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Asian Journal of Urology 2021年第3期8卷 327-331页

作者： Santosh Kumar Abhishek Chandna vignesh manoharan Kalpesh M.Parmar Subhajit Mandal Department of Urology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Hydatid disease(HD)is an accidental human parasitic infestation by cestodes and is most commonly caused by Echinococcus *** happens to be the most common site of involvement,although involvement of other organ symptoms is not *** of the retrovesical pouch by hydatidosis is generally secondary in nature with an incidence of 0.1%-0.5%*** retrovesical hydatid cyst(RVHC)is extremely rare with only few cases in existing *** can present with a wide gamut of symptoms ranging from asymptomatic to obstructive uropathy.A 38-year-old male presented to us with complaints of lower urinary tract symptoms(LUTS)and was found to have an isolated primary retrovesical hydatid cyst on *** RVHC had compressed the right ureter leading to a grossly hydronephrotic non-functional right *** patient was started on albendazole therapy and underwent robot assisted right nephroureterectomy and partial pericystectomy for the *** postoperative period was uneventful with resolution of *** report highlights the various clinical presentations of RVHC as well as the minimal invasive management of this rare entity.

关键词： Retrovesical hydatid cyst Robotic pericystectomy Hydatid disease

Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： vignesh BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA KUMAR SAMYAK PANDEY RAKSHA NAYAK V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

Solar‑Driven Sustainability:Ⅲ–ⅤSemiconductor for Green Energy Production Technologies

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Nano-Micro Letters 2024年第11期16卷 445-478页

作者： Chandran Bagavath Jeong‑Kyun Oh Sang‑Wook Lee Dae‑Young Um Sung‑Un Kim Veeramuthu vignesh Jin‑Seo Park Shuo Han Cheul‑Ro Lee Yong‑Ho Ra Division of Advanced Materials Engineering Engineering CollegeResearch Center for Advanced Materials Development(RCAMD)Jeonbuk National UniversityJeonju 54896Republic of Korea

Long-term societal prosperity depends on addressing the world’s energy and environmental problems,and photocatalysis has emerged as a viable *** the efficiency of photocatalytic processes is fundamentally achieved by optimizing the effective utilization of solar energy and enhancing the efficient separation of photogenerated *** has been demonstrated that the fabrication ofⅢ–Ⅴsemiconductor-based photocatalysts is effective in increasing solar light absorption,long-term stability,large-scale production and promoting charge *** focused review explores on the current developments inⅢ–Ⅴsemiconductor materials for solar-powered photocatalytic *** review explores on various subjects,including the advancement ofⅢ–Ⅴsemiconductors,photocatalytic mechanisms,and their uses in H2 conversion,CO_(2)reduction,environmental remediation,and photocatalytic oxidation and reduction *** order to design heterostructures,the review delves into basic concepts including solar light absorption and effective charge *** also highlights significant advancements in green energy systems for water splitting,emphasizing the significance of establishing eco-friendly systems for CO_(2)reduction and hydrogen *** main purpose is to produce hydrogen through sustainable and ecologically friendly energy *** review intends to foster the development of greener and more sustainable energy source by encouraging researchers and developers to focus on practical applications and advancements in solar-powered photocatalysis.

关键词： Green energy system Hydrogen evolution CO_(2)reduction Ⅲ-Ⅴsemiconductors Photo electrochemical water splitting

Molecular therapeutics in pancreas cancer

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World Journal of Gastrointestinal Oncology 2016年第4期8卷 366-379页

作者： vignesh Narayanan Colin D Weekes Division of Medical Oncology Department of Medicine Developmental Therapeutics Program University of Colorado Cancer Center University of Colorado School of Medicine

The emergence of the "precision-medicine" paradigm in oncology has ushered in tremendous improvements in patient outcomes in a wide variety of malignancies. However, pancreas ductal adenocarcinoma(PDAC) has remained an obstinate challenge to the oncology community and continues to be associated with a dismal prognosis with 5-year survival rates consistently less than 5%. Cytotoxic chemotherapy with gemcitabine-based regimens has been the cornerstone of treatment in PDAC especially because most patients present with inoperable disease. But in recent years remarkable basic science research has improved our understanding of the molecular and genetic basis of PDAC. Whole genomic analysis has exemplified the genetic heterogeneity of pancreas cancer and has led to ingenious efforts to target oncogenes and their downstream signaling cascades. Novel stromal depletion strategies have been devised based on our enhanced recognition of the complex architecture of the tumor stroma and the various mechanisms in the tumor microenvironment that sustain tumorigenesis. Immunotherapy using vaccines and immune checkpoint inhibitors has also risen to the forefront of therapeutic strategies against PDAC. Furthermore, adoptive T cell transfer and strategies to target epigenetic regulators are being explored with enthusiasm. This review will focus on the recent advances in molecularly targeted therapies in PDAC and offer future perspectives to tackle this lethal disease.

关键词： Pancreas neoplasm Vaccines Targeted therapy Immunotherapy Kirsten rat sarcoma oncogene

Optimized Deep Learning Methods for Crop Yield Prediction

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Computer Systems Science & Engineering 2023年第2期44卷 1051-1067页

作者： K.vignesh A.Askarunisa A.M.Abirami KLN College of Information Technology Pottapalaiyam630612India Sethu Institute of Technology Kariyapatti626115India Thiagarajar College of Engineering Madurai625015India

Crop yield has been predicted using environmental,land,water,and crop characteristics in a prospective research *** it comes to predicting crop production,there are a number of factors to consider,including weather con-ditions,soil qualities,water levels and the location of the farm.A broad variety of algorithms based on deep learning are used to extract useful crops for *** combination of data mining and deep learning creates a whole crop yield pre-diction system that is able to connect raw data to predicted crop *** sug-gested study uses a Discrete Deep belief network with Visual Geometry Group(VGG)Net classiﬁcation method over the tweak chick swarm optimization approach to estimate agricultural *** Network’s successively stacked layers were fed the data *** on the input parameters,a crop produc-tion prediction environment is constructed using the network *** the tweak chick swarm optimization technique,the best characteristics of input data are preprocessed,and the optimal output is used as input for the classiﬁcation *** Deep belief network with the Visual Geometry Group Net clas-siﬁer is used to classify the data and forecast agricultural *** sug-gested model correctly predicts crop output with 97 percent accuracy,exceeding existing models by maintaining the baseline data distribution.

关键词： Data mining deep learning crop production tweak chick swarm optimization algorithm discrete deep belief network with VGG Net classiﬁer

Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz Ayrton Bangolo vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni Sethi Gurpreet Singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

Impact of artificial intelligence in the management of esophageal,gastric and colorectal malignancies

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Artificial Intelligence in Gastrointestinal Endoscopy 2024年第2期5卷 1-14页

作者： Ayrton Bangolo Nikita Wadhwani vignesh K Nagesh Shraboni Dey Hadrian Hoang-Vu Tran Izage Kianifar Aguilar Auda Auda Aman Sidiqui Aiswarya Menon Deborah Daoud James Liu Sai Priyanka Pulipaka Blessy George Flor Furman Nareeman Khan Adewale Plumptre Imranjot Sekhon Abraham Lo Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States

The incidence of gastrointestinal malignancies has increased over the past decade at an alarming *** and gastric cancers are the third and fifth most commonly diagnosed cancers worldwide but are cited as the second and third leading causes of *** institution of appropriate therapy from timely diagnosis can optimize patient *** intelligence(AI)-assisted diagnostic,prognostic,and therapeutic tools can assist in expeditious diagnosis,treatment planning/response prediction,and post-surgical *** can intercept neoplastic lesions in their primordial stages,accurately flag suspicious and/or inconspicuous lesions with greater accuracy on radiologic,histopathological,and/or endoscopic analyses,and eliminate over-dependence on ***-based models have shown to be on par,and sometimes even outperformed experienced gastroenterologists and *** neural networks(state-of-the-art deep learning models)are powerful computational models,invaluable to the field of precision *** models not only reliably classify images,but also accurately predict response to chemotherapy,tumor recurrence,metastasis,and survival rates *** this systematic review,we analyze the available evidence about the diagnostic,prognostic,and therapeutic utility of artificial intelligence in gastrointestinal oncology.

关键词： Artificial intelligence Gastrointestinal malignancies Machine learning Helicobacter pylori State-of-the-art deep learning models

Therapeutics involved in managing initial and recurrent Clostridium difficile infection:An updated literature review

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 1-14页

作者： vignesh K Nagesh Hadrian Hoang-Vu Tran Daniel Elias Izage Kianifar Aguilar Tanni Sethi AiswaryaMenon Charlene Mansour Florchi Furman Kylie Tsotsos Talia Subar Auda Auda Aman Sidiqui JevonLamar Nikita Wadhwani Shraboni Dey Abraham Lo Adam Atoot Simcha Weissman Humberto Sifuentes Ayrton I Bangolo Department of Internal Medicine Hackensack Palisades Medical CenterNorth BergenNJ 07047United States Department of Gastroenterology Augusta UniversityAugustaGA 30912United States

Clostridium difficile infection(CDI)has been increasing due to the effect of recurrent *** use of antibiotics has been shown to alter the gut microbiome and lead to *** treatment is limited to three major antibiotics;however,the incidence of recurrent CDIs has been increasing and drug resistance is a major *** aspect is a growing concern in modern medicine especially in the elderly population,critical care patients,and immunocompromised individuals who are at high risk of developing *** difficile can lead to various complications including septic shock and fulminant colitis that could prove to be lethal in these *** modalities of treatment have been developed including bezlotoxumab,a monoclonal antibody and fecal microbiota *** have been studies showing asymptomatic carriers and drug resistance posing a major threat to the healthcare *** treatment options are being studied to treat and prevent *** review will provide an insight into the current treatment modalities,prevention and newer modalities of treatment and challenges faced in the treatment of CDIs.

关键词： Clostridium difficile Antibiotics Vancomycin Fidaxomicin Prevention Bezlotoxumab Fecal microbiota transplant

Sol-Gel Coating with 3-Mercaptopropyltrimethoxysilane as Precursor for Corrosion Protection of Aluminium Metal

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Journal of Materials Science & Technology 2014年第8期30卷 814-820页

作者： Rajendran Babhu vignesh Thomas Nesakumar Jebakumar Immanuel Edison Mathur Gopalakrishnan Sethuraman Department of Chemistry Gandhigram Rural Institute-Deemed UniversityGandhigram 624 302Tamil NaduIndia

Sol—gel coatings offer a number of advantages over other methods of protection for metallic *** the present work,3-mercaptopropyltrimethoxysilane（MPTS） was used as the precursor for sol—gel coating on aluminium *** gelation of MPTS sol—gel was characterized by Fourier transform infrared spectroscopy（FT-IR） *** formed film was found to be stable up to 350 ℃ as evident from thermogravimetric analysis.X-ray diffraction study and scanning electron microscopy supported the formation of MPTS coating on aluminium surface while the characterization of the coating was done by FT-IR *** corrosion inhibition potential of the sol—gel coatings on metal in 3.5%（w/v） of NaCI solution was assessed as a function of different concentrations of MPTS using electrochemical polarization and impedance *** corrosion inhibition efficiency was found to increase with increasing MPTS *** results of the study unravel the use of MPTS as a precursor in the formation of sol—gel coating over aluminium surface so as to protect the metallic surface from corrosion in neutral environment.

关键词： 3-Mercaptopropyltrimethoxysilane(MPTS) Sol-gel coating Surface protection Electrochemical studies FT-IR

Artificial neural networks based on memristive devices

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Science China(Information Sciences) 2018年第6期61卷 145-158页

作者： vignesh RAVICHANDRAN Can LI Ali BANAGOZAR J.Joshua YANG Qiangfei XIA Department of Electrical and Computer Engineering University of Massachusetts

The advent of memristive devices and the continuing research and development in the field of neuromorphic computing show great potential as an alternative to traditional von Neumann computing and bring us ever closer to realizing a true "thinking machine". Novel neural network architectures and algorithms inspired by the brain are becoming more and more attractive to keep up with computing needs,relying on intrinsic parallelism and reduced power consumption to outperform more conventional computing methods. This article provides an overview of various neural networks with an emphasis on networks based on memristive emerging devices, with the advantages of memristor neural networks compared with pure complementary metal oxide semiconductor(CMOS) implementations. A general description of neural networks is presented, followed by a survey of prominent CMOS networks, and finally networks implemented using emerging memristive devices are discussed, along with the motivation for developing memristor based networks and the computational potential these networks possess.

关键词： neuromorphic computing memristors neural networks