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Anticoagulant use before COVID-19 diagnosis prevent COVID-19 associated acute venous thromboembolism or not:A systematic review and meta-analysis

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World Journal of Methodology 2024年第3期14卷 141-162页

作者： Kinza Iqbal Akshat Banga Taha Bin Arif Sawai Singh Rathore Abhishek Bhurwal Syeda Kisa Batool Naqvi Muhammad Mehdi Pankaj Kumar Mitali Madhu Salklan Ayman Iqbal Jawad Ahmed Nikhil Sharma Amos Lal Rahul Kashyap vikas Bansal Juan Pablo Domecq Department of Internal Medicine Dow Medical CollegeKarachi 74200Pakistan Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Internal Medicine Dr.Sampurnanand Medical CollegeJodhpur 342003RajasthanIndia Department of Gastroenterology and Hepatology Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Department of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Research Wellspan HealthYorkPA 17403United States

BACKGROUND Coagulopathy and thromboembolic events are associated with poor outcomes in coronavirus disease 2019(COVID-19)*** is conflicting evidence on the effects of chronic anticoagulation on mortality and severity of COVID-19 *** To summarize the body of evidence on the effects of pre-hospital anticoagulation on outcomes in COVID-19 *** A Literature search was performed on LitCovid PubMed,WHO,and Scopus databases from inception(December 2019)till June 2023 for original studies reporting an association between prior use of anticoagulants and patient outcomes in adults with *** primary outcome was the risk of thromboembolic events in COVID-19 patients taking *** outcomes included COVID-19 disease severity,in terms of intensive care unit admission or invasive mechanical ventilation/intubation requirement in patients hospitalized with COVID-19 infection,and *** random effects models were used to calculate crude and adjusted odds ratios(aORs)with 95%confidence intervals(95%CIs).RESULTS Forty-six observational studies met our inclusion *** unadjusted analysis found no association between prior anticoagulation and thromboembolic event risk[n=43851,9 studies,odds ratio(OR)=0.67(0.22,2.07);P=0.49;I2=95%].The association between prior anticoagulation and disease severity was non-significant[n=186782;22 studies,OR=1.08(0.78,1.49);P=0.64;I2=89%].However,pre-hospital anticoagulation significantly increased all-cause mortality risk[n=207292;35 studies,OR=1.72(1.37,2.17);P<0.00001;I2=93%].Pooling adjusted estimates revealed a statistically non-significant association between pre-hospital anticoagulation and thromboembolic event risk[aOR=0.87(0.42,1.80);P=0.71],mortality[aOR=0.94(0.84,1.05);P=0.31],and disease severity[aOR=0.96(0.72,1.26);P=0.76].CONCLUSION Prehospital anticoagulation was not significantly associated with reduced risk of thromboembolic events,improved survival,and lower disease seve

关键词： Prior anticoagulation COVID-19 Prehospital anticoagulation Chronic anticoagulation Mortality Severity Thromboembolic events

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与授权代理商进行商业往来的好处

今日电子 2009年第9期 63-63页

作者： Ro chawla Altera亚太区

亚太地区的分销市场正在掀起一轮合并风潮。一些较大的代理商（包括全球代理商与中国大陆及台湾地区的大型本地代理商）纷纷收购那些规模较小的零售商。这种变化使得半导体公司必须不断调整他们的需求创造能力。

关键词：代理商商业授权半导体公司亚太地区台湾地区中国大陆创造能力

All ileo-cecal ulcers are not Crohn's:Changing perspectives of symptomatic ileocecal ulcers

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World Journal of Gastrointestinal Endoscopy 2017年第7期9卷 327-333页

作者： Jay Toshniwal Romesh chawlani Amit Thawrani Rajesh Sharma Anil Arora Hardik L Kotecha Mohan Goyal Vijendra Kirnake Pankaj Jain Pankaj Tyagi Naresh Bansal Munish Sachdeva Piyush Ranjan Mandhir Kumar Praveen Sharma vikas Singla Rinkesh Bansal Vineet Shah Sunita Bhalla Ashish Kumar Department of Gastroenterology Dr.Toshniwal’s Gastro-Liver Care Department of Gastroenterology Sir Gangaram Hospital Department of Histo-pathology Sir Gangaram Hospital

To investigated clinical, endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy. METHODSConsecutive symptomatic patients undergoing colonoscopy, and diagnosed to have ulcerations in the ileocecal (I/C) region, were enrolled. Biopsy was obtained and their clinical presentation and outcome were recorded. RESULTSOut of 1632 colonoscopies, 104 patients had ulcerations in the I/C region and were included in the study. Their median age was 44.5 years and 59% were males. The predominant presentation was lower GI bleed (55, 53%), pain abdomen ± diarrhea (36, 35%), fever (32, 31%), and diarrhea alone (9, 9%). On colonoscopy, terminal ileum was entered in 96 (92%) cases. The distribution of ulcers was as follows: Ileum alone 40% (38/96), cecum alone 33% (32/96), and both ileum plus cecum 27% (26/96). The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon. Based on clinical presentation and investigations, the etiology of ulcers was classified into infective causes (43%) and non-infective causes (57%). Fourteen patients (13%) were diagnosed to have Crohn’s disease (CD). CONCLUSIONNon-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region. And if all infections are clubbed together then infection is the most common (> 40%) cause of ulcerations of the I/C region. Cecal involvement and fever are important clues to infective cause. On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers. So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn’s.

关键词： Ileocecal Crohn’s disease Diffuse large B-cell non-hodgkin’s lymphoma

印度在线零售商的新策略他们用自己的方式挑战亚马逊

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经理人 2011年第10期 26-26页

作者： vikas Bajaj

几个月前，软件工程师普拉布·库马尔在亚马逊网站找到了一本他在本地书店买不到的书，价格是10美元，但要亚马逊把书送到他手里的话，他还要支付超过9美元的运费。不过库马尔现在不必这么做了，他已经找到另外一家在线书店FlipKart，... 详细信息

几个月前，软件工程师普拉布·库马尔在亚马逊网站找到了一本他在本地书店买不到的书，价格是10美元，但要亚马逊把书送到他手里的话，他还要支付超过9美元的运费。不过库马尔现在不必这么做了，他已经找到另外一家在线书店FlipKart，该网站可以在24小时之内把书籍、电话等物品送货上门，而且不收取额外的费用。书送到后，他既可以用现金结算，也可以用信用卡结算。

关键词：亚马逊网站在线零售商印度现金结算软件工程师信用卡书店美元

Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup

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World Journal of Gastroenterology 2012年第26期18卷 3400-3408页

作者： Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel vikas Singh Anne Marie Lennon Daniel C DeMarco Department of Gastroenterology and Hepatology University Medical Center Utrecht3508 GA UtrechtThe Netherlands Division of Gastroenterology and Hepatology Kansas City Veterans Administration Medical CenterKansas CityMO 64128United States Department of Gastroenterology Bayside Endoscopy Center33 Staniford StreetProvidenceRI 02905United States Department of Gastroenterology Cliniques Universitaires Saint-LucUniversité Catholique de LouvainB-1200 BrusselsBelgium Department of Gastroenterology and Hepatology Dartmouth-Hitchcock Medical CenterOne Medical Center DriveLebanonNH 03756United States Department of Gastroenterology Istituto Clinico Humanitas20089 RozzanoItaly Department of Internal Medicine Division of Gastroenterology and HepatologyJohns Hopkins HospitalBaltimoreMD 21205United States Wolfson Unit for Endoscopy St.Mark's HospitalHarrow HA1 3UJUnited Kingdom Department of Internal Medicine Division of GastroenterologyBaylor University Medical CenterDallasTX 75246United States

AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial ***:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward *** performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the *** were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice ***:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was *** reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to *** risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic *** RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic *** a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically ***

关键词： Colonoscopy Colorectal cancer Adenomas Miss rates Retrograde-viewing

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太阳能新天地

经理人 2012年第2期 21-21页

作者： vikas Bajaj

Azure Power公司在印度北部运营着占地63公顷、太阳能电池板数目多达36000块的太阳能发电站，但是每隔5天，便会上演一出高科技和人工的“结合”—_丁人们用长把拖布将每一块电池板从上到下地抹一遍。印度的国家电网因供电不足而臭名昭... 详细信息

Azure Power公司在印度北部运营着占地63公顷、太阳能电池板数目多达36000块的太阳能发电站，但是每隔5天，便会上演一出高科技和人工的“结合”—_丁人们用长把拖布将每一块电池板从上到下地抹一遍。印度的国家电网因供电不足而臭名昭著，于是为了用太阳能升级国家电网、也为了减少对火电厂的依赖，印度制定了许多雄心勃勃的计划，这就是其中之一。

关键词：太阳能电池板天地国家电网 Power 发电站高科技火电厂印度

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印度成外资热门市场

经理人 2010年第12期 24-24页

作者： vikas Bajaj

两年前，当华尔街的金融危机达到顶峰时，由于外国投资者从印度抽走了将近50亿美元的资金，原本一路走高的印度股市陡跌。

关键词：印度市场热门外资外国投资者金融危机华尔街资金

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让视障患者“看见”东西的智能眼镜

学苑创造(7-9年级阅读) 2018年第Z2期 42-42页

作者： Karan chawla Rishabh Doshi

Theia Vision智能眼镜是一款人类增强装置,可以帮助视障用户认知周围环境,是视障用户的超级眼睛。Theia Vision由一个可搭载在眼镜腿上的相机和手机APP组成,它可以把实况视频转换为音频反馈让佩戴者听到。也就是说戴上这个智能眼镜,就... 详细信息

Theia Vision智能眼镜是一款人类增强装置,可以帮助视障用户认知周围环境,是视障用户的超级眼睛。Theia Vision由一个可搭载在眼镜腿上的相机和手机APP组成,它可以把实况视频转换为音频反馈让佩戴者听到。也就是说戴上这个智能眼镜,就可以把所看到的所有事物翻译成音频传递给用户。

关键词：视障用户智能眼镜

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弹性纳米复合材料的最新研究进展

国外科技新书评介 2011年第12期 22-22页

作者： vikas Mittal 鞠思婷不详国家纳米科学中心

弹性纳米高分子材料是一类重要的高分子材料，将纳米填料与弹性体复合能够产生弹性性能显著提高的复合材料，从而扩大了此类材料的应用潜力。本书主要介绍了弹性纳米复合材料的合成、加工以及应用的最新科研进展。本书的内容主要分为三... 详细信息

弹性纳米高分子材料是一类重要的高分子材料，将纳米填料与弹性体复合能够产生弹性性能显著提高的复合材料，从而扩大了此类材料的应用潜力。本书主要介绍了弹性纳米复合材料的合成、加工以及应用的最新科研进展。本书的内容主要分为三大部分：1．简介弹性纳米复合材料及其制备方法；2．重点介绍弹性纳米复合材料的性能；3．描述弹性纳米复合材料的应用潜力。

关键词：纳米复合材料弹性性能高分子材料纳米填料制备方法体复合应用