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The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

Current Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles Medina Inés Laso García Fernando González Tello Sara Álvarez Rodríguez Manuel Hevia Palacios Marina Mata Alcaraz César Mínguez Ojeda Fernando Arias Funez victoria Gómez Dos Santos Francisco Javier Burgos Revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of Radiology Hospital Universitario Ramón y CajalMadridSpain

Background:Malignant ureteral obstruction(MUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November ***,clinical,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-Meier method,and univariate and multivariate Cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to MUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing MUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).Recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:Cancer patients with MUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival Prognosis

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H2H时代,人本营销怎么做

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国际公关 2024年第4期 46-55页

作者：杨杨程艳 victoria Guo 闫军庄俊郑雅丽不详创新奇智公关 SEC Newgate明泰策略胶囊时尚(厦门)网络科技有限公司内容山庄俱乐部

当前,技术进步和数字连接逐渐主导市场,随着不断变化的现代商业和营销领域,不同于传统的B2B、B2C模式,H2H(人与人)模式应运而生,开始聚焦于人们容易忽视的人与人的接触。H2H即人对人的营销,这一理念认为,消费者不仅是一个冷漠的、理性... 详细信息

当前,技术进步和数字连接逐渐主导市场,随着不断变化的现代商业和营销领域,不同于传统的B2B、B2C模式,H2H(人与人)模式应运而生,开始聚焦于人们容易忽视的人与人的接触。H2H即人对人的营销,这一理念认为,消费者不仅是一个冷漠的、理性的经济实体,而是具有情感、价值观和人际关系的个体。品牌应该如何利用该理念进行营销?H2H给公关带来了哪些新思考?本期焦点对话邀请嘉宾进行讨论,以期带来更多的理论知识和实操建议。

关键词：营销领域现代商业主导市场 B2C模式 B2B 人本营销经济实体消费者

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Protective effects of naringin on fipronil-induced cardiovascular and renal dysfunctions in rats

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Clinical Traditional Medicine and Pharmacology 2024年第3期5卷 13-21页

作者： Temitayo Olabisi Ajibade Esther Oluwaseyi Oliyide Oluwaseun Olanrewaju Esan Moses Olusola Adetona Omolola victoria Awoyomi Taiwo Olaide Oyagbemi Adewumi victoria Adeogun Ademola Adetokunbo Oyagbemi Temidayo Olutayo Omobowale Kehinde Olugboyega Soetan Sanah Malomile Nkadimeng Lyndy Joy McGaw Prudence Ngalula Kayoka-Kabongo Momoh Audu Yakubu Evaristus Nwulia Oluwafemi Omoniyi Oguntibeju Department of Veterinary Physiology and Biochemistry Faculty of Veterinary MedicineUniversity of IbadanIbadanOyo State 200001Nigeria Department of Veterinary Medicine Faculty of Veterinary MedicineUniversity of Ibadan IbadanOyo State 200001Nigeria Department of Anatomy Faculty of Basic Medical SciencesCollege of MedicineUniversity of IbadanIbadanOyo State 200001Nigeria Federal College of Animal Health and Production Technology Moor PlantationIbadanOyo State 200001Nigeria Department of Life and Consumer Sciences Collage of Agriculture and Environmental SciencesUniversity of South Africa Florida CampusUniversity of South AfricaUnisa 0003South Africa Department of Paraclinical Science Faculty of Veterinary ScienceUniversity of PretoriaOnderstepoort01100028South Africa Department of Environmental&Interdisciplinary Sciences College of ScienceEngineering&TechnologyCOPHSTexas Southern UniversityHoustonTX 77587USA Howard University College of MedicineDepartment of Psychiatry and Behavioral SciencesHoward University Hospital2041 Georgia AvenueWashingtonDC 20060USA Department of Biomedical Sciences Faculty of Health and Wellness SciencesCape Peninsula University of TechnologyBellvill 7535South Africa

Background:Naringin as a bioflavanone glycoside is abundant in citrus fruits,which since ancient times have been utilized as natural herbal treatments in traditional *** has potent antioxidant effect that may mitigate oxidative stress mediated cardiovascular and renal dysfunctions in mammalian ***:To explore probable modulatory actions of naringin on fipronil-induced cardio-renal ***:Twenty-four Wistar rats weighing 140±3.0 g were divided into four groups including normal control(saline),10 mg/kg Fipronil(FIP),FIP+100 mg/kg naringin,and 100 mg/kg *** of naringin and fipronil was by oral gavage for 28 consecutive ***,blood pressure monitoring,biochemical assays,histology,and immunohistochemical evaluations were ***:Naringin significantly(P<0.001)lessened blood pressure parameters,oxidative stress markers but significantly(P<0.001)heightened the systemic ***,naringin prevented fipronil-induced histopathological lesions such as congestion and cellular infiltration in cardiac and renal ***,naringin attenuated the immunohistochemical expression of troponin 1 and matrix metalloperoxidase-2 in cardiac tissues,but heightened angiotensin converting enzyme 2 expression in contrast to that of fipronil ***:The observation in this study shows potent attenuation of fipronil-induced toxicity by naringin,through inhibiting processes related to oxidation and inflammation.

关键词： Biomarkers of cardiorenal dysfunction Fipronil toxicity Naringin Immunohistochemistry

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Oxidized organic molecules in the tropical free troposphere over Amazonia

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National Science Review 2024年第1期11卷 174-184页

作者： Qiaozhi Zha Diego Aliaga Radovan Krejci victoria A.Sinclair Cheng Wu Giancarlo Ciarelli Wiebke Scholz Liine Heikkinen Eva Partoll Yvette Gramlich Wei Huang Markus Leiminger Joonas Enroth Otso Per?kyl? Runlong Cai Xuemeng Chen Alkuin Maximilian Koenig Fernando Velarde Isabel Moreno Tuukka Pet?j? Paulo Artaxo Paolo Laj Armin Hansel Samara Carbone Markku Kulmala Marcos Andrade Douglas Worsnop Claudia Mohr Federico Bianchi Institute for Atmospheric and Earth System Research/Physics University of Helsinki Joint International Research Laboratory of Atmospheric and Earth System Sciences Nanjing University Department of Environmental Science & Bolin Centre for Climate Research Stockholm University Department of Chemistry and Molecular Biology University of Gothenburg Institute for Ion and Applied Physics University of Innsbruck Ionicon Analytik GmbH Laboratory for Atmospheric Physics Institute for Physics Research Universidad Mayor de San Andrés Institute of Physics University of Sao Paulo Institute for Geosciences and Environmental Research (IGE) University of Grenoble Alpes Agrarian Sciences Institute Federal University of Uberl?ndia Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Department of Atmospheric and Oceanic Sciences University of Maryland Aerodyne Research Inc. Department of Environmental System Science ETH Zürich Switzerland and Laboratory of Atmospheric Chemistry Paul Scherrer Institute

New particle formation(NPF) in the tropical free troposphere(FT) is a globally important source of cloud condensation nuclei, affecting cloud properties and climate. Oxidized organic molecules(OOMs)produced from biogenic volatile organic compounds are believed to contribute to aerosol formation in the tropical FT, but without direct chemical observations. We performed in situ molecular-level OOMs measurements at the Bolivian station Chacaltaya at 5240 m above sea level, on the western edge of Amazonia. For the first time, we demonstrate the presence of OOMs, mainly with 4–5 carbon atoms, in both gas-phase and particle-phase(in terms of mass contribution) measurements in tropical FT air from Amazonia. These observations, combined with air mass history analyses, indicate that the observed OOMs are linked to isoprene emitted from the rainforests hundreds of kilometers away. Based on particle-phase measurements, we find that these compounds can contribute to NPF, at least the growth of newly formed nanoparticles, in the tropical FT on a continental scale. Thus, our study is a fundamental and significant step in understanding the aerosol formation process in the tropical FT.

关键词： oxidized organic molecules tropical aerosol formation Amazon free troposphere

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Comparison between Care Strategies for Patients with Osteoarthritis of the Hands Based on the Use of Joint Protection, Assistive Technology and Exercises

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Open Journal of Orthopedics 2024年第7期14卷 295-311页

作者： Daniele dos Santos Scarcella Talita Dias da Silva victoria Yanara Hernandes da Silva Maria Cândida de Miranda Luzo Selma Lancman Marcia Uchoa de Rezende Carlos Bandeira de Mello Monteiro Instituto de Ortopedia e Traumatologia Hospital das Clnicas HCFMUSP Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Programa de Ps-Graduao em Cincias da Reabilitao Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Escola de Artes Cincias e Humanidades Universidade de So Paulo So Paulo Brazil

Background: Osteoarthritis (OA) is a disabling disease that can affect 6% to 12% of the adult population and more than a third of people over 65 years of age. Purpose: To assess whether a group of people with hand osteoarthritis (hOA) who received different types of treatment improved their function after two years of follow-up. Method: The entire sample (n = 97) underwent three follow-up assessments regarding anthropometric parameters of the upper limbs and ability to perform functional activities. Subsequently, the sample was divided into two groups for the intervention periods, called the First Period (n = 73) and the Second Period (n = 24);the First Period kept the same protocol with orientations, and the Second Period went to an intervention with orientation strength exercises and use of orthosis. Findings: In the separate analysis of the three questions of the DASH pain module, no differences were found between the assessment moments for groups of guidelines, treatment, or symptoms. Significant effects were observed for F(2, 162) = 3.5, p = 0.033, η2 = 0.04, and interaction for moments and intervention F(2, 162) = 4.3, p = 0.016, η2 = 0.05. Implications: It can be concluded that only guidance treatment does not benefit patients with hand osteoarthritis. In contrast, guidance, exercise, and orthosis treatment can significantly improve the disease.

关键词： Hand Osteoarthritis Hand Deformities Occupational Therapy

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Investigation of electrophysical, photo- and gas-sensitive properties of ZnO–SnO_(2) sol–gel fflms

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Journal of Advanced Dielectrics 2024年第1期14卷 42-50页

作者： Irina A.Gulyaeva Alexandra P.Ivanisheva Maria G.Volkova victoria Yu.Storozhenko Soslan A.Khubezhov Ekaterina M.Bayan Victor V.Petrov Research and Education Centre“Microsystem Technics and Multisensory Monitoring Systems”Southern Federal University Russia Department of Chemistry Southern Federal UniversityRussia Department of Physics North-Ossetian State University362025 VladikavkazRussia Department of Physics and Engineering ITMO University191002 PetersburgRussia

Thin nanocomposite fflms based on tin dioxide with a low content of zinc oxide(0.5–5 mol.%)were obtained by the sol–gel *** synthesized fflms are 300–600 nm thick and contains pore sizes of 19–29 *** resulting ZnO–SnO_(2) fflms were comprehensively studied by atomic force and Kelvin probe force microscopy,X-ray diffraction,scanning electron microscopy,and high-resolution X-ray photoelectron spectroscopy *** photoconductivity parameters on exposure to light with a wavelength of 470 nm were also *** study of the photosensitivity kinetics of ZnO–SnO_(2) fflms showed that the fflm with the Zn:Sn ratio equal to 0.5:99.5 has the minimum value of the charge carrier generation time *** of the activation energy of the conductivity,potential barrier,and surface potential of ZnO–SnO_(2) fflms showed that these parameters have maxima at ZnO concentrations of 0.5 mol.%and 1 mol.%.Films with 1 mol.%ZnO exhibit high response values when exposed to 5–50 ppm of nitrogen dioxide at operating temperatures of 200℃ and 250℃.

关键词： Sol–gel method,ZnO–SnO_(2) films gas-sensitive properties surface potential potential barrier conduction activation energy

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Modelling the nesting-habitat of threatened vulture species in the caucasus:An ecosystem approach to formalising environmental factors in species distribution models

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Avian Research 2023年第4期14卷 572-585页

作者： Rustam Pshegusov victoria Chadaeva Tembotov Institute of Ecology of Mountain Territories of Russian Academy of Science I.Armand Str.37а360051NalchikRussia

Abiotic factors play an important role in species localisation,but biotic and anthropogenic predictors must also be considered in distribution modelling for models to be biologically *** this study,we formalised the biotic predictors of nesting sites for four threatened Caucasian vultures by including species distribution models(wild ungulates,nesting tree species)as biotic layers in the vulture Maxent *** was applied in the R dismo package and the best set of the model parameters were defined in the R ENMeval *** metrics were continuous Boyce index,Akaike's information criterion,the area under receiver operating curve and true skill *** also calculated and evaluated the null *** density estimation method was applied to assess the overlap of vulture ecological niches in the environmental *** accessibility of anthropogenic food resources was estimated using the Path Distance measure that considers elevation *** availability of pine forests(Scots Pine)and wild ungulates(Alpine Chamois and Caucasian Goat)contributed the most(29.6%and 34.3%)to Cinereous Vulture(Aegypius monachus)nesting site *** ungulate distribution also contributed significantly(about 46%)to the Bearded Vulture(Gypaetus barbatus)*** scavenger nests in the highlands of the Caucasus at a minimum distance of 5–10 km from anthropogenic *** contrast,livestock as a food source was most important in colony distribution of Griffon Vulture(Gyps fulvus).The contribution of distances to settlements and agricultural facilities to the model was 45%.The optimal distance from Egyptian Vulture(Neophron percnopterus)nesting sites to settlements was only 3–10 km,to livestock facilities no more than 15 km with the factor contribution of about 57%.Excluding the wild ungulate availability,the ecological niches of studied vultures overlapped *** similar foraging and nesting requirements,Caucasian vultures are no

关键词： Caucasian vultures Ecological niche differentiation Maxent Nesting sites Species distribution models

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Shop&Go:TSP heuristics for an optimal shopping with smartphones

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Science China(Information Sciences) 2013年第11期56卷 45-56页

作者： Inmaculada PARDINES victoria LOPEZ Department of Computer Architecture Faculty of Computer Science Universidad ComplutenseMadrid 28040 Spain

Mobile technology has been under constant growth in last *** emergence of smartphones has encouraged the development of a wide variety of mobile *** of them are related to daily *** this regard,we propose the Shop&Go mobile application which allows a supermarket customer to do the shopping covering the shortest distance1).An analysis of the routing problem applied to an efcient way of doing the shopping is made.A map with items distribution and distances between products is provided by the *** on these information two heuristics have been proposed to do the shopping following the optimum *** heuristics have been compared,proving that neither of them can be defned as the best one in all *** products in the shopping list determine which is the best solution for each ***,both algorithms have been included in our application,letting the user decide which route he/she wants to ***&Go has also other functionalities which are extensively described in the *** over an HTC Desire mobile are shown to demonstrate the proper tool ***,a study of consumer acceptance has been made to know its possibilities of success in the mobile technology market.

关键词： mobile applications routing problems Android operating system shopping list optimum path

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Fruit Fly as a Model Organism for Blood-Brain Barrier Penetration and Infectious Disease in the Nanomedical Niche

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Journal of Bionic Engineering 2020年第3期17卷 553-569页

作者： victoria Meng-Ting Wu Vuk Uskokovic MP Biomedicals 9 GoddardIrvineCA 92618USA Department of Mechanical and Aerospace Engineering University of CaliforniaEngineering Gateway 4200Irviney CA 92697USA

Drosophila melanogaster,*** common fhiit fly,is a simple organism that may give a rapid,high-throughput response in regard to the therapeutic efficacy of nanoparticles and drugs,while circumventing the high environmental and monetary cost of today's typical in vivo assays involving more complex animals,along with the immeasurable suffering imposed onto *** we give the progress report on our effort to turn *** into a model organism for the in vivo testing of Blood-Brain Barrier(BBB)penetration of nanoparticles and the treatment of infectious *** show that orally ingested superparamagnetic nanoparticles successfully cross the BBB in *** and localize to the optic lobes of the third instar larval brain,while causing no adverse effects to the invertebrate *** also show that both orally ingested calcium phosphate nanoparticles and biofilm-forming *** localize to the Drosophila crop,the food storage organ of the fly,which shrinks in response to *** model does not induce mortality consequential to infection and the effects of the internalization and proliferation of the microbes are evaluable by measuring the crop parameters,including fluorescence intensity and *** development of these two models could simplify the preclinical testing of medical treatments and of pharmaceutical agents for neurological and infectious disease,while ensuring robust and reliable levels of statistical significance at low cost.

关键词： animal model calcium phosphate in vivo iron oxide nanoparticle

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Preparation and Structural Chemistry of a Series of Rare Earth Compounds REPS_4

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Journal of Rare Earths 1999年第1期17卷 7-12页

作者： Huang, Zhongle Cajipe, victoria Molinic, Philippe Xiamen Univ Xiamen China

The thiophosphates of the rare earths REPS 4(RE=Y, La～Lu) were prepared by solid state reaction. Their unit cell parameters and the structures of HoPS 4, ErPS 4 and TmPS 4 were determined by X ray powder diffraction. All REPS 4(RE=Y, La～Yb) crystallize in the tetragonal space group I4 1/acd , a ≈1 1 nm, c ≈1 9 nm, Z =16 . Each RE 3+ is surrounded by eight sulfurs and thus forms a distorted tetragonal antiprism. This kind of structures has significant Van Der Waals′ vacant space with a diameter of about 0 625 nm along c axis and of 0 35 nm along a and b axis. But LuPS 4 crystallizes in a monoclinic structure which is most probably layered. The influence of lanthanide contraction on the stability of the tetragonal REAX 4 structure was studied and a criterion for the existence of the tetragonal structure in the REAX 4 series compounds is proposed. There is 2 4 d A X / r 1 9.

关键词： Rare earths Thiophosphate Crystal structure

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