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Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review

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Stroke & Vascular Neurology 2018年第1期3卷 28-33页

作者： Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers vijay k sharma The George Institute for Global Health NewtownNew South WalesAustralia Sydney Medical School The University of SydneySydneyNew South WalesAustralia Department of Neurology The Second Affiliated Hospital of Soochow UniversitySuzhouChina Department of Cerebrovascular Medicine National Cerebral and Cardiovascular CenterOsakaJapan Department of Neurology The First Affiliated Hospital of Chengdu Medical CollegeChengduChina Royal Prince Alfred Hospital CamperdownNew South WalesAustralia The George Institute China Peking University Health Science CenterBeijingChina Department of Neurology Oslo University HospitalOsloNorway Department of Cardiovascular Sciences and NIHR Biomedical Research Unit for Cardiovascular Diseases University of LeicesterLeicesterUK Yong Loo Lin School of Medicine National University of SingaporeSingapore Division of Neurology National University HospitalSingapore

The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian *** aimed to update the evidence regarding the use of low-dose versus standard-dose *** performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related *** outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects *** included 26 observational studies and 1 randomised controlled trial with a total of 23210 *** doses of rtPA were used for thrombolysis of AIS in ***-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian *** review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for ***-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH.

关键词： dosage doses acute

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Random Amplification Polymorphic DNA and Agro-Morphological Traits-Based Fingerprinting for Detection of Genetic Divergence in Indian Black Rice

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Rice science 2024年第4期31卷 366-370,I0004-I0014页

作者： Manisha sharma Dhananjay RATURI vijay Rani RAJPAL Manju CHAUDHARY Soom Nath RAINA Apekshita SINGH Amity Institute of Biotechnology Amity University Uttar PradeshSector-125UP 201313India Department of Botany Hansraj CollegeUniversity of DelhiDelhi 110007India

In this study, 32 black rice genotypes spanning diverse geographies in India were evaluated at both phenotypic and DNA sequence levels to gain insights into their genetic makeup. Significant variations were observed f... 详细信息

关键词： Indian Morphological Traits

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Effect of hydrogen bond formation/replacement on solubility characteristics, gastric permeation and pharmacokinetics of curcumin by application of powder solution technology

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Acta Pharmaceutica Sinica B 2016年第6期6卷 600-613页

作者： vijay sharma kamla Pathak Department of Pharmaceutics Rajiv Academy for Pharmacy

The present research aimed to improve the dissolution rate and bioavailability of curcumin using the potential of liquisolid technology. Twelve drug-loaded liquisolid systems (LS-1 to LS-12) were prepared using different vehicles (PEG 200, PEG 400 and Tween 80) and curcumin concentrations in vehicle (40%, 50%, 60% and 70%, w/w). The carrier [microcrystalline cellulose (MCC) PH102] to coat (Aerosil®) ratio was 20 in all formulations. The systems were screened for pre-compression properties before being compressed to liquisolid tablets (LT-1 to LT-12). Post compression tests and in vitro dissolution of LTs were conducted and the results compared with those obtained for a directly compressed tablet (DCT) made of curcumin, MCC PH102 and Aerosil®. LTs exhibited higher cumulative drug release (CDR) than the DCT and the optimum formulation, LT-9 (made using Tween 80), was studied by powder XRD, DSC, SEM and FTIR. Ex-vivo permeation of curcumin from LT-9 through goat gastrointestinal mucosa was significantly (P50) of LT-9 towards NCL 87 cancer cells was 40.2 µmol/L substantiating its anticancer efficacy. Accelerated stability studies revealed insignificant effects of temperature and humidity on LT-9. In summary, solubility enhancement of curcumin in LTs produced significant improvements in its permeation and bioavailability.

关键词： Liquisolid tablet Powder solution technology Curcumin Hydrogen bond formation Cytotoxicity Gastric permeation Bioavailability Pharmacokinetics

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VLSI scaling methods and low power CMOS buffer circuit

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Journal of Semiconductors 2013年第9期34卷 92-99页

作者： vijay kumar sharma Manisha Pattanaik Department of Information Technology ABV-Indian Institute of Information Technology & Management

Device scaling is an important part of the very large scale integration （VLSI） design to boost up the success path of VLSI industry, which results in denser and faster integration of the devices. As technology node moves towards the very deep submicron region, leakage current and circuit reliability become the key issues. Both are increasing with the new technology generation and affecting the performance of the overall logic circuit. The VLSI designers must keep the balance in power dissipation and the circuit＇s performance with scaling of the devices. In this paper, different scaling methods are studied first. These scaling methods are used to identify the effects of those scaling methods on the power dissipation and propagation delay of the CMOS buffer circuit. For mitigating the power dissipation in scaled devices, we have proposed a reliable leakage reduction low power transmission gate （LPTG） approach and tested it on complementary metal oxide semiconductor （CMOS） buffer circuit. All simulation results are taken on HSPICE tool with Berkeley predictive technology model （BPTM） BSIM4 bulk CMOS files. The LPTG CMOS buffer reduces 95.16% power dissipation with 84.20% improvement in figure of merit at 32 nm technology node. Various process, voltage and temperature variations are analyzed for proving the robustness of the proposed approach. Leakage current uncertainty decreases from 0.91 to 0.43 in the CMOS buffer circuit that causes large circuit reliability.

关键词： LPTG buffer power dissipation propagation delay scaling nanoscale CMOS figure of merit

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Extent of mismatch between the period of circadian clocks and light/dark cycles determines time-to-emergence in fruit flies

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Insect Science 2015年第4期22卷 569-577页

作者： Pankaj Yadav Deepak Choudhury Madhumala k. Sadanandappa vijay kumar sharma Chronobiology Laboratory Evolutionary and Organismal Biology Unit Jawaharlal Nehru Centre for Advanced Scientific Research Bangalore 560064 Kamataka India

Circadian clocks time developmental stages of fruit flies Drosophila melanogaster, while light/dark （LD） cycles delimit emergence of adults, conceding only during the ＂allowed gate.＂ Previous studies have revealed that time-to-emergence can be altered by mutations in the core clock gene period （per）, or by altering the length of LD cycles. Since this evidence came from studies on genetically manipulated flies, or on flies maintained under LD cycles with limited range of periods, inferences that can be drawn are limited. Moreover, the extent of shortening or lengthening of time-to-emergence re- mains yet unknown. In order to pursue this further, we assayed time-to-emergence of D. rnelanogaster under 12 different LD cycles as well as in constant light （LL） and constant dark conditions （DD）. Time-to-emergence in flies occurred earlier under LL than in LD cycles and DD. Among the LD cycles, time-to-emergence occurred earlier under T4-T8, followed by T36-T48, and then T12-T32, suggesting that egg-to-emergence duration in flies becomes shorter when the length of LD cycles deviates from 24 h, bearing a strong positive and a marginally negative correlation with day length, for values shorter and longer than 24 h, respectively. These results suggest that the extent of mismatch between the period of circadian clocks and environmental cycles determines the time-to-emergence in Drosophila.

关键词： circadian Drosophila light/dark regimes period time-to-emergence

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Codimension-2 bifurcation in a discrete predator-prey system with constant yield predator harvesting

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生物数学学报:英文版 2023年第5期16卷 165-191页

作者： Anuraj Singh vijay Shankar sharma ABV-Indian Institute of Information Technology and Management Gwalior Madhya PradeshIndia

This work investigates the bifurcation analysis in a discrete-time Leslie-Gower predatorprey model with constant yield predator *** stability analysis for the fixed points of the discretized model is shown *** this study,the model undergoes codimension-1 bifurcation such as fold bifurcation(limit point),flip bifurcation(perioddoubling)and Neimark-Sacker bifurcation at a positive fixed ***,the model exhibits codimension-2 bifurcations,including Bogdanov-Takens bifurcation and generalized fip bifurcation at the fixed *** each bifurcation,by using the critical normal form coefficient method,various critical states are *** validate our analytical findings,the bifurcation curves of fixed points are drawn by using *** system exhibits interesting rich dynamics including limit cycles and ***,it has been shown that the predator harvesting may control the chaos in the system.

关键词： Flip bifurcation Neimark-Sacker bifurcation generalized fip bifurcation Bogdanov-Takens bifurcation harvesting

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Recent research advances on Chromobacterium violaceum

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 810-818页

作者： vijay kothari Sakshi sharma Divya Padia Institute of Science Nirma UniversityAhmedabad-382481India

Chromobacterium violaceum is a gram-negative bacterium, which has been used widely in microbiology labs involved in quorum sensing(QS) research. Among the QS-regulated traits of this bacterium, violacein production has received the maximum attention. Violacein production in this organism, however is not under sole control of QS machinery, and other QSregulated traits of this bacterium also need to be investigated in better detail. Though not often involved in human infections, this bacterium is being viewed as an emerging pathogen. This review attempts to highlight the recent research advances on Chromobacterium violaceum, with respect to violacein biosynthesis, development of various applications of this bacterium and its bioactive metabolite violacein, and its pathogenicity.

关键词： Antibiotic resistance Chromobacterium violaceum Violacein Quorum Sensing Emerging pathogen

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Inclusion of Finite Permeability on Design and Optimization of an Electromagnetic Undulator

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Chinese Physics Letters 2014年第3期31卷 55-57页

作者： vijay Huse Geetanjali sharma Swati Mishra G. Mishra School of Physics Devi Ahilya University Indore 452001 (M.P.) India

We derive an alternate analytical expression for the optimum dimensions of an electromagnetic undulator with a finite permeability lamination core. The analytical expressions are compared with earlier results under an... 详细信息

关键词： WIGGLER magnets RESEARCH FREE electron lasers MATHEMATICAL optimization ELECTROMAGNETISM PHYSICS research

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DWT-SVD Based Image Steganography Using Threshold Value Encryption Method

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Computers, Materials & Continua 2022年第8期72卷 3299-3312页

作者： Jyoti khandelwal vijay kumar sharma Dilbag Singh Atef Zaguia School of Computing and Information Technology(SCIT) Manipal University JaipurJaipur302004India School of Electrical Engineering and Computer Science Gwangju Institute of Science and TechnologyGwangju61005Korea Department of Computer Science College of Computers and Information Technology Taif University11099Saudi Arabia

Digital image steganography technique based on hiding the secret data behind of cover image in such a way that it is not detected by the human visual *** paper presents an image scrambling method that is very useful for grayscale secret *** this method,the secret image decomposes in three parts based on the pixel’s threshold *** division of the color image into three parts is very easy based on the color channel but in the grayscale image,it is difficult to *** proposed image scrambling method is implemented in image steganography using discrete wavelet transform(DWT),singular value decomposition(SVD),and sorting *** is no visual difference between the stego image and the cover *** extracted secret image is also similar to the original secret *** proposed algorithm outcome is compared with the existed image steganography *** comparative results show the strength of the proposed technique.

关键词： Image steganography threshold value sorting discrete wave transformation singular value decomposition color band division permutation

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Enhanced Field-Based Detection of Potato Blight in Complex Backgrounds Using Deep Learning

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Plant Phenomics 2021年第1期3卷 209-221页

作者： Joe Johnson Geetanjali sharma Srikant Srinivasan Shyam kumar Masakapalli Sanjeev sharma Jagdev sharma vijay kumar Dua School of Computing&Electrical Engineering Indian Institute of Technology MandiKamandH.P.India BioX Center School of Basic SciencesIndian Institute of Technology MandiKamandH.P.India ICAR-Central Potato Research Institute H.P.ShimlaIndia

Rapid and automated identification of blight disease in potato will help farmers to apply timely remedies to protect their *** detection of blight disease can be cumbersome and may require trained *** overcome these issues,we present an automated system using the Mask Region-based convolutional neural network(Mask R-CNN)architecture,with residual network as the backbone network for detecting blight disease patches on potato leaves in field *** approach uses transfer learning,which can generate good results even with small *** model was trained on a dataset of 1423 images of potato leaves obtained from fields in different geographical locations and at different times of the *** images were manually annotated to create over 6200 labeled patches covering diseased and healthy portions of the *** Mask R-CNN model was able to correctly differentiate between the diseased patch on the potato leaf and the similar-looking background soil patches,which can confound the outcome of binary *** improve the detection performance,the original RGB dataset was then converted to HSL,HSV,LAB,XYZ,and YCrCb color spaces.A separate model was created for each color space and tested on 417 field-based test *** yielded 81.4%mean average precision on the LAB model and 56.9%mean average recall on the HSL model,slightly outperforming the original RGB color space *** analysis of the detection performance indicates an overall precision of 98%on leaf images in a field environment containing complex backgrounds.

关键词： Deep network backbone

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