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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 595-601页

作者： Mayank Gangwar vijay C verma Tryambak D Singh Sushil K Singh RK Goel Gopal Nath Department of Microbiology Institute of Medical Sciences Banaras Hindu University Department of Pharmacology Institute of Medical Sciences Banaras Hindu University Department of Medicinal Chemistry Institute of Medical Sciences Banaras Hindu University Department of Pharmaceutical Engineering Institute of Technology Banaras Hindu University

Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods: The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis ( M. philippinensis ) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus ( E. granulosus ), under in-vitro conditions with reference to the known standard drug Praziquantel . Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.

关键词： Protoscolicidal Echinococcus Hydatidosis Mallotus sp. Anti-helminthic agents Trypan blue

Evaluating the Impact of Software Security Tactics: A Design Perspective

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Computers, Materials & Continua 2021年第3期66卷 2283-2299页

作者： Mamdouh Alenezi Abhishek kumar Pandey Richa verma Mohd Faizan Shalini Chandra Alka Agrawal Rajeev kumar Raees Ahmad Khan College of Computer and Information Sciences Prince Sultan UniversitySaudi Arabia Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknowUttar PradeshIndia Department of Computer Science Babasaheb Bhimrao Ambedkar UniversityLucknowUttar PradeshIndia Department of Computer Application Shri Ramswaroop Memorial UniversityLucknowUttar PradeshIndia

Design architecture is the edifice that strengthens the functionalities as well as the security of web *** order to facilitate architectural security from the web application’s design phase itself,practitioners are now adopting the novel mechanism of security *** the intent to conduct a research from the perspective of security tactics,the present study employs a hybrid multi-criteria decision-making approach named fuzzy analytic hierarchy process-technique for order preference by similarity ideal solution(AHP-TOPSIS)method for selecting and assessing multi-criteria *** adopted methodology is a blend of fuzzy analytic hierarchy process(fuzzy AHP)and fuzzy technique for order preference by similarity ideal solution(fuzzy TOPSIS).To establish the efficacy of this methodology,the results are obtained after the evaluation have been tested on fifteen different web application projects(Online Quiz competition,Entrance Test,and others)of the Babasaheb Bhimrao Ambedkar University,Lucknow,*** tabulated outcomes demonstrate that the methodology of the Multi-Level Fuzzy Hybrid system is highly effective in providing accurate estimation for strengthening the security of web *** proposed study will help experts and developers in developing and managing security from any web application design phase for better accuracy and higher security.

关键词： Web application software security security tactics fuzzy AHP fuzzy TOPSIS

Purification and characterization of CHpro1, a thermotolerant, alkali-stable and oxidation-resisting protease of Chumathang hotspring

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Science Bulletin 2015年第14期60卷 1252-1260页

作者： Reena Singh Chirag Chopra Vishnu kumar Gupta Bashir Akhlaq Vijeshwar verma Shafaq Rasool School of Biotechnology Shri Mata Vaishno Devi University Lovely Professional University Indian Institute of Toxicology Research

Metagenomic approaches are recently used for searching novel open reading frames （ORFs） coding enzymes employed in pharmaceutical, rood industries, etc. In this study, a metagenornic library was constructed from Chumathang hotspring sediment DNA. The library consisted of approximately 9,000 clones and was screened for protease activity. A clone exhibiting protease activity was identified and named CHprol. Sequencing of CHprol revealed that the ORF encoded a functional protein of 363 amino acids belonging to peptidase S8-S53 superfamily. CHprol shared 41% sequence similarity with a reported protease （subtilase family） and 35 % structural similarity with the crystal structure of Pro-Tk sps. of Thermococcus kodarkaenasis. In silico modeling the 3D structure of CHprol showed that it has two beta sheets, 10 alpha helices and 11 strands. Catalytic triad prediction implied CHprol to be a serine protease. The optimum temperature and pH of the purified protease were found to be 80 ℃ and 11.0, respectively. The enzyme was active at 5 % concentration of hydrogen peroxide and retained 60 % of activity at 10 % concentration. The thermotolerant, alkalophilic and oxidant stable properties of the protease make it a potential can- didate for biotechnological applications.

关键词： Thermotolerant. Alkalophilic Oxidantstable Protease Hotspring Metagenomics

Current perspectives on neuroendocrine tumors

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hLife 2024年第11期2卷 563-575页

作者： Sunil kumar verma Renu Khare Devendra Singh Faculty of Biotechnology Institute of Biosciences and TechnologyShri Ramswaroop Memorial UniversityLucknow-Deva RoadBarabankiUttar Pradesh 225001India Faculty of Biosciences Institute of Biosciences and TechnologyShri Ramswaroop Memorial UniversityLucknow-Deva RoadBarabankiUttar Pradesh 225001India

Neoplasms arising from neuroendocrine cells form a heterogeneous group known as neuroendocrine tumors(NETs),which possess both endocrine and neural *** tumors can occur in various organs throughout the body,with the most prominent sites being the gastrointestinal tract,pancreas,and *** their relatively low incidence,NETs have gained significant attention due to their unique biology and clinical *** review intends to provide a widespread gestalt of the present perception of NETs,including their epidemiology,etiology,pathogenesis,classification,clinical presentation,diagnostic modalities,treatment options,and *** strategies for NETs depend on tumor grade,stage,location,and functional *** resection remains the pillar of curative treatment for localized disease;on the other hand,systemic therapies take account of targeted therapies like tyrosine kinase inhibitors(TKIs),peptide receptor radionuclide therapy(PRRT),somatostatin analogs,and immunotherapy have shown promising results in advanced *** conclusion,this review provides an up-to-date summary of our current knowledge regarding neuroendocrine *** research is needed to better understand the underlying molecular mechanisms driving tumor development and *** will aid in developing novel therapeutic strategies targeting specific pathways involved in NET pathogenesis to improve patient outcomes.

关键词： cancer clinical therapy metastasis endocrine

Therapeutic potential and pharmacological mechanism of visnagin

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Journal of Integrative Medicine 2024年第4期22卷 399-412页

作者： Poonam Yadav Sumeet kumar Singh Sayantap Datta Saloni verma Aarti verma Arnab Rakshit Anjana Bali Jasvinder Singh Bhatti Amit Khurana Umashanker Navik Department of Pharmacology School of Health SciencesCentral University of PunjabBathindaPunjab 151401India Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTX 77204-5000USA Department of Human Genetics and Molecular Medicine School of Health SciencesCentral University of PunjabBathindaPunjab 151401India

Visnagin is a furanochromone and one of the most important compound in the Ammi visnaga(L.)Lam(a synonym of Visnaga daucoides Gaertn.)plant,which is used to cure various *** investigations into the bioactive properties of visnagin have been studied to *** literature on visnagin demonstrates its biological properties,including anti-inflammatory,anti-diabetic,and beneficial effects in cardiovascular and renal ***,visnagin improves sperm quality parameters,stimulates steroidogenesis,and increases serum gonadotropins and testosterone levels,while decreasing proinflammatory cytokines,oxidative damage,genomic instability,and it modulates ***,visnagin has emerged as an exciting lead for further research,owing to its potential in various unmet clinical *** current review summarized its basic structure,pharmacokinetics,and pharmacological effects,focusing on its mechanisms of *** review will help to understand the potential of visnagin as an alternative treatment strategy for several diseases and provide insight into research topics that need further exploration for visnagin’s safe clinical use.

关键词： Visnagin Phytochemical Anti-inflammatory Ammi visnaga L. Visnaga daucoides Gaertn Cancer

A Novel Binary Emperor Penguin Optimizer for Feature Selection Tasks

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Computers, Materials & Continua 2022年第3期70卷 6239-6255页

作者： Minakshi Kalra vijay kumar Manjit Kaur Sahar Ahmed Idris Saban Oturk Hammam Alshazly Computer Science Department Government College BahadurgarhBahadurgarh124507India CSE Department National Institute of Technology Hamirpur177005India School of Engineering and Applied Sciences Bennett UniversityGreater Noida201310India College of Industrial Engineering King Khalid UniversityAbhaSaudi Arabia Department of Electrical and Electronics Engineering Amasya UniversityAmasyaTurkey Faculty of Computers and Information South Valley UniversityQena83523Egypt

Nowadays,due to the increase in information resources,the number of parameters and complexity of feature vectors *** offermore practical solutions instead of exact solutions for the solution of this *** Emperor PenguinOptimizer(EPO)is one of the highest performing meta-heuristic algorithms of recent times that imposed the gathering behavior of emperor *** shows the superiority of its performance over a wide range of optimization problems thanks to its equal chance to each penguin and its fast convergence *** traditional EPO overcomes the optimization problems in continuous search space,many problems today shift to the binary search ***,in this study,using the power of traditional EPO,binary EPO(BEPO)is presented for the effective solution of binary-nature *** algorithm uses binary search space instead of searching solutions like conventional EPO algorithm in continuous search *** this purpose,the sigmoidal functions are preferred in determining the emperor *** addition,the boundaries of the search space remain constant by choosing binary ***’s performance is evaluated over twenty-nine benchmarking *** evaluations are made to reveal the superiority of the BEPO *** addition,the performance of the BEPO algorithm was evaluated for the binary feature selection *** experimental results reveal that the BEPO algorithm outperforms the existing binary meta-heuristic algorithms in both tasks.

关键词： Metaheuristics optimization algorithms emperor penguin optimizer intensification diversification feature selection

Total hip replacement for arthritis following tuberculosis of hip

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World Journal of Orthopedics 2015年第8期6卷 636-640页

作者： vijay kumar Bhavuk Garg Rajesh Malhotra Department of Orthopaedics All India Institute of Medical Sciences

AIM: To present the results of total hip arthroplasty(THA) for post tubercular arthritis of the hip ***: Sixty-five patients(45 male, 20 female) with previously treated tuberculosis of the hip joint underwent cementless THA for post tubercular arthritis. The average age at the time of THA was 48 years(range 29 to 65 years). Erythrocyte sedimentation rate, C reactive protein, chest X-ray and contrast enhanced magnetic resonance imaging were done preoperatively to confirm resolution of the disease and to rule out any residual disease. Intra-operative samples were taken for microbiological examination, polymerase chain reaction(PCR) and histological examination. Patients were started on anti-tubercular drugs one week before the operation and continued for 6 mo post operatively. The patients were followed up clinically using the Harris hip score as well as radiologically for any loosening of the implants, osteolysis and any recurrence of tuberculosis. Any complications especially the recurrence of the infection was also ***: The mean interval from completion of antitubercular therapy for tuberculosis to surgery was 4.2 years(range, 2-6 years). Preoperatively, 17 patients had ankylosis whereas 48 patients had functional but painful range of motion. The mean surgical time was 97 min(range, 65-125) whereas the mean blood loss was 600 m L(range, 400-900 m L). The average follow up was 8.3 years(range 6-11 years). The average Harris Hip score improved from 27 preoperatively to 91 at the final follow up. Seventeen patients had acetabularprotrusion which was managed with impaction grafting and cementless acetabular cup. The bone graft had consolidated in all these 17 patients at the follow up. Two patients developed discharging sinuses at 9 and 11 mo postoperatively respectively. The discharge tested positive for tuberculosis on the PCR. Both these patients were put on antitubercular therapy for another year. Both of them recovered and had no evidence of

关键词： Total hip replacement Cementless hip replacement Tuberculosis hip Post-tubercular arthritis hip Total hip arthroplasty

Review of sub-synchronous interaction in wind integrated power systems: classification, challenges, and mitigation techniques

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Protection and Control of Modern Power Systems 2023年第2期8卷 13-38页

作者： Neevatika verma Narendra kumar Saket Gupta Hasmat Malik Fausto Pedro García Márquez Department of Electrical Engineering Delhi Technological UniversityDelhi 110042India Department of Electrical Power Engineering Faculty of Electrical EngineeringUniversiti Teknologi Malaysia(UTM)81310 JohorMalaysia Ingenium Research Group DepartmentUniversidad Castilla-La Mancha13071 Ciudad RealSpain Department of Electrical Engineering Graphic Era Deemed to be UniversityDehradun 248002India Instrumentation and Control Engineering Department Bharati Vidyapeeth’s College of EngineeringNew Delhi 110056India

Emerging sub-synchronous interactions(SSI)in wind-integrated power systems have added intense attention after numerous incidents in the US and China due to the involvement of series compensated transmission lines and power electronics *** phenomenon occurs when two power system elements exchange energy below the synchro-nous *** phenomenon related to wind power plants is one of the most significant challenges to main-taining stability,while SSI phenomenon in practical wind farms,which has been observed recently,has not yet been described on the source of conventional SSI *** paper first explains the traditional development of SSI and its classification as given by the IEEE,and then it proposes a classification of SSI according to the current research status,reviews several mitigation techniques and challenges,and discusses analysis techniques for *** paper also describes the effect of the active damping controllers,control scheme parameters,degree of series compensation,and various techniques used in wind power plants(WPPs).In particular,a supplementary damping controller with converter controllers in Doubly Fed Induction Generator based WPPs is briefly *** paper provides a real-istic viewpoint and a potential outlook for the readers to properly deal with SSI and its mitigation techniques,which can help power engineers for the planning,economical operation,and future expansion of sustainable development.

关键词： Damping controller Doubly fed induction generator(DFIG) Series compensations Sub-synchronous interactions(SSI) Sub-synchronous resonance(SSR)

Biorenewable materials for water remediation: The central role of cellulose in achieving sustainability

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Journal of Bioresources and Bioproducts 2024年第3期9卷 253-282页

作者： Kirti Mishra Samarjeet Singh Siwal Thandiwe Sithole Nirankar Singh Phil Hart vijay kumar Thakur Department of Chemistry M.M.Engineering CollegeMaharishi Markandeshwar(Deemed to be University)Haryana 133207India Department of Chemical Engineering University of JohannesburgDoornfontein 2088South Africa Biorefining and Advanced Materials Research Center Scotland’s Rural CollegeEdinburgh EH93JGUnited Kingdom Renewable and Sustainable Energy Research Centre Technology Innovation InstituteAbu Dhabi 9639United Arab Emirates School of Engineering University of Petroleum&Energy StudiesDehradun 248007India

As the population increases and manufacturing grows,greenhouse gas and other harmful emissions *** with chemicals such as dyes,pesticides,pharmaceuticals,oil,heavy metals or radionuclides,wastewater purification has become an urgent *** technologies exist that can remove these contaminants from wastewater sources,but they often demand high energy and/or high cost,and in some cases produce contaminant laden sludge that requires safe *** need for methods which are less capital intensive,less operationally costly and more environmentally friendly is ***-based materials have emerged as promising candidates for wastewater treatment due to their renewability,low cost,biodegradability,hydrophilicity,and antimicrobial *** this review article,we focussed on developing sustainable and biodegradable cellulose-based materials for wastewater *** article deals with cellulose-based materials’scope and their conversion into valuable products like hydrogel,aerogel,cellulose composites,and *** cellulose-based materials have no harmful environmental impact and are *** modified cellulose-based materials applying as membrane,adsorbent,sorbent,and beads to purify the wastewater were ***,the challenges and future prospects of cellulose-based materials for wastewater treatment were considered,emphasizing their potential to be sustainable and eco-friendly alternatives to traditional materials used in wastewater treatment.

关键词： Cellulose Wastewater treatment Hydrogel Nanocrystal Cellulose membrane

Progress in doping and crystal deformation for polyanions cathode based lithium-ion batteries

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Nano Materials Science 2024年第5期6卷 504-535页

作者： Sajeela Awasthi Srikanta Moharana Vaneet kumar Nannan Wang Elham Chmanehpour Anupam Deep Sharma Santosh K.Tiwari vijay kumar Yogendra kumar Mishra Department of Applied Sciences CT Institute of EngineeringManagement and TechnologyCT Group of InstitutionsShahpurIndia School of Applied Sciences Centurion University of Technology and ManagementOdishaIndia CTIEMT Department of Applied SciencesCT Group of InstitutionsJalandharPunjabIndia Key Laboratory of New Processing Technology for Nonferrous Metals and Materials Ministry of EducationSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanningChina Smart Materials NanoSYDMads Clausen InstituteUniversity of Southern DenmarkAlsion 2Sønderborg6400Denmark Department of Applied Sciences Chandigarh Group of CollegesJhanjeriMohaliPunjabIndia Centre for New Materials and Surface Engineering NMAMITNitte(Deemed to be university)Nitte574110KarnatakaIndia Department of Physics National Institute of Technology SrinagarJammu and Kashmir190006India

Polyanion-based materials are considered one of the most attractive and promising cathode materials for lithiumion batteries(LIBs)due to their good stability,safety,cost-effectiveness,suitable voltages,and minimal environmental ***,these materials suffer from poor rate capability and low-temperature performance owing to limited electronic and ionic conductivity,which restricts their practical *** developments,such as coating material particles with carbon or a conductive polymer,crystal deformation through the doping of foreign metal ions,and the production of nanostructured materials,have significantly enhanced the electrochemical performances of these *** successful applications of polyanion-based materials,especially in lithium-ion batteries,have been extensively *** comprehensive review discusses the current progress in crystal deformation in polyanion-based cathode materials,including phosphates,fluorophosphates,pyrophosphates,borates,silicates,sulfates,fluorosilicates,and ***,this review provides detailed discussions on their synthesis strategies,electrochemical performance,and the doping of various ions.

关键词： Crystal deformation in polyanions Metal ions doping Cathode materials Surface modification Lithium-ion batteries