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Hericium Erinaceus (Bull.:Fr.) Pers.,A Medicinal Mushroom,Activates Peripheral Nerve Regeneration

Chinese Journal of Integrative Medicine 2016年第10期22卷 759-767页

作者： Kah-Hui Wong Gowri Kanagasabapathy Murali Naidu Pamela David vikineswary sabaratnam Department of Anatomy Faculty of Medicine University of Malaya Mushroom Research Centre University of Malaya Institute of Biological Sciences Faculty of Science University of Malaya

Objective： To study the ability of aqueous extract of Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crush in Sprague-Dawley rats. Methods： Aqueous extract of Hericium erinaceus was given by daily oral administration following peroneal nerve crush injury in Sprague- Dawley rats. The expression of protein kinase B （Akt） and mitogen-activated protein kinase （MAPK） signaling pathways; and c-Jun and c-Fos genes were studied in dorsal root ganglia （DRG） whereas the activity of protein synthesis was assessed in peroneal nerves by immunohistochemical method. Results： Peripheral nerve injury leads to changes at the axonal site of injury and remotely located DRG containing cell bodies of sensory afferent neurons. Immunofluorescence studies showed that DRG neurons ipsilateral to the crush injury in rats of treated groups expressed higher immunoreactivities for Ak＇t, MAPK, c-Jun and c-Fos as compared with negative control group （P〈0.05）. The intensity of nuclear ribonucleoprotein in the distal segments of crushed nerves of treated groups was significantly higher than in the negative control group （P〈0.05）. Conclusion： H. erinaceus is capable of promoting peripheral nerve regeneration after injury. Potential signaling pathways include Akt, MAPK, c-Jun, and c-Fos, and protein synthesis have been shown to be involved in its action.

关键词： Hericium erinaceus dorsal root ganglia signaling pathways gene expression protein synthesis machinery peripheral nerve regeneration

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Bioluminescent fungi from Peninsular Malaysia-a taxonomic and phylogenetic overview

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Fungal Diversity 2015年第1期70卷 149-187页

作者： Audrey L.C.Chew Dennis E.Desjardin Yee-Shin Tan Md Yusoff Musa vikineswary sabaratnam Mushroom Research Centre University of Malaya50603 Kuala LumpurMalaysia Institute of Biological Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia Department of Biology San Francisco State University1600 Holloway Ave.San FranciscoCA 94132USA

Fifteen bioluminescent fungi recently collected from Peninsular Malaysia are analysed *** phylogeny of the Malaysian bioluminescent fungi and closely related taxa were evaluated with molecular data from the nuclear ribosomal large subunit(LSU),RNA polymerase 2 second largest subunit(RPB2)and internal transcribed spacers(ITS)gene *** sequences data support the circumscription of species based on the morphological species concept,but was unable to fully support the current sectional delimitation of genus *** the 15 taxa analysed here,four are novel species described herein,*** gombakensis,***,*** and Panellus luxfilamentus;while four taxa of Mycena *** were recently described as *** species(***)represents a new distribution record to Peninsular Malaysia,and six species(Neonothopanus nambi,Filoboletus manipularis,***,Roridomyces pruinosoviscidus,*** and ***)have been previously *** pruinosoviscidus is accepted as a new combination based on morphological and phylogenetic *** morphology data indicate its potential for taxon delimitation as axenic cultures of each species produced unique and distinguishable *** descriptions,illustrations and photographs are provided on basidiome and culture morphology.A key to aid in species identification,comparisons with allied species and data on basidiome and mycelium luminescence are also *** study gives the first report on mycelial luminescence for ***,***,*** as well as all new species described *** reports in this study bring the total known luminescent fungi worldwide to 81 species.

关键词： Basidiomycete Biodiversity Culture morphology Filoboletus Mycena Neonothopanus Panellus Phylogeny Roridomyces Systematics Taxonomy

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