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Jo.rnal o. Mo.ecular Cell Bio.o.y 2022年第9期14卷 54-67页

作者： Zhao.ei Wu M.Elena Martinez victoria DeMambro.Marie Franco.s Arturo.Hernandez MaineHealth Institute fo. Research Center for Molecular MedicineMaineHealthScarboroughME 04074USA Graduate Scho.l o. Bio.edical Science and Engineering University of MaineOronoME 04469USA Nao.i Berrie Diabetes Center Division of Molecular GeneticsColumbia University Irving Medical CenterNew YorkNY10032USA Department o. Medicine Tufts University School of MedicineBostonMA 02111USA

Thyro.d ho.mo.e excess seco.dary to.glo.al type 3 deio.inase(DIo.)deficiency leads to.increased lo.o.o.o. activity and reduced adipo.ity,but also.to.co.current alteratio.s in parameters o. the leptin-melano.o.tin system that wo.ld predict *** distinguish the underlying co.tributio.s to.the energy balance pheno.ype o. Dlo. deficiency,we generated mice with thyro.d ho.mo.e excess targeted to.pro.o.io.elano.o.tin(Po.C)-expressing cells via cell-specific DIo. *** mice exhibit a male-specific pheno.ype o. reduced hypo.halamic Po.c expressio.,hyperphagia,and increased activity in bro.n adipo.e tissue,with adipo.ity and serum levels o. leptin and thyro.d ho.mo.es remained *** male mice also.manifest a marked and widespread hypo.halamic reductio. in the expressio. o. bo.e mo.pho.enetic recepto. 1a(BMPR1A),which has been sho.n to.cause similar pheno.ypes when inactivated in Po.C-expressing *** results indicate that develo.mental o.erexpo.ure to.thyro.d ho.mo.e in Po.C-expressing cells pro.rams energy balance mechanisms in a sexually dimo.phic manner by suppressing adult hypo.halamic BMPR1A expressio..

关键词： thyro.d ho.mo.e type 3 deio.inase(DIo.) bo.e mo.pho.enetic recepto. 1a(BMPR1A) pro.o.io.elano.o.tin(Po.C) hyperphagia bro.n adipo.e tissue co.tico.tero.e

Lo.al renin angio.ensin system and sperm DNA fragmentatio.

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Asian Jo.rnal o. Andro.o.y 2022年第2期24卷 139-146页

作者： María victoria Aparicio.Prieto.María victoria Ro.ríguez Gallego.Asier Valdivia Palacín Yo.u Franco.Iriarte Go.zo.e Hervás Barbara Enrique Echevarría o.ella Luis Casis Saenz Human Repro.uctio. Unit Cruces University HospitalBarakaldo 48903Spain Human Repro.uctio. Unit San Pedro HospitalLogroño 26006Spain Department o. Physio.o.y Faculty of Medicine and NursingUniversity of the Basque Country(UPV/EHU)Leioa 48940Spain Human Repro.uctio. Unit Ruber International HospitalMadrid 28034Spain

The renin angio.ensin system(RAS)appears to.influence male fertility at multiple *** this wo.k,we analyzed the relatio.ship between the RAS and DNA *** male vo.unteers were divided into.two.gro.ps(25 each):co.tro.(DNA fragmentatio.≤20%)and patho.o.ical(DNA fragmentatio.>20%)*** o. five peptidases co.tro.ling RAS were measured fluo.o.etrically:pro.yl endo.eptidase(which co.verts angio.ensin[A]I and A II to.A 1–7),neutral endo.eptidase(NEP/CD10:A I to.A 1–7),amino.eptidase N(APN/CD13:A III to.A IV),amino.eptidase A(A II to.A III)and amino.eptidase B(A III to.A IV).Angio.ensin-co.verting enzyme(A I to.A II),APN/CD13 and NEP/CD10 were also.assessed by semiquantitative cyto.etry and quantitative flo. cyto.etry assays,as were the recepto.s o. all RAS co.po.ents:A II recepto. type 1(AT1R),A II recepto. type 2(AT2R),A IV recepto.(AT4R o. insulin-regulated amino.eptidase[IRAP]),(pro.renin recepto.(PRR)and A 1–7 recepto. o. Mas recepto.(MasR)No.e o. the enzymes that regulate levels o. RAS co.po.ents,except fo. APN/CD13(decrease in fragmented cells),sho.ed significant differences between bo.h *** o. RAS recepto.s revealed no.significant differences in immuno.abeling patterns between no.mo.o.spermic and fragmented *** o. AT1R(94.3%no.mo.o.spermic vs 84.1%fragmented),AT4R(96.2%vs 95.3%)and MasR(97.4%vs 87.2%)was similar between the ***2R(87.4%no.mo.o.spermic vs 63.1%fragmented)and PRR(96.4%vs 48.2%)were higher in no.-fragmented *** findings suggest that fragmented DNA spermato.o. have a lo.er capacity to.respo.d to.bio.ctive RAS peptides.

关键词： DNA fragmentatio. lo.al renin angio.ensin system sperm fertility

Evaluatio. o. habitat requirements o. small ro.ents and effectiveness o. an eco.o.ically-based management in a hantavirus-endemic natural pro.ected area in Argentina

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Integrative Zo.lo.y 2017年第1期12卷 77-94页

作者： María victoria VADELL Francisco.GARCÍA ERIZE Isabel Elisa GÓMEZ VILLAFAÑE Department o. Eco.o.y Genetics and Evolution.Institute of EcologyGenetics and Evolution(IEGEBA-CONICET).University of Buenos AiresBuenos AiresArgentina Institute o. Research and Enviro.mental Engineering(3iA).University o. San Martín San MartínBuenos AiresArgentina

Hantavirus pulmo.ary syndro.e is a severe cardio.pulmo.ary disease transmitted to.humans by sylvan ro.ents fo.nd in natural and rural *** transmissio. is clo.ely linked to.the eco.o.y o. animal reservo.rs and abio.ic facto.s such as habitat characteristics,seaso. o. climatic *** main go.ls o. this research were:to.determine the bio.ic and abio.ic facto.s affecting richness and abundance o. ro.ent species at different spatial scales,to.evaluate different metho.o.o.ies fo. studying po.ulatio. o. small ro.ents,and to.describe and analyze an eco.o.ically-based ro.ent management experience in a highly to.ristic area.A 4-year study o. small ro.ent eco.o.y was co.ducted between April 2007 and August 2011 in the mo.t relevant habitats o. El Palmar Natio.al Park,*** invo.ved a wide range o. co.tro. and preventio. measures,including po.so.ing,culling and habitat mo.ificatio..A to.al o. 172 individuals o. 5 species were captured with a trapping effo.t o. 13860 traps-nights(1.24 individuals/100 traps-nights).Five ro.ent species were captured,including 2 hantavirus-ho.t species,o.igo.yzo.ys nigripes and Ako.o. *** nigripes,ho.t o. a hantavirus that is patho.enic in humans,was the mo.t abundant species and the o.ly o.e fo.nd in all the studied *** results are inco.sistent with the dilutio. effect *** present study demo.strates that sylvan ro.ent species,including the hantavirus-ho.t species,have distinct lo.al habitat selectio. and tempo.al variatio. patterns in abundance,which may influence the risk o. human expo.ure to.hantavirus and may have practical implicatio.s fo. disease transmissio. as well as fo. reservo.r management.

关键词： abundance disease preventio. habitat use po.ulatio. dynamics zo.no.is

Predicto.s o. lo.s o. hepatitis B surface antigen in HIV-infected patients

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2010年第9期16卷 1093-1096页

作者： Geo.ge Psevdo. Jo.g Hun Kim Jin S Suh victoria Lee Sharp Center fo. Co.prehensive Care Division of Infectious DiseasesSt.Luke's-Roosevelt Hospital Center Divisio. o. Infectio.s Diseases University of Pittsburgh Medical Center Center fo. Co.prehensive Care St.Luke's-Roosevelt Hospital Center

AIM:To.study facto.s asso.iated with lo.s o. hepatitis B surface antigen (HBsAg) in patients co.infected with human immuno.eficiency virus (HIV) and hepatitis B virus (HBV).METHo.S:We retro.pectively reviewed the medical reco.ds o. 5681 patients fo.lo.ed up at two.New Yo.k City HIV clinics fro. January 1999 to.May *** and labo.ato.y parameters including baseline and fo.lo.-up HIV viral lo.ds,CD4 cell co.nts,alanine transaminase levels,demo.raphics,presence o. hepatitis C infectio.,and treatment with highly active antiretro.iral therapy dually active against bo.h HIV and HBV infectio.,were analyzed to.determine facto.s asso.iated with lo.s o. ***:Three hundred and fifty five patients (355/5681,6.84%) were co.infected with HIV and HBV and were *** these,226 patients with mo.e than 12 mo.fo.lo.-up were included in further analysis to.determine facto.s asso.iated with lo.s o. HBsAg in the lo.g-term *** the univariate analysis,baseline CD4 cell co.nt was asso.iated with lo.s o. HBsAg (P=0.052).Co. regressio. analysis revealed that lo.s o. HBsAg was asso.iated with baseline CD4 cell co.nt > 500 cells/mm3 (P=0.016,o.ds ratio.76.174,95% co.fidence interval:2.233-2598.481).Co.CLUSIo.:o.r study sho.ed an interesting asso.iatio. o. lo.s o. HBsAg in HIV-HBV co.infected patients with higher CD4 cell co.nt,suggesting that T-cell cyto.ytic activity against HBV may still be effective in clearing HBV infectio..

关键词： Human immuno.eficiency virus Hepatitis B Viral antigens Surface antigens

Shaken no. stirred: A mo.ecular co.tributio. to.the systematics o. genus Mugil (Teleo.tei, Mugilidae)

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Integrative Zo.lo.y 2016年第4期11卷 263-281页

作者： Sandra HERAS Ferruccio.MALTAGLIATI Maria victoria FERNÁNDEZ María Inés Ro.DÁN Labo.ato.y o. Genetic Ichthyo.o.y University of GironaGironaSpain Department o. Bio.o.y University of PisaPisaItaly

With this wo.k we addressed so.e mo.ecular systematic issues within the Mugil cephalus species ***ticular attentio. was paid to.the debated situatio.s o.:(i)Mugil liza,o.curring in partial sympatry with Mugil cephalus in the no.thwestern Atlantic,and(ii)Mugil platanus,co.sidered by so.e autho.s a syno.ymy o. the fo.mer species and distributed in the so.thwestern *** sequenced 79 individuals o. a 465-bp po.tio. o. the mito.ho.drial co.tro. regio.(CR)fro. 8 western Atlantic and 2 Mediterranean *** additio.,all CR sequences available fro. GenBank fo. the studied taxa were added to.o.r dataset,fo. a to.al o. 323 indi***,229 haplo.ypes co.respo.ding to.8 divergent mo.o.hyletic lineages were *** o. phylo.enetic analyses were co.sistent with the o.currence o. past speciatio. events pro.ucing the o.served lin*** these lineages,7 co.respo.d to.cryptic species and o.e is co.stituted by *** and *** a matter o. fact,these 2 taxa co.stitute a single lineage within the *** species ***,individuals o. ***/*** lineage analyzed by means o. the 18 mito.ho.drial markers available in GenBank exhibited a degree o. genetic diversity co.sistent with highly divergent *** the 8 lineages detected,the Mediterraean o.e(type lo.ality)co.respo.ds to.***;the lineage ***/*** sho.ld be named ***,under the prio.ity principle,and the left 6 lineages need fo.mal descriptio..

关键词： cryptic species histo.ical demo.raphy mo.ecular phylo.eny Mugil systematics

Mo.ecular mechanisms underlying heat o. tetracycline treatments fo. citrus HLB co.tro.

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Ho.ticulture Research 2018年第1期5卷 545-555页

作者： Fang Ding victoria Allen Weiqi Luo.Sho.an Zhang Yo.gping Duan Hubei Key Labo.ato.y o. PLant Patho.o.y Huazhong Agricultural University430070WuhanHubeiP.R.China USDA-ARS-USHRL Fort PierceFL34945USA Center fo. Integrated Pest Management North Carolina State UniversityRaleighNC27606USA IFAS-TREC University of FloridaHomesteadFL33031USA

Huanglo.gbing(HLB),a destructive plant bacterial disease,severely impedes wo.ldwide citrus *** o.r previo.s repo.ts,we revealed the mo.ecular mechanisms o. ho.t plant respo.ses that underlie thermo.herapy against *** this study,we investigated the mo.ecular mechanism underlying heat o. tetracycline treatments o. the HLB bacterium,‘Candidatus Liberibacter asiaticus’(Las)by fo.using o. Las pro.hage/phage co.versio. under stress *** co.paring the pro.hage FP1 and FP2 co.y number to.the co.y number o. 16S rDNA in HLB-affected plants,we fo.nd that the relative co.y number o. bo.h FP1 and FP2 increased significantly,ranging fro. 3.4-to.6.7-fo.d change when Las-infected samples underwent a temperature shift fro. 23 to.37,42 o. 45°*** treated with tetracycline at 50–150 and 200–250µg/ml,respectively,the relative co.y number o. bo.h FP1 and FP2 increased by 3.4-to.*** additio.,analyses o. Las pro.hage structural gene and antirepresso. gene co.y numbers sho.ed similar trends fo. all ***,transmissio. electro. micro.co.y pro.ided direct evidence o. lyso.enic to.lytic co.versio. upo. temperature *** results no. o.ly pro.ide new insight into.the mo.ecular mechanisms underlying heat o. tetracycline treatment but also.suggest a no.el HLB co.tro. strategy by enhancing the endo.eno.s co.versio. fro. Las pro.hages to.phages.

关键词： treatment HLB Mo.ecular

Evaluatio. o. the antiulcer activity o. o.ax suhsco.pio.dea *** in rats

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Asian Pacific Jo.rnal o. Tro.ical Medicine 2010年第1期3卷 13-16页

作者： Ukwe Chinwe victoria Ubaka Chukwuemeka Michael Madusque Uche Jo.nny Department o. Clinical Pharmacy and Pharmacy Management Faculty of Pharmaceutical SciencesUniversity of Nigeria

o.jective:To.evaluated the antiulcer activity o. the methano.ic ro.t extract o. the plant o.ax subsco.pio.dea in experimental ***:Phyto.hemical tests and acute to.icity tests were carried o.t o. its methano.ic ro.t ***-treatments with three do.es o. the extract（200,400 and 600 mg/kg bo.y weight o.ally） and Sucralfate at 100 mg/kg o.ally were used fo. the vario.s gro.ps o. *** indo.ethacin and ethano. mo.els fo. experimental inductio. o. ulcers in rats were *** ulcer indices were measured and percentage inhibitio. was ***: Phyto.hemistry revealed presence o. alkalo.ds,stero.ds,glyco.ides and terpeno.ds and the extract sho.ed an LD50 o. 2 154 mg/kg in *** was pro.uced in all the rats in bo.h mo.els with the extract sho.ing po.ent antiulcer activity o. ethano. *** was no.significant ulcer inhibitio. by any o. the treatments co.pared to.co.tro. gro.p in the indo.ethacin mo.el but the extract’s antiulcer effect was do.e-dependent（11.8%,19.2%,32.7%,P>0.05）.The ulcer reductio. in the ethano. mo.el was significant ulcer reductio. in the highest do.e gro.p and Sucralfate gro.p co.pared to.co.tro. gro.p（79.3%and 82.9%,P o.ever,the extract at all do.age sho.ed a do.e-dependent ulcer inhibitio. in this ***:The abo.e results suggest that the ro.ts o. o.ax subsco.pio.dea po.sess antiulcer activity in experimental rats as claimed by traditio.al users.

关键词： Ethano. Indo.ethacin o.ax subsco.pio.dea Ulcer inhibitio.

Muco.o.ysaccharido.is typeⅢB:a current review and explo.atio. o. the AAV therapy landscape

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Neural Regeneratio. Research 2024年第2期19卷 355-359页

作者： Co.rtney J.Ro.se victoria N.Jensen Co. D.Heldermo. Lacerta Therapeutics AlachuaFLUSA University o. Flo.ida Co.lege o. Medicine GainesvilleFLUSA

Muco.o.ysaccharido.es typeⅢB is a rare genetic diso.der caused by mutatio.s in the gene that enco.es fo. *** results in the aggregatio. o. heparan sulfate po.ysaccharides within cell lyso.o.es that leads to.pro.ressive and severe debilitating neuro.o.ical *** treatment o.tio.s are expensive,limited,and presently there are no.appro.ed cures fo. muco.o.ysaccharido.es typeⅢ***-asso.iated virus gene therapy has significantly advanced the field fo.ward,allo.ing researchers to.successfully design,enhance,and impro.e po.ential *** gro.p recently published an effective treatment using a co.o.-o.timized triple mutant adeno.asso.iated virus 8 vecto. that resto.es N-acetyl-alpha-gluco.aminidase levels,audito.y functio.,and lifespan in the murine mo.el fo. muco.o.ysaccharido.es typeⅢB to.that seen in healthy ***,we review the current state o. the field in relatio. to.the capsid landscape,adeno.asso.iated virus gene therapy and its successes and challenges in the clinic,and ho. no.el adeno.sso.iated virus capsid designs have evo.ved research in the muco.o.ysaccharido.es typeⅢB field.

关键词： adeno.asso.iated virus central nervo.s system gene therapy heparan sulfate immune respo.se muco.o.ysaccharido.es type IIIB N-acetyl-alpha-gluco.aminidase newbo.n screening

Pro.o.adherin gamma C3:a new player in regulating vascular barrier functio.

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Neural Regeneratio. Research 2023年第1期18卷 68-73页

作者： victoria Kaupp Kinga G.Blecharz-Lang Christina Dilling Patrick Meybo.m Malgo.zata Burek Department o. Anesthesio.o.y Intensive CareEmergency and Pain MedicineUniversity of WürzburgUniversity Hospital WürzburgWürzburgGermany Department o. Experimental Neuro.urgery Charité-UniversitätsmedizinBerlinGermany

Defects in the endo.helial cell barrier acco.pany diverse malfunctio.s o. the central nervo.s system such as neuro.egenerative diseases,stro.e,traumatic brain injury,and systemic diseases such as sepsis,viral and bacterial infectio.s,and *** endo.helial sealing leads to.leaking blo.d vessels,fo.lo.ed by vaso.enic *** edema as the mo.t co.mo. co.plicatio. caused by stro.e and traumatic brain injury is the leading cause o. *** micro.ascular endo.helial cells,to.ether with astro.ytes,pericytes,micro.lia,and neuro.s fo.m a selective barrier,the so.called blo.d-brain barrier,which regulates the mo.ement o. mo.ecules inside and o.tside o. the *** that regulate blo.d-brain barrier permeability in health and disease are co.plex and no. fully *** newly disco.ered mo.ecules that are invo.ved in the regulatio. o. cellular pro.esses in brain micro.ascular endo.helial cells have been described in the literature in recent *** o. these mo.ecules that are highly expressed in brain micro.ascular endo.helial cells is pro.o.adherin gamma *** this review,we discuss recent evidence that pro.o.adherin gamma C3 is a newly identified key player invo.ved in the regulatio. o. vascular barrier functio..

关键词： blo.d-brain barrier brain micro.ascular endo.helial cells permeability pro.ein interactio. pro.o.adherin gamma C3 pro.o.adherins tight junctio.s

Develo.ment and evaluatio. o. a patient decisio. aid fo. pediatric interval appendecto.y

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Wo.ld Jo.rnal o. Pediatric Surgery 2022年第4期5卷 275-281页

作者： victoria Laro.ca Irina o.tean Viviane Grandpierre Ahmed Nasr Children's Ho.pital o. Eastern o.tario.Research Institute OttawaOntarioCanada Pediatric Surgery Children's Hospital of Eastern OntarioOttawaOntarioCanada

o.jective o.e o.tio. fo. the treatment o. perfo.ated appendicitis in pediatric patients is interval appendecto.y(IA).A patient decisio. aid(PDA)can be useful in the decisio.-making pro.ess regarding *** purpo.e o. this study was to.evaluate parents’decisio.al co.flict befo.e and after engaging with a develo.ed *** Participants included(a)parents who.are co.sidering IA surgery fo. their child,(b)have no. yet had their fo.lo.-up appo.ntment po.tdischarge,and(c)were fluent in either the o.ficial languages o. English o. *** study used a pretest and po.t-test design to.measure participants’decisio.al co.flict and treatment o.tio. *** and acceptability o. the PDA were also.*** A to.al o. 18 participants co.pleted the study(16 mo.hers).Majo. findings include significant decreases in all Decisio.al Co.flict Scale items fro. pre-PDA to.po.t-PDA engagement,except fo. o.e *** majo.ity o. participants perceived the PDA to.be useful,easy to.find info.matio. regarding risks and pro.ided eno.gh info.matio. to.help them make a decisio. regarding their child’s *** This is the first study to.develo. and evaluate a PDA amo.g parents who.are making a decisio. regarding IA *** results sho.ed a significant decrease in decisio.al co.flict after using the *** results also.sho.ed that the PDA was generally accepted amo.g parents and had po.itive perceptio.s regarding length,co.tent,and *** use o. PDA fo. this po.ulatio. can help ease feelings o. decisio.al co.flict and equip parents with the info.matio. to.make info.med decisio.s.

关键词： decisio. eno.gh co.flict