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Association between physical activity and cardiovascular risk factors:Dose and sex matter

Journal of Sport and Health Science 2021年第5期10卷 604-606页

作者： Alejandro Santos-Lozano Alberto Torres Barran Pablo Fernandez-Navarro Pedro L.Valenzuela Adrian Castillo-Garcia Luis MRuilope David Rios Insua Jose M.Ordovas victoria ley Alejandro Lucia i+HeALTH Department of Health SciencesEuropean University Miguel de CervantesValladolid 47012Spain Research Institute of the Hospital 12 de Octubre(imas12 PaHerg group)and(CIBER en Fragilidad y Envejecimiento Saludable-CIBEFES)Madrid 28041Spain Institute of Mathematical Sciences(ICMAT-CSIC) Madrid 28049Spain d Cancer and Environmental Epidemiology Unit National Center for EpidemiologyCarlos III Institute of HealthMadrid 28029Spain Consortium for Biomedical Research in Epidemiology&Public Health(CIBER en Epidemiologia y Salud Publica-CIBERESP) Madrid 28029Spain Department of Systems Biology University of AlcalaMadrid 28801Spain Fissac-Physiology Health and Physical ActivityMadrid 28801Spain Hypertension Unit and Cardiorenal Translational Laboratory Research Institute of the Hospital 12 de Octubre(imas12)Madrid 28041Spain Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University BostonMA 02111USA Spanish State Research Agency Ministry of ScienceInnovation and UniversitiesMadrid 28046Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain

Dear Editor,ETadegn TagedPFailure to meet World Health Organization(WHO)-determined minimum physical activity(PA)levels is an established risk factor for cardiovascular disease(CVD),^(1)but evidence is still scarce on its effects on other CVD risk ***,whether or not there are sex-specific effects on the association between PA and CVD risk is a matter of controversy,with some authors observing a protective effect of PA in men but not in women,^(2)and others finding the opposite trend.^(3)

关键词： cardiovascular protective finding

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Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

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Journal of Molecular Cell Biology 2015年第2期7卷 119-131页

作者： Jason Howitt ley-Hian Low Ulrich Putz Anh Doan Jenny Lackovic Choo-Peng Goh Jenny Gunnersen John Silke Seong-Seng Tan Brain Development and Regeneration Division Florey Institute of Neuroscience and Mental HealthThe University of MelbourneParkvilleVictoria 3010Australia Department of Anatomy and Neuroscience The University of MelbourneParkvilleVictoria 3010Australia Cell Signalling and Cell Death Laboratory Walter and Eliza Hall InstituteThe University of MelbourneParkvilleVictoria 3010Australia

Pten controls a signaling axis that is implicated to regulate cell proliferation,growth,survival,migration,and *** molecular mechanisms underlying the specificity of Pten responses to such diverse cellular functions are currently poorly *** report the control of Pten activity and signaling specificity during the cell cycle by Ndfip1 regulation of Pten spatial *** deletion of Ndfip1 resulted in a loss of Pten nuclear compartmentalization and increased cell proliferation,despite cytoplasmic Pten remaining active in regulating PI3K/Akt *** lacking nuclear Pten were found to have dysregulated levels of Plk1 and cyclin D1 that could drive cell *** vivo,transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors,resulting in *** results show that local partitioning of Pten from the cytoplasm to the nucleus represents a key mechanism contributing to the specificity of Pten signaling during cell proliferation.

关键词： Akt autism cancer cell cycle microcephaly nuclear trafficking ubiquitin

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