检索结果-南通市图书馆

Overlap in oncogenic and pro-inflammatory pathways associated with areca nut and nicotine exposure

Cancer Pathogenesis and Therapy 2024年第3期2卷 187-194页

作者： Krati Garg Anuj Kumar vidisha kizhakkethil Pramod Kumar Shalini Singh Department of Biochemical Engineering and Biotechnology Indian Institute of Technology(IIT)DelhiDelhi 110016India Division of Molecular Biology ICMR-National Institute of Cancer Prevention and Research(ICMR-NICPR)Indian Council of Medical ResearchNoidaUttar Pradesh 201301India Department of Biotechnology Vellore Institute of Technology(VIT)VelloreTamil Nadu 632024India ICMR-National Institute of Cancer Prevention&Research(ICMR-NICPR) Indian Council of Medical ResearchNoidaUttar Pradesh 201301India

Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of *** other psychoactive substances,such as nicotine,the mechanisms underlying addiction to areca nuts and related oncogenesis remain *** reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human ***,this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on ***:A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings(MeSH).Protein-protein interaction(PPI)networks and functional enrichment were *** results obtained for both psychoactive substances were ***:Given the limited number of common proteins(36/226,16%)in the two sets,a substantial overlap(612/1176 nodes,52%)was observed in the PPI networks,as well as in Gene *** nuts mainly affect signaling pathways through three hub proteins(alpha serine/threonine-protein kinase,tumor protein 53,and interleukin-6),which are common to both psychoactive substances,as well as two unique hub proteins(epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism).Areca nut-related proteins are associated with unique pathways,such as extracellular matrix organization,lipid storage,and metabolism,which are not found in nicotine-associated ***:Areca nuts affect regulatory mechanisms,leading to systemic toxicity and *** nuts also affect unique pathways that can be studied as potential markers of exposure,as well as targets for anticancer therapeutic agents.

关键词： Cancer Areca nut Nicotine Interactome Cell signaling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders(Amorphous,Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

引用

Journal of Materials Science & Technology 2015年第5期31卷 437-444页

作者： Nicole Ostrowski vidisha Sharma Abhijit Roy Prashant N.Kumta Department of Bioengineering University of Pittsburgh Center of Complex Engineered Multifunctional Materials University of Pittsburgh Department of Chemical and Petroleum Engineering University of Pittsburgh Department of Mechanical Engineering and Materials Science University of Pittsburgh

Magnesium phosphate cements have come under investigation in recent years for use as an alternative to calcium phosphate cements for bone void repair *** indicates that magnesium phosphate cements obtain higher initial strengths after cement reaction and resorption in more clinically appropriate time frames than commercially available calcium phosphate *** this study,amorphous,partially amorphous and crystalline tri-magnesium phosphate powders were synthesized via an aqueous precipitation reaction with subsequent thermal treatment,and characterized using techniques such as X-ray diffraction and Fourier transform infrared *** materials were assessed for their functionality in cementing reaction with a 3.0 mol/L,pH 7.0 ammonium phosphate solution,including setting time and pH evolution in phosphate buffered saline *** indicated that the amorphous and semi-crystalline tri-magnesium phosphate powders were highly reactive with the setting solution but resulted in mechanically weak cements,while the crystalline tri-magnesium phosphate powder reacted efficiently with the cement solution and were mechanically strong following the cement reaction.X-ray diffraction and scanning electron microscopy analyses indicated significant changes in the phase composition and morphology of the cements following incubation in phosphate buffered *** were perceived to be detrimental to the integrity of the amorphous and semi-crystalline tri-magnesium phosphate derived cements but not to those created with fully crystalline tri-magnesium *** crystalline tri-magnesium phosphate material resulted in the most functional cement as this embodiment displayed the most clinically relevant setting time as well as the highest mechanical resilience and neutral pH during incubation in saline solution rendering them potentially viable as bone void fillers.

关键词： Amorphous magnesium phosphate Tri-magnesium phosph

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Species of Euphlyctis (Amphibia, Anura, Dicroglossidae) from the West Coastal Plains of India

引用

Asian Herpetological Research 2016年第4期7卷 229-241页

作者： Hebbar PRITI Chandrakanth Rukkappa NAIK Kadaba Shamanna SESHADRI RamitSINGAL Madhava Kulkarni vidisha Gudasalmani RAVIKANTH KotambyluVasudeva GURURAJA Ashoka Trust for Research in Ecology and the Environment (ATREE) Royal Enclave Sriramapura Jakkur (P.O) Bangalore 560054 India Manipal University Manipal 576104 India Wildlife Range Kumbaravada Nujji Section Dandeli Anshi Tiger Reserve Joida Taluk 581187 India Department of Biological Sciences National University of Singapore 14 Science Drive 4 Block S3 Singapore Independent Researcher B-14 Law Apartments Karkardooma Delhi 110092 India Gubbi Labs LLP Science and Media Center WS-5 I Floor Entrepreneurship Center Indian Institute of Science Campus Bengaluru 560012 India Srishti Institute of Art Design and Technology N4 Yelahanka New Town Bengaluru 560064 India

The genus Euphlyctis is widely distributed across Southwestern Arabian Peninsula into parts of Southeast Asia. Five of the seven known Euphlyctis species are found within the Indian subcontinent. Here, we describe a new species, Euphlyctis karaavali sp. nov. from South-west coast of India, which was discovered during surveys engaging citizens. This species was identified to be distinct based on molecular and morphological evidence. We provide a detailed description of this species along with its call description and compare it with closest congeners. Previous studies in the region had identified this species as E. hexadactylus but suggested the possibility of it being cryptic. Genetically E. karaavali sp. nov. is distinct from E. hexadactylus with a genetic divergence of 9.2% （12S and 16S） and shows a high divergence with E. kalasgramensis and E. ehrenbergii （13.04% each）. Our findings are discussed in the context of cryptic species discovery, citizen engagement in scientific progress and conservation measures while suggesting future directions.

关键词： Karaavali skittering frog citizen science molecular identification agriculture cryptic species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sexual Dimorphism of Foramen Magnum between Two Different Groups of Indian Population: A Cross‑Sectional Cone‑Beam Computed Tomography Study

引用

Journal of Forensic Science and Medicine 2018年第3期4卷 150-155页

作者： vidisha Gargi Ravi Prakash SM Sangeeta Malik Nagaraju K Sumit Goel Swati Gupta Department of Oral Medicine and Radiology Subharti Dental CollegeMeerutUttar PradeshIndia

The foramen magnum (FM), being a vital landmark at the base of the skull, includes interests to many fields of medicine. Many authors haverecounted the usefulness of the FM in gender determination. The emphasis of this study is to evaluate the shape and dimensions of the FM among males and females and to establish its role in sexual dimorphism using cone-beam computed tomography (CBCT). Furthermore, to evaluate the area and FM index (FMI) among males and females and finally to evaluate the differences in FM measurements if any in twodifferent regions of an Indian population. One hundred and ten CBCT scans (55 males and 55 females;age range, 20–80 years) were selectedfor this study. The sagittal diameter, transverse diameter, area, FMI, and circumference of FM were measured, and data were subjected to discriminant analysis for the evaluation of sexual dimorphism. The area of FM was the best discriminant parameter which was used to study the sexual dimorphism with an overall accuracy of 90.9%. It can be concluded that the reconstructed CBCT image provides valuable measurements for the FM and could be used for gender determination.

关键词： Craniometry dimorphism foramen magnum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：