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Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2137-2152页

作者： Tarik Zahr vijay K.Boda Jian Ge Lexiang Yu Zhongzhi Wu Jianwen Que Wei Li Li Qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNY 10032USA Department of Molecular Pharmacology and Therapeutics Columbia UniversityNew YorkNY 10032USA Department of Pharmaceutical Sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Division of Digestive and Liver Diseases Columbia UniversityNew YorkNY 10032USA Center for Human Development Columbia UniversityNew YorkNY 10027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 10032USA Department of Medicine Columbia UniversityNew YorkNY 10032USA

Estrogen is imperative to mammalian reproductivity,metabolism,and ***,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain *** contrast,ERβis more broadly expressed in metabolic tissues and the ***,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERα***,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or *** of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in *** further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound ***,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.

关键词： Estrogen receptorβ Aging Metabolism Skin injury Muscle metabolism Small molecule conjugates Regeneration Adiposity

Multidimensional evaluation of salt tolerance in groundnut genotypes through biochemical responses

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Oil Crop Science 2024年第2期9卷 102-110页

作者： Rushita D.Parmar Vaishali G.Varsani vijay Parmar Suhas Vyas Dushyant Dudhagara Department of Life Sciences Bhakta Kavi Narsinh Mehta UniversityJunagadhGujaratIndia

The manuscript explores the complex interplay between groundnut genotypes,salt tolerance and hormonal influence,shedding light on the dynamic responses of three specific groundnut genotypes,KDG-128,TG-37 A and GG-20,to salt treatments and gibberellic acid(GA3).The study encompasses germination,plant growth,total protein content and oil content as key *** comprehensive analysis,it identifies TG-37 A and KDG-128 as salt-tolerant genotypes,and GG-20 as salt-susceptible genotypes,which highlighting the potential for targeted breeding efforts to develop more resilient groundnut ***,the quantification of protein and oil content under different treatments provides vital data for optimizing nutritional profiles in groundnut *** Component Analysis(PCA) underscores the significance of the first principal component(PC1)in explaining the majority of variance,capturing primary trends and differences in plant *** of Variance(ANOVA) and hierarchical analysis confirm the presence of statistically significant differences in protein and oil content among the ***'s correlation coefficient matrix analysis reveals strong positive correlations between plant length and protein content,plant length and oil content,and a moderately positive correlation between protein content and oil *** findings provide valuable insights into groundnut physiology,salt tolerance,and nutritional composition,with implications for future research in sustainable agriculture and crop improvement.

关键词： Groundnut Salt tolerance Genotypes Salt-hormone interaction Protein and oil content Statistical analysis

Biorenewable materials for water remediation: The central role of cellulose in achieving sustainability

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Journal of Bioresources and Bioproducts 2024年第3期9卷 253-282页

作者： Kirti Mishra Samarjeet Singh Siwal Thandiwe Sithole Nirankar Singh Phil Hart vijay Kumar Thakur Department of Chemistry M.M.Engineering CollegeMaharishi Markandeshwar(Deemed to be University)Haryana 133207India Department of Chemical Engineering University of JohannesburgDoornfontein 2088South Africa Biorefining and Advanced Materials Research Center Scotland’s Rural CollegeEdinburgh EH93JGUnited Kingdom Renewable and Sustainable Energy Research Centre Technology Innovation InstituteAbu Dhabi 9639United Arab Emirates School of Engineering University of Petroleum&Energy StudiesDehradun 248007India

As the population increases and manufacturing grows,greenhouse gas and other harmful emissions *** with chemicals such as dyes,pesticides,pharmaceuticals,oil,heavy metals or radionuclides,wastewater purification has become an urgent *** technologies exist that can remove these contaminants from wastewater sources,but they often demand high energy and/or high cost,and in some cases produce contaminant laden sludge that requires safe *** need for methods which are less capital intensive,less operationally costly and more environmentally friendly is ***-based materials have emerged as promising candidates for wastewater treatment due to their renewability,low cost,biodegradability,hydrophilicity,and antimicrobial *** this review article,we focussed on developing sustainable and biodegradable cellulose-based materials for wastewater *** article deals with cellulose-based materials’scope and their conversion into valuable products like hydrogel,aerogel,cellulose composites,and *** cellulose-based materials have no harmful environmental impact and are *** modified cellulose-based materials applying as membrane,adsorbent,sorbent,and beads to purify the wastewater were ***,the challenges and future prospects of cellulose-based materials for wastewater treatment were considered,emphasizing their potential to be sustainable and eco-friendly alternatives to traditional materials used in wastewater treatment.

关键词： Cellulose Wastewater treatment Hydrogel Nanocrystal Cellulose membrane

A Framework for Cybersecurity Alert Distribution and Response Network (ADRIAN)

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Journal of Software Engineering and Applications 2024年第5期17卷 396-420页

作者： Akarshita Shankar vijay Madisetti School of Cybersecurity and Privacy Georgia Institute of Technology Atlanta USA

Security Information and Event Management (SIEM) platforms are critical for organizations to monitor and manage their security operations centers. However, organizations using SIEM platforms have several challenges such as inefficiency of alert management and integration with real-time communication tools. These challenges cause delays and cost penalties for organizations in their efforts to resolve the alerts and potential security breaches. This paper introduces a cybersecurity Alert Distribution and Response Network (Adrian) system. Adrian introduces a novel enhancement to SIEM platforms by integrating SIEM functionalities with real-time collaboration platforms. Adrian leverages the uniquity of mobile applications of collaboration platforms to provide real-time alerts, enabling a two-way communication channel that facilitates immediate response to security incidents and efficient SIEM platform management. To demonstrate Adrian’s capabilities, we have introduced a case-study that integrates Wazuh, a SIEM platform, to Slack, a collaboration platform. The case study demonstrates all the functionalities of Adrian including the real-time alert distribution, alert customization, alert categorization, and enablement of management activities, thereby increasing the responsiveness and efficiency of Adrian’s capabilities. The study concludes with a discussion on the potential expansion of Adrian’s capabilities including the incorporation of artificial intelligence (AI) for enhanced alert prioritization and response automation.

关键词： SIEM Platforms Alert Distribution Incident Response Automation SIEM Management Collaboration Platform

高速火焰喷涂VC-CuNiCr涂层的耐腐蚀性能

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Journal of Central South University 2024年第5期31卷 1385-1397页

作者： SINGH Vikrant BANSAL Anuj SINGLA Anil Kumar KUMAR vijay Sant Longowal Institute of Engineering and Technology Longowal Sangrur 148106India Industrial and Production Engineering Department Dr B R Ambedkar National Institute of TechnologyJalandhar 144011India

本研究采用高速火焰喷涂(HVOF)沉积技术,将碳化钒(VC)和铜镍铬(CuNiCr)复合涂层应用于SS316不锈钢上,以解决不锈钢在海洋环境中的腐蚀问题。在室温环境下,在3.5%氯化钠溶液中进行电化学腐蚀,通过扫描电子显微镜(SEM)和能量色散光谱(EDS... 详细信息

本研究采用高速火焰喷涂(HVOF)沉积技术,将碳化钒(VC)和铜镍铬(CuNiCr)复合涂层应用于SS316不锈钢上,以解决不锈钢在海洋环境中的腐蚀问题。在室温环境下,在3.5%氯化钠溶液中进行电化学腐蚀,通过扫描电子显微镜(SEM)和能量色散光谱(EDS)对有涂层和未覆涂层样品的表面形貌进行检测。结果表明,涂层内由铜(Cu)、镍(Ni)和铬(Cr)组成的金属间黏合剂在氯化钠介质的影响下发生变质,从而导致出现衬底间的局部点蚀现象。有趣的是,在涂层配方中加入碳化钒(VC)显著地增强了表面的耐腐蚀性能,从而阻止了密闭腐蚀凹坑的出现。在不同类的涂层中,加入VC的效果最好,最小的腐蚀速率为72.38×10^(-3)mm/a,相比之下,SS316基底的腐蚀速率最快。

关键词：高速火焰喷涂碳化钒铜镍铬电化学腐蚀氯化钠溶液

Advancing orthopaedic trauma care through WhatsApp:An analysis of clinical and non-clinical applications,challenges,and future directions

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World Journal of Orthopedics 2024年第6期15卷 529-538页

作者： Ravi Saini Madhan Jeyaraman Naveen Jeyaraman vijay Kumar Jain Swaminathan Ramasubramanian Karthikeyan P Iyengar Department of Orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr Ram Manohar Lohia HospitalNew Delhi 110001India Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Trauma and Orthopaedics Southport and Ormskirk HospitalsMersey and West Lancashire Teaching NHS TrustSouthport PR86PNUnited Kingdom

The integration of WhatsApp,a widely-used instant messaging application(IMA),into the realm of orthopaedics and trauma surgery has emerged as a significant development in recent *** paper explores the multifaceted role of WhatsApp in orthopaedics,focusing on its clinical and non-clinical applications,advantages,disadvantages,and future *** study synthesizes findings from various research papers,emphasizing the growing reliance on mobile technology in ***’s role in orthopaedics is notable for its ease of use,real-time communication,and ***,it facilitates triage,teleconsultation,diagnosis,treatment,patient advice,and post-operative ***-clinically,it supports telemedicine,teleradiology,virtual frac-ture clinics,research,and education in orthopaedic *** application has proven beneficial in enhancing communication among healthcare teams,providing quick responses,and motivating junior *** use in educational settings has been shown to improve learner’s understanding and patient ***,the use of WhatsApp in orthopaedics is not without *** include the potential spread of misleading information,privacy concerns,and issues with image quality affecting diagnosis and treatment *** paper acknowledges the importance of maintaining professional boundaries and the need for oversight measures to ensure content *** forward,the potential of WhatsApp and similar IMAs in orthopaedics lies in their ability to streamline data collection and retrieval,improve doctor-patient communication,and address challenges like bureaucratic red tape and limited *** paper suggests that future orthopaedic practice,particularly in emergency departments,will increasingly rely on such technologies for efficient patient *** shift,however,must be approached with an understanding of the ethical,legal,and practical implications of integrating social media and mobile

关键词： Social media WhatsApp Orthopaedics Trauma Research

Certis: Cloud Asset Management & Threat Evaluation Using Behavioral Fingerprinting at Application Layer

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Journal of Software Engineering and Applications 2024年第6期17卷 474-486页

作者： Kumardwij Bhatnagar vijay K. Madisetti School of Cybersecurity & Privacy Georgia Institute of Technology Atlanta GA USA

This paper introduces Certis, a powerful framework that addresses the challenges of cloud asset tracking, management, and threat detection in modern cybersecurity landscapes. It enhances asset identification and anomaly detection through SSL certificate parsing, cloud service provider integration, and advanced fingerprinting techniques like JARM at the application layer. Current work will focus on cross-layer malicious behavior identification to further enhance its capabilities, including minimizing false positives through AI-based learning techniques. Certis promises to offer a powerful solution for organizations seeking proactive cybersecurity defenses in the face of evolving threats.

关键词： Certis SSL Certificate Parsing JARM Fingerprinting Anomaly Detection Proactive Defense

Sher: A Secure Broker for DevSecOps and CI/CD Workflows

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Journal of Software Engineering and Applications 2024年第5期17卷 321-339页

作者： Pranau Kumar vijay K. Madisetti School of Cybersecurity and Privacy Georgia Institute of Technology Atlanta USA

GitHub Actions, a popular CI/CD platform, introduces significant security challenges due to its integration with GitHub’s open ecosystem and its use of flexible workflow configurations. This paper presents Sher, a Python-based tool that enhances the security of GitHub Actions by automating the detection and remediation of security issues in workflows. Self-Hosted Ephemeral Runner, or Sher, acts as a broker between GitHub’s APIs and a customizable, isolated environment, analyzing workflows through a static rules engine and automatically fixing identified issues. By providing a secure, ephemeral runner environment and a dynamic analysis tool, Sher addresses common misconfigurations and vulnerabilities, contributing to the resilience and integrity of DevSecOps practices within software development pipelines.

关键词： CI/CD Pipelines GitHub GitOps DevSecOps Isolation Security SAST

A Comparative Analysis of Cybersecurity Threat Taxonomies for Healthcare Organizations

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Journal of Software Engineering and Applications 2024年第5期17卷 359-377页

作者： Mahima Jaikanth vijay K. Madisetti School of Cybersecurity and Privacy Georgia Institute of Technology Atlanta GA USA

Information technology is critical in coordinating patient records, smart devices, operations, and critical infrastructure in healthcare organizations, and their constantly changing digital environment, including suppliers, doctors, insurance providers, and regulatory agencies. This dependence on interdependent systems makes this sector vulnerable to various information technology risks. Such threats include common cybersecurity risks such as data breaches and malware attacks, unique problems occurring in healthcare settings such as unauthorized access to patient records, disruptions in services provided at medical facilities, and potential harm caused to patients due to the compromise of medical devices. The threat taxonomies, such as the Open Threat Taxonomy, NIST, or ENISA, are foundational frameworks for grasping and categorizing IT threats. However, these taxonomies were not specifically designed to deal with the complexities of the healthcare industry. The problem arises from the gap between these taxonomies’ general nature and the industry-specific threats and vulnerabilities that affect healthcare organizations. As a result, many healthcare institutions fail to holistically address and eliminate the unique risks related to confidentiality, integrity, and availability of patients’ data as well as critical systems used in healthcare. This paper aims to narrow this gap by carefully assessing these taxonomies to determine the frame-work best suited for addressing the threat environment in the healthcare sector.

关键词： Threat Taxonomies Open Threat Taxonomy (OTT)