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World Journal of Orthopedics 2016年第7期7卷 426-433页

作者： Raju Vaishya Vipul Vijay vikas p birla Amit K Agarwal Department of Orthopaedics Joint Replacement and ArthroscopyIndraprastha Apollo Hospital

AIM: To compare the postoperative mechanical alignment achieved after total knee arthroplasty(TKA) using computer tomography(CT) based patient specific blocks(pSB) to conventional instruments(CI).METHODS: Total 80 knees were included in the study, with 40 knees in both the groups operated using pSB and CI. All the knees were performed by a single surgeon using the same cruciate sacrificing implants. In our study we used CT based pSB to compare with CI. postoperative mechanical femoro-tibial angle(MFT angle) was measured on long leg x-rays using picture archiving and communication system(pACS). We compared mechanical alignment achieved using pSB and CI in TKA using statistical ***: The pSB group(group 1) included 17 females and seven males while in CI group(group 2) there were 15 females and eight males. The mean age of patients in group 1 was 60.5 years and in group 2 it was 60.2 years. The mean postoperative MFT angle measured on long-leg radiographs in group 1 was 178.23°(SD = 2.67°, range: 171.9° to 182.5°) while in group 2, the mean MFT angle was 175.73°(SD = 3.62°, range: 166.0° to 179.8°). There was significant improvement in postoperative mechanical alignment(p value = 0.001), in pSB group compared to CI. Number of outliers were also found to be less in group operated with pSB(7 Knee) compared to those operated with CI(17 Knee).CONCLUSION: pSB improve mechanical alignment after total knee arthroplasty, compared to CI. This may lead to lower rates of revision in the pSB based TKA as compared to the conventional instrumentation.

关键词： Knee Replacement Arthroplasty patient specific jigs Conventional jigs

Available drugs and supplements for rapid deployment for treatment of COVID-19

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Journal of Molecular Cell Biology 2021年第3期13卷 232-236页

作者： Danielle Cicka vikas p.Sukhatme Department of pharmacology and Chemical Biology Emory University School of MedicineAtlantaGAUSA Department of Medicine Department of Hematology and Medical OncologyMorningside Center for Innovative and Affordable MedicineEmory University School of MedicineAtlantaGAUSA

Effective treatment for COVID-19 remains elusive,though urgently needed in the current *** marketed therapies may be an effective strategy for finding treatments quickly and recently,in vitro and clinical testing of such therapies against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has ***,not all marketed drugs showing in vitro efficacy could achieve therapeutic concentrations in humans and discernment of drugs that have favorable pharmacokinetic properties can save time and resources for future studies.

关键词： treatment drugs finding

Cryogenic and conventional milling of AZ91 magnesium alloy

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Journal of Magnesium and Alloys 2024年第6期12卷 2503-2519页

作者： vikas Marakini Srinivasa pai p Gururaj Bolar Bhaskara p Achar Department of Mechanical Engineering Nitte(Deemed to be University)NMAM Institute of Technology(NMAMIT)Nitte 574110India Department of Mechanical and Industrial Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal 576104India

Use of magnesium is the need of the hour due to its low density as well as its high strength-to-weight and stiffness-to-weight ratio *** study focuses on the effectiveness of liquid nitrogen(LN_(2))assisted cryogenic machining on the surface integrity(SI)characteristics of AZ91 magnesium *** milling using uncoated carbide inserts have been performed under liquid nitrogen(LN_(2))assisted cryogenic condition and compared with conventional(dry)*** are performed using machining parameters in terms of cutting speeds of 325,475,625 m/min,feed rates of 0.05,0.1,0.15 mm/teeth and depth of cuts of 0.5,1,1.5 mm *** significant surface integrity characteristics such as surface roughness,microhardness,microstructure,and residual stresses have been *** of SI characteristics with respect to milling parameters have been identified using statistical technique such as ANOVA and signal-to-noise(S/N)ratio ***,the multi criteria decision making(MCDM)techniques such as additive ratio assessment method(ARAS)and complex proportional assessment(COpRAS)have been utilized to identify the optimal conditions for milling AZ91 magnesium alloy under both dry and cryogenic *** of LN_(2)during machining,resulted in reduction in machining temperature by upto 29%with a temperature drop from 251.2℃under dry condition to 178.5℃in cryogenic *** showed the advantage of performing cryogenic milling in improving the surface integrity to a significant *** machining considerably minimized the roughness by upto 28%and maximised the microhardness by upto 23%,when compared to dry *** speed has caused significant impact on surface roughness(95.33%-dry,92.92%-cryogenic)and surface microhardness(80.33%-dry,82.15%-cryogenic).Due to the reduction in machining temperature,cryogenic condition resulted in compressive residual stresses(maximumσ║=-113 Mpa)on the alloy *** indicate no

关键词： Magnesium alloy Cryogenic machining Roughness Microhardness Microstructure Residual stress Multi criteria decision making

Studies on induction hardening of powder-metallurgy-processed Fe–Cr/Mo alloys

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International Journal of Minerals,Metallurgy and Materials 2017年第8期24卷 918-925页

作者： Sandeep Chauhan vikas Verma Ujjwal prakash p.C.Tewari Dinesh Khanduja Department of Mechanical Engineering National Institute of Technology Department of Metallurgical & Materials Engineering Indian Institute of Technology

Induction hardening of dense Fe–Cr/Mo alloys processed via the powder-metallurgy route was studied. The Fe-3Cr-0.5Mo, Fe-1.5Cr-0.2Mo, and Fe-0.85 Mo pre-alloyed powders were mixed with 0.4wt%, 0.6wt%, and 0.8wt% C and compacted at 500, 600, and 700 Mpa, respectively. The compacts were sintered at 1473 K for 1 h and then cooled at 6 K/min. Ferrite with pearlite was mostly observed in the sintered alloys with 0.4wt% C, whereas a carbide network was also present in the alloys with 0.8wt% C. Graphite at prior particle boundaries led to deterioration of the mechanical properties of alloys with 0.8wt% C, whereas no significant induction hardening was achieved in alloys with 0.4wt% C. Among the investigated samples, alloys with 0.6wt% C exhibited the highest strength and ductility and were found to be suitable for induction hardening. The hardening was carried out at a frequency of 2.0 kHz for 2–3 s. A case depth of 2.5 mm was achieved while maintaining the bulk(interior) hardness of approximately HV 230. A martensitic structure was observed on the outer periphery of the samples. The hardness varied from HV 600 to HV 375 from the sample surface to the interior of the case hardened region. The best combination of properties and hardening depth was achieved in case of the Fe-1.5Cr-0.2Mo alloy with 0.6wt% C.

关键词： Fe–Cr/Mo alloys powder metallurgy sintered density tensile strength induction hardening case depth

Gamma Irradiation of Embryogenic Callus Cultures and In vitro Selection for Salt Tolerance in Sugarcane (Saccharum officinarum L.)

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Agricultural Sciences in China 2008年第9期7卷 1147-1152页

作者： vikas Y patade p Suprasanna V A Bapat plant Cell Culture Technology Section Nuclear Agriculture & Biotechnology DivisionBhabha Atomic Research Centre

Radiation induced mutagenesis followed by in vitro selection was employed for salt tolerance in popular Indian sugarcane （Saccharum officinarum L.） cv. CoC-671. Embryogenic calli were gamma irradiated and exposed to different levels of NaCl （42.8, 85.6, 128.3, 171.1,213.9, 256.7, 299.5, or 342.2 mM）. The relative growth rate （RGR） decreased progressively with increasing salt stress and was the least with a salt stress of 256.7 mM （0.25±0.009）, almost 10 fold lesser than the control. The RGR was significantly lower in 85.6 mM and higher salt stressed calli than the control. The survival percent also decreased, with an increase in NaCl concentration. In case of 10 and 20 Gy irradiated calli, regeneration was observed up to 85.6 mM NaCl selection, medium, whereas, higher treatments （128.3 mM and beyond） exhibited browning initially. However, in the subsequent subcultures, regeneration was obtained in the case of 10 and 20 Gy irradiated calli on 128.3 and 171.1 mM NaCl selections. Higher dose of gamma irradiation （40 Gy） also showed regeneration, but only with 85.6 mM NaCI selection. The unirradiated calli regenerated the highest number of plantlets followed by 10 and 20 Gy irradiated calli on salt selection. A total of 147 plantlets were selected from different salt levels. The salt selected plants are being tested for their field performance.

关键词： sugarcane in vitro mutagenesis in vitro selection salt tolerance

Synthesis,characterization and evaluation of polyacrylamide graft starch/clay nanocomposite hydrogel system for enhanced oil recovery

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petroleum Science 2017年第4期14卷 765-779页

作者： Rituraj Singh vikas Mahto Department of petroleum Engineering Indian Institute ofTechnology(Indian School of Mines)Dhanbad 826004India

In this paper the suitability of a graft polymer nanocomposite hydrogel system for enhanced oil recovery was examined using polyacrylamide graft starch/clay nanocomposite(a laboratory synthesized product) and chromium(III) acetate(crosslinker). X-ray diffraction analysis,Fourier transform infrared spectrometry analysis, field-emission scanning electron microscopy and transmission electron microscopy were carried out to reveal the laboratory synthesized product as a nanocomposite. The effects of various parameters like salt concentration, p H, temperature, polymer concentration and crosslinker concentration on the properties of the developed gel system were systematically *** thermal stability of the nanocomposite gel and the conventional gel system were also determined by thermogravimetric analysis. The graft polymer nanocomposite gel system exhibited acceptable gel strength, gelation time and gel stability compared with the conventional gel system. The nanocomposite gels prepared using a low crosslinker concentration showed higher gel strength and required longer gelation time than the conventional gel which is more desirable properties for the effective placement of gel during enhanced oil recovery operations. In addition, sand pack flooding experiments show that the graft polymer nanocomposite gels had better plugging capacity than the conventional gel systems under reservoir conditions. Hence, this gel system may be suitable in the water shutoff treatments required for enhanced oil recovery from oilfields.

关键词： Nanocomposite Graft polymer Nanoclay Hydrogel Water shutoff

HIGHER-ORDER NON-SYMMETRIC DUALITY FOR NONDIFFERENTIABLE MINIMAX FRACTIONAL pROGRAMS WITH SQUARE ROOT TERMS

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Acta Mathematica Scientia 2020年第1期40卷 127-140页

作者： SONALI vikas SHARMA Navdeep KAILEY School of Mathematics Thapar Institute of Engineering and TechnologyPatialaIndia

In this paper,we emphasize on a nondifferentiable minimax fractional programming(NMFp)problem and obtain appropriate duality results for higher-order dual model under higher-order B-(p,r)-invex *** provide a nontrivial illustration of a function which belongs to the class of higher-order B-(p,r)-invex but not in the class of second-order B-(p,r)-invex functions already existing in *** example of finding a minimax solution of NMFp problem by using higher-order B-(p,r)-invex functions has also been *** known results are discussed as particular cases.

关键词： nonlinear programming higher-order duality fractional programming minimax programming B-(p,r)-invexity

Immunostimulatory role of rBmHSp60 from filarial parasite Brugia malayi

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Asian pacific Journal of Tropical Biomedicine 2021年第1期11卷 20-28页

作者： vikas Kushwaha Sukhbir Kaur Leishmania Research Laboratory Department of ZoologyPanjab UniversitySector-14Chandigarh 160014India

Objective:To evaluate the immunostimulatory potential of crossreactive molecule heat shock protein 60(HSp60)of filarial parasite Brugia malayi and Leishmania ***:HSp60 of Brugia malayi(BmHSp60)was amplified using gene-specific primer,cloned in p Tri Ex4 vector,expressed in BL21-DE3 cells,and recombinant HSp60(rHSp60)of~65 k Da was purified by affinity chromatography using Ni-NTA *** recombinant protein was desalted by the dialysis membrane,and the presence of endotoxin level was determined by Limulus amebocyte lysate *** recombinant protein was tested for cell proliferation,nitric oxide release,expression of Th1 and Th2 cytokines,and transcription factors(STATs)in vitro using murine macrophage cell line(J774 A.1).Results:Higher cell proliferation indicated that BmHSp60 had immunostimulatory ***60 exposure upregulated the expression of iNOS,STAT1,STAT4,Th1 cytokines(IFN-γ,TNF-α,IL-12),and nitric oxide *** addition,no remarkable change was observed in the expression of IL-6,IL-10,and STAT3 in macrophage cell line J774 *** ELISA analysis showed the levels of IFN-γ,TNF-α,and IL-12 were upregulated while IL-10 level was downregulated,revealing that BmHSp60 triggered a Th1 immune ***:Our study demonstrates that rBmHSp60 has immunogenic properties which effectively enhances the Th1 type immune responses,and can be used as an immunoprophylactic agent against ***,in vivo studies are in progress to determine the protective role of rBmHSp60 against Leishmania donovani infection in a mouse model.

关键词： Brugia malayi Heat shock protein 60 Leishmania donovani Th1 cytokines Th2 cytokines

Facile In Situ Fabrication of Nanostructured Graphene–CuO Hybrid with Hydrogen Sulfide Removal Capacity

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Nano-Micro Letters 2016年第4期8卷 312-319页

作者： Sunil p.Lonkar Vishnu V.pillai Samuel Stephen Ahmed Abdala vikas Mittal Department of Chemical Engineering The Petroleum Institute

A simple and scalable synthetic approach for one-step synthesis of graphene–Cu O(TRGC) nanocomposite by an in situ thermo-annealing method has been *** graphene oxide(GO) and copper hydroxide as a precursors reagent,the reduction of GO and the uniform deposition of in situ formed Cu O nanoparticles on graphene was simultaneously *** method employed no solvents,toxic-reducing agents,or organic *** resulting nanostructured hybrid exhibited improved H2 S sorption capacity of 1.5 mmol H2S/g-sorbent(3 g S/100 g-sorbent).Due to its highly dispersed sub-20 nm Cu O nanoparticles and large specific surface area,TRGC nanocomposite exhibits tremendous potential for energy and environment applications.

关键词： CuO/graphene Adsorption Breakthrough capacity Hydrogen sulfide Thermal stability In situ synthesis

Effect of short- and long-term immunization of recombinant disorganized muscle protein-1(rDIM-1) against human filarial parasite Brugia malayi in rodents

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Asian pacific Journal of Tropical Medicine 2021年第7期14卷 287-298页

作者： vikas Kushwaha puvvada Kalpana Murthy Division of parasitology CSIR-Central Drug Research InstituteNew CampusBS 10/1Sector 10Jankipuram ExtensionSitapur RoadLucknow 226031India

Objective: To evaluate the effect of short-term and long-term immunization of recombinant disorganized muscle protein-1(r DIM-1) in rodents against human filarial parasite Brugia ***: Recombinant Brugia malayi DIM-1(rDIM-1 bm) protein was cloned, expressed and purified using a Ni-NTA affinity column. Mastomys coucha were immunized with rDIM-1 bm in three immunization schedules: short-term(3-dose of rDIM-1 bm), and long-term(booster doses till 3-and 6-week) and subsequently challenged with infective third-stage larvae of filarial parasite Brugia malayi(L3). Microfilaraemia was monitored in L3 exposed groups on day 90 post larval inoculation(p.l.i.) and continued till day 205 p.l.i. On day 205 p.l.i. all the infected animals were killed and total worm burden was estimated. Cellular proliferative response, macrophage activity, nitric oxide(NO) release, specific IgG and its subtypes, IgE, IgA and Th1(IFN-γ, TNF-ααand IL-2) and Th2(IL-4, IL-5, IL-6, IL-10 and IL-13) cytokine release were determined. Results: Of the 3 different immunization schedules, shortterm immunization(3-dose schedule) showed better reduction in microfilarial burden(36%-63%) in the peripheral circulation, adult worm load(52%), whereas long-term immunization(3-and 6-week schedule) exerted less effect on peripheral microfilariae count(9%-58%), and adult worm burden(9%-12.5%). Short-term immunization resulted in upregulation of cellular proliferation, macrophages activity, NO release, specific IgG, IgG1, IgG2 a, Ig G2 b, IgE and IgA levels and both Th1(IFN-γ, TNF-α and IL-2) and Th2(IL-4, IL-5, IL-6, IL-10 and IL-13) cytokine release whereas long-term immunization(3-and 6-week schedule) exerted less effect on parasite burden and showed mixed immunological responses. None of the rDIM-1 bm administration schedules induced any pathology in lymphoid tissues, or alteration in mast cell number and granularity. Conclusions: The short-term immunization with rDIM-1 bm(3-dose schedule) induces robust i

关键词： Brugia malayi Disorganized muscle protein-1 Th1/Th2 cytokines Macrophage activity