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Phenotypic plasticity in Drosophila cactophilic species the effect of competition, density, and breeding sites

Insect Science 2017年第4期24卷 675-683页

作者： Juan Jose Fanara victoria Werenkraut Departamento de Ecologia Genetica y Evolucion Instituto de Ecologia GeneUca y Evolucion de Buenos Aires (CONICET-UBA) Facultad de Ciencias Exactas y Naturales Ciudad Universitaria Pabellon II Universidad de Buenos Aires Buenos Aires Laboratorio Ecotono Centro Regional Universitario Bariloche Universidad Nacional del ComahuelINIBIOMA-CONICET Quintral 1250 Bariloche Rio Negro Argentina

Changes in the environmental conditions experienced by naturally occurring populations are frequently accompanied by changes in adaptive traits allowing the organ- ism to cope with environmental unpredictability. Phenotypic plasticity is a major aspect of adaptation and it has been involved in population dynamics of interacting species. In this study, phenotypic plasticity （i,e., environmental sensitivity） of morphological adap- tive traits were analyzed in the cactophilic species Drosophila buzzatii and Drosophila koepferae （Diptera： Drosophilidae） considering the effect of crowding conditions （low and high density）, type of competition （intraspecific and interspecific competition） and cacti hosts （Opuntia and Columnar cacti）. All traits （wing length, wing width, thorax length, wing loading and wing aspect） showed significant variation for each environmental factor considered in both Drosophila species. The phenotypic plasticity pattern observed for each trait was different within and between these cactopbilic Drosophila species depending on the environmental factor analyzed suggesting that body size-related traits respond almost independently to environmental heterogeneity. The effects of ecological factors analyzed in this study are discussed in order to elucidate the causal factors investigated （type of com- petition, crowding conditions and alternative host） affecting the election of the breeding site and/or the range of distribution of these cactophilic species.

关键词： adaptation body size colonization Drosophila cactophilic species wingaspect wing loading

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Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens

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Plant Communications 2024年第1期5卷 55-68页

作者： Antoni Garcia-Molina victoria Pastor Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB C/Vall MorontaEdifici CRAG08193 Bellaterra(Cerdanyola del Valles)BarcelonaSpain Department of Biology Biochemistryand Natural SciencesSchool of Technology and Experimental SciencesUniversitat Jaume I12006 Castellode la PlanaSpain

Understanding plant immune responses is complex because of the high interdependence among biological processes in homeostatic ***,the integration of environmental cues causes network rewiring that interferes with defense ***,plants retain molecular signatures configured under abiotic stress periods to rapidly respond to recurrent stress,and these can alter *** changes imposed by abiotic stressors are persistent,although their impact on defense remains to be *** this study,we profiled metabolomes of Arabidopsis plants under several abiotic stress treatments applied individually or simultaneously to capture temporal trajectories in metabolite composition during adverse conditions and *** systemic analysis was performed to address the relevance of me-tabolome changes and extract central features to be tested in *** results demonstrate irreversibility in major fractions of metabolome changes as a general pattern in response to abiotic stress ***-tionalanalysisofmetabolomesandco-abundancenetworkspoints toconvergence inthereconfigurationof organic acid and secondary metabolite *** mutant lines for components related to these metabolic pathways showed altered defense capacities against different ***,our data suggest that sustained metabolome changes configured in adverse environments can act as mod-ulators of immune responses and provide evidence for a new layer of regulation in plant defense.

关键词： abiotic stress Arabidopsis biotic stress combinatorial stress metabolomics systems biology

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Magnetic Properties of Rare Earth Thiophosphates REPS_4

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Journal of Rare Earths 1999年第2期17卷 32-35页

作者： Huang, Zhongle Cajipe, victoria Molinie, Philippe Xiamen Univ Xiamen China

The magnetic susceptibilities of REPS4(RE=LaYb) compounds series were measured in the temperature range of 2300 K. The variations of the susceptibility and the inverse susceptibility along with the temperature were studied for each case. The CurieWeiss constants(C and and the effect moment eff for each paramagnetic RE3+ were obtained by simulating the susceptibility data measured in the temperature range of 50300 K.

关键词： Rare earths REPS4 Magnetic susceptibility CurieWeiss law Magnetic moment

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Intrahepatic cholestasis of pregnancy

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World Journal of Gastroenterology 2009年第17期15卷 2049-2066页

作者： victoria Geenes Catherine Williamson Maternal and Fetal Disease Group Institute of Reproductive and Developmental Biology Imperial College London London W12 0NN United Kingdom

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICP.

关键词： Cholestasis Pregnancy Pruritus Bile acid

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Contemporary climate infuence on variability patterns of Anadenanthera colubrina ***,a key species in seasonally dry tropical forests

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Journal of Forestry Research 2022年第1期33卷 89-101页

作者： María victoria García María Eugenia Barrandeguy Kathleen Prinz Genética de Poblaciones y Cuantitativa-Departamento de Genética-Facultad de Ciencias Exactas Químicas y Naturales-Universidad Nacional deMisionesInstituto de Biología Subtropical(UNaM-CONICET)Nodo PosadasFélix de Azara 15523300 PosadasArgentina Consejo Nacional de Investigaciones Científicas Y Técnicas(CONICET) PosadasMisionesArgentina Institute of Systematic Botany With Herbarium Haussknecht and Botanical Gardens Friedrich-Schiller-University Jena07743 JenaGermany

The distribution of many plant species has been shaped by climate changes,and their current phenotypic and genetic variability refect microclimatically suitable *** study relates contemporary climate to variability patterns of phenotypic traits and molecular markers in the Argentinean distribution of Anadenanthera colubrina ***,as well as to identify the most relevant phenotypic trait or molecular marker associated with those *** from four populations in both biogeographic provinces,Paranaense and Yungas,were *** analyses and multiple linear regressions were carried out to determine relationships among phenotypic traits and nuclear microsatellites,respectively,to climatic variables,and to identify the phenotypic traits as well as nuclear microsatellite loci most sensitive to *** and three clusters of individuals were detected based on genetic and phenotypic data,*** clusters based on genetic data refected the biogeographic origin of *** traits were the most relevant indicators of climatic *** microsatellite locus Ac41.1 appeared to be non-neutral presenting a strong correlation with climate variable temperature *** findings show complex patterns of genetic and phenotypic variability in the Argentinean distribution of *** *** related to the present or contemporary climate,and provides an example for an integrative approach to better understand climate impact on contemporary genetic and phenotypic variability in light of global climate change.

关键词： Contemporary climate Curupay Genetic variability Phenotypic variability Seasonally dry tropical forests

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Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: Mesenchymal stem cells from induced pluripotent stem cells

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World Journal of Stem Cells 2021年第8期13卷 1094-1111页

作者： victoria Dupuis Elisa Oltra Facultédes Sciences et d’Ingénierie Sorbonne UniversitéParis 75252France Department of Pathology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Centro de Investigación Traslacional San Alberto Magno Universidad Católica de Valencia San Vicente MártirValencia 46001Spain

Mesenchymal stem cells(MSCs)have received significant attention in recent years due to their large potential for cell ***,they secrete a wide variety of immunomodulatory factors of interest for the treatment of immune-related disorders and inflammatory *** can be extracted from multiple tissues of the human ***,several factors may restrict their use for clinical applications:the requirement of invasive procedures for their isolation,their limited numbers,and their heterogeneity according to the tissue of origin or *** addition,MSCs often present early signs of replicative senescence limiting their expansion in vitro,and their therapeutic capacity in *** to the clinical potential of MSCs,a considerable number of methods to differentiate induced pluripotent stem cells(iPSCs)into MSCs have *** represent a new reliable,unlimited source to generate MSCs(MSCs derived from iPSC,iMSCs)from homogeneous and well-characterized cell lines,which would relieve many of the above mentioned technical and biological ***,the use of iPSCs prevents some of the ethical concerns surrounding the use of human embryonic stem *** this review,we analyze the main current protocols used to differentiate human iPSCs into MSCs,which we classify into five different categories:MSC Switch,Embryoid Body Formation,Specific Differentiation,Pathway Inhibitor,and Platelet *** also evaluate common and method-specific culture components and provide a list of positive and negative markers for MSC *** guidance on material requirements to produce iMSCs with these methods and on the phenotypic features of the iMSCs obtained is *** information may help researchers identify protocol options to design and/or refine standardized procedures for large-scale production of iMSCs fitting clinical demands.

关键词： Mesenchymal stem cells Induced pluripotent stem cells Mesenchymal stem cells derived from induced pluripotent stem cells Differentiation methods Culture components Mesenchymal stem cell markers

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Molecular mechanisms underpinning sarcomas and implications for current and future therapy

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2135-2153页

作者： victoria Damerell Michael SPepper Sharon Prince Division of Cell Biology Department of Human BiologyFaculty of Health SciencesUniversity of Cape TownObservatoryCape TownSouth Africa lnstitute for Cellular and Molecular Medicine Department of ImmunologySAMRC Extramural Unit for Stem Research and TherapyFaculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa

Sarcomas are complex mesenchymal neoplasms with a poor *** clinical management is highly challenging due to their heterogeneity and insensitivity to current *** there have been advances in understanding specific genomic alterations and genetic mutations driving sarcomagenesis,the underlying molecular mechanisms,which are likely to be unique for each sarcoma subtype,are not fully *** is in part due to a lack of consensus on the cells of origin,but there is now mounting evidence that they originate from mesenchymal stromal/stem cells(MSCs).To identify novel treatment strategies for sarcomas,research in recent years has adopted a mechanism-based search for molecular markers for targeted therapy which has included recapitulating sarcomagenesis using in vitro and in vivo MSC *** review provides a comprehensive up to date overview of the molecular mechanisms that underpin sarcomagenesis,the contribution of MSCs to modelling sarcomagenesis in vivo,as well as novel topics such as the role of epithelial-to-mesenchymal-transition(EMT)/mesenchymal-to-epithelial-transition(MET)plasticity,exosomes,and microRNAs in *** also reviews current therapeutic options including ongoing pre-clinical and clinical studies for targeted sarcoma therapy and discusses new therapeutic avenues such as targeting recently identified molecular pathways and key transcription factors.

关键词： sarcoma neoplasms alterations

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Neoadjuvant treatment of esophageal cancer

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World Journal of Gastroenterology 2010年第30期16卷 3793-3803页

作者： Nicholas P Campbell victoria M Villaflor Section of Hematology/Oncology Department of MedicineThe University of Chicago Pritzker School of MedicineChicagoIL 60637United States

The management of esophageal cancer has been evolving over the past 30 years. In the United States, multimodality treatment combining chemotherapy and radiotherapy (RT) prior to surgical resection has come to be accepted by many as the standard of care, although debate about its overall effect on survival still exists, and rightfully so. Despite recent improvements in detection and treatment, the overall survival of patients with esophageal cancer remains lower than most solid tumors, which highlights why further advances are so desperately needed. The aim of this article is to provide a complete review of the history of esophageal cancer treatment with the addition of chemotherapy, RT, and more recently, targeted agents to the surgical management of resectable disease.

关键词： Esophageal cancer Multimodality therapy Neoadjuvant therapy Chemotherapy Radiotherapy Targeted agents Disease management

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Early detection of pancreatic cancer

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Chinese Journal of Cancer Research 2015年第4期27卷 321-331页

作者： victoria M.Kim Nita Ahuja Department of Surgery and Medical Oncology The Sol Goldman Pancreatic Cancer Research Center The Johns Hopkins University School of Medicine Department of Urology Johns Hopkins University School of Medicine

Pancreatic adenocarcinoma is a low-incident but highly mortal disease. It accounts for only 3% of estimated new cancer cases each year but is currently the fourth common cause of cancer mortality. By 2030, it is expected to be the 2nd leading cause of cancer death. There is a clear need to diagnose and classify pancreatic cancer at earlier stages in order to give patients the best chance at a definitive cure through surgery. Three precursor lesions that distinctly lead to pancreatic adenocarcinoma have been identified, and we have increasing understanding the non-genetic and genetic risk factors for the disease. With increased understanding about the risk factors, the familial patters, and associated accumulation of genetic mutations involved in pancreatic cancer, we know that there are mutations that occur early in the development of pancreatic cancer and that improved genetic risk-based strategies in screening for pancreatic cancer may be possible and successful at saving or prolonging lives. The remaining challenge is that current standards for diagnosing pancreatic cancer remain too invasive and too costly for widespread screening for pancreatic cancer. Furthermore, the promises of noninvasive methods of detection such as blood, saliva, and stool remain underdeveloped or lack robust testing. However, significant progress has been made, and we are drawing closer to a strategy for the screening and early detection of pancreatic cancer.

关键词： Early detection screening pancreatic cancer familial pancreatic cancer

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An experimental investigation of properties of polyethylene reinforced with Al powders

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第8期12卷 583-592页

作者： victoria CHIFOR Zafer TEKINER Mehmet TURKER Radu ORBAN Department of Materials Science and Technology Faculty of Materials Science and EngineeringTechnical University of Cluj-Napoca Mechanical/Metallurgy Education Department Faculty of Technical EducationGazi University

Mechanical and physical properties, such as tensile strength, elongation at break, modulus of elasticity, Shore D hardness, melt flow rate (MFR), and electrical and thermal conductivities of composites with high density polyethylene matrix reinforced with Al powders were investigated experimentally. Measurements of the mechanical and physical properties were performed up to a reinforcing component concentration of 30% volume Al powder and compared with mathematical models from the literature. The obtained results have shown that experimental data were in good agreement with theoretical data. The ultimate tensile strength (UTS) and elongation at break decreased with increasing Al powder content, which was attributed to the intro-duction of discontinuities in the polymer structure, and modulus of elasticity increased with increasing Al content. The composite preparation conditions allowed the formation of a random distribution of metallic particles in the polymer matrix volume for system high density polyethylene-Al (HDPE-Al). There was a cluster formation of Al particles at higher Al contents in the polymer matrix. Electrical and thermal conductivity values of HDPE-Al composites were higher than pure HDPE values.

关键词： Polymer composite Mechanical properties Melt flow rate(MFR) Thermal conductivity Electrical conductivity

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