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Mangiferin,a natural xanthone,accelerates gastrointestinal transit in mice involving cholinergic mechanism

World Journal of Gastroenterology 2012年第25期18卷 3207-3214页

作者： Talita Cavalcante Morais Synara Cavalcante Lopes Karine Maria Martins Bezerra Carvalho Bruno Rodrigues Arruda Francisco Thiago Correia de Souza Maria Teresa Salles Trevisan vietla satyanarayana rao Flávia Almeida Santos Department of Physiology and Pharmacology Brazilian SemiArid Institute of BiomedicineFaculty of MedicineFederal University of CearáFortaleza 60430-270Brazil Post-Graduate Programme in Medical Sciences Faculty of MedicineFederal University of CearáFortaleza 60430-140Brazil Department of Organic and Inorganic Chemistry Federal University of CearáFortaleza 60451-970Brazil

AIM： To investigate the effects of mangiferin on gas- trointestinal transit （GIT） in normal and constipated mice, together with the possible ***： Intragastrically-administered charcoal mealwas used to measure GIT in overnight starved Swiss mice. In the first experiments, mangiferin （3 mg/kg, 10 mg/kg, 30 mg/kg, and 100 mg/kg, po） or tegaserod （1 mg/kg, ip） were administered 30 min before the char- coal meal to study their effects on normal transit. In the second series, mangiferin （30 mg/kg） was tested on delayed GIT induced by several different pharma- cological agonists （morphine, clonidine, capsaicin） or antagonists （ondansetron, verapamil, and atropine） whereas in the third series, mangiferin （30 mg/kg, 100 mg/kg and 300 mg/kg） or tegaserod （1 mg/kg） were tested on 6 h fecal pellets outputted by freely fed mice. The ratio of wet to dry weight was calculated and used as a marker of fecal water content. RESULTS： Mangiferin administered orally significantly （P 〈 0.05） accelerated GIT at 30 mg/kg and 100 mg/kg （89% and 93%, respectively）, similarly to 5-hydroxytrypta- mine4 （5-H%） agonist tegaserod （81%） when compared to vehicle-treated control （63%）. Co-administered man- giferin （30 mg/kg） totally reversed the inhibitory effect of opioid agonist morphine, 5-HT3-receptor antagonist ondansetron and transient receptor potential vanilloid-1 receptor agonist capsaicin on GIT, but only to a partial extent with the GIT-delay induced by ~2-adrenoceptor agonist clonidine, and calcium antagonist verapamil. However, co-administered atropine completely blocked the stimulant effect of mangiferin on GIT, suggesting the involvement of muscarinic acetylcholine receptor activation. Although mangiferin significantly enhanced the 6 h fecal output at higher doses （245.5±10.43 mg vs 161.9±10.82 mg and 227.1±20.11 mg vs 161.9±10.82 mg of vehicle-treated control, at 30 and 100 mg/ kg, P 〈 0.05, respectively）, the effect of tegaserod was more potent （297.4±7.42 mg vs 161.9±1

关键词： Mangiferin Glucosylxanthone Gastrointes-tinal transit Prokinetic action Cholinergic mechanism

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α,β-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats

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World Journal of Gastroenterology 2010年第34期16卷 4272-4280页

作者： Caroline Mouro Melo Karine Maria Martins Bezerra Carvalho Julliana Catharina de Sousa Neves Talita Cavalcante Morais vietla satyanarayana rao Flávia Almeida Santos Gerly Anne de Castro Brito Mariana Helena Chaves Department of Physiology and Pharmacology Biomedical Institute of Brazilian Semiarid Faculty of Medicine Federal University of Ceará Department of Morphology Faculty of Medicine Federal University of Ceará Department of Organic and Inorganic Chemistry Federal University of Piauí

AIM: To study the benef icial effects of triterpene α,β-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHODS: Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 × 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of α,β-amyrin (10, 30 and 100 mg/kg),methylprednisolone (30 mg/kg) and vehicle (3% Tween 80). A saline (0.9% NaCl) treated group served as a normal control. Efficacy was assessed at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-6], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation [thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Tissue histology and the immunoreactivity for TNF-α and inducible nitric oxide synthetase (iNOS) were performed. RESULTS: α,β-amyrin and methylprednisolone treatments significantly (P < 0.05) attenuated the L-arginine-induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6, as compared to the vehicle control. Also, pancreatic levels of MPO activity, TBARS, and nitrate/nitrite were signifi cantly lower. Histological f indings and TNF-α and iNOS immunostaining further confirmed the amelioration of pancreatic injury by α,β-amyrin. CONCLUSION: α,β-amyrin has the potential to combat acute pancreatitis by acting as an anti-in? ammatory and antioxidant agent.

关键词： Acute pancreatitis L-arginine Cytokines Lipid peroxidation α,β-amyrin

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Dietary Green Tea Extract and Antioxidants Improve Insulin Secretory Functions of Pancreatic β-Cells in Mild and Severe Experimental Rodent Model of Chronic Pancreatitis

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Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 53-72页

作者： Galande Sheethal Ranjeet K. Tokala Pavan Pondugala Krishna Vemula Vijayalakshmi Venkatesan Pothani Suresh Surya satyanarayana Singh Guduru Venkat rao Duvvur Nageshwar Reddy Mitnala Sasikala Basic Science and Translational Research Division Asian Healthcare Foundation AIG Hospitals Hyderabad India Division of Cell and Molecular Biology National institute of Nutrition Hyderabad India National Animal Resource Facility for Biomedical Research Hyderabad India Department of Biochemistry Osmania University Hyderabad India Department of Surgical Gastroenterology Asian Institute of Gastroenterology Hyderabad India Department of Gastroenterology Asian Institute of Gastroenterology Hyderabad India

Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (T3c Diabetes) is often brittle, and is difficult to attain normoglycemia with conventional treatment requiring multiple doses of insulin. Mild and severe model of CP was induced in mice by repeated intraperitoneal injections of cerulein and L-arginine respectively with an intent to study islet dysfunction and develop therapeutic strategy in animal models of CP. Dietary intervention of epigallocatechin-3-gallate (EGCG) was tested in both the models of CP for its beneficial effects on insulin secretory functions. Pancreata collected upon euthanasia were used to study alterations in the morphology of pancreatic parenchyma and inflammation by staining with H&E and fibrotic changes by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal glucose tolerance test was performed to monitor the glucose homeostasis before and after the dietary intervention. Both the models resulted in CP with dispersed acini, inflammation and fibrosis. The loss of acini and extent of fibrosis was more in L-arginine model. 2-fold improvement in glucose-stimulated insulin secretory functions of islets was observed with 0.5% EGCG dietary intervention in cerulein model of CP and 1.6-fold in L-arginine model of CP. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with EGCG. Our results thus demonstrate and highlight the therapeutic potential of dietary green tea (EGCG) supplementation in reversing islet dysfunction and improving glucose homeostasis in experimental chronic pancreatitis in mice.

关键词： Dietary Intervention C57BL6/J Mice Epigallocatechin-3-Gallate N-Acetyl Cysteine Curcumin Chronic Pancreatitis Islets Glucose Stimulated Insulin Secretion

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Development of Ultra Fast Liquid Chromatography (UFLC) Method for Fluorescence Detection of Domperidone in Human Serum and Application to Pharmacokinetic Study

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American Journal of Analytical Chemistry 2016年第1期7卷 12-21页

作者： Chinna Reddy Palem satyanarayana Goda Narendar Reddy Dudhipala Madhusudan rao Yamsani National Facilities in Engineering and Technology with Industrial Collaboration (NAFETIC) Centre University College of Pharmaceutical Sciences Kakatiya University Warangal India

A simple and sensitive fluorescence detection of domperidone by ultra fast liquid chromatographic method was developed and validated in human serum. For the evaluation of new drug delivery systems, conducting of pharmacokinetic studies in human volunteers is essential for approval to marketing after preclinical evaluation in animal models. The present method consists of protein precipitation, extraction of analytes from human serum into dichloromethane and separation using reversed-phase C18 column. Propranolol hydrochloride was used as an internal standard and the eluent was monitored by fluorescence detector at excitation 282 and emission 328 nm. The mobile phase used was 62:38 ratio of 10 mM phosphate buffer pH adjusted to 3.1 with OPA and methanol at a flow rate of 1 mL·min-1. The method was evaluated for assay, LLOD, LLOQ, recovery and stability studies. The retention times for domperidone and propranolol hydrochloride were found to be 6.36 and 7.94 minutes respectively. The intraday and inter-day coefficient of variation and percent error values of assay method were less than 5%;mean recovery was more than 96% for each analyte and the method was found to be precise, accurate and specific during study. The method was successfully applied for pharmacokinetic study of immediate and controlled release bioadhesive hot melt extruded buccal patches of domperidone after buccal administration to healthy human volunteers. The Cmax, Tmax, and AUC0–24 of domperidone from immediate and controlled release buccal patches were found to be 129.7 ng·mL-1, 1.5 h, 455.1 ng·h·mL-1 and 145.7 ng·mL-1, 5.25 h, 911.0 ng·h·mL-1 respectively. A simple, sensitive and reliable method for the fluorescence determination of domperidone in human serum by UFLC method was developed and validated.

关键词： Domperidone Ultra Fast Liquid Chromatography Fluorescence Human Serum Buccal Patches Pharmacokinetics

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Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D<sub>3</sub>Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

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American Journal of Analytical Chemistry 2015年第13期6卷 1050-1058页

作者： R. K. Bhogadi A. satyanarayana N. Someswara rao Srinivas Arutla A. Malleswara Reddy Dr. Reddy’s Laboratories Ltd. IPDO Bachupally Hyderabad India Department of PNCO Andhra University Visakhapatnam India Department of Inorganic and Analytical Chemistry Andhra University Visakhapatnam India

A single RP-HPLC method is developed for estimation of isomeric impurities of vitamin D3 analogue-Calcipotriol/Calcipotriene (Calci) and impurities of Betamethasone dipropionate (BD). The developed method is capable of separating impurities of Calci and BD, specifically pre-Calcipotriene (Pre-Calci) from other known and unknown impurities. Pre-Calci is isolated and is characterised using few analytical techniques. These impurities are separated using a RP-C18 150 × 4.6 mm, 2.7 μm column maintained at 50°C. The mobile phase consisted of mixture of water, methanol, acetonitrile and tetrahydrofuran eluted in gradient mode. Detection was done at 264 nm and 240 nm for Calci and BD impurities respectively. The method can be used for determining quality of Calci and BD drugs and ointment based drug products. It is stability indicating related substance method for both the drugs and drug products.

关键词： Calcipotriene Pre-Calcipotriene HPLC Photo Isomers Ointment

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Catalyst Free One-Pot Synthesis of Chromeno Quinolines and Their Antibacterial Activity

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Green and Sustainable Chemistry 2017年第2期7卷 141-151页

作者： Sruthi Vasamsetty Sunitha Medidi Satheesh Ampolu Ravi Kumar Majji Mastan rao Kotupalli Chikurumilli China satyanarayana Annapurna Nowduri Paul Douglas Sanasi Department of Engineering Chemistry AU College of Engineering (A) Andhra University Visakhapatnam India SKR College for Women Rajamahendravaram India Department of Chemistry Dodoma University Dodoma Tanzania SKBR College Amalapuram India

An efficient greener one pot synthesis of dimethyl-dihydro-7H-chromeno[3, 2-h]quinolin-8(9H)-one derivatives has been synthesized through cyclization of aromatic aldehyde, dimidone and 8-hydroxy-quinoline through one-pot condensation method is described. The synthesized compounds are screened for further biological activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Bacillus using cut plate method and disc diffusion method.

关键词： Dimethyl-Dihydro-7H-Chromeno[3 2-h]Quinolin-8(9H)-One Derivatives Syn-thesis Biological Activity and One-Pot Condensation

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Detection of Quarry Blasts in the Koyna-Warna Region, Western India

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Open Journal of Earthquake Research 2014年第4期3卷 162-169页

作者： D. Shashidhar K. Mallika N. Purnachandra rao H. V. S. satyanarayana H. K. Gupta CSIR-National Geophysical Research Institute Hyderabad India

Koyna-Warna is a seismically active region, characterized by earthquakes triggered by loading of artificial water reservoirs. In this region quarrying is ongoing and sometimes the quarry blasts are confused with triggered seismic events. About 410 events around a known mining area were ob-served during January 2007-October 2013. In general the quarry blasts are carried out mostly during the day time. Based on this fact a well known method of [1] is implemented, which has the capability of detecting the areas of quarry blast activity. Also, discrimination of quarry blasts from earthquakes has been achieved by studying waveforms at key seismic stations located close to the quarrying area. Further, distinction is achieved through spectral analysis in the frequency band of 3 - 15 Hz. Ratio of day-time to night-time events, waveform pattern and spectral analysis approach confirm the presence of quarry blasts aligned south-east of the Warna reservoir.

关键词： Quarry Blasts Koyna Reservoir Seismicity Warna Frequency

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Breeding and biotechnological efforts in Jatropha curcas *** sustainable yields

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Oil Crop Science 2021年第4期6卷 180-191页

作者： S.Arockiasamy Jyothirmayi Kumpatla Sainath Hadole Vijay Yepuri Manoj Patil Vineeta Shrivastava Chandrasekhara rao Nagesh Kancharla Saakshi Jalali Alok Varshney Neeta Madan Sai Pothakani Vinod Nair Sridhar Peyyala Vishwnadharaju Mudunuri Ananthan Gopal Niranjan S.Kumar Jawahar Pachiyannan satyanarayana Seelamanthula J.V.Narasimham Makarand Phadke Anindya B Ajit Sapre Santanu Dasgupta Agronomy Division Reliance Technology GroupReliance Industries LtdGhansoliNavi Mumbai400701India Jatropha Breeding Station Reliance Industries LtdIDA-PeddapuramADB Road SamalkotaAndhra Pradesh533440India

Jatropha is a non-edible,important bioenergy plant,which can grow in marginalized *** seeds possess about 36%oil and this would be converted into biodiesel or *** provides an option for sustainable feed and fuel production due to its inherent qualities including hardy nature,drought tolerance and surviving with limited amount of water,tolerance to unfavorable conditions and excessive ***,heterozygosity,low productivity and poor understanding of its genome are the major impediments to elite line ***,classical breeding and advanced technological investments remain limited owing to long juvenile phase and breeding *** technologies that lead to identification of elite genotypes and development of high yielding elite Jatropha lines and effective methods of detoxification of seeds needs immediate *** tissue culture system,doubled haploids(DH)and genomic tools are increasingly made available to improve the seed yield and its oil quantity through the development of geminivirus disease resistant *** application of advanced,sequencing technologies has presented a repertoire of genomic information for this important yet orphan *** the present investigation,we highlight the achievements made in Jatropha towards development of high yielding,virus resistant elite lines and hybrids with yield potential ranging from 3 to 5 tons per hectare in a year,which is a first ever report in the *** also developed potential biotechnological tools such as genetic transformation,genome editing and next generation genomics tools including linkage maps and QTLs for accelerating breeding efforts through marker assisted *** of our concerted and continuous efforts during the past 15 years,we have overcome all the obstacles and developed high yielding,disease resistant hybrids/lines,advanced cultivation technologies with thorough knowledge on Agronomy of the Jatropha *** Jatropha cultivat

关键词： Breeding Hybrids Micropropagation Transformation Sequencing Mapping QTLs CRISPR

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Threefold Increase in the Number of Drug Resistant TB Cases after Introduction of Universal Drug Susceptibility Testing: Experiences from Two South India Districts

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Journal of Tuberculosis Research 2020年第2期8卷 42-52页

作者： Sanath Kumar Gurram Krishnamurthy Sharath Burugina Nagaraja Tanu Anand Karuna D. Sagili Cheluve Gowda Shailaja Basavaraj Poojar Srinath satyanarayana Department of Health and Family Tumkur District Karnataka India Department of Community Medicine ESIC Medical College and PGIMSR Bengaluru India Department of Community Medicine North Delhi Municipal Corporation Medical College Hindu Rao Hospital Delhi India Department of TB and Communicable Diseases the Union South East Asia Office New Delhi India Department of Community Medicine Sri Siddhartha Medical College Tumkur Karnataka India Department of Health and Family Belgaum District Karnataka India Department of Pharmacology Kasturba Medical College Mangalore Manipal Academy of Higher Education Manipal India The Union South East Asia Office New Delhi India

Background: In India, tuberculosis (TB) is a major public health problem, and the advent of drug resistance TB (DR-TB) has worsened the situation. The Revised National TB Control Programme (RNTCP) has introduced universal drug susceptibility testing (UDST) for all diagnosed TB cases in 2018. We conducted this study to know the advantage of implementing UDST when compared to selective testing existent in 2017 on key diagnostic cascade parameters and to identify the challenges in the implementation of UDST. Methods: The study was conducted in two districts of Karnataka, India during January 2017-December 2018. The quantitative part consisted of before-and-after design and the qualitative part consisted of descriptive design. Results: In 2017 (during selective testing/“before” period) out of the 2440 TB patients, 80 (3%) were diagnosed with Isoniazid and Rifampicin resistance patients;in contrast in 2018 (during UDST/“after” period) of the 5129 TB patients 258 (5%) were diagnosed with Isoniazid and Rifampicin resistance. However, the proportion of eligible patients tested for rifampicin resistance during the “after” period was 60% when compared to 100% during the “before” period and median turnaround time for testing was also longer during the “after” period when compared to the “before” period (32.5 days vs 27.5 days). Major reasons for these two gaps were found to be difficulties in collecting sputum specimens and transportation. Conclusion: The rollout of UDST has led to a three-fold increase in a number of DR-TB cases detected in the region. There is a need for the programme to increase the proportion tested for DST by increasing the laboratory capacity and address the challenges in sputum collection and transportation.

关键词： Operational Research Criteria C Line Probe Assay Universal Drug Susceptibility Testing Culture and Drug Susceptibility Testing

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科依纳可能发生一次5级地震

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世界地震译丛 2006年第4期37卷 81-83页

作者： H. Gupta P. Mandal H.V.S. satyanarayana D. Shashidhar B. Sairam M. Shekar A. Singh E.U. Devi M. Kousalya N.P. rao V.P. Dimri 杨智娴（译）陈运泰（校）不详中国地震局地球物理研究所

位于印度西海岸附近的科依纳（Koyna）是众所周知的人造水库触发地震最显著的地方（Gupta，1992）。自从科依纳大坝建成之后斯瓦季萨加（Shivajisagar）湖蓄水以来的44年中，发生了震级M6．3的最大的触发地震（1967年12月10R）以及19个... 详细信息

位于印度西海岸附近的科依纳（Koyna）是众所周知的人造水库触发地震最显著的地方（Gupta，1992）。自从科依纳大坝建成之后斯瓦季萨加（Shivajisagar）湖蓄水以来的44年中，发生了震级M6．3的最大的触发地震（1967年12月10R）以及19个大于等于5级的地震。震级为4级左右的地震约170个，还有数千个更小的地震。最近的一次5级地震发生于2005年3月14R，在上一次5级地震发生了4年半之后（satyanarayana et al，2005）。

关键词：触发地震地震发生印度西海岸震级

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