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Randomized intervention to assess the effectiveness of an educational video on organ donation intent among Hispanics in the New York metropolitan area

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World Journal of Transplantation 2023年第4期13卷 190-200页

作者： Renee Pekmezaris Edgardo Cigaran vidhi patel Damian Clement Christine L Sardo Molmenti Ernesto Molmenti Feinstein Institutes for Medical Research Northwell HealthManhassetNY 11030United States Department of Nephrology Northwell Health/Zucker School of Medicine at HosftraManhassetNY 11030United States

BACKGROUND The Hispanic community has a high demand for organ donation but a shortage of *** investigating factors that could promote or hinder organ donation have examined emotional video *** acting as barriers to organ donation registration have been classified as:(1)Bodily integrity;(2)medical mistrust;(3)“ick”-feelings of disgust towards organ donation;and(4)“jinx”-fear that registration may result in one dying due to premeditated *** predict that by providing necessary information and education about the donation process via a short video,individuals will be more willing to register as organ *** To determine perceptions and attitudes regarding barriers and facilitators to organ donation intention among Hispanic residents in the New York metropolitan *** This study was approved by the Institutional Review Board at Northwell *** approval reference number is No.19-0009(as presented in Supplementary material).Eligible participants included Hispanic New York City(NYC)residents,18 years of age and above,who were recruited voluntarily through Cloud Research and participated in a larger randomized survey study of NYC *** survey an 85-item Redcap survey measured participant demographics,attitudes,and knowledge of organ donation as well as the intention to register as an organ *** checks were implemented throughout the survey,and responses were excluded for those who did *** were randomly assigned two-between subject conditions:To view a short video on organ donation and then proceed to complete the survey(i.e.,video first)and view the same video at the end of the survey(video last).No intra-group activities were *** study utilized an evidenced-based emotive educational intervention(video)which was previously utilized and was shown to increase organ donation registration rates at the Ohio Department of Motor *** were analyzed using Jamovi statistical softw

关键词： Community engagement and health Health equity Diversity and inclusion Health policy Kidney donation Minority health and disparities Organ transplant

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Effectiveness of m-health technology-enabled physical activity program on physical activity adoption and adherence in people with hypertension in India:A randomized controlled trial protocol

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Chronic Diseases and Translational Medicine 2024年第2期10卷 92-101页

作者： vidhi Thakar Sureshkumar Kamalakannan V.Prakash Ashok&Rita patel Institute of Physiotherapy Charotar University of Science and TechnologyChangaAnandGujaratIndia Department of Social Work Education and Community-WellbeingNorthumbria UniversityNewcastle upon TyneUK

Background Exercise and medication have similar benefits in reducing blood pressure(BP);however,hypertension management initiatives primarily focus on *** is due to scarce research on the effectiveness of implementation strategies for optimal exercise adoption and *** were found to be effective in delivering hypertension care and increase exercise *** this,only a small number of research projects in India have used smartphones as a strategy for managing *** We hypothesized that smartphone application-based care would lead to higher exercise adherence among adults(30–79 years)with hypertension compared to those who receive usual *** will be a multicentric,randomized controlled,parallel-design,superiority clinical *** outcome assessor and data analyst will be blinded to group *** in the intervention group will receive mobile application-based care for 6 *** in the usual care group will receive a standard *** groups will receive the same number of *** The primary outcome is the difference in the proportion of people adherent to the recommended level of physical activity evaluated using an exercise adherence rating scale in the intervention group and the control *** adoption will be measured as the percentage of eligible participants in each study setting willing to initiate the exercise *** secondary outcome includes differences in systolic and diastolic BP and self-management(evaluated using the Hypertension Self-Care Profile).The trial outcome will be accompanied by a process *** This research will inform about the comparative effectiveness of conventional and m-health interventions for exercise adoption and adherence in people with hypertension in resource-constrained settings.

关键词： hypertension low-and middle-income countries m-health physical activity adherence

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Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders

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World Journal of Diabetes 2022年第6期13卷 434-441页

作者： Arjun Jain Kristof Bozovicar vidhi Mehrotra Tomaz Bratkovic Martin H Johnson Ira Jha ET-Traps Limited Cambridge CB30JEUnited Kingdom Department of Physiology Development and NeuroscienceUniversity of CambridgeCambridge CB23DYUnited Kingdom Accelerate Cambridge Judge Business SchoolUniversity of CambridgeCambridge CB21AGUnited Kingdom Department of Pharmaceutical Biology Faculty of PharmacyUniversity of LjubljanaSlovenia 1000Slovenia

BACKGROUND Endothelin(ET)-traps are Fc-fusion proteins with a design based on the physiological receptors of *** work has shown that use of the selected ET-traps potently and significantly reduces different markers of diabetes pathology back to normal,non-disease *** To demonstrate the selected ET-traps potently and significantly bind to *** We performed phage display experiments to test different constructs of ET-traps,and conducted bio-layer interferometry binding assays to verify that the selected ET-traps bind specifically to ET-1 and display binding affinity in the double-digit picomolar range(an average of 73.8 rM,n=6).RESULTS These experiments have confirmed our choice of the final ET-traps and provided proof-of-concept for the potential use of constructs as effective biologics for diseases associated with pathologically elevated *** There is increased need for such therapeutics as they could help save millions of lives around the world.

关键词： Endothelin-1 Endothelin-traps Diabetes Heart failure Chronic kidney disease Novel therapeutic

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CXCL12 G801A Polymorphism and Cancer Risk: An Updated Meta-analysis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第3期35卷 319-326页

作者：孟丹邬引翔 vidhi Heerah 彭双褚梦迪徐永健熊维宁许淑云 Department of Respiratory and Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Many studies have reported the relationship between CXCL12 G801 A polymorphism and cancer risk, with conflicting results. In this study, we tried to clarify the possibility that this polymorphism may increase cancer risk by conducting an updated meta-analysis. Pub Med and EMbase were searched for case-control studies regarding the association of the gene polymorphism and cancer risk. Data were extracted and odds ratios（ORs） with 95% confidence intervals（95% CIs） were used to assess the strength of the association. Heterogeneity among articles and publication bias was also assessed. Significantly increased risk for cancer was found（A vs. G： OR=1.26, 95% CI=1.13-1.40, P〈0.01; AA＋AG vs. GG： OR=1.33, 95% CI=1.16-1.52, P〈0.01）. In subgroup analysis, statistically elevated cancer risk was found in both Asian and Caucasian populations（for Asian, AA＋AG vs. GG： OR=1.74, 95% CI=1.22-2.47, P〈0.01; for Caucasian, AA＋AG vs. GG： OR=1.24, 95% CI=1.09-1.42, P〈0.01）. Our result indicated that CXCL12 G801 A polymorphism is a risk factor for cancer. To validate the finding, further large-size case-control studies are warranted.

关键词： CXCL12 polymorphism cancer risk meta-analysis

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Pelvic arterial embolization in obstetric hemorrhage

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World Journal of Obstetrics and Gynecology 2013年第4期2卷 185-191页

作者： vidhi Chaudhary Poonam Sachdeva Raksha Arora Devender Kumar Priya Karanth Department of Obstetrics and Gynecology Maulana Azad Medical College and associated Lok Nayak Hospital and GB Pant Hospital New Delhi 110002 India

AIM: To analyze safety and efficacy of pelvic arterial embolization(PAE) in preventing and treating obstetrical ***: A consecutive study of eight cases undergoing pelvic artery embolization from January 2010 to October 2012 in Department of Obstetric and Gynecology of Maulana Azad Medical College for intractable obstetric hemorrhage was done. All embolization were carried out in cath lab of cardiology Department at associated GB Pant ***: Clinical success was defined as arrest of bleeding after PAE without need for repeat PAE or additional surgery which was 75% in our series. PAE was successful in controlling obstetrical hemorrhage in all except one who had mortality. Other had hysterectomy due to secondary hemorrhage. Five resumed menstruation. None of the women intended to conceive, hence are practicing contraception. CONCLUSION: PAE is minimally invasive procedure which should be offered early for hemostasis in intractable obstetrical haemorrhage unresponsive to uterotonic. It is a fertility sparing option with minor complications.

关键词：盆腔动脉栓塞术产科治疗方法临床分析

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Concept of dushi visha(latent poison)a review in ayurveda

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TMR Theory and Hypothesis 2019年第2期2卷 166-172页

作者： Dr.Deepti patel Dr.S.R.Inchulkar Dr.YuvrajKaushik Dr.N.S.Chauhan Department of Agad Tantra Evam vidhi Vaidyak Govt. Ayurveda CollegeRaipurIndia Senior Scientific Officer Grade-II Drug Testing Laboratory Avam Anusandhan Kendra RaipurIndia

A poison,which is having fewer properties,which means less thanit’s own ten classical properties or the poison which is having lesser potency of all ten properties,attains a accumulative or hidden stage in the body is called Dushi Visha(latent poison).Low potency of all the ten qualities of poison are said to be responsible for the delayed action and cumulative toxicity on the body.A much detailed description about DushiVisha is not seen in Ayurvedic *** concept of DushiVisha is still an *** understand Dushi Visha,it is important to understand that what are theoriginating factors can be considered under DushiVisha,how it remains in the body without undergoing elimination,how does it causes cumulative toxicity,which factors will aggravate DushiVisha,how the clinical features of DushiVisha will be presented in the *** get proper answer to all these practical queries,it is necessary to go through it’*** an attempt is made to review the concept of DushiVisha in detail.

关键词： DushiVisha Latent poison Virudhahara Cumulative toxicity

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