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Confounders in Adenoma Detection at Initial Screening Colonoscopy: A Factor in the Assessment of Racial Disparities as a Risk for Colon Cancer

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Journal of Cancer Therapy 2019年第4期10卷 269-289页

作者： Yakira David Lorenzo Ottaviano Jihye Park Sadat Iqbal Michelle Likhtshteyn Samir Kumar Helen Lyo Ayanna E. Lewis Brandon E. Lung Jesse T. Frye Li Huang Ellen Li Jie Yang Laura Martello Shivakumar vignesh Joshua D. Miller Michele Follen Evan B. Grossman Department of Medicine SUNY Downstate Medical Center Brooklyn NY USA Department of Gastroenterology Icahn School of Medicine at Mount Sinai New York City NY USA Department of Medicine Stony Brook University Stony Brook NY USA Department of Applied Mathematics and Statistics Stony Brook University Stony Brook NY USA Department of Family Population and Preventive Medicine Stony Brook University Stony Brook NY USA Department of Obstetrics and Gynecology NYC HNC/Kings County Brooklyn NY USA Department of Medicine Division of Gastroenterology NYC Health and Hospitals/Kings County Brooklyn NY USA

Background and Aims: The incidence and mortality of colorectal cancer is persistently highest in Black/African-Americans in the United States. While access to care, barriers to screening, and poverty might explain these findings, there in increased interest in examining biological factors that impact the colonic environment. Our group is examining biologic factors that contribute to disparities in development of adenomas prospectively. In preparation for this and to characterize a potential patient population, we conducted a retrospective review of initial screening colonoscopies in a cohort of patients. Methods: A retrospective review was performed on initial average risk screening colonoscopies on patients (age 45 - 75 years) during 2012 at three institutions. Descriptive statistics and multivariable logistic regression models were used to examine the relationship between potential risk factors and the detection of adenomas. Results: Of the 2225 initial screening colonoscopies 1495 (67.2%) were performed on Black/African-Americans and 566 (25.4%) on Caucasians. Multivariable logistic regression revealed that older age, male sex, current smoking and teaching gastroenterologists were associated with higher detection of adenomas and these were less prevalent among Black/African-Americas except for age. Neither race, ethnicity, BMI, diabetes mellitus, HIV nor insurance was associated with adenoma detection. Conclusion: In this sample, there was no association between race and adenoma detection. While this may be due to a lower prevalence of risk factors for adenomas in this sample, our findings were confounded by a lower detection rate by consultant gastroenterologists at one institution. The study allowed us to rectify the problem and characterize patients for future trials.

关键词： Colorectal Cancer Screening Adenoma Quality

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Identification of SNP and InDel variations in the promoter and 5′ untranslated regions of γ-tocopherol methyl transferase (ZmVTE4) affecting higher accumulation of α-tocopherol in maize kernel

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The Crop Journal 2019年第4期

作者： Abhijit Kumar Das Rashmi Chhabra vignesh Muthusamy Hema Singh Chauhan Rajkumar Uttamrao Zunjare Firoz Hossain

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A review of conventional and renewable biodiesel production

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中国化学工程学报（英文版） 2021年第12期

作者： P.vignesh A.R.Pradeep Kumar N.Shankar Ganesh V.Jayaseelan K.Sudhakar

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