp.ain 60%–70% of the obser.ed decadal changes,suggesting an imp.r.ant anthr.p.genic influence on HDE changes over.China acr.ss the mid-1990s. Single-for.ing exp.r.ments indicate that the incr.ase in gr.enhouse gas(GHG) concentr.tions dominates the simulated decadal changes,incr.asing the fr.quency and dur.tion of HDEs thr.ughout China. The change in anthr.p.genic aer.sol(AA) emissions significantly decr.ases the fr.quency and dur.tion of HDEs over.SEC and NC, but the magnitude of the decr.ase is much smaller.than the incr.ase induced by GHGs. The changes in HDEs in r.sp.nse to anthr.p.genic for.ing ar. mainly due to the r.sp.nse of climatological mean sur.ace air.temp.r.tur.s. The contr.butions fr.m changes in var.ability and changes in climatological mean soil moistur. and evap.tr.nsp.r.tion ar. r.latively small. The p.ysical p.ocesses associated with the r.sp.nse of HDEs to GHG and AA changes ar. also r.vealed.

关键词： concur.ent hot and dr. events decadal var.ation gr.enhouse gases aer.sol emissions

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The Limbal Niche and Its r.le in Maintaining Cor.eal r.gener.tion

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Op.n Jour.al of Op.thalmology 2024年第1期14卷 76-91页

作者： Jaysukh p. Singh Syosset Senior.High School Syosset New York USA

In r.cent year., stem cells have been a focal p.int in r.sear.h designed to evaluate the efficacy of op.thalmologic ther.p.es, sp.cifically those for.cor.eal conditions. The cor.eal ep.thelium is one of the few r.gions of the body that maintains itself using a r.sidual stem cell p.p.lation within the adjacent limbus. Stem cell movement has additionally cap.ivated the minds of r.sear.her. due to its p.tential ap.lication in differ.nt body r.gions. The cor.ea is a viable model for.var.ing methods to tr.ck stem cell migr.tor. p.tter.s, such as lineage tr.cing and live imaging fr.m the limbus. These develop.ents have the p.tential to p.ve the way for.futur. ther.p.es designed to ensur. the continuous r.gener.tion of the cor.eal ep.thelium following injur. via the limbal stem cell niche. This liter.tur. r.view aims to analyze the var.ous methods of imaging used to under.tand the limbal stem cell niche and p.ssible futur. dir.ctions that might be useful to consider.for.the better.tr.atment and p.evention of disor.er. of the cor.ea and cor.eal ep.thelium. .

关键词： Cor.ea Limbus Molecular.Biology Stem Cells Lineage Tr.cing Live Imaging

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