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Journal of Clinical and Translational Hepatology 2021年第2期9卷 256-264页

作者： Madhumita premkumar Chandan Kumar Kedarisetty Departments of Hepatology Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Hepatology and Liver transplantation Gleneagles Global HospitalHyderabadIndia

The coronavirus pandemic has resulted in increased rates of hepatic decompensation,morbidity and mortality in patients suffering from existing liver disease,and deranged liver biochemistries in those without liver *** patients with cirrhosis with coronavirus disease 2019(COVID-19),new onset organ failures manifesting as acute-onchronic liver failure have also been *** severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)also directly binds to enterocytes and cholangiocytes via the angiotensin converting enzyme receptor 2,although the lung remains the portal of *** with the COVID-19 related bystander hepatitis,a systemic inflammatory response is noted due to unregulated macrophage activation syndrome and cytokine ***,the exact definition and diagnostic criteria of the‘cytokine storm’in COVID-19 are yet *** addition,inflammatory markers like C-reactive protein,ferritin,D-dimer and procalcitonin are frequently *** in turn leads to disease progression,activation of the coagulation cascade,vascular microthrombi and immune-mediated injury in different organ *** liver chemistries are also noted due to the cytokine storm,and synergistic hypoxic or ischemic liver injury,drug-induced liver injury,and use of hepatotoxic antiviral agents all contribute to deranged liver *** of an unregulated cytokine storm at an early stage may avert disease morbidity and *** immunomodulator drugs and repurposed immunosuppressive agents have been used in COVID-19 with varying degrees of success.

关键词： Chronic liver disease COVID-19 Cytokines Hepatitis Gut-liver axis

Influence of Na_(2)SiO_(3)/NaOH Ratio on Calcined Magnesium Silicate Based Geopolymer——Experimental and Predictive Study

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1077-1085页

作者： premkumar R Ramesh Babu Chokkalingam Meyyappan PL Shanmugasundaram M Kalasalingam Academy of Research and Education Krishnan KoilTamil Nadu626126 India Vellore Institute of Technology-Chennai Tamilnadu600127 India

This study aims to investigate the behavior of alkali activated mortar,which is made of naturally available magnesium silicate as source *** magnesium silicate,ultrafine natural steatite powder(UFNSP)is used as the primary source of binder,and the activation is initiated through the alkali liquid which is proportioned in various combinations of silicate to hydroxide ratio(Na_(2)SiO_(3)/Na OH)ratio,and this ratio in this study varies from 1 to *** UFNSP is calcined at two difierent temperatures,700 and 1000℃.The mortar mix is proportioned as 1:3 between powder and the fine aggregate,and the mortar is prepared with hydroxide molarity(M)of 10 *** mortar is cured for 48 hours at 60℃and the compressive strength was *** the mix were studied for its microstructural behavior along with compressive *** mix proportion of the mortar,and the results obtained through microstructural characterization were combinedly formed as input for artificial neural network(ANN)predictive *** model is designed to predict the compressive strength,which is trained through Bayesian regularization algorithm with varying hidden neurons of 7 to *** experimental and predictive study shows that the strength is influenced by both Na_(2)SiO_(3)/Na OH ratio and calcination *** the ANN is influenced by mainly calcination temperature and uncorrelation occurs in selected samples of 1000℃calcined UFNSP mix.

关键词： magnesium silicate silicate alkali activation geopolymer UFNSP prediction

Kombucha SCOBY-based carbon and graphene oxide wrapped sulfur/polyacrylonitrile as a high-capacity cathode in lithium-sulfur batteries

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Frontiers of Chemical Science and Engineering 2020年第6期14卷 976-987页

作者： Krishnaveni Kalaiappan Subadevi Rengapillai Sivakumar Marimuthu Raja Murugan premkumar Thiru Energy Materials Lab Department of PhysicsScience BlockAlagappa UniversityKaraikudi630003 Tamil NaduIndia Electrochemical Power Systems Division CSIR-Central Electrochemical Research InstituteKaraikudi630003 Tamil NaduIndia

Hierarchically-porous carbon nano sheets were prepared as a conductive additive for sulfur/polyacrylonitrile(S/PAN)composite cathodes using a simple heat *** this study,kombucha(that was derived from symbiotic culture of bacteria and yeast)carbon(KC)and graphene oxide(GO)were used as a carbon host *** rational-designed S/PAN/KC/GO hybrid composites greatly suppress the diffusion of polysulfides by providing strong physical and chemical *** cathode delivered an initial discharge capacity of 1652 mAh·g^-1 at a 0.1 C rate and a 100th cycle capacity of 1193 mAh·g^-*** nano sheets with embedded hierarchical pores create a conductive network that provide effective electron transfer and fast electrochemical ***,the nitrogen component of PAN can raise the affinity/interaction of the carbon host with lithium polysulfides,supporting the cyclic *** results exploit the cumulative contribution of both the conductive carbon matrix and PAN in the enhanced performance of the positive electrode.

关键词： sulfur cathode kombucha SCOBY graphene oxide polyacrylonitrile lithium-sulfur battery

DARTS-Drone and Artificial Intelligence Reconsolidated Technological Solution for Increasing the Oil and Gas Pipeline Resilience

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International Journal of Disaster Risk Science 2022年第5期13卷 810-821页

作者： premkumar Ravishankar Seokyon Hwang Jing Zhang Ibrahim X.Khalilullah Berna Eren-Tokgoz Department of Industrial and Systems Engineering Lamar UniversityBeaumontTX 77710USA Construction Management Program Lamar UniversityBeaumontTX 77710USA Department of Computer Science Lamar UniversityBeaumontTX 77710USA

The need for safe operation and effective maintenance of pipelines grows as oil and gas demand ***,it is increasingly imperative to monitor and inspect the pipeline system,detect causes contributing to developing pipeline damage,and perform preventive maintenance in a timely ***,pipeline inspection is performed at pre-determined intervals of several months,which is not sufficiently robust in terms of *** research proposes a drone and artificial intelligence reconsolidated technological solution(DARTS) by integrating drone technology and deep learning *** solution is aimed to detect the targeted potential root problems-pipes out of alignment and deterioration of pipe support system-that can cause critical pipeline failures and predict the progress of the detected problems by collecting and analyzing image data *** test results show that DARTS can be effectively used to support decision making for preventive pipeline maintenance to increase pipeline system s afety and resilience.

关键词： Artifcial intelligence Asset management Drone application Midstream industry Pipeline resilience Predictive maintenance

A New Metaheuristic Optimization Algorithms for Brushless Direct Current Wheel Motor Design Problem

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Computers, Materials & Continua 2021年第5期67卷 2227-2242页

作者： M.premkumar R.Sowmya Pradeep Jangir Kottakkaran Sooppy Nisar Mujahed Aldhaifallah Department of Electrical and Electronics Engineering GMR Institute of TechnologyRajam532127India Department of Electrical and Electronics Engineering National Institute of TechnologyTiruchirappalli620015India Rajasthan Rajya Vidyut Prasaran Nigam Sikar305001India Department of Mathematics College of Arts and SciencesPrince Sattam bin Abdulaziz UniversityWadi Aldawaser11991Saudi Arabia Systems Engineering Department King Fahd University of Petroleum&MineralsDhahranSaudi Arabia

The Equilibrium Optimizer(EO),Grey Wolf Optimizer(GWO),and Whale Optimizer(WO)algorithms are being recently developed for engineering optimization *** this paper,the EO,GWO,and WO algorithms are applied individually for a brushless direct current(BLDC)design optimization *** EO algorithm is inspired by the models utilized to find the system’s dynamic state and equilibrium *** GWO and WO algorithms are inspired by the hunting behavior of the wolf and the whale,*** primary purpose of any optimization technique is to find the optimal configuration by maximizing motor efficiency and/or minimizing the total ***,two objective functions are being used to achieve these *** first refers to a design with high power output and *** second is a constraint imposed by the reality that the motor is built into the wheel of the vehicle and,therefore,a lightweight is *** EO,GWO,and WOA algorithms are then utilized to optimize the BLDC motor’s design variables to minimize the motor’s total mass or maximize the motor efficiency by simultaneously satisfying the six inequality *** simulation is carried out using MATLAB simulation software,and the simulation results prove the dominance of the proposed *** paper also suggests an efficient method from the proposed three methods for the BLDC motor design optimization problem.

关键词： BLDC motor constrained equilibrium optimizer singleobjective optimization

Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats

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Food Science and Human Wellness 2015年第2期4卷 66-74页

作者： Balan Rajan Rajendran Ravikumar Thandavamoorthy premkumar Thiruvengadam Devaki Department of Biochemistry Guindy CampusUniversity of MadrasChennai 600025TNIndia

Carvacrol is a main constituent in the essential oils of countless aromatic plants including Origanum Vulgare and Thymus vulgari,which has been assessed for substantial pharmacological *** recent years,notable research has been embarked on to establish the biological actions of Carvacrol for its promising use in clinical *** present study is an attempt to reveal the protective role of Carvacrol against NNitrosodiethylamine(DEN)induced hepatic injury in male Wistar albino *** is an egregious toxin,present in numerous environmental factors,which enhances chemical driven liver damage by inducing oxidative stress and cellular *** of DEN(200 mg/kg bodyweight,I.P)to rats results in elevated marker enzymes(in both serum and tissue).Carvacrol(15 mg/kg body weight)suppressed the elevation of marker enzymes(in both serum and tissue)and augmented the antioxidants *** hoisted activities of Phase I enzymes and inferior activities of Phase II enzymes were observed in DEN-administered animals,whereas Carvacrol treated animals showed improved near normal *** observations also support the protective role of Carvacrol against DEN induced liver *** outcome from our findings intimate that Carvacrol might be beneficial in attenuating toxin induced liver damage.

关键词： protective damage rats

Protection against symptomatic SARS-CoV-2 infection during the second wave among individuals with pre-existing binding antibodies to SARS-CoV-2: A population-based study from Puducherry, India

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Asian Pacific Journal of Tropical Medicine 2023年第10期16卷 476-478页

作者： premkumar Ramasubramani Dhanajayan Govindan Nandini Balakrishnan Krishnan Tamilarasu Kadhiravan Sitanshu Sekhar Kar Department of Preventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)PuducherryIndia Department of General Medicine Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)PuducherryIndia

During the COVID-19 pandemic,several studies have shown that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is associated with a substantial reduction in the risk of subsequent reinfection with a... 详细信息

关键词： infection acute respiratory

A Novel Single Switch High Gain DC-DC Converter Topology for Renewable Energy Systems

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Energy Engineering 2021年第2期118卷 199-209页

作者： G.Indira Kishore M.premkumar Ramesh Kumar Tripathi Chandra Sekhar Nalamati GMR Institute of Technology RajamSrikakulamAndhra Pradesh532127India Motilal Nehru National Institute of Technology AllahabadUttar Pradesh211004India

Renewable energy with sources such as photovoltaic(PV)or fuel cells can be utilized for the generation of elec-trical *** these sources generate fewer voltage values and therefore require high gain converters to match with DC bus voltage in *** high gain converters can be implemented with switched capacitors to meet the required DC bus *** capacitors operate in a series and parallel combination during switch-ing operation and produce high static gain,limits reverse voltage that appears across the components.A novel converter is proposed that satisfies all the features such as high voltage gain,only one switch,forces less potential stress cross the components,ripple current is *** features of the proposed converter are verified through MATLAB/SIMULINK.

关键词： DC-DC converter high gain renewable energy switched capacitors

Multi-Objective Grey Wolf Optimization Algorithm for Solving Real-World BLDC Motor Design Problem

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Computers, Materials & Continua 2022年第2期70卷 2435-2452页

作者： M.premkumar Pradeep Jangir B.Santhosh Kumar Mohammad A.Alqudah Kottakkaran Sooppy Nisar Department of Electrical and Electronics Engineering GMR Institute of TechnologyRajam532127Andhra PradeshIndia Rajasthan Rajya Vidyut Prasaran Nigam Sikar332025RajasthanIndia Department of Computer Science and Engineering GMR Institute of TechnologyRajam532127Andhra PradeshIndia German Jordanian University Amman11180Jordan Department of Mathematics College of Arts and SciencesPrince Sattam Bin Abdulaziz UniversityWadi Aldawaser11991Saudi Arabia

The first step in the design phase of the Brushless Direct Current(BLDC)motor is the formulation of the mathematical framework and is often used due to its analytical ***,the BLDC motor design problem is considered to be an optimization *** this paper,the analytical model of the BLDC motor is presented,and it is considered to be a basis for emphasizing the optimization *** analytical model used for the experimentation has 78 non-linear equations,two objective functions,five design variables,and six non-linear constraints,so the BLDC motor design problem is considered as highly non-linear in electromagnetic ***-objective optimization becomes the forefront of the current research to obtain the global best solution using metaheuristic *** bio-inspired multi-objective grey wolf optimizer(MOGWO)is presented in this paper,and it is formulated based on Pareto optimality,dominance,and archiving *** performance of theMOGWO is verified on standard multi-objective unconstraint benchmark functions and applied to the BLDC motor design *** results proved that the proposedMOGWO algorithm could handle nonlinear constraints in electromagnetic optimization *** performance comparison in terms of Generational Distance,inversion GD,Hypervolume-matrix,scattered-matrix,and coverage metrics proves that the MOGWO algorithm can provide the best solution compared to other selected *** source code of this paper is backed up with extra online support at https://***/mysite and https://***/matlabcentral/fileexchange/75259-multiobjective-non-sorted-grey-wolf-mogwo-nsgwo.

关键词： BLDC motor electromagnetics metaheuristic multi-objective grey wolf optimizer