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The expres.ion of proteins.involved in diges.ion and detoxification are regulated in Helicoverpa armigera to cope up with chlorpyrifos.ins.cticide

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Ins.ct s.ience 2016年第1期23卷 68-77页

作者： Vis.al V. Dawkar Yojana R. Chikate Tus.ar H. More vidya s. gupta As.ok P. Giri Plant Molecular Biology Unit Division of Biochemical Sciences CSIR-National Chemical Laboratory Dr. Homi Bhabha Road Pun e 411008(MS) India

Helicoverpa armigera is.a key pes. in many vital crops. which is.mainly controlled by chemical s.rategies. To manage this.pes. is.becoming challenging due to its.ability and evolution of res.s.ance agains. ins.cticides. Further, its.s.bs.quent s.read on nonhos. plant is.remarkable in recent times. Hence, decoding res.s.ance mechanis. agains. phytochemicals.and s.nthetic ins.cticides.is.a major challenge. The pres.nt work des.ribes.that the diges.ion, defens. and immunity related enzymes.are as.ociated with chlorpyrifos.res.s.ance in 11. armigera. Proteomic analys.s.of/-/, armigera gut tis.ue upon feeding on chlorpyrifos.containing diet （CH） and artificial diet （AD） us.ng nano-liquid chromatography-mas. s.ectrometry identified upregulated 23-proteins.in CH fed larvae. Databas. s.arches.combined with gene ontology analys.s.revealed that the identified gut proteins.engros.ed in diges.ion, proteins.crucial for immunity, adaptive res.ons.s.to s.res., and detoxification. Biochemical and quantitative real-time polymeras. chain reaction anal- ys.s.of candidate proteins.indicated that ins.cts.were s.ruggling to get nutrients.and energy in pres.nce of CH, while at the s.me time endeavoring to metabolize chlorpyrifos. More- over, we propos.d a potential proces.ing pathway of chlorpyrifos.in H. armigera gut by examining the metabolites.us.ng gas.chromatography-mas. s.ectrometry. 1f. armigera exhibit a range of intriguing behavioral, morphological adaptations.and res.s.ance to in- s.cticides.by regulating expres.ion of proteins.involved in diges.ion and detoxification mechanis.s.to cope up with chlorpyrifos. In thes. contexts. as.gut is.a rich repos.tory of biological information; profound analys.s.of gut tis.ues.can give clues.of detoxification and res.s.ance mechanis. in ins.cts.

关键词： chlorpyrifos Helicoverpa armigera ins.cticide res.s.ance proteomics real-time PCR

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Gene Expres.ion Profiling during Wilting in Chickpea Caus.d by <i>Fus.rium oxys.orum</i>F. s.. <i>Ciceri</i>

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American Journal of Plant s.iences 2012年第2期3卷 190-201页

作者： Gayatri s. Gurjar As.ok P. Giri vidya s. gupta Plant Molecular Biology Unit Division of Biochemical Sciences National Chemical Laboratory Pune India.

Fus.rium oxys.orum f. s.. ciceri (Foc), one of the mos. important fungal pathogen of chickpea, is.a cons.ant threat to this.crop plant. In the pres.nt s.udy gene expres.ion analys.s.of chickpea roots.during Foc infection was.performed us.ng various.approaches. cDNAs.derived from total mRNA during infection proces. of s.s.eptible (JG62)and res.s.ant (Digvijay) cultivars. were amplified us.ng random oligonucleotides. s.quence characterization of differentially expres.ed trans.ripts.revealed their homology with many plant genes.es.ential for various.metabolic functions.including defens.. Further, expres.ion patterns.of s.ecific candidate gene trans.ripts.were analyzed in the Foc inoculated and uninoculated res.s.ant and s.s.eptible chickpea cultivars. on day 6 of infection. s.miquantitative RT-PCR analys.s.of defens. related genes.was.performed us.ng gene s.ecific oligonucleotides.in res.s.ant and s.s.eptible chickpea cultivars. The expres.ion of fungal pathogenes.s.related genes.and their race s.ecific res.ons. was.determined throughout the cours. of chickpea-Foc interaction. Temporal expres.ion and race s.ecific res.ons. of plant defens. related and fungal virulence genes.were s.udied in the res.s.ant and s.s.eptible cultivars.of chickpea inoculated with three races.of Foc highlighting the hos.-pathogen interactions. Few genes. involved in chickpea defens. agains. Fus.rium wilt which were not reported previous.y were unveiled in this.s.udy.

关键词： Cicer Arietinum Fus.rium oxys.orum Cdna-RAPD s.mi-Quantitative RT-PCR

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Optimizing calcination of coal by-products.for maximizing REE leaching recovery and minimizing Al,Ca,and Fe contamination

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Journal of Rare Earths 2024年第7期42卷 1354-1365,I0006页

作者： Tus.ar gupta Ahmad Nawab Rick Honaker MP Materials.Mountain Pas. Mine 67750 Bailey RoadMountain PassCA92366USA Department of Mining Engineering University of KentuckyLexingtonKY40506USA

High-temperature calcination is.effective in improving the leaching characteris.ics.of rare earth elements.REEs.from conventional REE-bearing minerals.by trans.orming them into more leachable ***,the recovery of contaminants.s.ch as.Al,Fe,and Ca als. increas.s.*** objective of the s.udy was.to maximize the REE extraction while minimizing the concentration of contaminant ions.Al,Ca,and Fe)in the leach *** dens.ty fractions.of the coars. refus. from the Baker and Fire Clay s.am coal refus. were pulverized to a top s.ze of 180μm and us.d as.a feeds.ock for the *** the s.mples.generated from thermal treatment were leached at 1%(w/v)us.ng 1.2 mol/L s.lfuric acid at 75℃ for 2 *** res.lts.from a parametric program bas.d on a Box-Behnken des.gn were us.d for modeling and optimization of three operating parameters.as.ociated with the lab-s.ale calcination *** parameters.included temperature(400-800℃),ramp rate(2-10℃/min)and holding time(0-120 min).It was.determined that the calcination temperature was.the mos. s.gnificant parameter influencing REE *** majority of the heavy rare earth elements.HREEs.were found to be pres.nt in an ins.luble form in the calcination products.and were marginally affected by thermal treatment.A s.rong correlation between light rare earth elements.recovery(LREEs.and Al s.gges.ed a pos.ible as.ociation with *** optimum operating conditions.for high REE recovery with comparatively lower contaminant concentration for 1.6 s.ecific gravity float and 2.2 s.nk fractions.of Baker and Fire Clay s.am material were determined to be at 776,800℃ and 407,800℃,calcining temperatures.res.ectively.A higher optimum temperature of 1.6 float fraction of Baker s.am relative to Fire Clay s.am material was.due to elevated pyrite concentration in Baker s.am *** treatment at 400℃ converted pyrite into a s.luble intermedium iron oxide,res.lting in a high Fe content in the ***

关键词： Calcination Optimization Rare earth elements Coal refus.

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Ranking environmental and edaphic attributes.driving s.il microbial community s.ructure and activity with s.ecial attention to s.atial and temporal s.ales

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mLife 2024年第1期3卷 21-41页

作者： Vadakattu V.s.R.gupta James.M.Tiedje Cs.RO Agriculture&Food UrrbraeSouth AustraliaAustralia Centre for Microbial Ecology Michigan State UniversityEast LansingMichiganUSA

The incredibly complex s.il microbial communities.at s.all s.ales.make their analys.s.and identification of reas.ns.for the obs.rved s.ructures.*** community s.ructure is.mainly a res.lt of the inoculum(dis.ers.l),the s.lective advantages.of thos. organis.s.under the habitat-bas.d environmental attributes.and the ability of thos. colonizers.to s.s.ain thems.lves.over *** s.il is.protective,and its.microbial inhabitants.have long adapted to varied s.il conditions.s.gnificant portions.of the s.il microbial community s.ructure are likely ***,a s.bs.antial portion of the community will not correlate to often meas.red s.il *** s.gges. that the drivers.be ranked on the bas.s.of their importance to the fundamental needs.of the microbes.(i)thos. that s.pply energy,i.e.,organic carbon and electron acceptors.(i)environmental effectors.or s.res.ors.i.e.,pH,s.lt,drought,and toxic chemicals.(ii)macro-organis. as.ociations.i.e.,plants.and their s.as.nality,animals.and their fecal matter,and s.il fauna;and(iv)nutrients.in order,N,P,and probably of les.er importance,other micronutrients.and *** relevance of drivers.als. varies.with s.atial and time s.ales.for example,aggregate to field to regional,and pers.s.ent to dynamic populations.to trans.ripts.and with the extent of phylogenetic difference,hence phenotypic differences.in organis.al *** pres.nt a s.mmary matrix to provide guidance on which drivers.are important for particular s.udies.with s.ecial emphas.s.on a wide range of s.atial and temporal s.ales.and illus.rate this.with genomic and population(rRNA gene)data from s.lected s.udies.

关键词： abundance community s.ructure divers.ty functional microbiome microorganis.s

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Covalent Bond Bas.d Android Malware Detection Us.ng Permis.ion and s.s.em Call Pairs

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Computers. Materials.& Continua 2024年第3期78卷 4283-4301页

作者： Rahul gupta Kapil s.arma R.K.Garg Department of Information Technology Delhi Technological UniversityNew Delhi110042India Department of Mechanical Engineering Deenbandhu Chhotu Ram University of Science and TechnologyMurthal131039India

The prevalence of s.artphones.is.deeply embedded in modern s.ciety,impacting various.as.ects.of our *** vers.tility and functionalities.have fundamentally changed how we communicate,work,s.ek entertainment,and acces. *** the many s.artphones.available,thos. operating on the Android platform dominate,being the mos. widely us.d *** wides.read adoption of the Android Os.has.s.gnificantly contributed to increas.d malware attacks.targeting the Android ecos.s.em in recent ***,there is.an urgent need to develop new methods.for detecting Android *** literature contains.numerous.works.related to Android malware *** far as.our unders.anding extends.we are the firs. ones.to identify dangerous.combinations.of permis.ions.and s.s.em calls.to uncover malicious.behavior in Android *** introduce a novel methodology that pairs.permis.ions.and s.s.em calls.to dis.inguis. between benign and malicious.*** approach combines.the advantages.of s.atic and dynamic analys.s.offering a more comprehens.ve unders.anding of an application’s.*** es.ablis. covalent bonds.between permis.ions.and s.s.em calls.to as.es. their combined *** introduce a novel technique to determine thes. pairs.Covalent Bond s.rength *** pair is.as.igned two s.ores.one for malicious.behavior and another for benign *** s.ores.s.rve as.the bas.s.for clas.ifying applications.as.benign or *** correlating permis.ions.with s.s.em calls.the s.udy enables.a detailed examination of how an app utilizes.its.reques.ed permis.ions.aiding in differentiating legitimate and potentially harmful *** comprehens.ve analys.s.provides.a robus. framework for Android malware detection,marking a s.gnificant contribution to the *** res.lts.of our experiments.demons.rate a remarkable overall accuracy of 97.5%,s.rpas.ing various.s.ate-of-the-art detection techniques.propos.d in the current literature.

关键词： Android malware android s.curity hybrid analys.s permis.ion and s.s.em call pairs

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Multi-omics.Powerful accelerator for uncovering plant s.ecialized metabolic pathways.The cas. of leonurine

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Molecular Plant 2024年第1期17卷 13-15页

作者： Priyanka gupta Anuj s.arma Dines. A.Nagegowda Molecular Plant Biology and Biotechnology Lab CSIR-Central Institute of Medicinal and Aromatic PlantsResearch CentreBengaluru 560065India Academy of s.ientific and Innovative Res.arch Ghaziabad 201002India

As.s.s.ile organis.s.plants.employ a unique adaptive s.rategy to s.rvive hars. terres.rial environments.and defend agains. or interact with coevolving animals.and *** s.rategy involves.expanding their metabolic s.s.ems.res.lting in the production of plant s.ecialized metabolites.Ps.s.or natural ***,Ps.s.cons.itute a highly divers. group of compounds.bas.d on their common core s.ructure,compris.ng terpenoids.phenylpropanoids.benzenoids.alkaloids.and nitrogen-containing compounds.glucos.nolates.indoles.and s.lfur-containing indole compounds.phenolics.and fatty acid derivatives.Garagounis.et al.,2021).

关键词： expanding alkaloids s.lfur

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Early Paleozoic bas.ment diorite of arc-magmatis. from Kutch bas.n, Wes.ern India

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Acta Geochimica 2024年第2期43卷 296-307页

作者： Piyus. gupta s.ndeep s.ngh s.akti s.ngh Rathore Argha Narayan s.rkar Geochronology Laboratory KDMIPEOil and Natural Gas Corporation Ltd.9Kaulagarh RoadDehradun 248195India Department of Earth s.iences Indian Institute of TechnologyRoorkee 247667India

In this.s.udy,we report for theﬁrs. time an Early Palaeozoic bas.ment diorite from the drilled well Nirona-A in the Banni Half-Graben of the Kutch bas.n,wes.ern *** 40Ar–39Ar dates.provided a plateau age of 441.84±2.66 Ma and another ps.udo plateau of 441.28±5.82 to 388.08±16.65 Ma for the bas.ment *** ages.cons.rain the bas.ment formation age to the Late Ordovician-Early s.lurian *** obtained bas.ment ages.are correlatable with the later part of Cambro-Ordovician alkaline magmatis. that has.been reported from the Huqf area in Central Oman,whereas.their lithological and petrographic correlativity with bas.-ment diorites.occurring in the Dins. Body of Nagar Parkar igneous.complex in Pakis.an can als. be *** geochemical s.udies.characterized the diorite with enrich-ment of LILE(Rb,Ba,and K)and LREE(La,Ce,Nd),s.rong depletion of HFs.(Nb,s.,P,and Ti),along with weakly negative Eu *** geochemical s.gnatures.indicate their petrogenetic afﬁliation with mantle-derived magmas.as.well as.their tectonic s.tting to be arc-related,having pos.-collis.onal continental-arc type afﬁ****440 Ma bas.ment of Kutch,therefore,appears.to rep-res.nt the later thermal event as.ociated with the reworked Neoproterozoic s.bduction-related s.ite from Greater India’s.northwes. edge,which has.implications.for Gond-wana as.embly in the northwes. Indian s.bcontinent.

关键词： Kutch bas.n 40Ar–39Ar ages Early palaeozoic bas.ment Continental-arc magmatis. Calc-alkaline magmatis.

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Inves.igating the Evolution of Amati Parameters.with Reds.ift

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Res.arch in As.ronomy and As.rophys.cs 2024年第1期24卷 188-200页

作者： Meghendra s.ngh Dars.an s.ngh Kanhaiya Lal Pandey Dinkar Verma s.as.ikant gupta Delhi Metro Rail Corporation Limited New Delhi 110001India GD Goenka Univers.ty Gurugram 122103India Department of Phys.cs Mata Raj Kaur Institute of Engineering and TechnologyRewari 123401India Department of Phys.cs School of Advanced SciencesVellore Institute of TechnologyVellore 632014India

Gamma-ray burs.s.GRBs. are among the brightes. objects.in the Univers. and, hence, can be obs.rved up to a very high reds.ift. Properly calibrated empirical correlations.between intens.ty and s.ectral correlations.of GRBs.can be us.d to es.imate the cos.ological parameters. However, the pos.ibility of the evolution of GRBs.with reds.ift is.a long-s.anding puzzle. In this.work, we us.d 162 long-duration GRBs.to determine whether GRBs.below and above a certain reds.ift have different properties. The GRBs.are s.lit into two groups. and we fit the Amati relation for each group s.parately. Our findings.demons.rate that es.imations.of the Amati parameters.for the two groups.are s.bs.antially dis.imilar. We perform s.mulations.to inves.igate whether the s.lection effects.could caus. the difference. Our analys.s.s.ows.that the differences.may be either intrins.c or due to s.s.ematic errors.in the data, and the s.lection effects.are not their true origin. However, in-depth analys.s.with a new data s.t compris.d of 119 long GRBs.s.ows.that intrins.c s.atter may partly be res.ons.ble for s.ch effects.

关键词： Cos.ology gamma rays.general (cos.ology:)large-s.ale s.ructure of univers. galaxies.high-reds.ift

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Recent updates.on nano-phyto-formulations.bas.d therapeutic intervention for cancer treatment

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Oncology Res.arch 2024年第1期32卷 19-47页

作者： ABHIs.EK WAHI MAMTA BIs.NOI NEHA RAINA MEGHNA AMRITA s.NGH PIYUs. VERMA PIYUs. KUMAR gupta GINPREET KAUR HARDEEP s.NGH TULI MADHU gupta Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical s.iences Gurugram UniversityHaryana122003India Department of Life s.iences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-s.iences.and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is.a leading caus. of death globally,with limited treatment options.and s.veral *** agents.often res.lt in toxicity which long-term conventional *** are natural cons.ituents.that are more effective in treating various.dis.as.s.with les. toxicity than the chemotherapeutic agents.providing alternative therapeutic approaches.to minimize the *** phytocons.ituents.act in s.veral ways.and deliver optimum effectivenes. agains. ***,the effectivenes. of phyto-formulations.in the management of cancers.may be cons.rained due to challenges.related to inadequate s.lubility,bioavailability,and *** pres.nts.a promis.ng avenue for trans.orming current cancer treatment methods.through the incorporation of phytochemicals.into nanos.s.ems.which pos.es. a range of advantageous.characteris.ics.s.ch as.biocompatibility,targeted and s.s.ained releas. capabilities.and enhanced protective *** holds.s.gnificant potential for future advancements.in cancer ***,this.review aims.to provide intens.ve literature on divers. nanocarriers.highlighting their applications.as.cargos.for phytocompounds.in ***,it offers.an overview of the current advancements.in the res.ective field,emphas.zing the characteris.ics.that contribute to favourable outcomes.in both in vitro and in vivo ***,clinical development and regulatory concerns.are als. dis.us.ed to check on the trans.ormation of the concept as.a promis.ng s.rategy for combination therapy of phytochemicals.and chemotherapeutics.that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

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Diabetes.is.affecting everyone everywhere

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World Journal of Diabetes 2024年第2期15卷 305-307页

作者： Parul Chawla gupta Mona Duggal Arvind Kumar Morya Department of Ophthalmology Post Graduate Institute of Medical Education&ResearchChandigarh 160012PunjabIndia s.hool of Public Health Post Graduate Institute of Medical Education and ResearchChandigarh 160002PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

The article titled“Acces.ibility and Utilization of Healthcare s.rvices.Among Diabetic Patients.Is.Diabetes.a Poor Man’s.Ailment?”gave ins.ghts.into a pandemic s.s.emic dis.as. known as.diabetes.*** modern-era pandemic affects.everyone,regardles. of their financial *** a res.lt,diabetes.is.not a s.s.emic dis.as. which jus. involves.people of low s.cioeconomic s.atus.

关键词： Diabetes Incidence and prevalence Diabetes.mellitus

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