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Anticoagulant use before COVID-19 diagnosis prevent COVID-19 associated acute venous thromboembolism or not:A systematic review and meta-analysis

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World Journal of Methodology 2024年第3期14卷 141-162页

作者： Kinza Iqbal Akshat Banga Taha Bin Arif Sawai Singh Rathore Abhishek Bhurwal Syeda Kisa Batool Naqvi Muhammad Mehdi Pankaj Kumar Mitali Madhu Salklan Ayman Iqbal Jawad Ahmed Nikhil Sharma Amos Lal Rahul Kashyap vikas bansal Juan Pablo Domecq Department of Internal Medicine Dow Medical CollegeKarachi 74200Pakistan Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Internal Medicine Dr.Sampurnanand Medical CollegeJodhpur 342003RajasthanIndia Department of Gastroenterology and Hepatology Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Department of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Research Wellspan HealthYorkPA 17403United States

BACKGROUND Coagulopathy and thromboembolic events are associated with poor outcomes in coronavirus disease 2019(COVID-19)*** is conflicting evidence on the effects of chronic anticoagulation on mortality and severity of COVID-19 *** To summarize the body of evidence on the effects of pre-hospital anticoagulation on outcomes in COVID-19 *** A Literature search was performed on LitCovid PubMed,WHO,and Scopus databases from inception(December 2019)till June 2023 for original studies reporting an association between prior use of anticoagulants and patient outcomes in adults with *** primary outcome was the risk of thromboembolic events in COVID-19 patients taking *** outcomes included COVID-19 disease severity,in terms of intensive care unit admission or invasive mechanical ventilation/intubation requirement in patients hospitalized with COVID-19 infection,and *** random effects models were used to calculate crude and adjusted odds ratios(aORs)with 95%confidence intervals(95%CIs).RESULTS Forty-six observational studies met our inclusion *** unadjusted analysis found no association between prior anticoagulation and thromboembolic event risk[n=43851,9 studies,odds ratio(OR)=0.67(0.22,2.07);P=0.49;I2=95%].The association between prior anticoagulation and disease severity was non-significant[n=186782;22 studies,OR=1.08(0.78,1.49);P=0.64;I2=89%].However,pre-hospital anticoagulation significantly increased all-cause mortality risk[n=207292;35 studies,OR=1.72(1.37,2.17);P<0.00001;I2=93%].Pooling adjusted estimates revealed a statistically non-significant association between pre-hospital anticoagulation and thromboembolic event risk[aOR=0.87(0.42,1.80);P=0.71],mortality[aOR=0.94(0.84,1.05);P=0.31],and disease severity[aOR=0.96(0.72,1.26);P=0.76].CONCLUSION Prehospital anticoagulation was not significantly associated with reduced risk of thromboembolic events,improved survival,and lower disease seve

关键词： Prior anticoagulation COVID-19 Prehospital anticoagulation Chronic anticoagulation Mortality Severity Thromboembolic events

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Hypotension after intensive care unit drop-off in adult cardiac surgery patients

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World Journal of Critical Care Medicine 2020年第2期9卷 20-30页

作者： Sabina Cengic Muhammad Zuberi vikas bansal Robert Ratzlaff Eduardo Rodrigues Emir Festic Department of Critical Care Medicine Mayo ClinicJacksonvilleFL 32224United States Department of General Surgery Stadtspital TriemliZurich 8063Switzerland Department of Anesthesiology and Perioperative Medicine Mayo ClinicJacksonvilleFL 32224United States

BACKGROUND Hypotension is a frequent complication in the intensive care unit(ICU)after adult cardiac *** To describe frequency of hypotension in the ICU following adult cardiac surgery and its relation to the hospital *** A retrospective study of post-cardiac adult surgical patients at a tertiary academic medical center in a two-year *** abstracted baseline demographics,comorbidities,and all pertinent clinical *** primary predictor variable was the development of hypotension within the first 30 min upon arrival to the ICU from the operating room(OR).The primary outcome was hospital mortality,and other outcomes included duration of mechanical ventilation(MV)in hours,and ICU and hospital length of stay in *** Of 417 patients,more than half(54%)experienced hypotension within 30 min upon arrival to the *** of OR hypotension immediately prior to ICU transfer was significantly associated with ICU hypotension(odds ratio=1.9;95%confidence interval:1.21-2.98;P<0.006).ICU hypotensive patients had longer MV,5(interquartile ranges 3,15)vs 4 h(interquartile ranges 3,6),P=*** patients who received vasopressor boluses(n=212)were more likely to experience ICU drop-off hypotension(odds ratio=1.45,95%confidence interval:0.98-2.13;P=0.062),and they experienced longer MV,ICU and hospital length of stay(P<0.001,for all).CONCLUSION Hypotension upon anesthesia-to-ICU drop-off is more frequent than previously reported and may be associated with adverse clinical outcomes.

关键词： Hypotension Cardiac surgery Intensive care Postoperative care Care transfer Drop-off

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Genomics in medicine: A new era in medicine

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World Journal of Methodology 2021年第5期11卷 231-242页

作者： Vishwanath Pattan Rahul Kashyap vikas bansal Narsimha Candula Thoyaja Koritala Salim Surani Division of Endocrinology Wyoming Medical CenterCasperWY 82601United States Department of Anesthesiology and Peri-operative Medicine Mayo ClinicRochesterMN 55905United States Hospital Medicine University Florida HealthJacksonvilleFL 32209United States Hospital Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Internal Medicine Texas A&M UniversityCorpus ChristiTX 78405United States

The sequencing of complete human genome revolutionized the genomic ***,the complex interplay of gene-environment-lifestyle and influence of non-coding genomic regions on human health remain largely *** medicine has great potential for diagnoses or disease prediction,disease prevention and,targeted ***,many of the promising tools of genomic medicine are still in their infancy and their application may be limited because of the limited knowledge we have that precludes its use in many clinical *** this review article,we have reviewed the evolution of genomic methodologies/tools,their limitations,and scope,for current and future clinical application.

关键词： Genomic medicine Medical genetics Gene sequencing DNA sequencing RNA sequencing Clustered regularly interspaced short palindromic repeat Gene based therapy Genomic tools Genome editing

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Association of non-alcoholic fatty liver and metabolic-associated fatty liver with COVID-19 outcomes:A systematic review and metaanalysis

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World Journal of Gastroenterology 2023年第21期29卷 3362-3378页

作者： Gowthami Sai Kogilathota Jagirdhar Rakhtan K Qasba Harsha Pattnaik Kaanthi Rama Akshat Banga Shiva Teja Reddy Anna Carolina Flumignan Bucharles Rahul Kashyap Praveen Reddy Elmati vikas bansal Yatinder Bains Theodore DaCosta Salim Surani Department of Medicine Saint Michaels Medical CenterNewarkNJ 07102United States Department of Medicine Green Life Medical College and HospitalDhaka 1205Bangladesh Department of Medicine Lady Hardinge Medical CollegeNew Delhi 110001India Department of Medicine Gandhi Medical CollegeTelangana 500003India Department of Medicine Sawai Man Singh Medical CollegeJaipur 302004RajistanIndia Department of Medicine Universidade PositivoCuritiba 81290-000PRBrazil Research WellSpan HealthYorkPA 17403United States Department of Interventional Pain Medicine University of LouisvilleLouisvilleKY 40292United States Department of Internal Medicine Mayo ClinicRochesterMN 55902United States Department of Gastroenterology Saint Michaels Medical CenterNewarkNJ 07102United States Department of Medicine Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and metabolic-associated fatty liver disease(MAFLD)are on the rise like any other liver disease,and tend to affect 25%of the United States *** impact of NAFLD and MAFLD on patients with coronavirus disease 2019(COVID-19)remains *** To identify the association of NAFLD and MAFLD with mortality,hospitalization,hospital length of stay,and supplemental oxygen utilization in COVID-19 *** A systematic review of literature on Cochrane,Embase,PubMed,ScienceDirect,and Web of Science databases was conducted from January 2019 to July *** that evaluated NAFLD/MAFLD using laboratory methods,noninvasive imaging,or liver biopsy were *** study protocol was registered in PROSPERO(ID CRD42022313259)and PRISMA guidelines were *** National Institutes of Health quality assessment tool was used to assess the quality of the *** analysis was conducted using software Rev Man version *** stability of the results was assessed using sensitivity *** Thirty-two studies with 43388 patients were included in the meta-analysis of whom 8538(20%)patients were observed to have *** were 42254 patients from 28 studies included in the mortality analysis.A total of 2008 patients died from COVID-19;837(10.52%)in the NAFLD group and 1171(3.41%)in the non-NAFLD *** odds ratio(OR)was 1.38 for mortality with a 95%confidence interval(95%CI)=0.97-1.95 and P=0.07.A total of 5043 patients from eight studies were included in the hospital length of stay *** were 1318 patients in the NAFLD group and 3725 patients in the non-NAFLD group.A qualitative synthesis showed that the mean difference in hospital length of stay was about 2 d between the NAFLD and non-NAFLD groups with a 95%CI=0.71-3.27 and P=*** hospitalization rates,the OR was 3.25 with a 95%CI of 1.73-6.10 and P=*** supplemental oxygen utilization,the OR was 2.04 with a 95%CI of 1.17-3.5

关键词： Non-alcoholic fatty liver Fatty liver Coronavirus COVID-19 Metabolic-associated fatty liver

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Realization of 16 Gbit/s all-optical Toggle memory utilizing change in polarization state of light in single-mode optical fiber

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Optoelectronics Letters 2024年第2期20卷 76-82页

作者： Dipti bansal Lovkesh Department of Electronics&Communication Engineering Punjabi UniversityPatiala 147002India1

In this investigation,all-optical Toggle flip-flop event-driven memory is explored with data rate of 16 Gbit/*** mode optical fiber model is used as a nonlinear medium to generate the output set and reset pulses of a Toggle flip-flop,and the model is based on the bidirectional optical transmission principle,considering the fundamental effects of cross phase modulation and self-phase modulation with change in polarization *** performance of a flip-flop is evaluated using truth table conditions and performance parameters such as Q factor,which is obtained as 380.92 d B for Q and 272.9 d B for■,and rising and falling times of 7.304 ps and 5.79 ps,respectively are obtained,which makes flip-flop design fast as compared to earlier design techniques.

关键词： Gbit/s polarization optical

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Operator Equations Inducing Some Generalizations of Slant Hankel Operators

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Acta Mathematica Sinica,English Series 2024年第8期40卷 2017-2036页

作者： Gopal DATT Bhawna bansal GUPTA Department of Mathematics PGDAV CollegeUniversity of DelhiNew Delhi-110065India Department of Mathematics Miranda HouseUniversity of DelhiDelhi-110007India

An extension of slant Hankel operator,namely,the kth-orderλ-slant Hankel operator on the Lebesgue space L^(2)(T^(n)),where T is the unit circle and n≥1,a natural number,is described in terms of the solution of a system of operator equations,which is subsequently expressed in terms of the product of a slant Hankel operator and a unitary *** study is further lifted in Calkin algebra in terms of essentially kth-orderλ-slant Hankel operators on L^(2)(T^(n)).

关键词： Hankel operator Lebesgue space of n-dimensional torus kth-order slant Hankel operator essentially kth-orderλ-slant Hankel operator

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Editorial

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Big Data Mining and Analytics 2024年第2期7卷 I0001-I0002页

作者： Kumar, Sunil Mapp, Glenford bansal, Abhay Cengiz, Korhan University of Surrey United Kingdom Middlesex University United Kingdom Amity University India Trakya University Turkey

Advanced technologies in science explore the study of business and *** can learn from and make predictions and decisions based on collected data through intelligent *** by technological advances in Big Data,Artificial Intelligence(AI),and Machine Learning(ML),such systems potentially have many applications,roles,and impacts on business and *** stay ahead of the competition,companies must think creatively about incorporating the latest technologies like AI,ML,and Big Data into their policy.

关键词： such companies Foster

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Do natural resources impact economic growth:An investigation of P5+1 countries under sustainable management

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Geoscience Frontiers 2024年第3期15卷 192-208页

作者： Sanjeet Singh Gagan Deep Sharma Magdalena Radulescu Daniel Balsalobre-Lorente Pooja bansal University Centre for Research and Development Chandigarh UniversityGharuanMohaliPunjabIndia University School of Management Studies Guru Gobind Singh Indraprastha UniversityDwarkaDelhiIndia Department of Finance Accounting and EconomicsUniversity of PitestiPitesti 110040Romania Institute for Doctoral and Post-Doctoral Studies University“Lucian Blaga”SibiuSibiu 550024Romania Department of Applied Economics I University of Castilla-La ManchaSpain Department of Management Faculty of Economics and ManagementCzech University of Life Sciences PraguePrague 16500Czech Republic

Natural resources represent the base of our living and the entire economic *** depletion is a major challenge for the economic development of both developed and developing *** effi-cient use is an indispensable requirement and must be the aim of the public policies designed by the authorities *** this research,we have investigated the impact of the natural resources rent on the economic growth in some major wealthy economies of the world(P5+1 countries namely:US,UK,France,China,Russia,and Germany).We have applied a quantile-on-quantile regression to analyse this impact on different quantiles and a cross-sectional autoregressive distributed lag(CS-ARDL)approach for the panel of these six *** Dumitrescu-Hurlin panel causality test was also used to check the causality between natural resource rents and economic growth in these *** show a negative relationship between natural resources rent and economic growth for the panel but a different impact on quantiles in each *** for China and the US,a positive effect can be noticed for both lower and higher quantiles of natural resources and economic *** Dumitrescu-Hurlin causality test shows that natural resources can predict economic growth only in China,the U.S.,and the *** contrast,no causality was found for the other four countries included in the *** suggest that nations invest in wind and solar projects,use biofuels and nuclear energy,introduce a temporary profit tax to protect consumers from escalating energy prices,and increase energy efficiency in buildings and *** would benefit from a regulatory framework that is uniform and exhaustive,as well as easier to traverse and more receptive to innovation and ***-private partnership investments in innovation,innovation incentives,and environmental sector opportunities may foster long-term economic growth。

关键词： Natural resources rent Economic growth Quantile-on-quantile regression Cross-sectional ARDL P5+1 countries

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Pharmacological potential of Manilkara zapota(L.)***(Sapodilla):a narrative review

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Journal of Traditional Chinese Medicine 2024年第2期44卷 403-407页

作者： Priyanka Sharma Aakash Deep Harish Kumar Nitin bansal Sanjiv Kumar Arun Davinder Kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021India Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001India

Herbal medicine is safe and effective in treating various *** herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health *** plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological *** genus Manilkara contains 135 plants around the *** overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)***(***),also known as *** has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.

关键词： herbal medicine Manilkara zapota phytoconstituents pharmacological activity review

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Critical care practice in India:Results of the intensive care unit need assessment survey(ININ2018)

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World Journal of Critical Care Medicine 2020年第2期9卷 31-42页

作者： Rahul Kashyap Kirtivardhan Vashistha Chetan Saini Taru Dutt Dileep Raman vikas bansal Harpreet Singh Geeta Bhandari Nagarajan Ramakrishnan Harshit Seth Divya Sharma Premkumar Seshadri Mradul Kumar Daga Mohan Gurjar Yash Javeri Salim Surani Joseph Varon 无 Department of Anesthesiology and Perioperative Medicine Mayo ClinicRochesterMN 55905United States Department of Infectious Disease Mayo ClinicRochesterMN 55905United States Department of Internal Medicine Allegheny General HospitalPittsburghPA 15212United States Department of Radiology Mayo ClinicRochesterMN 55905United States Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 14061United States Department of Neurology Mayo ClinicRochesterMN 55905United States and Department of PsychiatryHennepin County Medical CenterMinneapolisMN 55415United States Department of Medicine Cloud Physician HealthcareBangalore 560038India Department of Critical Care Medicine Mayo ClinicRochesterMN 55905United States Department of Internal Medicine Maulana Azad Medical College&Associated HospitalsNew DelhiDelhi 110002India Department of Anesthesiology Government Medical CollegeHaldwaniNainital 263129India Department of Critical Care Medicine Apollo HospitalsChennai 600006India Department of Hospitalist Medicine Allegany ClinicAllegany Health NetworkPittsburghPA 15222United States Premkumar Seshadri Department of MedicineMAAGF HealthcareChennai 600024India Department of Internal Medicine and Center for Occupational and Environment Health Maulana Azad Medical CollegeNew DelhiDelhi 110002India Department of Critical Care Medicine Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India Department of Critical Care Medicine Regency Super Speciality HospitalLucknow 208005India Nayati Healthcare New DelhiDelhi 110065India Department of Pulmonary and Critical Care Medicine Texas A&M UniversityCollege StationTX 77843United States Department of Critical Care United Memorial Medical CenterHoustonTX 77091United States ININ-2018 Investigators Team

BACKGROUND A diverse country like India may have variable intensive care units(ICUs)practices at state and city *** To gain insight into clinical services and processes of care in ICUs in India,this would help plan for potential educational and quality improvement *** The Indian ICU needs assessment research group of diverse-skilled individuals was formed.A pan-India survey"Indian National ICU Needs"assessment(ININ 2018-I)was designed on google forms and deployed from July 23rd-August 25th,*** survey was sent to select distribution lists of ICU providers from all 29 states and 7 union territories(UTs).In addition to emails and phone calls,social medial applications-WhatsApp™,Facebook™and LinkedIn™were used to remind and motivate *** completing and submitting the survey,providers gave their consent for research *** study was deemed eligible for category-2 Institutional Review Board exempt *** There were total 134 adult/adult-pediatrics ICU responses from 24(83%out of 29)states,and two(28%out of 7)UTs in 61 *** had median(IQR)16(10-25)beds and most,were mixed medical-surgical,111(83%),with 108(81%)being adult-only *** responders were young,median(IQR),38(32-44)years age and majority,n=108(81%)were *** consultants were,n=101(75%).A total of 77(57%)reported to have 24 h in-house intensivist.A total of 68(51%)ICUs reported to have either 2:1 or 2≥:1 patient:nurse *** than 80%of the ICUs were open,and mixed *** followed regularly by the ICUs included sepsis care,ventilator-associated pneumonia(83%each);nutrition(82%),deep vein thrombosis prophylaxis(87%),stress ulcer prophylaxis(88%)and glycemic control(92%).Digital infrastructure was found to be poor,with only 46%of the ICUs reporting high-speed internet *** In this large,national,semi-structured,need-assessment survey,the need for improved manpower including;in-house intensivists,and decreasing

关键词： Intensive care unit Critical care India Survey Intensive care unit survey Intensive care unit needs

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