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肥厚性幽门狭窄患儿是否需要进行泌尿道超声扫描检查

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 4-4页

作者： Cascio s. siddiqui M. M. F. Barrett A. M. 李开 Department of Paediatric surgery Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP United Kingdom

Aim: Few retrospective studies have evaluated infants with hypertrophic pyloric stenosis (HPs) for associated urological anomalies. They have led to contradictory conclusions. The aim of this study was to evaluate the incidence of urinary tract anomalies in infants with HPs and to establish the clinical significance of this association. Methods: One hundred and twenty-two infants (100 boys) who underwent pyloromyotomy between 1992 and 2002 were prospectively evaluated. screening ultrasound (Us) of the urinary tract was performed in 107 infants, while 15 did not attend their ultrasound appointment. Results: Renal ultrasound was abnormal in 4 (4%) of 107 screened patients with HPs. Three patients were found to have mild hydronephrosis and, in one patient, a small, normal kidney was detected. Two patients with hydronephrosis had Us follow-up and the third patient underwent Tc-99 mercaptoacetyl triglycine (MAG 3) scan. In all three patients, the hydronephrosis resolved completely on follow-up scan. Conclusion: The incidence of abnormal renal ultrasound in children with HPs is similar to the reported incidence of 3-6%determined with routine ultrasound screening of healthy newborns. The abnormalities detected were not clinically relevant and did not require surgical intervention. We do not recommend screening of the urinary tract in infants with HPs.

关键词：肥厚性幽门狭窄超声扫描超声筛查肾积水健康新生儿追踪随访临床相关性

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多症状卵巢癌患者的医患交流和感知控制

世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 51-51页

作者： Donovan H.s. Hartenbach E.M. Method M.W. 张丽娟 Department of Acute and Tertiary Care University of Pittsburgh School of Nursing 336 Victoria Building 3500 Victoria Street Pittsburgh PA 15261 United State

Objectives. Optimal cancer symptom management requires effective patient-health care provider (HCP) communication. The goals of this study were to 1) describe symptom experiences of women with ovarian cancer, 2) evaluate frequency of patient-HCP communication about symptoms, and 3) evaluate whether communication is associated with patients’confidence in managing symptoms. Methods. This was a cross-sectional mailed survey study. The symptom Experience survey, containing valid, reliable measures of symptom severity and controllability; symptom communication; and symptom-related coping strategies, was mailed to members of the National Ovarian Cancer Coalition. Descriptive statistics, t tests, correlations, and ANCOVA were used to address study objectives. Results. This analysis focuses on the 279 respondents who had active disease. The majority of women had recurrent disease (96%)-and were on chemotherapy (57%). Women reported a mean of 12 concurrent symptoms. Fatigue, bowel disturbances, and peripheral neuropathies were the most severe and most noticed symptoms. Only 61%of women had discussed their most noticed symptom with an HCP in the past month, and only 50%of women reported that they had received symptom management recommendations. Women reported low levels of perceived control over symptoms (M = 1.97 on a 0-4 scale). There was a significant interaction effect for symptom discussions and management recommendations on perceived control. Women who had never received recommendations had low perceived control whether or not they had discussed their symptom with an HCP in the past month. For women who had received recommendations, those who had discussed their symptom with an HCP in the past month had higher perceived control compared to those who had not discussed their symptom. Conclusions. Women with ovarian cancer experience multiple symptoms, but many do not discuss symptoms with their HCPs and fewer report receiving symptom management recommendations. Women woul

关键词：医患交流处理建议健康护理横断面调查肠功能紊乱关联性分析处理效果统计分析协方差分析可

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利妥昔单抗治疗僵人综合征

世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 31-31页

作者： Baker M.R. Das M. Isaacs j. D. Bates 王孝文 Department of Neurology Royal Victoria Infirmary Queen Victoria Road Newcastle upon Tyne NE1 4LP Unit ed Kingdom Prof.

This case report is about the novel use of the anti- CD20 antibody, rituxima b, in the treatment of a 41 year old woman with stiff person syndrome. she was a dmitted to hospital as an emergency with prolonged and painful extensor spasms a ffecting the neck and back, arms, and legs. The disease had progressed despite a favourable initial response to conventional treatment with intravenous immunogl obulin and cytotoxics. Treatment with rituximab induced a lasting clinical remis sion.

关键词：僵人综合征利妥昔单抗临床缓解细胞毒素急症入院静脉输注肌痉挛免疫球蛋白初始反应

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FH／Wjd大鼠嗜酒的行为特性

中国药理通讯 2008年第3期25卷 40-40页

作者：景丽张振华王卫平张敏罗娟 CHEN Feng Andrew j Lawrence 梁建辉北京大学中国药物依赖性研究所北京100191 澳大利亚RMIT大学医学院 Victoria3083 澳大利亚Melbourne大学Howard Florey研究所 Victoria3010

目的：系统考察FH／Wjd大鼠嗜酒的行为特性。方法：采用双瓶（5％或10％酒精和自来水）自由选择的方法，观察FH／Wjd大鼠的饮酒量、饮水量和酒精偏爱率，并进一步探讨FH／Wjd大鼠饮酒的昼夜差异性；在酒精剥夺实验中，研究酒精剥夺24h... 详细信息

目的：系统考察FH／Wjd大鼠嗜酒的行为特性。方法：采用双瓶（5％或10％酒精和自来水）自由选择的方法，观察FH／Wjd大鼠的饮酒量、饮水量和酒精偏爱率，并进一步探讨FH／Wjd大鼠饮酒的昼夜差异性；在酒精剥夺实验中，研究酒精剥夺24h对FH／Wjd大鼠饮酒量和酒精偏爱率的影响；选用固定比率（FR1）实验程序，探讨FH／Wjd大鼠操作性自身饮酒的行为特点。结果：在双瓶自由选择饮酒实验中，

关键词：行为特点大鼠嗜酒酒精偏爱实验程序饮酒量固定比率自来水

4cm Z轴与16cm Z轴覆盖范围的多层螺旋CT灌注对比研究

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国际医学放射学杂志 2010年第4期 407-407页

作者： M.Page D.Nandurkar M.P.Crossett s.L.stuckey K.P.Lau N.Kenning 赵芳 Department of Diagnostic Imaging Southern Health NetworkMonash Medical Centre246 Clayton RdClayton3168VictoriaAustralia

目的对比研究4cm Z轴与16cm Z轴覆盖范围的320层多层螺旋CT(MDCT)颅脑CT灌注成像(CTP)。方法回顾性非随机研究2008年9月-2009年1月间,320层MDCT所行CTP检查。由2名有经

关键词：对比研究 CT cm 覆盖范围多层螺旋

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香港维多利亚港码头的附着生物群落

海洋学报 1999年第2期21卷 86-92页

作者：黄玉山黄宗国刘培生刘文华香港科技大学研究中心国家海洋局第三海洋研究所厦门361005

香港维多利港自东至西6座码头的附着生物群落较旺盛，物种多样性比较丰富（183种），其中还有一些外来物种．各湖区的群落结构差别很大．高潮区以滨螺（Littorinabrevicula等3种）-笠贝（Cellanatoreuma等）为标志；中潮区是笠藤壶（Tet... 详细信息

香港维多利港自东至西6座码头的附着生物群落较旺盛，物种多样性比较丰富（183种），其中还有一些外来物种．各湖区的群落结构差别很大．高潮区以滨螺（Littorinabrevicula等3种）-笠贝（Cellanatoreuma等）为标志；中潮区是笠藤壶（Tetraclitaspp．）-牡蛎（saccostreaechinata）带；低潮区是翡翠贻贝-瘤海鞘-海绵和网纹藤壶带．流急、浪大是群落较旺盛发展主要因子．

关键词：香港维多利亚港附着生物群落滨螺笠贝牡蛎

小胶质细胞在光/暗周期过程中调节海马突触传递和睡眠持续时间

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神经损伤与功能重建 2022年第5期17卷 310-310页

作者：杜一星(编译) Department of Physiology and Pharmacology Sapienza University of Rome Axe Neurosciences Centre de Recherche du CHU de Québec Université Laval Quebec City Department of Neurology San Raffaele of Cassino 4. National Research Council Institute of Biochemistry and Cell Biology (EMMA/Infrafrontier/IMPC ) International Campus "A. Buzzati-Traverso" INRAE Bordeaux INP NutriNeuro UMR 1286 Bordeaux University Tecniplast s.P.A. Buguggiate Department of Molecular Medicine Sapienza University INsERM Neurocentre Magendie Physiopathologie de la Plasticité Neuronale Division of Medical sciences University of Victoria The Department of Biochemistry and Molecular Biology The University of British Columbia Department of Physiology and Pharmacology Sapienza University Laboratory affiliated to Istituto Pasteur Italia Department of Neurophysiology Neuropharmacology Inflammaging IRCCS Neuromed

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研... 详细信息

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研究。以光作为授时提示,我们研究了用集落刺激因子-1受体拮抗剂PLX5622消除小胶质细胞对雄性小鼠睡眠/觉醒周期和海马突触传递的影响。我们的数据表明,小胶质细胞几乎完全的耗竭会增加NREM睡眠的持续时间并减少海马兴奋性神经传递。由于cx3cr1GFP/GFP小鼠显现与PLX5622处理的小鼠中发现的相同情况,趋化因子fractalkine受体CX3CR1在这些效应中起相关作用。此外,在光照阶段小胶质细胞表达较低水平的cx3cr1;当培养的小胶质细胞受到ATP(一种在睡眠期间释放的嘌呤能分子)的刺激时其cx3cr1表达降低。我们的研究结果表明,小胶质细胞参与调节睡眠,调整其cx3cr1表达以响应光/暗阶段,并以时相依赖性方式调节突触活动。

关键词： cx3cr1 脑电图长期增强小胶质细胞耗竭微型兴奋性突触后电流睡觉眠自发兴奋性突触后电流

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