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Molecular therapeutics in pancreas cancer

World Journal of Gastrointestinal Oncology 2016年第4期8卷 366-379页

作者： vignesh narayanan Colin D Weekes Division of Medical Oncology Department of Medicine Developmental Therapeutics Program University of Colorado Cancer Center University of Colorado School of Medicine

The emergence of the "precision-medicine" paradigm in oncology has ushered in tremendous improvements in patient outcomes in a wide variety of malignancies. However, pancreas ductal adenocarcinoma(PDAC) has remained an obstinate challenge to the oncology community and continues to be associated with a dismal prognosis with 5-year survival rates consistently less than 5%. Cytotoxic chemotherapy with gemcitabine-based regimens has been the cornerstone of treatment in PDAC especially because most patients present with inoperable disease. But in recent years remarkable basic science research has improved our understanding of the molecular and genetic basis of PDAC. Whole genomic analysis has exemplified the genetic heterogeneity of pancreas cancer and has led to ingenious efforts to target oncogenes and their downstream signaling cascades. Novel stromal depletion strategies have been devised based on our enhanced recognition of the complex architecture of the tumor stroma and the various mechanisms in the tumor microenvironment that sustain tumorigenesis. Immunotherapy using vaccines and immune checkpoint inhibitors has also risen to the forefront of therapeutic strategies against PDAC. Furthermore, adoptive T cell transfer and strategies to target epigenetic regulators are being explored with enthusiasm. This review will focus on the recent advances in molecularly targeted therapies in PDAC and offer future perspectives to tackle this lethal disease.

关键词： Pancreas neoplasm Vaccines Targeted therapy Immunotherapy Kirsten rat sarcoma oncogene

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Thymoquinone as a potential therapeutic for Alzheimer’s disease in transgenic Drosophila melanogaster model

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BIOCELL 2021年第5期45卷 1251-1262页

作者： narayanan NAMPOOTHIRI V.P. vignesh SUNDARARAJAN PALLAVI DAN G.DEVANAND VENKATASUBBU SAHABUDEEN SHEIK MOHIDEEN Department of Biotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur603203India Department of Physics and Nanotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur603203India

Alzheimer’s disease(AD)is one of the most common forms of *** dysfunction and memory loss are the two main clinical symptoms of *** melanogaster models of AD,which are based on overexpression of human amyloidβ(Aβ)or human tau(hTau)protein,have been used to study the mechanism underlying AD and to screen potential therapeutic *** that are currently available for AD provide only symptomatic *** unmet medical needs exists to slow,stop,or reverse the progression of ***(TQ)is an active ingredient isolated from Nigella sativa(NS)and possesses various pharmacological activities,and it is also a potential neuropharmacological *** current study was performed to investigate the effect of dietary administration of TQ at concentrations of 12.5μM and 25μM for 15 and 30 days on biochemical and behavioral parameters,gene,and protein expression of hTau,using Drosophila models of *** Drosophila models exhibiting pan-neuronal and eye-specific expression of hTau were generated using the GAL4/UAS *** with TQ at both concentrations resulted in a significant increase in behavioral activity,a significant reduction in the amount of reactive oxygen species(ROS),and restoration of depleted superoxide dismutase(SOD)and acetylcholine esterase(AChE)activities.A significant decrease in gene and protein expression of hTau was also observed at the molecular level for both concentrations of ***,TQ has the potential to be investigated as a potential therapeutic phytochemical for the treatment of AD in future studies.

关键词： hTau GAL4/UAS system Nigella sativa

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Chemopreventive effect of apple and berry fruits against colon cancer

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World Journal of Gastroenterology 2014年第45期20卷 17029-17036页

作者： Saravana Kumar Jaganathan Muthu vignesh Vellayappan Gayathri Narasimhan Eko Supriyanto Dyah Ekashanti Octorina Dewi Aqilah Leela T narayanan Arunpandian Balaji Aruna Priyadarshini Subramanian Mustafa Yusof IJN-UTM Cardiovascular Engineering Centre Faculty of Bioscience and Medical Engineering Universiti Teknologi Malaysia Department of Research and Development PSNA College of Engineering and Technology Department of Pharmacology

Colon cancer arises due to the conversion of precancerous polyps(benign)found in the inner lining of the *** is better than cure,and this is very true with respect to colon *** epidemiologic studies have linked colorectal cancer with food *** and berry juices are widely consumed among various ethnicities because of their nutritious *** this review article,chemopreventive effects of these fruit juices against colon cancer are *** dealing with bioavailability,in vitro and in vivo effects of apple and berry juices are emphasized in this article.A thorough literature survey indicated that various phenolic phytochemicals present in these fruit juices have the innate potential to inhibit colon cancer cell *** review proposes the need for more preclinical evidence for the effects of fruit juices against different colon cancer cells,and also strives to facilitate clinical studies using these juices in humans in large *** conclusion of the review is that these apple and berry juices will be possible candidates in the campaign against colon cancer.

关键词： Apple Berry Chemoprevention Colon cancer Fruit juices Phytochemicals

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