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世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 45-46页

作者： Chockalingam A. Gnanavelu G. venkatesan S. 高登峰 Department of Cardiology Madras Medical College Research Institute Chennai 600 003 India

Purpose: We aimed to assess the effects of sildenafil and evaluate optimal dosing in primary pulmonary hypertension(PPH). Sildenafil selectively inhibits phosphodiesterase 5(PDE5), which is abundant in pulmonary and penile tissue. This results in increasing nitric oxide(NO) at tissue level leading to pulmonary vasodilatation. Subjects and methods: Our study was a prospective study of sildenafil in 15 consecutive patients with severe symptomatic PPH of NYHA class III-IV. All patients were stabilized for a minimum period of 5 days with antifailure medications. Sildenafil was started at 50 mg twice daily for 4 weeks and increased to 100 mg bid for 4 more weeks in a step-up protocol. Primary end-points were change in Borg dyspnea index, NYHA class and 6-min walk distance, estimated at baseline 1, 2, 4 and 8 weeks. Results: NYHA class(baseline 3.8±0.4 vs. 4 weeks 2.4±0.5, p=0.002),Borg dyspnea index(8.1±1.7 vs. 4.4±1.9, p=0.0007), 6-min walk distance(234±44 vs. 377±128 m, p=0.001) and Pulmonary artery pressure(125±15 vs. 113±18 mm Hg p=0.05) are significantly improved with sildenafil 50 mg bid at 4 weeks. Increasing the dose to 100 mg bid did not produce further benefit. Echocardiography parameters of right heart dimensions and functions did not change markedly in the study period. Conclusion: Sildenafil is well tolerated with no adverse effects in severe pulmonary hypertension. It reduces symptoms, improves effort tolerance and controls refractory heart failure significantly by 2 weeks in 70%of patients at 50 mg twice daily.

关键词：最佳剂量多芬肺动脉高压呼吸困难难治性心力衰竭治疗终点基础水平磷酸二酯酶肺动脉压药物治疗

甲基化转移酶EZH2通过甲基化踝蛋白调控白细胞的黏附和迁移

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中国肿瘤生物治疗杂志 2015年第4期22卷 535-535页

作者：李霞张迁 Gunawan M venkatesan N Loh JT

在免疫反应中,白细胞经过系列的表型改变快速向外周和淋巴组织浸润。招募循环系统中的中性粒细胞和DC细胞前体至炎症部位取决于整合素分子的相互识别与结合,和这些细胞沿血管内皮细胞的滚动。迁移的动态过程需要大量的胞质和穿膜蛋白分... 详细信息

在免疫反应中,白细胞经过系列的表型改变快速向外周和淋巴组织浸润。招募循环系统中的中性粒细胞和DC细胞前体至炎症部位取决于整合素分子的相互识别与结合,和这些细胞沿血管内皮细胞的滚动。迁移的动态过程需要大量的胞质和穿膜蛋白分子的协同作用,并且这些蛋白分子的功能通常被蛋白翻译后修饰精确调控。踝蛋白(Talin)在调控细胞迁移中发挥重要作用,该蛋白可以直接将整合素连接到细胞骨架的肌动蛋白上。

关键词：踝蛋白 EZH2 翻译后修饰整合素分子炎症部位蛋白分子血管内皮细胞免疫反应细胞骨架甲基化转移酶

以阅片者和病例为变量的乳腺X线照片特殊表现的阳性预测值

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国际医学放射学杂志 2009年第3期 274-275页

作者： A.venkatesan K.Kerlikowske E.A.Sickles R.Smith-Bindman 黄庭 School of Medicine University of CaliforniaSan Francisco513 Parnassus AveRoom S-245San FranciscoCA 94143-0454USA

目的评价在乳腺照片检查中异常结果与特殊表现(肿块、钙化、结构扭曲、不对称)相关的癌症的危险性(阳性预测值),以确定这些表现在诊断为癌症或非癌症病人中的分布,并分析以阅片者和病人为因子的阳性预测值的离散度(variation)。方法本... 详细信息

目的评价在乳腺照片检查中异常结果与特殊表现(肿块、钙化、结构扭曲、不对称)相关的癌症的危险性(阳性预测值),以确定这些表现在诊断为癌症或非癌症病人中的分布,并分析以阅片者和病人为因子的阳性预测值的离散度(variation)。方法本研究得到伦理委员会的批准,并符合HIPAA。

关键词：乳腺乳房侵袭性癌阳性预测值特殊表现病例照片

High Efficient Reconfigurable and Self Testable Architecture for Sensor Node

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Computer Systems Science & Engineering 2023年第9期46卷 3979-3991页

作者： G.venkatesan N.Ramadass Department of Electronics and Instrumentation Engineering Meenakshi College of EngineeringChennaiIndia Department of Electronics and Communication Engineering CEG CampusAnna UniversityChennaiIndia

Sensor networks are regularly sent to monitor certain physical properties that run in length from divisions of a second to many months or indeed several *** must advance their energy use for expanding network *** fault detection of the network node is very significant for guaranteeing the correctness of monitoring *** to different network resource constraints and malicious attacks,security assurance in wireless sensor networks has been a difficult *** implementation of these features requires larger space due to distributed *** research work proposes new sensor node architecture integrated with a self-testing core and cryptoprocessor to provide fault-free operation and secured data *** proposed node architecture was designed using Verilog programming and implemented using the Xilinx ISE tool in the Spartan 3E *** proposed system supports the real-time application in the range of 33 *** obtained results have been compared with the existing Microcontroller-based *** power consumption of the proposed system consumes only 3.9 mW,and it is only 24%percentage of AT mega-based node architecture.

关键词： Cryptography FPGA microcontroller sensor node reconfigurable architecture

Antiurolithiatic activity of Aavarai Bhavanai Chooranam a Siddha polyherbal formulation on ethylene glycol-induced urolithiasis in Wister albino rats

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Drug Combination Therapy 2022年第4期4卷 25-29页

作者： Harishanbuselvan venkatesan Arthi Gurumurthy Rathinam Jayaraj Lakshmanakumar Venkatachalam Resident Medical Officer National Institute of SiddhaChennai 600047Tamil NaduIndia Sai Siddha Clinic Salem 636354Tamil NaduIndia Govt upgraded Primary Health Centre EriayamangalamNamakkal 637210Tamil NaduIndia All India Institute of Medical Sciences(AIIMS) Raipur 492099ChattishgarhIndia

Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for the management of ***:The study is carried out to scientifically validate the traditional formulation and to study the mechanism of ***:In the present study,the antiurolithiatic activity of ABC was evaluated in Wister albino rats by using ethylene glycol through drinking *** I acted as the standard control group and was given unlimited access to conventional rat food and *** II-V was given ethylene glycol(0.75%)in water to induce renal calculi for 28 *** III got the typical anti-urolithiatic medication,Cystone(750 mg/kg),from the 15th day to the 28th day,whereas Group II functioned as the lithiatic control group and received the *** Bhavanai Chooranam(200 mg/kg)was administered to Group IV from the 15th to the 28th day as a curative *** the first day to the 28th day,Group V received Aavarai Bhavanai Chooranam(200 mg/kg),which was administered as a preventative *** groups'urine samples were taken,and using accepted techniques,their calcium,magnesium,oxalate,inorganic phosphate,protein,and creatinine levels were *** treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline condition in the urinary system which probably mediates the antilithiatic ***:ABC provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.

关键词： Aavarai Bhavanai Chooranam ethylene glycol kalladaippu Siddha drug urolithiasis

Mortality of critical care interventions in the COVID-19:A systematic review

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World Journal of Meta-Analysis 2021年第1期9卷 64-73页

作者： Joshua Davis Rebecca Leff Anuj Patel Sriram venkatesan Department of Emergency Medicine VituityWichitaKS 67214United States School of Medicine Faculty of Health SciencesBen-Gurion University of the NegevBeer-Sheva 8414501Israel College of Osteopathic Medicine University of New EnglandBiddefordME 04005United States College of Medicine Sri Ramachandra Medical College and Research InstituteChennai 600116India

BACKGROUND The novel coronavirus severe acute respiratory syndrome coronavirus 2 is associated with a severe disease known as coronavirus disease 2019(COVID-19).A small percentage of patients with COVID-19 will require intensive care and possibly mechanical *** mortality of intensive care interventions in patients with COVID-19 remains *** To identify mortality rate of COVID-19 patients receiving different interventions in the critical care *** We searched OVID Medline,SCOPUS,MedRxIv,***,and Centers for Disease Control databases from November 2019 to April 10,2020 for articles on *** of 2 independent reviewers reviewed titles and abstract for studies that reported mortality of human adults with COVID-19 and exposure to a critical care intervention[Intensive care admission,mechanical ventilation,acute hemodialysis,extracorporeal membrane oxygenation,or cardiopulmonary resuscitation(CPR)].We used a descriptive analysis and unweighted averages of mortality across *** Our search identified 6973 articles and 20 met inclusion:17 for intensive care,13 for mechanical ventilation,5 for hemodialysis,2 for extracorporeal membrane oxygenation,and 1 for *** associated with intensive care admission ranged from 9%-83%,with overall mortality 32.5%(95%CI:32.4%-32.6%).Mortality associated with intubation from 16.7%-100%with overall mortality 64.0%(95%CI:62.4%-65.5%).In patients requiring hemodialysis,mortality ranged from 0%-100%,with average mortality 75.3%(95%CI:72.6%-77.4%).CONCLUSION Patients with COVID-19 requiring intensive care have high mortality *** can use this data to establish pharmacoeconomic studies to make decisions about allocation of scarce resources if necessary.

关键词： Coronavirus SARS-CoV-2 COVID-19 Mortality Systematic review Critical care

Molecular docking analysis to validate the efficacy of traditional Siddha polyherbal Formulation Aavarai Bhavanai Chooranam(ABC)against enzyme alpha-glucosidase for Type II Diabetes Mellitus

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TMR Integrative Medicine 2023年第1期7卷 1-11页

作者： Venkatachalam Lakshmanakumar Gurumurthy Arthi Jayaraj Rathinam venkatesan Harishanbuselvan Dhanasekaran Sivaraman AIIMS Raipur Chhattisgarh 492099India Sai Siddha Clinic SalemTamil Nadu 636354India GUPHC EriyamangalamNamakkal 637210Tamil NaduIndia National Institute of Siddha ChennaiTamil Nadu 600047India Department of Biotechnology Pandit Deenadayal Energy UniversityKnowledge CorridorRaisan VillagePDPU RoadGandhi NagarGujarat 382426India

Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable *** more than 62 million people in India already living with diabetes,the disease is quickly gaining the status of a possible *** has been demonstrated that this medical theory contains anti-diabetic *** goal of this work is to assess in silico computational investigations of the phytoconstituents in the traditional Siddha polyherbal preparation ABC,which is frequently used to treat ***:Alpha-Glucosidase was used as the target enzyme in docking calculations for recovered *** the help of Auto Dock tools,necessary hydrogen atoms,Kollman unified atom type charges,and solvation parameters were *** Lamarckian genetic algorithm and the Solis and Wets local search approach were used to simulate ***:A total of 13 bioactive lead compounds were identified from the Siddha Formulation *** to the herb’s stated data,the target enzyme Alpha-Glucosidase can interact with the phytochemicals Beta-Sitosterol,Amyrin,Lupeol,Arjunic acid,Arjungenin,Tinosporide,and Tembetarine up to four or five *** second-placed substances,which had a maximum of two to three interactions with the target enzyme Alpha-Glucosidase,were betulonic acid,kaempferol,gallic acid,and ***:The implementation of these formulations in future preclinical and clinical studies could result in the effective management of Type II Diabetes Mellitus.

关键词： Aavarai Bhavanai Chooranam molecular docking polyherbal diabetes traditional siddha

Experimental Investigation on the Properties of Manganese Phosphate Coating on AISI D2 Tool Steel

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材料科学与工程（中英文版） 2011年第4期5卷 455-461页

作者： Anant K. Arulmozhi Ilaiyavel S Aditya Sai. V. Neethi Murali venkatesan A Department of Mechanical Engineering Sri Venkateswara College of Engineering TN India Department of Chemical Engineering Sri Venkateswara College of Engineering TN India

Manganese Phosphating is the most widely used metal pre treatment process for the surface treatment and finishing of ferrous metals. Due to its economy, speed of operation and ability to afford excellent corrosion resistance, wear resistance, adhesion and oil retaining properties, which ultimately improves its lubricating properties, it plays a significant role in the manufacturing and process industries. ASTM A681 or AISI D2 tool steel is a versatile high-carbon, high-chromium, air-hardened tool steel, which has been taken for this study is a highly wear resistance steel, used for making dies, punches, tools and cutters. But it posses mild resistance to corrosion at hardened condition though it has chromium content in it. Thus the aim of the present study is to investigate the corrosion resistance, oil retaining and adhesive properties of manganese phosphate coated AISI D2 Tool steel at various surface roughness values (Ra). Corrosion analysis using scanning electron microscope (SEM) images has also been carried out and the results provide some useful information pertaining to manganese phosphate coatings.

关键词： AISI 润滑性能工具钢磷化膜扫描电子显微镜锰实验金属表面处理

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